MA52177A - Rongeurs humanisés pour tester des agents thérapeutiques - Google Patents

Rongeurs humanisés pour tester des agents thérapeutiques

Info

Publication number
MA52177A
MA52177A MA052177A MA52177A MA52177A MA 52177 A MA52177 A MA 52177A MA 052177 A MA052177 A MA 052177A MA 52177 A MA52177 A MA 52177A MA 52177 A MA52177 A MA 52177A
Authority
MA
Morocco
Prior art keywords
therapeutic agents
test therapeutic
humanized rodents
rodents
humanized
Prior art date
Application number
MA052177A
Other languages
English (en)
Inventor
Lynn Macdonald
John Mcwhirter
Corey Momont
Andrew J Murphy
Naxin Tu
Vera Voronina
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MA52177A publication Critical patent/MA52177A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
MA052177A 2018-03-26 2019-03-25 Rongeurs humanisés pour tester des agents thérapeutiques MA52177A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862648197P 2018-03-26 2018-03-26
US201862689628P 2018-06-25 2018-06-25

Publications (1)

Publication Number Publication Date
MA52177A true MA52177A (fr) 2021-02-17

Family

ID=66041822

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052177A MA52177A (fr) 2018-03-26 2019-03-25 Rongeurs humanisés pour tester des agents thérapeutiques

Country Status (12)

Country Link
US (2) US11576984B2 (fr)
EP (1) EP3772926A1 (fr)
JP (2) JP7328243B2 (fr)
KR (1) KR20210004994A (fr)
CN (2) CN112105260B (fr)
AU (1) AU2019242586A1 (fr)
CA (1) CA3093850A1 (fr)
IL (1) IL277355A (fr)
MA (1) MA52177A (fr)
SG (1) SG11202008620VA (fr)
TW (1) TWI829679B (fr)
WO (1) WO2019190990A1 (fr)

Families Citing this family (8)

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EP3585164B1 (fr) 2017-11-30 2023-12-27 Regeneron Pharmaceuticals, Inc. Rats comprenant un locus trkb humanisé
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CN112638154B (zh) 2018-07-16 2022-10-18 瑞泽恩制药公司 Ditra疾病的非人动物模型及其用途
MX2021009855A (es) 2019-02-22 2021-09-10 Regeneron Pharma Roedores que tienen canales de sodio modificados geneticamente y metodos de uso de los mismos.
ES2966625T3 (es) 2019-04-04 2024-04-23 Regeneron Pharma Roedores que comprenden un locus del factor de coagulación 12 humanizado
JP2022534867A (ja) 2019-06-04 2022-08-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法
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CN116848254A (zh) 2020-12-16 2023-10-03 瑞泽恩制药公司 表达人源化Fcα受体的小鼠

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WO2016203597A1 (fr) * 2015-06-18 2016-12-22 株式会社トランスジェニック Souris humanisée par un organe
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KR20240016444A (ko) 2016-05-20 2024-02-06 리제너론 파마슈티칼스 인코포레이티드 다중 가이드 RNAs를 이용한 면역학적 내성 파괴 방법
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EP3585164B1 (fr) 2017-11-30 2023-12-27 Regeneron Pharmaceuticals, Inc. Rats comprenant un locus trkb humanisé
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AU2019242586A1 (en) 2020-10-01
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EP3772926A1 (fr) 2021-02-17
US20190290783A1 (en) 2019-09-26
SG11202008620VA (en) 2020-10-29
RU2020133441A (ru) 2022-04-26
CN116420679A (zh) 2023-07-14
TW202003852A (zh) 2020-01-16
KR20210004994A (ko) 2021-01-13
TWI829679B (zh) 2024-01-21
WO2019190990A1 (fr) 2019-10-03
WO2019190990A4 (fr) 2020-01-02
CA3093850A1 (fr) 2019-10-03
CN112105260A (zh) 2020-12-18
JP7328243B2 (ja) 2023-08-16
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