SG11202002456WA - Non-human animals comprising a humanized trkb locus - Google Patents
Non-human animals comprising a humanized trkb locusInfo
- Publication number
- SG11202002456WA SG11202002456WA SG11202002456WA SG11202002456WA SG11202002456WA SG 11202002456W A SG11202002456W A SG 11202002456WA SG 11202002456W A SG11202002456W A SG 11202002456WA SG 11202002456W A SG11202002456W A SG 11202002456WA SG 11202002456W A SG11202002456W A SG 11202002456WA
- Authority
- SG
- Singapore
- Prior art keywords
- human animals
- trkb locus
- humanized trkb
- humanized
- locus
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title 1
- 101150056950 Ntrk2 gene Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762592905P | 2017-11-30 | 2017-11-30 | |
| US201862661373P | 2018-04-23 | 2018-04-23 | |
| PCT/US2018/063390 WO2019108983A1 (en) | 2017-11-30 | 2018-11-30 | Non-human animals comprising a humanized trkb locus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202002456WA true SG11202002456WA (en) | 2020-04-29 |
Family
ID=64734209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202002456WA SG11202002456WA (en) | 2017-11-30 | 2018-11-30 | Non-human animals comprising a humanized trkb locus |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11419318B2 (en) |
| EP (2) | EP4299732A3 (en) |
| JP (2) | JP7361031B2 (en) |
| KR (1) | KR20200090770A (en) |
| CN (2) | CN116064611A (en) |
| AU (1) | AU2018375796A1 (en) |
| CA (1) | CA3076377A1 (en) |
| IL (2) | IL310006A (en) |
| SG (1) | SG11202002456WA (en) |
| WO (1) | WO2019108983A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202002456WA (en) | 2017-11-30 | 2020-04-29 | Regeneron Pharma | Non-human animals comprising a humanized trkb locus |
| SG11202008620VA (en) | 2018-03-26 | 2020-10-29 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| SG11202011284RA (en) | 2018-07-16 | 2020-12-30 | Regeneron Pharma | Non-human animal models of ditra disease and uses thereof |
| EP4099821A1 (en) * | 2020-02-07 | 2022-12-14 | Regeneron Pharmaceuticals, Inc. | <smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use |
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| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| WO1999005266A2 (en) | 1997-07-26 | 1999-02-04 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
| WO2002003071A2 (en) | 2000-07-05 | 2002-01-10 | Pangene Corporation | Modulators of trk protein activity, compositions and uses |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| AUPR451401A0 (en) | 2001-04-20 | 2001-05-24 | Monash University | A method of nuclear transfer |
| US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
| CA2583750C (en) | 2004-10-19 | 2015-11-24 | Regeneron Pharmaceuticals, Inc. | Methods for generating a rodent having a genetic modification |
| CN101117633B (en) | 2006-08-03 | 2011-07-20 | 上海交通大学附属儿童医院 | Nucleus transplantation method |
| CN101157730A (en) * | 2006-09-25 | 2008-04-09 | 南方医科大学珠江医院 | Fusion protein penetrating blood-brain barrier with nerve nourishment gene and encoding gene and uses thereof |
| AU2008316474A1 (en) * | 2007-10-23 | 2009-04-30 | Novartis Ag | Use of TrkB antibodies for the treatment of respiratory disorders |
| WO2009126161A1 (en) | 2008-04-11 | 2009-10-15 | Utc Fuel Cells, Llc | Fuel cell and bipolar plate having manifold sump |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| RU2425880C2 (en) | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Method of producing transgene mice |
| US8354389B2 (en) | 2009-08-14 | 2013-01-15 | Regeneron Pharmaceuticals, Inc. | miRNA-regulated differentiation-dependent self-deleting cassette |
| WO2011059799A1 (en) | 2009-10-29 | 2011-05-19 | Regeneron Pharmaceuticals, Inc. | Multifunctional alleles |
| MX358390B (en) | 2011-10-28 | 2018-08-17 | Regeneron Pharma | Humanized il-6 and il-6 receptor. |
| EP3563680B1 (en) | 2011-10-28 | 2023-08-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| KR101926442B1 (en) | 2011-10-28 | 2018-12-12 | 리제너론 파아마슈티컬스, 인크. | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| WO2013163394A1 (en) | 2012-04-25 | 2013-10-31 | Regeneron Pharmaceuticals, Inc. | Nuclease-mediated targeting with large targeting vectors |
| SI3241902T1 (en) | 2012-05-25 | 2018-07-31 | The Regents Of The University Of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| WO2014033644A2 (en) | 2012-08-28 | 2014-03-06 | Novartis Ag | Methods of nuclease-based genetic engineering |
| NZ631614A (en) | 2012-11-05 | 2016-10-28 | Regeneron Pharma | Genetically modified non-human animals and methods of use thereof |
| PL3138912T3 (en) | 2012-12-06 | 2019-04-30 | Sigma Aldrich Co Llc | Crispr-based genome modification and regulation |
| SG11201505968WA (en) | 2013-02-20 | 2015-08-28 | Regeneron Pharma | Genetic modification of rats |
