RU2017129763A - Гуманизированные il-6 и рецептор il-6 - Google Patents
Гуманизированные il-6 и рецептор il-6 Download PDFInfo
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- RU2017129763A RU2017129763A RU2017129763A RU2017129763A RU2017129763A RU 2017129763 A RU2017129763 A RU 2017129763A RU 2017129763 A RU2017129763 A RU 2017129763A RU 2017129763 A RU2017129763 A RU 2017129763A RU 2017129763 A RU2017129763 A RU 2017129763A
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- 108090001005 Interleukin-6 Proteins 0.000 title claims 4
- 102000010781 Interleukin-6 Receptors Human genes 0.000 title 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 title 1
- 241001529936 Murinae Species 0.000 claims 28
- 241001465754 Metazoa Species 0.000 claims 19
- 241000699666 Mus <mouse, genus> Species 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 230000001105 regulatory effect Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 241000699670 Mus sp. Species 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 claims 2
- 108700024394 Exon Proteins 0.000 claims 1
- 101100286713 Homo sapiens IL6 gene Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 1
- 101000599053 Mus musculus Interleukin-6 receptor subunit alpha Proteins 0.000 claims 1
- 210000004436 artificial bacterial chromosome Anatomy 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Proteomics, Peptides & Aminoacids (AREA)
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- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
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Claims (14)
1. Генетически модифицированное животное семейства мышиных, несущее замену генного фрагмента животного семейства мышиных, кодирующего внеклеточный домен IL-6Rαa животного семейства мышиных в эндогенном локусе IL-6Rα животного семейства мышиных, на геномный фрагмент человека, кодирующий внеклеточный домен IL-6Rα человека, с получением гуманизированного гена IL-6Rα, где гуманизированный ген IL-6Rα находится под управлением эндогенных регуляторных элементов животного семейства мышиных в эндогенном локусе IL-6Rα животного семейства мышиных, при этом животное семейства мышиных представляет собой мышь или крысу.
2. Животное семейства мышиных по п. 1, где гуманизированный ген IL-6Rα содержит эндогенную последовательность трансмембранного домена IL-6Rα животного семейства мышиных и эндогенную последовательность цитоплазматического домена IL-6Rα животного семейства мышиных.
3. Животное семейства мышиных по п. 1, где животное семейства мышиных представляет собой мышь.
4. Животное семейства мышиных по п. 1, где животное семейства мышиных представляет собой крысу.
5. Животное семейства мышиных по п. 3, где непрерывная геномная последовательность мыши, содержащая экзоны с 1 по 8 IL-6Rα мыши, замещена непрерывным геномным фрагментом последовательности IL-6Rα человека, кодирующей внеклеточный домен IL-6Rα человека.
6. Животное семейства мышиных по п. 5, где непрерывный геномный фрагмент последовательности IL-6Rα человека, кодирующий внеклеточный домен IL-6Rα человека, происходит из бактериальной искусственной хромосомы CTD-2192J23.
7. Животное семейства мышиных по любому из пп. 1-6, дополнительно несущее замену гена IL-6R животного семейства мышиных в эндогенном локусе IL-6R животного семейства мышиных на ген IL-6 человека, с получением гуманизированного гена IL-6.
8. Животное семейства мышиных по п. 7, где гуманизированный ген IL-6 находится под управлением эндогенных регуляторных элементов животного семейства мышиных в локусе IL-6 животного семейства мышиных.
9. Способ получения генетически модифицированного животного семейства мышиных, включающий замену геномного фрагмента животного семейства мышиных, кодирующего внеклеточный домен IL-6Rα животного семейства мышиных в эндогенном локусе IL-6Rα животного семейства мышиных на геномный фрагмент человека, кодирующий внеклеточный домен IL-6Rα человека, с получением гуманизированного гена IL-6Rα, где гуманизированный ген IL-6Rα находится под управлением эндогенных регуляторных элементов животного семейства мышиных в эндогенном локусе IL-6Rα животного семейства мышиных, при этом животное семейства мышиных представляет собой мышь или крысу.
10. Способ по п. 9, где животное семейства мышиных представляет собой мышь.
11. Способ по п. 9, где животное семейства мышиных представляет собой крысу.
12. Выделенная ES-клетка животного семейства мышиных, содержащая замену последовательности, кодирующей внеклеточный домен IL-6Rα животного семейства мышиных, в эндогенном локусе IL-6Rα животного семейства мышиных, на последовательность, кодирующую внеклеточный домен IL-6Rα человека, с получением гуманизированного гена IL-6Rα, где гуманизированный ген IL-6Rα содержит эндогенную трансмембранную последовательность IL-6Rα животного семейства мышиных и эндогенную цитоплазматическую последовательность IL-6Rα животного семейства мышиных, и гуманизированный ген IL-6Rα находится под управлением эндогенных регуляторных элементов животного семейства мышиных в локусе IL-6Rα, при этом животное семейства мышиных представляет собой мышь или крысу.
