MX2018005389A - Animales no humanos que tienen un gen 3 de activacion linfocitaria humanizado. - Google Patents

Animales no humanos que tienen un gen 3 de activacion linfocitaria humanizado.

Info

Publication number
MX2018005389A
MX2018005389A MX2018005389A MX2018005389A MX2018005389A MX 2018005389 A MX2018005389 A MX 2018005389A MX 2018005389 A MX2018005389 A MX 2018005389A MX 2018005389 A MX2018005389 A MX 2018005389A MX 2018005389 A MX2018005389 A MX 2018005389A
Authority
MX
Mexico
Prior art keywords
human animals
activation gene
human
lag3
lymphocyte
Prior art date
Application number
MX2018005389A
Other languages
English (en)
Inventor
J Murphy Andrew
O Mujica Alexander
Burova Elena
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2018005389A publication Critical patent/MX2018005389A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se proporcionan animales no humanos, y métodos y composiciones para generar y usar los mismos, en donde dichos animales no humanos comprenden una humanización de un gen 3 de activación de linfocitaria (Lag-3). Dichos animales no humanos pueden describirse, en algunas modalidades, como que tienen una modificación genética para un Iocus Lag-3 endógeno de manera que dichos animales no humanos expresan un polipéptido Lag-3 que incluye una porción humana y una porción endógena (por ejemplo, una porción no humana).
MX2018005389A 2015-11-20 2016-11-18 Animales no humanos que tienen un gen 3 de activacion linfocitaria humanizado. MX2018005389A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562258181P 2015-11-20 2015-11-20
US201662370430P 2016-08-03 2016-08-03
PCT/US2016/062733 WO2017087780A1 (en) 2015-11-20 2016-11-18 Non-human animals having a humanized lymphocyte-activation gene 3

Publications (1)

Publication Number Publication Date
MX2018005389A true MX2018005389A (es) 2018-09-05

Family

ID=57543170

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005389A MX2018005389A (es) 2015-11-20 2016-11-18 Animales no humanos que tienen un gen 3 de activacion linfocitaria humanizado.

Country Status (26)

Country Link
US (3) US10306874B2 (es)
EP (1) EP3376857B1 (es)
JP (1) JP6997708B2 (es)
KR (1) KR102454546B1 (es)
CN (1) CN108366548B (es)
AU (1) AU2016358101B2 (es)
BR (1) BR112018010158A2 (es)
CA (1) CA3003786C (es)
CY (1) CY1124171T1 (es)
DK (1) DK3376857T3 (es)
ES (1) ES2872799T3 (es)
HK (1) HK1253683A1 (es)
HR (1) HRP20210824T1 (es)
HU (1) HUE054612T2 (es)
IL (1) IL258841B (es)
LT (1) LT3376857T (es)
MX (1) MX2018005389A (es)
NZ (1) NZ742447A (es)
PL (1) PL3376857T3 (es)
PT (1) PT3376857T (es)
RS (1) RS61866B1 (es)
RU (1) RU2745403C2 (es)
SG (1) SG11201803409UA (es)
SI (1) SI3376857T1 (es)
WO (1) WO2017087780A1 (es)
ZA (1) ZA201802717B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017087780A1 (en) 2015-11-20 2017-05-26 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized lymphocyte-activation gene 3
AU2017228293B2 (en) 2016-02-29 2023-05-25 Regeneron Pharmaceuticals, Inc. Rodents having a humanized Tmprss gene
DK3476865T3 (da) 2016-06-28 2023-12-18 Biocytogen Pharmaceuticals Beijing Co Ltd Fremgangsmåde til konstruktion af pd-1-gen-modificeret humaniseret dyremodel og anvendelse deraf
CN107815468B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
CN108070613B (zh) 2016-11-11 2020-03-13 百奥赛图江苏基因生物技术有限公司 人源化基因改造动物模型的制备方法及应用
WO2018086583A1 (en) * 2016-11-11 2018-05-17 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric lag-3
WO2019006034A1 (en) * 2017-06-27 2019-01-03 Regeneron Pharmaceuticals, Inc. NON-HUMAN ANIMALS COMPRISING A HUMANIZED ASGR1 LOCUS
BR112020001364A2 (pt) 2017-07-31 2020-08-11 Regeneron Pharmaceuticals, Inc. métodos para testar e modificar a capacidade de uma crispr/cas nuclease.
WO2019028023A2 (en) 2017-07-31 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR EVALUATING CRISPR / CAS MEDIATED DISRUPTION OR EXCISION AND CRISPR / CAS INDUCED RECOMBINATION USING IN VIVO EXOGENIC DONOR NUCLEIC ACID
WO2019072241A1 (en) * 2017-10-13 2019-04-18 Beijing Biocytogen Co., Ltd NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC
CN109666701B (zh) * 2017-10-13 2021-08-24 百奥赛图(北京)医药科技股份有限公司 一种pd-1基因修饰人源化动物模型的构建方法及其应用
EP3585164B1 (en) 2017-11-30 2023-12-27 Regeneron Pharmaceuticals, Inc. Rats comprising a humanized trkb locus
KR102647714B1 (ko) 2018-03-19 2024-03-18 리제너론 파마슈티칼스 인코포레이티드 CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절
SG11202008620VA (en) 2018-03-26 2020-10-29 Regeneron Pharma Humanized rodents for testing therapeutic agents
CN112638154B (zh) 2018-07-16 2022-10-18 瑞泽恩制药公司 Ditra疾病的非人动物模型及其用途
WO2020125763A1 (en) * 2018-12-20 2020-06-25 Biocytogen Jiangsu Co., Ltd. Genetically modified non-human animal with human or chimeric lag3
CN109929875B (zh) * 2019-03-12 2021-02-19 江苏集萃药康生物科技股份有限公司 一种lag3基因人源化动物模型的构建方法及其应用
ES2966625T3 (es) 2019-04-04 2024-04-23 Regeneron Pharma Roedores que comprenden un locus del factor de coagulación 12 humanizado
JP2022534867A (ja) 2019-06-04 2022-08-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法
EP3796776A1 (en) 2019-06-07 2021-03-31 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized albumin locus

