SG11202008620VA - Humanized rodents for testing therapeutic agents - Google Patents

Humanized rodents for testing therapeutic agents

Info

Publication number
SG11202008620VA
SG11202008620VA SG11202008620VA SG11202008620VA SG11202008620VA SG 11202008620V A SG11202008620V A SG 11202008620VA SG 11202008620V A SG11202008620V A SG 11202008620VA SG 11202008620V A SG11202008620V A SG 11202008620VA SG 11202008620V A SG11202008620V A SG 11202008620VA
Authority
SG
Singapore
Prior art keywords
therapeutic agents
testing therapeutic
humanized rodents
rodents
humanized
Prior art date
Application number
SG11202008620VA
Inventor
Vera Voronina
Corey Momont
John Mcwhirter
Naxin Tu
Lynn Macdonald
Andrew J Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202008620VA publication Critical patent/SG11202008620VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
SG11202008620VA 2018-03-26 2019-03-25 Humanized rodents for testing therapeutic agents SG11202008620VA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862648197P 2018-03-26 2018-03-26
US201862689628P 2018-06-25 2018-06-25
PCT/US2019/023899 WO2019190990A1 (en) 2018-03-26 2019-03-25 Humanized rodents for testing therapeutic agents

Publications (1)

Publication Number Publication Date
SG11202008620VA true SG11202008620VA (en) 2020-10-29

Family

ID=66041822

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202008620VA SG11202008620VA (en) 2018-03-26 2019-03-25 Humanized rodents for testing therapeutic agents

Country Status (12)

Country Link
US (2) US11576984B2 (en)
EP (1) EP3772926A1 (en)
JP (2) JP7328243B2 (en)
KR (1) KR20210004994A (en)
CN (2) CN116420679A (en)
AU (1) AU2019242586A1 (en)
CA (1) CA3093850A1 (en)
IL (1) IL277355A (en)
MA (1) MA52177A (en)
SG (1) SG11202008620VA (en)
TW (1) TWI829679B (en)
WO (1) WO2019190990A1 (en)

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KR20210031868A (en) 2018-07-16 2021-03-23 리제너론 파마슈티칼스 인코포레이티드 Non-human animal model of DITRA disease and uses thereof
EP3927153A1 (en) 2019-02-22 2021-12-29 Regeneron Pharmaceuticals, Inc. Rodents having genetically modified sodium channels and methods of use thereof
SG11202108454RA (en) 2019-04-04 2021-09-29 Regeneron Pharma Non-human animals comprising a humanized coagulation factor 12 locus
CA3137761A1 (en) 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
MX2021015122A (en) 2019-06-07 2022-04-06 Regeneron Pharma Non-human animals comprising a humanized albumin locus.
KR20230147048A (en) 2020-12-16 2023-10-20 리제너론 파마슈티칼스 인코포레이티드 Mice expressing humanized Fc alpha receptors

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Also Published As

Publication number Publication date
MA52177A (en) 2021-02-17
US11576984B2 (en) 2023-02-14
CA3093850A1 (en) 2019-10-03
WO2019190990A4 (en) 2020-01-02
WO2019190990A1 (en) 2019-10-03
CN116420679A (en) 2023-07-14
EP3772926A1 (en) 2021-02-17
CN112105260A (en) 2020-12-18
CN112105260B (en) 2023-04-28
AU2019242586A1 (en) 2020-10-01
TWI829679B (en) 2024-01-21
US20190290783A1 (en) 2019-09-26
TW202003852A (en) 2020-01-16
JP7328243B2 (en) 2023-08-16
RU2020133441A (en) 2022-04-26
JP2023116487A (en) 2023-08-22
IL277355A (en) 2020-11-30
US20230277692A1 (en) 2023-09-07
KR20210004994A (en) 2021-01-13
JP2021519418A (en) 2021-08-10

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