CY1119773T1 - Ανθρωποποιημενα il-4 και il-4r αλφα ζωα - Google Patents

Ανθρωποποιημενα il-4 και il-4r αλφα ζωα

Info

Publication number
CY1119773T1
CY1119773T1 CY20181100040T CY181100040T CY1119773T1 CY 1119773 T1 CY1119773 T1 CY 1119773T1 CY 20181100040 T CY20181100040 T CY 20181100040T CY 181100040 T CY181100040 T CY 181100040T CY 1119773 T1 CY1119773 T1 CY 1119773T1
Authority
CY
Cyprus
Prior art keywords
human
humanized
gene
animals
human animals
Prior art date
Application number
CY20181100040T
Other languages
English (en)
Inventor
Li-Hsien Wang
Yingzi Xue
Andrew J. Murphy
Sean Stevens
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of CY1119773T1 publication Critical patent/CY1119773T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Abstract

Δίδονται ζώα μη-άνθρωποι που περιέχουν μία ανθρώπινη ή ανθρωποποιημένη IL4 και/ή IL-4R αλληλουχία νουκλεϊκών οξέων. Περιγράφονται ζώα μη-άνθρωποι τα οποία περιέχουν μία συνολική ή μερική αντικατάσταση του ενδογενούς IL4 γονιδίου και/ή IL-4R γονιδίου με ένα ανθρώπινο IL4 γονίδιο κα/ή IL-4R γονίδιο και μέθοδοι για τη δημιουργία και χρήση ζώων μη-ανθρώπων. Δίδονται επίσης ζώα μη-άνθρωποι που περιέχουν ένα ανθρώπινο ή ανθρωποποιημένο IL4 γονίδιο υπό τον έλεγχο μη-ανθρώπινων IL4 ρυθμιστικών στοιχείων, όπου συμπεριλαμβάνονται ζώα μη-άνθρωποι που έχουν μία αντικατάσταση μίας μη-ανθρώπινης αλληλουχίας που κωδικοποιεί IL4 με μία ανθρώπινη αλληλουχία που κωδικοποιεί IL4 σε έναν ενδογενή μη-ανθρώπινο IL4 τόπο. Δίδονται επίσης ζώα μη-άνθρωποι που περιέχουν ένα ανθρώπινο ή ανθρωποποιημένο IL-4R γονίδιο υπό τον έλεγχο μη-ανθρώπινων IL-4R ρυθμιστικών στοιχείων, όπου συμπεριλαμβάνονται ζώα μη-άνθρωποι που έχουν μία αντικατάσταση μίας μη-ανθρώπινης αλληλουχίας που κωδικοποιεί IL-4R με ανθρώπινη ή ανθρωποποιημένη αλληλουχία που κωδικοποιεί IL-4R σε έναν ενδογενή μη-ανθρώπινο IL-4R τόπο. Δίδονται ζώα μη-άνθρωποι που περιέχουν ανθρώπινο ή ανθρωποποιημένο IL4 γονίδιο και/ή IL-4R αλληλουχίες, όπου τα ζώα μη-άνθρωποι είναι τρωκτικά, π.χ. ποντικοί ή αρουραίοι.
CY20181100040T 2014-05-07 2018-01-15 Ανθρωποποιημενα il-4 και il-4r αλφα ζωα CY1119773T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461989757P 2014-05-07 2014-05-07
PCT/US2015/029638 WO2015171861A1 (en) 2014-05-07 2015-05-07 Humanized il-4 and il-4r alpha animals

Publications (1)

Publication Number Publication Date
CY1119773T1 true CY1119773T1 (el) 2018-06-27

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CY20181100040T CY1119773T1 (el) 2014-05-07 2018-01-15 Ανθρωποποιημενα il-4 και il-4r αλφα ζωα
CY20211100805T CY1124605T1 (el) 2014-05-07 2021-09-14 Ζωα με εξανθρωπισμενα il-4 και il-4r αλφα

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Country Status (25)

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US (7) US9565841B2 (el)
EP (3) EP3281521B1 (el)
JP (4) JP6640740B2 (el)
KR (2) KR102473565B1 (el)
CN (2) CN110269047B (el)
AU (2) AU2015255977B2 (el)
BR (1) BR112016025745A2 (el)
CA (2) CA3207834A1 (el)
CY (2) CY1119773T1 (el)
DK (2) DK3281521T3 (el)
ES (2) ES2656529T3 (el)
HR (2) HRP20211455T1 (el)
HU (2) HUE038028T2 (el)
IL (3) IL297105B2 (el)
LT (2) LT3281521T (el)
MX (1) MX370672B (el)
NO (1) NO2785538T3 (el)
PH (1) PH12016502058A1 (el)
PL (2) PL3027015T3 (el)
PT (2) PT3027015T (el)
RS (2) RS57073B1 (el)
RU (1) RU2703139C2 (el)
SG (2) SG11201608570YA (el)
SI (2) SI3281521T1 (el)
WO (1) WO2015171861A1 (el)

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HRP20180242T1 (hr) 2018-03-09
AU2015255977B2 (en) 2021-09-02
EP3027015A1 (en) 2016-06-08
PL3281521T3 (pl) 2022-01-03
US10477842B2 (en) 2019-11-19
US11109578B2 (en) 2021-09-07
IL297105B2 (en) 2024-01-01
CA2947307A1 (en) 2015-11-12
US20230027494A1 (en) 2023-01-26
SI3281521T1 (sl) 2021-11-30
RS62345B1 (sr) 2021-10-29
KR20220165814A (ko) 2022-12-15
SI3027015T1 (en) 2018-02-28
WO2015171861A1 (en) 2015-11-12
EP3281521B1 (en) 2021-06-30
IL304841A (en) 2023-09-01
AU2021218060B2 (en) 2024-04-11
IL297105B1 (en) 2023-09-01
US20180000056A1 (en) 2018-01-04
CY1124605T1 (el) 2022-07-22
JP7145250B2 (ja) 2022-09-30
JP2022171841A (ja) 2022-11-11
KR102517112B1 (ko) 2023-04-03
PH12016502058A1 (en) 2017-01-09
KR102473565B1 (ko) 2022-12-02
EP3027015B1 (en) 2017-11-08
EP3906781A1 (en) 2021-11-10
JP2020058379A (ja) 2020-04-16
RU2016143376A3 (el) 2018-11-22
IL248358B2 (en) 2023-03-01
LT3027015T (lt) 2018-01-25
CN110269047B (zh) 2021-11-02
CN106470545B (zh) 2019-08-20
US9565841B2 (en) 2017-02-14
IL248358B (en) 2022-11-01
IL248358A0 (en) 2016-11-30
JP2021087434A (ja) 2021-06-10
AU2015255977A1 (en) 2016-11-17
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