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1110557C (zh) * 1994-05-06 2003-06-04 古斯达威罗斯研究所 Lag－3蛋白的可溶性多肽组分;生产方法、治疗组合物、抗独特型抗体
US5670356A (en) 1994-12-12 1997-09-23 Promega Corporation Modified luciferase
US5874304A (en) 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
PT1897548E (pt) * 2003-02-28 2013-11-19 Univ Johns Hopkins Regulação de células t
AU2005295269B2 (en) 2004-10-19 2010-05-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
AR072999A1 (es) * 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
WO2011020005A1 (en) 2009-08-14 2011-02-17 Regeneron Pharmaceuticals, Inc. miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE
EP3417701B1 (en) 2009-10-06 2021-12-15 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
US20130061340A1 (en) * 2011-09-02 2013-03-07 Stem Centrx, Inc. Identification and Enrichment of Cell Subpopulations
CN103547148B (zh) 2011-02-15 2016-06-08 再生元制药公司 人源化m-csf小鼠
SG10201909638UA (en) 2011-10-28 2019-11-28 Regeneron Pharma Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
WO2013063361A1 (en) 2011-10-28 2013-05-02 Regeneron Pharmaceuticals, Inc. Genetically modified t cell receptor mice
PT2770821T (pt) 2011-10-28 2017-12-18 Regeneron Pharma Ratinhos de complexo principal de histocompatibilidade principal modificados geneticamente
US8878001B2 (en) 2011-10-28 2014-11-04 Regeneron Pharmaceuticals, Inc. Humanized IL-6 and IL-6 receptor
AR091649A1 (es) * 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
DK2892330T3 (da) 2012-09-07 2023-01-30 Univ Yale Genetisk modificeret mus og fremgangsmåder til anvendelse deraf
CN104812244B (zh) * 2012-09-17 2018-10-30 卡莱克汀医疗有限公司 增强癌症治疗中特异性免疫疗法的方法
EP2914102B1 (en) 2012-11-05 2017-10-18 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals and methods of use thereof
DK2958938T3 (da) 2013-02-20 2019-07-15 Regeneron Pharma Mus, der eksprimerer humaniserede T-celle-co-receptorer
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
PL2958937T3 (pl) 2013-02-22 2019-01-31 Regeneron Pharmaceuticals, Inc. Myszy ekspresjonujące humanizowany główny układ zgodności tkankowej
BR112015026197B1 (pt) 2013-04-16 2022-12-06 Regeneron Pharmaceuticals, Inc Método para modificação marcada de um lócus genômico de interesse em uma célula de rato pluripotente
KR102370419B1 (ko) 2013-09-23 2022-03-04 리제너론 파마슈티칼스 인코포레이티드 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물
AU2014353346B2 (en) 2013-11-19 2020-05-14 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized B-cell activating factor gene
PL3129400T3 (pl) 2014-04-08 2020-09-07 Regeneron Pharmaceuticals, Inc. Zwierzęta inne niż człowiek mające humanizowane receptory fc-gamma
NO2785538T3 (es) 2014-05-07 2018-08-04
CA2947309A1 (en) 2014-05-19 2015-11-26 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals expressing human epo
ES2783424T3 (es) 2014-06-19 2020-09-17 Regeneron Pharma Animales no humanos que tienen un gen de muerte celular programada 1 humanizado
KR20240055876A (ko) 2014-11-24 2024-04-29 리제너론 파마슈티칼스 인코포레이티드 인간화 cd3 복합체를 발현하는 비인간 동물
EP3850946B1 (en) 2014-12-05 2023-09-27 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 47 gene
HUE052606T2 (hu) 2014-12-09 2021-05-28 Regeneron Pharma Humanizált differenciációs klaszter 274 génnel rendelkezõ nem humán állatok
PT3280257T (pt) 2015-04-06 2023-09-12 Regeneron Pharma Respostas imunes mediadas por células t humanizadas em animais não humanos
WO2017087780A1 (en) 2015-11-20 2017-05-26 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized lymphocyte-activation gene 3

