HRP20170380T1 - Životinje s humaniziranim il-5 - Google Patents
Životinje s humaniziranim il-5 Download PDFInfo
- Publication number
- HRP20170380T1 HRP20170380T1 HRP20170380TT HRP20170380T HRP20170380T1 HR P20170380 T1 HRP20170380 T1 HR P20170380T1 HR P20170380T T HRP20170380T T HR P20170380TT HR P20170380 T HRP20170380 T HR P20170380T HR P20170380 T1 HRP20170380 T1 HR P20170380T1
- Authority
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- Croatia
- Prior art keywords
- human
- mouse
- exons
- humanized
- protein
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title 1
- 108090000172 Interleukin-15 Proteins 0.000 claims 35
- 102000003812 Interleukin-15 Human genes 0.000 claims 31
- 108090000623 proteins and genes Proteins 0.000 claims 20
- 108700024394 Exon Proteins 0.000 claims 14
- 101001055166 Mus musculus Interleukin-15 Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 238000011144 upstream manufacturing Methods 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims 4
- 241001529936 Murinae Species 0.000 claims 4
- 102000056003 human IL15 Human genes 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 108091036066 Three prime untranslated region Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0387—Animal model for diseases of the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (12)
1. Genetički modificirani miš, naznačen time što mu genom sadrži zamjenu u endogenom mišjem lokusu IL-15, u mišjem genomskom fragmentu koji kodira zreli mišji polipeptid IL-15, ljudskim genomskim segmentom koji kodira zreli ljudski polipeptid IL-15, gdje ljudske egzone u IL-15 u navedenom ljudskom genomskom segmentu čine ljudski egzoni 3, 4, 5 i 6 koji kodiraju protein IL-15, kako bi se dobilo humanizirani gen za IL-15, gdje su egzoni u IL-15 tako obrojčani da je prvi kodirajući egzon egzon 1, te gdje je humanizirani gen za IL-15 pod kontrolom svih endogenih mišjih uzvodnih regulacijskih elemenata za IL-15 na endogenom mišjem lokusu IL-15.
2. Genetički modificirani miš u skladu s patentnim zahtjevom 1, naznačen time što humanizirani gen koji kodira IL-15 kodira protein koji sadrži aminokiselinski slijed sa SEQ ID NO: 5.
3. Genetički modificirani miš u skladu s patentnim zahtjevom 1, naznačen time što ljudski genomski segment dodatno sadrži slijed ljudskog introna uzvodno od naj-5′-smještenog ljudskog egzona i ljudski slijed koji ne kodira protein nizvodno od ljudskog stop kodona i nizvodno od ljudskog 3′ UTR.
4. Postupak dobivanja gentički modificiranog miša, naznačen time što se sastoji u modificiranju mišjeg genoma zamjenom mišjeg genomskog fragmenta koji kodira zreli mišji polipeptid IL-15 na endogenom mišjem lokusu IL-15 ljudskim genomskim segmentom koji kodira zreli ljudski polipeptid IL-15, gdje ljudske egzone u IL-15 u navedenom ljudskom genomskom segmentu čine ljudski egzoni 3, 4, 5 i 6 koji kodiraju protein IL-15, kako bi se dobilo humanizirani gen za IL-15, gdje su egzoni u IL-15 tako obrojčani da je prvi kodirajući egzon egzon 1, te gdje je humanizirani gen za IL-15 pod kontrolom svih endogenih mišjih uzvodnih regulacijskih elemenata za IL-15 na endogenom mišjem lokusu IL-15.
5. Postupak u skladu s patentnim zahtjevom 4, naznačen time što ljudski genomski segment dodatno sadrži slijed ljudskog introna uzvodno od naj-5′-smještenog ljudskog egzona i ljudski slijed koji ne kodira protein nizvodno od ljudskog stop kodona i nizvodno od ljudskog 3′ UTR.
6. Postupak u skladu s patentnim zahtjevom 4, naznačen time što humanizirani gen koji kodira IL-15 kodira protein koji sadrži aminokiselinski slijed sa SEQ ID NO: 5.
7. Genetički modificirani miš, naznačen time što mu genom sadrži humanizirani gen za IL-15, gdje navedeni humanizirani gen za IL-15 sadrži mišje egzone 1 i 2 koji kodiraju protein IL-15 i ljudski genomski segment, gdje ljudske egzone u IL-15 u navedenom ljudskom genomskom segmentu čine ljudski egzoni 3, 4, 5 i 6 koji kodiraju protein IL-15, gdje su egzoni u IL-15 tako obrojčani da je prvi kodirajući egzon egzon 1, gdje je humanizirani gen za IL-15 pod kontrolom svih mišjih regulacijskih elemenata za IL-15 uzvodno od endogenog mišjeg lokusa IL-15, te gdje navedeni humanizirani gen za IL-15 kodira protein koji sadrži slijed zrelog ljudskog polipeptida IL-15.
