MX2016006511A - Animales no humanos que tienen un gen del factor activador de celulas b. - Google Patents

Animales no humanos que tienen un gen del factor activador de celulas b.

Info

Publication number
MX2016006511A
MX2016006511A MX2016006511A MX2016006511A MX2016006511A MX 2016006511 A MX2016006511 A MX 2016006511A MX 2016006511 A MX2016006511 A MX 2016006511A MX 2016006511 A MX2016006511 A MX 2016006511A MX 2016006511 A MX2016006511 A MX 2016006511A
Authority
MX
Mexico
Prior art keywords
humanized
activating factor
cell activating
human animals
factor gene
Prior art date
Application number
MX2016006511A
Other languages
English (en)
Other versions
MX356809B (es
Inventor
J Murphy Andrew
Macdonald Lynn
Mcwhirter John
Gurer Cagan
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2016006511A publication Critical patent/MX2016006511A/es
Publication of MX356809B publication Critical patent/MX356809B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
    • C12N2015/8536—Animal models for genetic diseases
    • C12N2015/8563—Animal models for genetic diseases for autoimmune diseases, e.g. Insulin-dependent diabetes mellitus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se proporcionan animales no humanos, células, métodos y composiciones para generar y usar los mismos, en donde los animales no humanos y las células comprenden un gen humanizado del factor activador de células B. Se describen los animales no humanos y las células que expresan una proteína humana o humanizada del factor activador de células B a partir de un locus endógeno del factor activador de células B.
MX2016006511A 2013-11-19 2014-11-10 Animales no humanos que tienen un gen del factor activador de celulas b. MX356809B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361905983P 2013-11-19 2013-11-19
PCT/US2014/064806 WO2015077071A1 (en) 2013-11-19 2014-11-10 Non-human animals having a humanized b-cell activating factor gene

Publications (2)

Publication Number Publication Date
MX2016006511A true MX2016006511A (es) 2016-08-04
MX356809B MX356809B (es) 2018-06-13

Family

ID=51982794

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016006511A MX356809B (es) 2013-11-19 2014-11-10 Animales no humanos que tienen un gen del factor activador de celulas b.

Country Status (16)

Country Link
US (5) US20150143558A1 (es)
EP (2) EP3409110A1 (es)
JP (1) JP6505689B2 (es)
KR (1) KR102173260B1 (es)
CN (1) CN105792646B (es)
AU (1) AU2014353346B2 (es)
BR (1) BR112016011003A2 (es)
CA (1) CA2929846C (es)
ES (1) ES2700972T3 (es)
HK (2) HK1223505A1 (es)
IL (1) IL245418B (es)
MX (1) MX356809B (es)
MY (1) MY183188A (es)
RU (1) RU2670016C1 (es)
SG (2) SG10201900003WA (es)
WO (1) WO2015077071A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016011003A2 (pt) 2013-11-19 2017-12-05 Regeneron Pharma animal roedor geneticamente modificado, célula tronco embrionária de camundongo, embrião de camundongo, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo
SI3129400T1 (sl) 2014-04-08 2020-07-31 Regeneron Pharmaceuticals, Inc. Živali, ki niso človek in imajo humanizirane receptorje FC-gama
NO2785538T3 (es) 2014-05-07 2018-08-04
LT3157956T (lt) 2014-06-19 2020-05-11 Regeneron Pharmaceuticals, Inc. Nepriklausantys žmonėms gyvūnai, turintys humanizuotą užprogramuotos ląstelių žūties 1 geną
PL3689140T3 (pl) 2014-11-24 2022-09-05 Regeneron Pharmaceuticals, Inc. Zwierzęta inne niż ludzie eksprymujące humanizowany kompleks CD3
TR201903891T4 (tr) 2014-12-05 2019-04-22 Regeneron Pharma Bir insanlaştırılmış farklılaşma kümesi 47 genine sahip olan insan dışı hayvanlar.
SI3376857T1 (sl) 2015-11-20 2021-09-30 Regeneron Pharmaceuticals, Inc. Nehumane živali, ki imajo humaniziran gen 3 za aktivacijo limfocitov
CN108779159B (zh) 2016-02-04 2022-12-30 瑞泽恩制药公司 具有经改造的angptl8基因的非人动物
DK3422845T3 (da) * 2016-02-29 2021-08-30 Regeneron Pharma Gnavere med et humaniseret tmprss-gen
AU2018375796A1 (en) 2017-11-30 2020-04-23 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized TRKB locus
MA52177A (fr) 2018-03-26 2021-02-17 Regeneron Pharma Rongeurs humanisés pour tester des agents thérapeutiques
AU2019308205A1 (en) 2018-07-16 2020-11-19 Regeneron Pharmaceuticals, Inc. Non-human animal models of DITRA disease and uses thereof
EP4096396A1 (en) * 2020-01-28 2022-12-07 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
CN116075221A (zh) 2020-04-21 2023-05-05 瑞泽恩制药公司 具有人源化cxcl13基因的非人动物