13. ES-клетка по п. 12, где животное семейства мышиных представляет собой мышь.
14. ES-клетка по п. 12, где животное семейства мышиных представляет собой крысу.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161552900P | 2011-10-28 | 2011-10-28 | |
US61/552,900 | 2011-10-28 | ||
US201161556579P | 2011-11-07 | 2011-11-07 | |
US61/556,579 | 2011-11-07 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2014121324A Division RU2634417C2 (ru) | 2011-10-28 | 2012-10-29 | Гуманизированные il-6 и рецептор il-6 |
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RU2021118181A Division RU2021118181A (ru) | 2021-06-22 | Гуманизированные il-6 и рецептор il-6 |
Publications (3)
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RU2017129763A true RU2017129763A (ru) | 2019-02-05 |
RU2017129763A3 RU2017129763A3 (ru) | 2020-12-18 |
RU2751240C2 RU2751240C2 (ru) | 2021-07-12 |
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RU2014121324A RU2634417C2 (ru) | 2011-10-28 | 2012-10-29 | Гуманизированные il-6 и рецептор il-6 |
RU2017129763A RU2751240C2 (ru) | 2011-10-28 | 2012-10-29 | Гуманизированные il-6 и рецептор il-6 |
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US (9) | US8878001B2 (ru) |
EP (2) | EP2818478B1 (ru) |
JP (2) | JP6120451B2 (ru) |
KR (2) | KR102234632B1 (ru) |
CN (2) | CN104039821A (ru) |
AU (1) | AU2015207889B2 (ru) |
BR (1) | BR112014008529A2 (ru) |
CA (1) | CA2853731C (ru) |
CY (2) | CY1116614T1 (ru) |
DK (2) | DK2663575T3 (ru) |
ES (2) | ES2624605T3 (ru) |
HK (2) | HK1190408A1 (ru) |
HR (2) | HRP20141192T1 (ru) |
HU (1) | HUE033400T2 (ru) |
IL (4) | IL231896B (ru) |
IN (1) | IN2014CN03920A (ru) |
LT (1) | LT2818478T (ru) |
MX (1) | MX358390B (ru) |
MY (2) | MY172726A (ru) |
PL (2) | PL2818478T3 (ru) |
PT (2) | PT2663575E (ru) |
RS (2) | RS53683B1 (ru) |
RU (2) | RU2634417C2 (ru) |
SG (3) | SG11201400945UA (ru) |
SI (2) | SI2663575T1 (ru) |
SM (1) | SMT201400187B (ru) |
WO (1) | WO2013063556A1 (ru) |
ZA (1) | ZA201402635B (ru) |
Families Citing this family (70)
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JP5874881B2 (ja) | 2009-10-06 | 2016-03-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 遺伝子改変されたマウスおよび移植方法 |
MX350385B (es) | 2011-02-15 | 2017-09-04 | Regeneron Pharma | Ratones de m-csf humanizada. |
MY172726A (en) | 2011-10-28 | 2019-12-11 | Regeneron Pharma | Humanized il-6 and il-6 receptor |
US20130261016A1 (en) * | 2012-03-28 | 2013-10-03 | Meso Scale Technologies, Llc | Diagnostic methods for inflammatory disorders |
US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
JP6283031B2 (ja) | 2012-09-07 | 2018-02-21 | イエール ユニバーシティ | 遺伝学的に修飾された非ヒト動物およびその使用法 |
JP6282591B2 (ja) * | 2012-09-13 | 2018-02-21 | 中外製薬株式会社 | 遺伝子ノックイン非ヒト動物 |
WO2014071397A2 (en) * | 2012-11-05 | 2014-05-08 | Regeneron Pharmaceuticals | Genetically modified non-human animals and methods of use thereof |
PL2958937T3 (pl) | 2013-02-22 | 2019-01-31 | Regeneron Pharmaceuticals, Inc. | Myszy ekspresjonujące humanizowany główny układ zgodności tkankowej |
GB2513884B (en) | 2013-05-08 | 2015-06-17 | Univ Bristol | Method and apparatus for producing an acoustic field |
KR102407354B1 (ko) * | 2013-09-23 | 2022-06-10 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물 |
PL2908626T3 (pl) | 2013-10-15 | 2017-05-31 | Regeneron Pharmaceuticals, Inc. | Zwierzęta z humanizowaną |
AU2014353346B2 (en) * | 2013-11-19 | 2020-05-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized B-cell activating factor gene |
SG10201811701YA (en) | 2013-11-19 | 2019-01-30 | Regeneron Pharma | Non-human animals having a humanized a proliferation-inducing ligand gene |
US9612658B2 (en) | 2014-01-07 | 2017-04-04 | Ultrahaptics Ip Ltd | Method and apparatus for providing tactile sensations |
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