SG10201403703XA - Methods of producing humanized non-human mammals - Google Patents

Methods of producing humanized non-human mammals

Info

Publication number
SG10201403703XA
SG10201403703XA SG10201403703XA SG10201403703XA SG10201403703XA SG 10201403703X A SG10201403703X A SG 10201403703XA SG 10201403703X A SG10201403703X A SG 10201403703XA SG 10201403703X A SG10201403703X A SG 10201403703XA SG 10201403703X A SG10201403703X A SG 10201403703XA
Authority
SG
Singapore
Prior art keywords
methods
human mammals
producing humanized
humanized non
producing
Prior art date
Application number
SG10201403703XA
Inventor
Qingfeng Chen
Jianzhu Chen
Original Assignee
Qingfeng Chen
Jianzhu Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qingfeng Chen, Jianzhu Chen filed Critical Qingfeng Chen
Publication of SG10201403703XA publication Critical patent/SG10201403703XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG10201403703XA 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals SG10201403703XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22143809P 2009-06-29 2009-06-29

Publications (1)

Publication Number Publication Date
SG10201403703XA true SG10201403703XA (en) 2014-10-30

Family

ID=43411395

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201403703XA SG10201403703XA (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals
SG2011084647A SG176118A1 (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2011084647A SG176118A1 (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

Country Status (6)

Country Link
US (1) US20120157667A1 (en)
EP (1) EP2449094A4 (en)
JP (1) JP2012531896A (en)
CN (1) CN102725400A (en)
SG (2) SG10201403703XA (en)
WO (1) WO2011002727A1 (en)

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EP3056082B1 (en) 2009-10-06 2018-09-05 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
ES2948210T3 (en) 2011-02-15 2023-09-06 Regeneron Pharma Mice humanized with M-CSF and their use
EP2788758A4 (en) * 2011-12-06 2015-06-10 Massachusetts Inst Technology Use of humanized mice to determine toxicity
CN103387955B (en) * 2012-05-10 2015-04-29 上海南方模式生物科技发展有限公司 Making method and use of non-human mammal B lymphocyte defect animal model
WO2014039733A1 (en) * 2012-09-05 2014-03-13 University Of Southern California Methods and compositions for detecting, imaging, and treating small cell lung cancer utilizing post-translationally modified residues and higher molecular weight antigenic complexes in proteins
KR102340059B1 (en) * 2012-09-07 2021-12-17 예일 유니버시티 Genetically modified non-human animals and methods of use thereof
MX370856B (en) 2012-11-05 2020-01-08 Regeneron Pharma Genetically modified non-human animals and methods of use thereof.
WO2014121840A1 (en) * 2013-02-07 2014-08-14 Medizinische Hochschule Hannover Induced dendritic cells and uses thereof
US20160135437A1 (en) * 2013-06-05 2016-05-19 Agency For Science, Technology And Research Humanized mouse model for study of bona fide hepatitis virus infection and use thereof
NO2785538T3 (en) * 2014-05-07 2018-08-04
SG10202002187WA (en) * 2014-05-19 2020-04-29 Regeneron Pharma Genetically modified non-human animals expressing human epo
RU2730599C2 (en) 2015-04-13 2020-08-24 Ридженерон Фармасьютикалз, Инк. Humanised mice with sirpa-il15 nokin and methods for using them
JP6654001B2 (en) * 2015-05-27 2020-02-26 公益財団法人実験動物中央研究所 Human IL-15 secreting immunodeficient mouse
EP3383173B1 (en) * 2015-11-30 2020-11-25 H. Hoffnabb-La Roche Ag Generation of human macrophages in immunodeficient mice
US20200315147A1 (en) * 2017-11-17 2020-10-08 University Of Tsukuba Non-human animal and method for producing same
WO2020135518A1 (en) 2018-12-25 2020-07-02 Biocytogen Jiangsu Co., Ltd. Genetically modified non-human animal with human or chimeric il15
CN111172190B (en) * 2018-12-25 2021-07-30 百奥赛图江苏基因生物技术有限公司 Construction method and application of humanized cell factor CSF2 gene modified non-human animal
CN113473849A (en) * 2019-01-28 2021-10-01 公益财团法人实验动物中央研究所 Non-human animals with human IL-34 and uses thereof
US20220136002A1 (en) * 2019-02-13 2022-05-05 The Jackson Laboratory Transgenic mouse models supporting innate immune function
EP3950949A4 (en) * 2019-03-28 2022-12-28 Central Institute For Experimental Animals Immunodeficient rodent
CN111485001A (en) * 2020-04-14 2020-08-04 澎立生物医药技术（上海）有限公司 Construction method of humanized immune system mouse with NK (Natural killer) cell and ADCC (advanced Charge coupled device) capabilities
CN115997017A (en) * 2020-07-08 2023-04-21 杰克逊实验室 Transgenic mouse model supporting human innate immunity
CN112042597B (en) * 2020-07-22 2022-04-29 南京普恩瑞生物科技有限公司 Construction method of double humanized tumor xenograft model
WO2022222958A1 (en) * 2021-04-20 2022-10-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric genes

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EP2414523B1 (en) * 2009-04-03 2020-07-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Dendritic cell-boosted humanized immune system mice
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EP3056082B1 (en) * 2009-10-06 2018-09-05 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment

Also Published As

Publication number Publication date
JP2012531896A (en) 2012-12-13
WO2011002727A1 (en) 2011-01-06
CN102725400A (en) 2012-10-10
WO2011002727A9 (en) 2011-02-24
SG176118A1 (en) 2011-12-29
EP2449094A4 (en) 2013-07-10
EP2449094A1 (en) 2012-05-09
US20120157667A1 (en) 2012-06-21

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