Also Published As

Publication number Publication date
SG11201803409UA (en) 2018-05-30
RU2018117944A3 (es) 2020-04-06
JP2018533963A (ja) 2018-11-22
HK1253683A1 (zh) 2019-06-28
AU2016358101B2 (en) 2022-12-01
IL258841A (en) 2018-06-28
IL258841B (en) 2021-04-29
PT3376857T (pt) 2021-05-27
EP3376857A1 (en) 2018-09-26
RS61866B1 (sr) 2021-06-30
DK3376857T3 (da) 2021-05-25
CY1124171T1 (el) 2022-05-27
AU2016358101A1 (en) 2018-05-31
ZA201802717B (en) 2023-05-31
CA3003786C (en) 2023-09-12
SI3376857T1 (sl) 2021-09-30
KR20180083381A (ko) 2018-07-20
CN108366548B (zh) 2021-10-08
HUE054612T2 (hu) 2021-09-28
BR112018010158A2 (pt) 2018-11-21
JP6997708B2 (ja) 2022-02-04
US20190320632A1 (en) 2019-10-24
HRP20210824T1 (hr) 2021-07-09
RU2745403C2 (ru) 2021-03-24
NZ742447A (en) 2022-12-23
US20170142943A1 (en) 2017-05-25
LT3376857T (lt) 2021-06-25
PL3376857T3 (pl) 2021-09-13
WO2017087780A1 (en) 2017-05-26
KR102454546B1 (ko) 2022-10-14
CA3003786A1 (en) 2017-05-26
US11102961B2 (en) 2021-08-31
US10306874B2 (en) 2019-06-04
CN108366548A (zh) 2018-08-03
ES2872799T3 (es) 2021-11-02
RU2018117944A (ru) 2019-12-20
US20210360908A1 (en) 2021-11-25
EP3376857B1 (en) 2021-02-24

Similar Documents

Publication Publication Date Title
MX2018005389A (es) Animales no humanos que tienen un gen 3 de activacion linfocitaria humanizado.
PH12016500342A1 (en) Non-human animals having a humanized signal-regulatory protein gene
MX2017007293A (es) Animales no humanos que tienen un gen del grupo de diferenciacion 47 humanizado.
MX2016016903A (es) Animales no humanos que tienen un gen de muerte celular programada 1 humanizado.
MX2017007636A (es) Animales no humanos que tienen un gen del grupo de diferenciacion 274 humanizado.
CY1123163T1 (el) Αντισωματα που δεσμευουν beta klotho επικρατεια 2 και μεθοδοι χρησης αυτων
MX2018003689A (es) Proteinas de union a pd-1 y metodos para usarlas.
MX2016006513A (es) Animales no humanos que tienen un gen humanizado de un ligando inductor de la proliferacion.
SG10201900003WA (en) Non-human animals having a humanized b-cell activating factor gene
SA517381703B1 (ar) C10orf54 - أجسام مضادة لـ واستخداماتها
MX2017006802A (es) Animales no humanos que expresan el complejo cd3 humanizado.
EP3699195A3 (en) Bispecific antibodies that bind to cd38 and cd3
MX2016013241A (es) Animales no humanos que tienen receptores fc gamma humanizados.
EP3507373A4 (en) GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERAL PD-L1
MX2019000641A (es) Composiciones de mucina1-receptor de antigeno quimerico y metodos para su uso.
EP3320773A4 (en) NON-HUMAN ANIMAL HAVING A CD3 HUMAN GENE SUBSTITUTED WITH ENDOGENOUS CD3 GENE
MX2018009513A (es) Animales no humanos que tienen un gen angptl8 modificado genéticamente.
EP4249507A3 (en) Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules
MX2022011973A (es) Composiciones de proteina anti-vegf y metodos para producir la misma.
NZ739560A (en) Novel anti-human gpvi antibodies and uses thereof
SA516370731B1 (ar) عملية لتحضير جزء وجبة تباع الشمس عالية البروتين