PT3687994T - Agentes de contraste à base de pcta que suportam gadolínio - Google Patents
Agentes de contraste à base de pcta que suportam gadolínioInfo
- Publication number
- PT3687994T PT3687994T PT197532963T PT19753296T PT3687994T PT 3687994 T PT3687994 T PT 3687994T PT 197532963 T PT197532963 T PT 197532963T PT 19753296 T PT19753296 T PT 19753296T PT 3687994 T PT3687994 T PT 3687994T
- Authority
- PT
- Portugal
- Prior art keywords
- pcta
- gadolinium
- bearing
- contrast agents
- based contrast
- Prior art date
Links
- 229910052688 Gadolinium Inorganic materials 0.000 title 1
- 239000002872 contrast media Substances 0.000 title 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical group [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18187422 | 2018-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3687994T true PT3687994T (pt) | 2020-12-07 |
Family
ID=63165233
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT197532963T PT3687994T (pt) | 2018-08-06 | 2019-08-06 | Agentes de contraste à base de pcta que suportam gadolínio |
| PT201938248T PT3770160T (pt) | 2018-08-06 | 2019-08-06 | Agentes de contraste à base de pcta que suportam gadolínio |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT201938248T PT3770160T (pt) | 2018-08-06 | 2019-08-06 | Agentes de contraste à base de pcta que suportam gadolínio |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10973934B2 (pt) |
| EP (3) | EP3687994B1 (pt) |
| JP (1) | JP2021533165A (pt) |
| KR (1) | KR20210041566A (pt) |
| CN (1) | CN112533921A (pt) |
| AU (1) | AU2019319599B2 (pt) |
| BR (1) | BR112021001102B1 (pt) |
| CA (1) | CA3105610C (pt) |
| DK (2) | DK3770160T3 (pt) |
| ES (2) | ES2841070T3 (pt) |
| FI (1) | FI3770160T3 (pt) |
| PL (2) | PL3687994T3 (pt) |
| PT (2) | PT3687994T (pt) |
| WO (1) | WO2020030618A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3770160T3 (da) * | 2018-08-06 | 2023-02-20 | Bracco Imaging Spa | Kontrastmidler baseret på gadolinium-indeholdende pcta |
| US11370804B2 (en) | 2019-01-17 | 2022-06-28 | Guerbet | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
| FR3091873B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| US11426470B2 (en) | 2019-01-17 | 2022-08-30 | Guerbet | Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method |
| FR3091872B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
| PT4143153T (pt) * | 2020-07-16 | 2023-12-19 | Guerbet Sa | Método para sintetizar diésteres de ácido 2-bromoglutárico |
| WO2022013454A1 (fr) * | 2020-07-17 | 2022-01-20 | Guerbet | Procede de preparation d'un ligand chelateur derive de pcta |
| WO2024046832A1 (de) | 2022-08-30 | 2024-03-07 | Bayer Aktiengesellschaft | Erzeugen von synthetischen radiologischen aufnahmen |
| WO2024046833A1 (de) | 2022-08-30 | 2024-03-07 | Bayer Aktiengesellschaft | Erzeugen von synthetischen radiologischen aufnahmen |
| WO2024046831A1 (de) | 2022-08-30 | 2024-03-07 | Bayer Aktiengesellschaft | Erzeugen von synthetischen radiologischen aufnahmen |
| WO2024049087A1 (ko) * | 2022-09-01 | 2024-03-07 | 주식회사 테라노큐어 | 신규한 화합물 및 이를 포함하는 mri 조영제 |
| WO2024052156A1 (de) | 2022-09-05 | 2024-03-14 | Bayer Aktiengesellschaft | Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen |