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ224241A (en) * 1987-04-14 1991-03-26 Bresatec Ltd Method of producing new animal breeds using plasmid expression vectors; plasmid expression vectors
US5175384A (en) * 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5413927A (en) * 1991-09-03 1995-05-09 North Carolina State University Feline immunodeficiency virus isolate NCSU1Lb
CZ299819B6 (cs) * 1999-01-25 2008-12-03 Biogen Idec Ma Inc. Farmaceutické kompozice obsahující protilátky specifické pro rozpustný BAFF
WO2001019842A1 (en) * 1999-09-17 2001-03-22 Genzyme Transgenics Corporation Subunit optimized fusion proteins
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
WO2004016737A2 (en) * 2002-08-14 2004-02-26 Eli Lilly And Company Novel htnfsf13b protein variants
US8853367B1 (en) * 2004-09-15 2014-10-07 The Uab Research Foundation Compositions and methods for modulating rank activities
WO2006044962A1 (en) 2004-10-19 2006-04-27 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
US7759541B2 (en) * 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
EP1907566A4 (en) * 2005-05-27 2008-12-10 Memory Pharm Corp ALZHEIMER TRANSGENIC MOUSE MODEL VECTORS AND USES THEREOF
US20070028316A1 (en) * 2005-06-02 2007-02-01 Xiaoxia Li Transgenic non-human Act1-deficient mammals and uses thereof
US8354389B2 (en) 2009-08-14 2013-01-15 Regeneron Pharmaceuticals, Inc. miRNA-regulated differentiation-dependent self-deleting cassette
WO2011031835A1 (en) * 2009-09-09 2011-03-17 The Uab Research Foundation Chimeric dr5 polypeptides and uses thereof
KR102109172B1 (ko) * 2011-02-15 2020-05-12 리제너론 파마슈티칼스 인코포레이티드 인간화된 ｍ－ｃｓｆ 마우스
MX358390B (es) * 2011-10-28 2018-08-17 Regeneron Pharma Interleucina 6 y receptor de interleucina 6, humanizados.
AR090626A1 (es) * 2012-04-20 2014-11-26 Lilly Co Eli Anticuerpos anti-baff-anti-il-17 biespecificos
BR112016011003A2 (pt) 2013-11-19 2017-12-05 Regeneron Pharma animal roedor geneticamente modificado, célula tronco embrionária de camundongo, embrião de camundongo, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo
CA2984413A1 (en) * 2015-04-30 2016-11-03 Institute Of Immunology Co., Ltd. Transgenic non-human animal expressing human specific molecule and human fc.gamma. receptor family

Also Published As

Publication number Publication date
MX356809B (es) 2018-06-13
US9629347B2 (en) 2017-04-25
US20150143558A1 (en) 2015-05-21
US11000020B2 (en) 2021-05-11
CN105792646A (zh) 2016-07-20
BR112016011003A2 (pt) 2017-12-05
EP3071024B1 (en) 2018-09-05
CN105792646B (zh) 2018-03-02
ES2700972T3 (es) 2019-02-20
JP2016536985A (ja) 2016-12-01
US20170188556A1 (en) 2017-07-06
US20210329895A1 (en) 2021-10-28
HK1258505A1 (zh) 2019-11-15
US10219494B2 (en) 2019-03-05
KR102173260B1 (ko) 2020-11-03
AU2014353346B2 (en) 2020-05-14
IL245418B (en) 2020-06-30
KR20160078497A (ko) 2016-07-04
EP3409110A1 (en) 2018-12-05
IL245418A0 (en) 2016-06-30
JP6505689B2 (ja) 2019-04-24
RU2016123708A (ru) 2017-12-25
EP3071024A1 (en) 2016-09-28
US20150143561A1 (en) 2015-05-21
AU2014353346A1 (en) 2016-06-02
MY183188A (en) 2021-02-18
SG10201900003WA (en) 2019-02-27
CA2929846C (en) 2020-09-15
US20190124897A1 (en) 2019-05-02
RU2670016C1 (ru) 2018-10-17
CA2929846A1 (en) 2015-05-28
SG11201603360QA (en) 2016-05-30
HK1223505A1 (zh) 2017-08-04
WO2015077071A1 (en) 2015-05-28

Similar Documents

Publication Publication Date Title
MY183188A (en) Non-human animals having a humanized b-cell activating factor gene
MX2016006513A (es) Animales no humanos que tienen un gen humanizado de un ligando inductor de la proliferacion.
PH12016500342A1 (en) Non-human animals having a humanized signal-regulatory protein gene
SA518391159B1 (ar) مترافقات الألفة- قليلة النيوكليوتيد واستخداماتها
HK1250331A1 (zh) 閉合蛋白-18‧2特異性免疫受體和t細胞表位
MX2017007293A (es) Animales no humanos que tienen un gen del grupo de diferenciacion 47 humanizado.
EP3507373A4 (en) GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERAL PD-L1
EP3206251A4 (en) Lithium-air battery
EP3320773A4 (en) NON-HUMAN ANIMAL HAVING A CD3 HUMAN GENE SUBSTITUTED WITH ENDOGENOUS CD3 GENE
GB201813178D0 (en) Cell
GB201712733D0 (en) Methods & cells
EP3384038A4 (en) METHODS AND COMPOSITIONS FOR CELL REPROGRAMMING
MX2016013241A (es) Animales no humanos que tienen receptores fc gamma humanizados.
GB201803079D0 (en) Cell
MX2020012893A (es) Formulaciones de proteinas.
GB201819540D0 (en) T cell modification
EP3350867A4 (en) METAL-AIR FUEL CELL
GB201807693D0 (en) Cell
EP3731856A4 (en) MEDITOP-ACTIVATED T-CELLS
GB201816399D0 (en) Cell
GB2577995B (en) Cell
GB201820463D0 (en) Electrochemical sythenesis
GB201820443D0 (en) Cell
GB201810070D0 (en) Cell
GB201810059D0 (en) Cell

Legal Events

Date Code Title Description
FG Grant or registration