MX2016015609A - Animales con dipeptidil peptidasa iv (dpp4) humanizada. - Google Patents

Animales con dipeptidil peptidasa iv (dpp4) humanizada.

Info

Publication number
MX2016015609A
MX2016015609A MX2016015609A MX2016015609A MX2016015609A MX 2016015609 A MX2016015609 A MX 2016015609A MX 2016015609 A MX2016015609 A MX 2016015609A MX 2016015609 A MX2016015609 A MX 2016015609A MX 2016015609 A MX2016015609 A MX 2016015609A
Authority
MX
Mexico
Prior art keywords
human
dpp4
animals
humanized
human animals
Prior art date
Application number
MX2016015609A
Other languages
English (en)
Inventor
Kyratsous Christos
Mujica Alexander
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2016015609A publication Critical patent/MX2016015609A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
    • C12Y304/14005—Dipeptidyl-peptidase IV (3.4.14.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases

Abstract

Animales no humanos que comprenden una secuencia de ácido nucleico de DPP4 humano o humanizado. Se describen animales no humanos que comprenden un reemplazo del gen Dpp4 endógeno con un gen DPP4 humano o humanizado o animales no humanos que comprenden un gen DPP4 humano o humanizado además del gen Dpp4 endógeno. Además, se proporcionan animales no humanos que comprenden un gen DPP4 humano o humanizado bajo el control de elementos reguladores de DPP4 humano o no humano, que incluyen animales no humanos que tienen un reemplazo de la secuencia codificante de Dpp4 no humano con una secuencia codificante de DPP4 humano en un locus de Dpp4 no humano endógeno. Se proporcionan animales no humanos que comprenden secuencias de genes DPP4 humanos o humanizados, en donde los animales no humanos son roedores, por ejemplo, ratones o ratas. Se describen métodos para elaborar y usar los animales no humanos.
MX2016015609A 2014-05-30 2015-05-28 Animales con dipeptidil peptidasa iv (dpp4) humanizada. MX2016015609A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462005476P 2014-05-30 2014-05-30
US201462051626P 2014-09-17 2014-09-17
US201462072692P 2014-10-30 2014-10-30
PCT/US2015/033024 WO2015184164A1 (en) 2014-05-30 2015-05-28 Humanized dipeptidyl peptidase iv (dpp4) animals

Publications (1)

Publication Number Publication Date
MX2016015609A true MX2016015609A (es) 2017-08-02

Family

ID=53366330

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016015609A MX2016015609A (es) 2014-05-30 2015-05-28 Animales con dipeptidil peptidasa iv (dpp4) humanizada.
MX2020004803A MX2020004803A (es) 2014-05-30 2015-05-28 Animales con dipeptidil peptidasa iv (dpp4) humanizada.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020004803A MX2020004803A (es) 2014-05-30 2015-05-28 Animales con dipeptidil peptidasa iv (dpp4) humanizada.

Country Status (17)

Country Link
US (5) US9497945B2 (es)
EP (2) EP2993977B1 (es)
JP (2) JP6212659B2 (es)
KR (1) KR101737432B1 (es)
CN (2) CN111118047B (es)
AU (1) AU2015266841C1 (es)
BR (1) BR112016026245A2 (es)
CA (1) CA2947899C (es)
ES (2) ES2877275T3 (es)
HK (2) HK1257297A1 (es)
IL (1) IL248702B (es)
MX (2) MX2016015609A (es)
NZ (1) NZ726355A (es)
PH (1) PH12016502170A1 (es)
RU (1) RU2648166C1 (es)
SG (1) SG11201609154TA (es)
WO (1) WO2015184164A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3701B1 (ar) * 2014-05-23 2021-01-31 Regeneron Pharma مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
MX2016015609A (es) 2014-05-30 2017-08-02 Regeneron Pharma Animales con dipeptidil peptidasa iv (dpp4) humanizada.
JP7139419B2 (ja) * 2017-09-29 2022-09-20 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｔｔｒ遺伝子座を含む非ヒト動物および使用方法
CN109022489B (zh) * 2018-08-09 2023-03-31 中国食品药品检定研究院 人dpp4基因敲入的小鼠模型、其产生方法和用途
MX2021009855A (es) 2019-02-22 2021-09-10 Regeneron Pharma Roedores que tienen canales de sodio modificados geneticamente y metodos de uso de los mismos.
US20210227812A1 (en) * 2020-01-28 2021-07-29 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
KR102207249B1 (ko) * 2020-02-28 2021-01-25 대한민국(관리청: 특허청장, 승계청: 질병관리청장) 한국형 중동호흡기증후군 코로나바이러스 감염에 감수성을 가지는 인간 dpp4 유전자를 전신에 발현하는 형질전환마우스와 이의 용도
KR102243416B1 (ko) * 2020-02-28 2021-04-22 대한민국(질병관리청장) 한국형 중동호흡기증후군 코로나바이러스 감염에 감수성을 가지는 인간 dpp4 유전자를 폐 조직 특이적으로 발현하는 형질전환마우스와 이의 용도
CN113355325B (zh) * 2020-03-06 2023-07-14 中国科学院广州生物医药与健康研究院 人源化ace2基因改造小鼠胚胎干细胞模型制备方法及应用
US20230232796A1 (en) * 2020-06-26 2023-07-27 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ace2 locus