| CN111484999A (en) | 2013-02-20 | 2020-08-04 | 瑞泽恩制药公司 | Humanized T cell co-receptor mice |
| ES2697248T3 (en) | 2013-02-22 | 2019-01-22 | Regeneron Pharma | Mice expressing major human histocompatibility complex |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| DK3456831T3 (en) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | TARGETED MODIFICATION OF RAT GENOMES |
| SI3175706T1 (en) | 2013-09-23 | 2019-03-29 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized signal-regulatory protein gene |
| CN105792646B (en) | 2013-11-19 | 2018-03-02 | 瑞泽恩制药公司 | The non-human animal of B cell activation factor gene with humanization |
| EP3430898A1 (en) | 2013-11-19 | 2019-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| SG10201700961TA (en) | 2013-12-11 | 2017-04-27 | Regeneron Pharma | Methods and compositions for the targeted modification of a genome |
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| SI3129400T1 (en) | 2014-04-08 | 2020-07-31 | Regeneron Pharmaceuticals, Inc. | Non-human animals having humanized fc-gamma receptors |
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| KR20240017405A (en) | 2014-05-19 | 2024-02-07 | 리제너론 파마슈티칼스 인코포레이티드 | Genetically modified non-human animals expressing human epo |
| SI3157956T1 (en) | 2014-06-19 | 2020-06-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| RU2707911C2 (en) | 2014-06-23 | 2019-12-02 | Регенерон Фармасьютикалз, Инк. | Nuclease-mediated dna assembly |
| PL3161128T3 (en) | 2014-06-26 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modifications and methods of use |
| ES2949172T3 (en) | 2014-07-16 | 2023-09-26 | Novartis Ag | Method of encapsulating a nucleic acid in a lipid nanoparticle host |
| US20160081314A1 (en) | 2014-09-19 | 2016-03-24 | Regeneron Pharmaceuticals, Inc. | Chimeric Antigen Receptors |
| EP3521437A1 (en) | 2014-11-21 | 2019-08-07 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| PT3689140T (en) | 2014-11-24 | 2022-07-27 | Regeneron Pharma | Non-human animals expressing humanized cd3 complex |
| KR102617691B1 (en) | 2014-12-05 | 2023-12-27 | 리제너론 파마슈티칼스 인코포레이티드 | Non-human animals having a humanized cluster of differentiation 47 gene |
| SI3230320T1 (en) | 2014-12-09 | 2021-02-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| ES2954865T3 (en) | 2015-04-06 | 2023-11-27 | Regeneron Pharma | Immune responses mediated by humanized T lymphocytes in non-human animals |
| RU2745403C2 (en) | 2015-11-20 | 2021-03-24 | Регенерон Фармасьютикалз, Инк. | Non-human animals having humanized lymphocyte-activation gene 3 |
| SG11202002456WA (en) | 2017-11-30 | 2020-04-29 | Regeneron Pharma | Non-human animals comprising a humanized trkb locus |
| SG11202008620VA (en) | 2018-03-26 | 2020-10-29 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| SG11202011284RA (en) | 2018-07-16 | 2020-12-30 | Regeneron Pharma | Non-human animal models of ditra disease and uses thereof |
-
2018
- 2018-11-30 SG SG11202002456WA patent/SG11202002456WA/en unknown
- 2018-11-30 CN CN202211340155.0A patent/CN116064611A/en active Pending
- 2018-11-30 WO PCT/US2018/063390 patent/WO2019108983A1/en unknown
- 2018-11-30 JP JP2020527921A patent/JP7361031B2/en active Active
- 2018-11-30 AU AU2018375796A patent/AU2018375796A1/en active Pending
- 2018-11-30 US US16/206,330 patent/US11419318B2/en active Active
- 2018-11-30 IL IL310006A patent/IL310006A/en unknown
- 2018-11-30 KR KR1020207013978A patent/KR20200090770A/en not_active Application Discontinuation
- 2018-11-30 CN CN201880087972.5A patent/CN111655031B/en active Active
- 2018-11-30 IL IL274740A patent/IL274740B1/en unknown
- 2018-11-30 EP EP23207807.1A patent/EP4299732A3/en active Pending
- 2018-11-30 CA CA3076377A patent/CA3076377A1/en active Pending
- 2018-11-30 EP EP18821882.0A patent/EP3585164B1/en active Active
-
2022
- 2022-06-30 US US17/810,029 patent/US20220361464A1/en active Pending
-
2023
- 2023-10-02 JP JP2023171306A patent/JP2024009849A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021508236A (en) | 2021-03-04 |
| RU2020113566A (en) | 2021-12-30 |
| EP3585164B1 (en) | 2023-12-27 |
| US20220361464A1 (en) | 2022-11-17 |
| CN111655031B (en) | 2022-11-18 |
| US11419318B2 (en) | 2022-08-23 |
| EP3585164C0 (en) | 2023-12-27 |
| US20190159436A1 (en) | 2019-05-30 |
| AU2018375796A1 (en) | 2020-04-23 |
| KR20200090770A (en) | 2020-07-29 |
| WO2019108983A1 (en) | 2019-06-06 |
| IL274740A (en) | 2020-07-30 |
| CA3076377A1 (en) | 2019-06-06 |
| EP4299732A3 (en) | 2024-03-27 |
| JP2024009849A (en) | 2024-01-23 |
| RU2020113566A3 (en) | 2022-02-10 |
| EP4299732A2 (en) | 2024-01-03 |
| IL310006A (en) | 2024-03-01 |
| EP3585164A1 (en) | 2020-01-01 |
| CN111655031A (en) | 2020-09-11 |
| IL274740B1 (en) | 2024-02-01 |
| JP7361031B2 (en) | 2023-10-13 |
| CN116064611A (en) | 2023-05-05 |
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