8. Genetički modificirani miš u skladu s patentnim zahtjevom 7, naznačen time što humanizirani gen koji kodira IL-15 kodira protein koji sadrži aminokiselinski slijed sa SEQ ID NO: 5.
9. Genetički modificirani miš u skladu s patentnim zahtjevom 7, naznačen time što ljudski genomski segment dodatno sadrži slijed ljudskog introna uzvodno od naj-5′-smještenog ljudskog egzona i ljudski slijed koji ne kodira protein nizvodno od ljudskog stop kodona i nizvodno od ljudskog 3′ UTR.
10. Genetički modificirani miš u skladu s patentnim zahtjevom 7, naznačen time što je humanizirani gen za IL-15 na položaju u mišjem genomu koji nije endogeni lokus IL-15.
11. Postupak dobivanja gentički modificiranog miša, naznačen time što se sastoji u uvođenju u mišji genom humaniziranog gena za IL-15 koji sadrži mišje egzone 1 i 2 koji kodiraju protein IL-15 i ljudski genomski segment, gdje ljudske egzone u IL-15 u navedenom ljudskom genomskom segmentu čine ljudski egzoni 3, 4, 5 i 6 u IL-15, gdje su egzoni u IL-15 tako obrojčani da je prvi kodirajući egzon egzon 1, gdje je humanizirani gen za IL-15 pod kontrolom svih mišjih regulacijskih elemenata za IL-15 uzvodno od endogenog mišjeg lokusa IL-15, te gdje navedeni humanizirani gen za IL-15 kodira protein koji sadrži slijed zrelog ljudskog polipeptida IL-15.
12. Postupak u skladu s patentnim zahtjevom 11, naznačen time što je humanizirani gen za IL-15 integriran u genom na položaju koji nije endogeni lokus IL-15.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361891013P | 2013-10-15 | 2013-10-15 | |
| PCT/US2014/060568 WO2015057758A1 (en) | 2013-10-15 | 2014-10-15 | Humanized il-15 animals |
| EP14790452.8A EP2908626B1 (en) | 2013-10-15 | 2014-10-15 | Humanized il-15 animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170380T1 true HRP20170380T1 (hr) | 2017-05-19 |
Family
ID=51830649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170380TT HRP20170380T1 (hr) | 2013-10-15 | 2017-03-07 | Životinje s humaniziranim il-5 |
| HRP20190542TT HRP20190542T1 (hr) | 2013-10-15 | 2019-03-20 | Životinje s humaniziranim il-15 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190542TT HRP20190542T1 (hr) | 2013-10-15 | 2019-03-20 | Životinje s humaniziranim il-15 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US9155290B2 (hr) |
| EP (3) | EP2908626B1 (hr) |
| JP (3) | JP6492095B2 (hr) |
| KR (1) | KR102376041B1 (hr) |
| CN (2) | CN109090037B (hr) |
| AU (2) | AU2014337526B2 (hr) |
| BR (1) | BR112016008175A2 (hr) |
| CA (1) | CA2926090C (hr) |
| CY (2) | CY1118675T1 (hr) |
| DK (2) | DK2908626T3 (hr) |
| ES (2) | ES2613379T3 (hr) |
| HK (1) | HK1210659A1 (hr) |
| HR (2) | HRP20170380T1 (hr) |
| HU (2) | HUE043969T2 (hr) |
| IL (2) | IL244525B (hr) |
| LT (2) | LT2908626T (hr) |
| MX (1) | MX2016004781A (hr) |
| NZ (1) | NZ718655A (hr) |
| PL (2) | PL3138397T3 (hr) |
| PT (2) | PT2908626T (hr) |
| RS (2) | RS58465B1 (hr) |
| RU (1) | RU2674910C2 (hr) |
| SG (2) | SG10201607768YA (hr) |
| SI (2) | SI3138397T1 (hr) |
| SM (1) | SMT201700024B (hr) |
| TR (1) | TR201904342T4 (hr) |
| WO (1) | WO2015057758A1 (hr) |
| ZA (1) | ZA201601676B (hr) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3417701T (pt) | 2009-10-06 | 2022-03-16 | Univ Yale | Ratinhos modificados geneticamente e enxerto |
| FI3375284T3 (fi) | 2011-02-15 | 2023-06-15 | Regeneron Pharma | Humanisoituja m-csf-hiiriä ja niiden käyttötapoja |
| KR102340059B1 (ko) | 2012-09-07 | 2021-12-17 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| ES2748662T3 (es) | 2012-11-05 | 2020-03-17 | Institute For Res In Biomedicine Irb | Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos |
| PL3138397T3 (pl) | 2013-10-15 | 2019-06-28 | Regeneron Pharmaceuticals, Inc. | Zwierzęta z humanizowanym IL-15 |
| CN106659146B (zh) | 2014-05-05 | 2020-06-23 | 再生元制药公司 | 人源化c5和c3动物 |
