DK3687994T3 - Gadolinium-bærende pcta-baserede kontrastmidler - Google Patents

Gadolinium-bærende pcta-baserede kontrastmidler Download PDF

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Publication number
DK3687994T3
DK3687994T3 DK19753296.3T DK19753296T DK3687994T3 DK 3687994 T3 DK3687994 T3 DK 3687994T3 DK 19753296 T DK19753296 T DK 19753296T DK 3687994 T3 DK3687994 T3 DK 3687994T3
Authority
DK
Denmark
Prior art keywords
pcta
gadolinium
bearing
contrast agents
based contrast
Prior art date
Application number
DK19753296.3T
Other languages
English (en)
Inventor
Roberta Napolitano
Luciano Lattuada
Zsolt Baranyai
Nicole Guidolin
Giuseppe Marazzi
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63165233&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3687994(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of DK3687994T3 publication Critical patent/DK3687994T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
DK19753296.3T 2018-08-06 2019-08-06 Gadolinium-bærende pcta-baserede kontrastmidler DK3687994T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18187422 2018-08-06
PCT/EP2019/071075 WO2020030618A1 (en) 2018-08-06 2019-08-06 Gadolinium bearing pcta-based contrast agents

Publications (1)

Publication Number Publication Date
DK3687994T3 true DK3687994T3 (da) 2021-01-25

Family

ID=63165233

Family Applications (2)

Application Number Title Priority Date Filing Date
DK20193824.8T DK3770160T3 (da) 2018-08-06 2019-08-06 Kontrastmidler baseret på gadolinium-indeholdende pcta
DK19753296.3T DK3687994T3 (da) 2018-08-06 2019-08-06 Gadolinium-bærende pcta-baserede kontrastmidler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK20193824.8T DK3770160T3 (da) 2018-08-06 2019-08-06 Kontrastmidler baseret på gadolinium-indeholdende pcta

Country Status (14)

Country Link
US (2) US10973934B2 (da)
EP (3) EP3687994B1 (da)
JP (1) JP2021533165A (da)
KR (1) KR20210041566A (da)
CN (1) CN112533921A (da)
AU (1) AU2019319599B2 (da)
BR (1) BR112021001102B1 (da)
CA (1) CA3105610A1 (da)
DK (2) DK3770160T3 (da)
ES (2) ES2841070T3 (da)
FI (1) FI3770160T3 (da)
PL (2) PL3770160T3 (da)
PT (2) PT3687994T (da)
WO (1) WO2020030618A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10973934B2 (en) * 2018-08-06 2021-04-13 Bracco Imaging S.P.A. Gadolinium bearing PCTA-based contrast agents
FR3091873B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
US11426470B2 (en) 2019-01-17 2022-08-30 Guerbet Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
US11370804B2 (en) 2019-01-17 2022-06-28 Guerbet Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
US20220315616A1 (en) * 2019-09-03 2022-10-06 Ge Healthcare As Manganese chelate isomers
KR102588221B1 (ko) * 2020-07-16 2023-10-13 게르브 2-브로모글루타르산 디에스테르를 합성하는 방법
US20230339945A1 (en) * 2020-07-17 2023-10-26 Guerbet Method for preparing a chelating ligand derived from pcta
WO2024046833A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024046832A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024046831A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024049087A1 (ko) * 2022-09-01 2024-03-07 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
WO2024052156A1 (de) 2022-09-05 2024-03-14 Bayer Aktiengesellschaft Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0992245A1 (en) 1998-09-16 2000-04-12 Goldham Bioglan Pharma GmbH Radio-contrast agents
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
FR2836916B1 (fr) 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
FR2883562B1 (fr) * 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
DK2988756T4 (da) 2013-04-26 2022-08-08 Guerbet Sa Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde
US10973934B2 (en) * 2018-08-06 2021-04-13 Bracco Imaging S.P.A. Gadolinium bearing PCTA-based contrast agents
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

Also Published As

Publication number Publication date
ES2938015T3 (es) 2023-04-03
BR112021001102B1 (pt) 2022-12-20
EP4151637A1 (en) 2023-03-22
US20200376145A1 (en) 2020-12-03
PL3687994T3 (pl) 2021-05-04
FI3770160T3 (fi) 2023-03-16
EP3687994B1 (en) 2020-11-04
EP3770160B1 (en) 2022-11-23
DK3770160T3 (da) 2023-02-20
CN112533921A (zh) 2021-03-19
EP3687994A1 (en) 2020-08-05
CA3105610A1 (en) 2020-02-13
AU2019319599A1 (en) 2021-01-28
KR20210041566A (ko) 2021-04-15
PT3687994T (pt) 2020-12-07
BR112021001102A2 (pt) 2021-04-20
US10973934B2 (en) 2021-04-13
PL3770160T3 (pl) 2023-05-29
PT3770160T (pt) 2023-02-21
US20210196840A1 (en) 2021-07-01
ES2841070T3 (es) 2021-07-07
EP3770160A1 (en) 2021-01-27
WO2020030618A1 (en) 2020-02-13
JP2021533165A (ja) 2021-12-02
AU2019319599B2 (en) 2024-01-04

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