| WO2024083466A1 (de) | 2022-10-17 | 2024-04-25 | Bayer Aktiengesellschaft | Automatisches analysieren von radiologischen aufnahmen |
| EP4369353A1 (de) | 2022-11-12 | 2024-05-15 | Bayer Aktiengesellschaft | Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0992245A1 (en) | 1998-09-16 | 2000-04-12 | Goldham Bioglan Pharma GmbH | Radio-contrast agents |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| FR2836916B1 (fr) | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
| FR2883562B1 (fr) | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| DK2988756T4 (da) | 2013-04-26 | 2022-08-08 | Guerbet Sa | Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde |
| DK3770160T3 (da) * | 2018-08-06 | 2023-02-20 | Bracco Imaging Spa | Kontrastmidler baseret på gadolinium-indeholdende pcta |
| FR3091873B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
-
2019
- 2019-08-06 DK DK20193824.8T patent/DK3770160T3/da active
- 2019-08-06 PT PT197532963T patent/PT3687994T/pt unknown
- 2019-08-06 FI FIEP20193824.8T patent/FI3770160T3/fi active
- 2019-08-06 JP JP2021506481A patent/JP2021533165A/ja active Pending
- 2019-08-06 KR KR1020217003707A patent/KR20210041566A/ko not_active Application Discontinuation
- 2019-08-06 ES ES19753296T patent/ES2841070T3/es active Active
- 2019-08-06 PL PL19753296T patent/PL3687994T3/pl unknown
- 2019-08-06 EP EP19753296.3A patent/EP3687994B1/en active Active
- 2019-08-06 PT PT201938248T patent/PT3770160T/pt unknown
- 2019-08-06 EP EP22205189.8A patent/EP4151637A1/en active Pending
- 2019-08-06 CN CN201980052546.2A patent/CN112533921A/zh active Pending
- 2019-08-06 PL PL20193824.8T patent/PL3770160T3/pl unknown
- 2019-08-06 ES ES20193824T patent/ES2938015T3/es active Active
- 2019-08-06 AU AU2019319599A patent/AU2019319599B2/en active Active
- 2019-08-06 EP EP20193824.8A patent/EP3770160B1/en active Active
- 2019-08-06 US US16/766,619 patent/US10973934B2/en active Active
- 2019-08-06 CA CA3105610A patent/CA3105610C/en active Active
- 2019-08-06 WO PCT/EP2019/071075 patent/WO2020030618A1/en active Application Filing
- 2019-08-06 DK DK19753296.3T patent/DK3687994T3/da active
- 2019-08-06 BR BR112021001102-1A patent/BR112021001102B1/pt active IP Right Grant
-
2021
- 2021-03-11 US US17/199,122 patent/US12036289B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20210196840A1 (en) | 2021-07-01 |
| CN112533921A (zh) | 2021-03-19 |
| US12036289B2 (en) | 2024-07-16 |
| PT3770160T (pt) | 2023-02-21 |
| AU2019319599B2 (en) | 2024-01-04 |
| US20200376145A1 (en) | 2020-12-03 |
| FI3770160T3 (fi) | 2023-03-16 |
| AU2019319599A1 (en) | 2021-01-28 |
| PL3687994T3 (pl) | 2021-05-04 |
| BR112021001102B1 (pt) | 2022-12-20 |
| CA3105610C (en) | 2024-05-28 |
| JP2021533165A (ja) | 2021-12-02 |
| US10973934B2 (en) | 2021-04-13 |
| EP3687994B1 (en) | 2020-11-04 |
| EP3687994A1 (en) | 2020-08-05 |
| DK3770160T3 (da) | 2023-02-20 |
| EP4151637A1 (en) | 2023-03-22 |
| CA3105610A1 (en) | 2020-02-13 |
| BR112021001102A2 (pt) | 2021-04-20 |
| WO2020030618A1 (en) | 2020-02-13 |
| EP3770160B1 (en) | 2022-11-23 |
| DK3687994T3 (da) | 2021-01-25 |
| ES2841070T3 (es) | 2021-07-07 |
| KR20210041566A (ko) | 2021-04-15 |
| EP3770160A1 (en) | 2021-01-27 |
| ES2938015T3 (es) | 2023-04-03 |
| PL3770160T3 (pl) | 2023-05-29 |
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