| NO2785538T3 (hr) | 2014-05-07 | 2018-08-04 | ||
| FI3841877T3 (fi) | 2014-05-19 | 2023-12-01 | Regeneron Pharma | Ihmisen epo:a ilmentäviä geneettisesti muunneltuja hiiriä |
| HUE043132T2 (hu) | 2014-12-05 | 2019-07-29 | Regeneron Pharma | Nem-humán állatok, amelyek egy humanizált differenciáció klaszter 47 gént tartalmazzák |
| CN113424798B (zh) | 2015-04-13 | 2023-01-13 | 再生元制药公司 | 人源化SIRPα-IL15敲入小鼠及其使用方法 |
| WO2017136712A1 (en) | 2016-02-04 | 2017-08-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| WO2018001241A1 (zh) | 2016-06-28 | 2018-01-04 | 北京百奥赛图基因生物技术有限公司 | 一种pd-1基因修饰人源化动物模型的构建方法及其应用 |
| WO2018041121A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric ctla-4 |
| CN107815467B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| DK3507373T3 (da) | 2016-08-31 | 2023-10-30 | Biocytogen Pharmaceuticals Beijing Co Ltd | Genetisk modificeret ikke-menneskeligt dyr med human eller kimær pd-l1 |
| CN107815468B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018041120A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tigit |
| CN108070613B (zh) | 2016-11-11 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018086594A1 (en) | 2016-11-11 | 2018-05-17 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tim-3 |
| CN108239659B (zh) | 2016-12-23 | 2020-03-03 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| CN108424928B (zh) | 2016-12-30 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| CN108467873B (zh) | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用 |
| CN108588126B (zh) | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Cd47基因人源化改造动物模型的制备方法及应用 |
| WO2018177441A1 (en) | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| CN109136261B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化cd28基因改造动物模型的制备方法及应用 |
| CN109136275B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化gitr基因改造动物模型的制备方法及应用 |
| CN109136274B (zh) | 2017-06-19 | 2021-04-23 | 百奥赛图江苏基因生物技术有限公司 | 人源化cd40基因改造动物模型的制备方法及应用 |
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| WO2019072241A1 (en) | 2017-10-13 | 2019-04-18 | Beijing Biocytogen Co., Ltd | NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC |
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| CN111304248B (zh) * | 2018-12-25 | 2021-08-24 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子il15基因改造非人动物的构建方法及应用 |
| WO2020147829A1 (zh) * | 2019-01-17 | 2020-07-23 | 北京百奥赛图基因生物技术有限公司 | 人源化转基因动物 |
| AU2020253532A1 (en) | 2019-04-04 | 2021-09-02 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
| KR20220016869A (ko) | 2019-06-04 | 2022-02-10 | 리제너론 파마슈티칼스 인코포레이티드 | 베타-슬립 돌연변이를 갖는 인간화 ttr 좌위를 포함하는 비-인간 동물 및 사용 방법 |
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| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| PT3417701T (pt) | 2009-10-06 | 2022-03-16 | Univ Yale | Ratinhos modificados geneticamente e enxerto |
| KR102178064B1 (ko) * | 2009-12-21 | 2020-11-12 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 ＦｃγＲ 마우스 |
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| SG10202100485XA (en) * | 2011-10-28 | 2021-02-25 | Regeneron Pharma | Humanized il-6 and il-6 receptor |
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| KR102340059B1 (ko) | 2012-09-07 | 2021-12-17 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| ES2748662T3 (es) | 2012-11-05 | 2020-03-17 | Institute For Res In Biomedicine Irb | Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos |
| CA2900824A1 (en) | 2013-02-22 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
| SI3175706T1 (sl) | 2013-09-23 | 2019-03-29 | Regeneron Pharmaceuticals, Inc. | Nehumane živali s humaniziranim genom signal-regulatornega proteina |
| PL3138397T3 (pl) | 2013-10-15 | 2019-06-28 | Regeneron Pharmaceuticals, Inc. | Zwierzęta z humanizowanym IL-15 |
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