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6368604B1 (en) * 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
US7413031B2 (en) 2000-07-18 2008-08-19 The Charles Machine Works, Inc. Apparatus and method for maintaining control of a drilling machine
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
WO2004104216A2 (en) * 2003-05-21 2004-12-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4)
AU2005295269B2 (en) 2004-10-19 2010-05-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
WO2006128163A2 (en) 2005-05-27 2006-11-30 Memory Pharmaceuticals Corp. Transgenic alzheimer's mouse model vectors and uses thereof
WO2008080052A1 (en) * 2006-12-22 2008-07-03 Genentech, Inc. Transgenic mice expressing humanized vegf
WO2010110914A2 (en) * 2009-03-27 2010-09-30 Zirus, Inc. Mammalian genes involved in infection
CN105950654B (zh) 2010-11-27 2020-03-20 朱坚 一种人源化的转基因动物
CN103547148B (zh) * 2011-02-15 2016-06-08 再生元制药公司 人源化m-csf小鼠
US8878001B2 (en) * 2011-10-28 2014-11-04 Regeneron Pharmaceuticals, Inc. Humanized IL-6 and IL-6 receptor
EP2898067B1 (en) * 2012-09-23 2020-01-15 Erasmus University Medical Center Rotterdam Human betacoronavirus lineage c and identification of n-terminal dipeptidyl peptidase as its virus receptor
SG10201706741VA (en) 2013-02-20 2017-10-30 Regeneron Pharma Genetic modification of rats
BR112015026197B1 (pt) 2013-04-16 2022-12-06 Regeneron Pharmaceuticals, Inc Método para modificação marcada de um lócus genômico de interesse em uma célula de rato pluripotente
CN103554235B (zh) * 2013-06-17 2015-06-24 清华大学 MERS-CoV病毒膜蛋白中的RBD片段及其编码基因和应用
CN103724406A (zh) * 2013-11-20 2014-04-16 中国疾病预防控制中心病毒病预防控制所 一种具有中和活性的MERS-CoV合成肽疫苗及其应用
RU2725520C2 (ru) * 2013-12-11 2020-07-02 Регенерон Фармасьютикалс, Инк. Способы и композиции для направленной модификации генома
MX2016015609A (es) 2014-05-30 2017-08-02 Regeneron Pharma Animales con dipeptidil peptidasa iv (dpp4) humanizada.

Also Published As

Publication number Publication date
JP2017524336A (ja) 2017-08-31
AU2015266841B2 (en) 2017-04-13
US20160007579A1 (en) 2016-01-14
CN106413394A (zh) 2017-02-15
US20170112107A1 (en) 2017-04-27
BR112016026245A2 (pt) 2018-02-20
HK1257297A1 (zh) 2019-10-18
CA2947899A1 (en) 2015-12-03
PH12016502170A1 (en) 2017-02-06
ES2691529T3 (es) 2018-11-27
HK1216822A1 (zh) 2016-12-09
MX2020004803A (es) 2021-10-13
EP2993977B1 (en) 2018-07-18
ES2877275T3 (es) 2021-11-16
AU2015266841C1 (en) 2018-06-07
RU2648166C1 (ru) 2018-03-22
US20210235674A1 (en) 2021-08-05
SG11201609154TA (en) 2016-12-29
KR101737432B1 (ko) 2017-05-18
JP6636486B2 (ja) 2020-01-29
IL248702A0 (en) 2017-01-31
US11013220B2 (en) 2021-05-25
US20150351372A1 (en) 2015-12-10
CN106413394B (zh) 2020-02-11
US9532555B2 (en) 2017-01-03
WO2015184164A1 (en) 2015-12-03
JP6212659B2 (ja) 2017-10-11
CA2947899C (en) 2020-09-08
AU2015266841A1 (en) 2016-12-08
EP3381279A1 (en) 2018-10-03
CN111118047B (zh) 2023-09-22
EP3381279B1 (en) 2021-04-14
IL248702B (en) 2018-11-29
NZ726355A (en) 2018-08-31
US20190124896A1 (en) 2019-05-02
CN111118047A (zh) 2020-05-08
EP2993977A1 (en) 2016-03-16
US10212923B2 (en) 2019-02-26
US9497945B2 (en) 2016-11-22
JP2017213006A (ja) 2017-12-07
KR20170003931A (ko) 2017-01-10

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