ES2691529T3 - Animales con dipeptidil peptidasa iv (dpp4) humanizada - Google Patents
Animales con dipeptidil peptidasa iv (dpp4) humanizada Download PDFInfo
- Publication number
- ES2691529T3 ES2691529T3 ES15727832T ES15727832T ES2691529T3 ES 2691529 T3 ES2691529 T3 ES 2691529T3 ES 15727832 T ES15727832 T ES 15727832T ES 15727832 T ES15727832 T ES 15727832T ES 2691529 T3 ES2691529 T3 ES 2691529T3
- Authority
- ES
- Spain
- Prior art keywords
- dpp4
- rodent
- animals
- dipeptidyl peptidase
- dpp4 gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 101150093210 DPP4 gene Proteins 0.000 title abstract 6
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 title 1
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 title 1
- 241001465754 Metazoa Species 0.000 title 1
- 241000283984 Rodentia Species 0.000 abstract 6
- 108700024394 Exon Proteins 0.000 abstract 2
- 241000711573 Coronaviridae Species 0.000 abstract 1
- 101100332180 Homo sapiens DPP4 gene Proteins 0.000 abstract 1
- 241000127282 Middle East respiratory syndrome-related coronavirus Species 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
- C12Y304/14005—Dipeptidyl-peptidase IV (3.4.14.5)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
Abstract
Un roedor, que comprende una sustitución en el locus de Dpp4 endógeno de roedor de los exones 2 al 26 del gen Dpp4 con los exones 2 al 26 de un gen DPP4 humano para formar un gen DPP4 modificado, en donde la expresión del gen DPP4 modificado está bajo el control de elementos reguladores endógenos de roedor del locus de Dpp4 endógeno de roedor, en donde el roedor es un ratón o una rata, y en donde el roedor muestra inflamación pulmonar cuando se infecta con el coronavirus que provoca el síndrome respiratorio del Oriente Medio (MERS-CoV).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462005476P | 2014-05-30 | 2014-05-30 | |
US201462051626P | 2014-09-17 | 2014-09-17 | |
US201462072692P | 2014-10-30 | 2014-10-30 | |
PCT/US2015/033024 WO2015184164A1 (en) | 2014-05-30 | 2015-05-28 | Humanized dipeptidyl peptidase iv (dpp4) animals |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2691529T3 true ES2691529T3 (es) | 2018-11-27 |
Family
ID=53366330
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES15727832T Active ES2691529T3 (es) | 2014-05-30 | 2015-05-28 | Animales con dipeptidil peptidasa iv (dpp4) humanizada |
ES18173004T Active ES2877275T3 (es) | 2014-05-30 | 2015-05-28 | Animales con dipeptidil peptidasa IV (DPP4) humanizada |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES18173004T Active ES2877275T3 (es) | 2014-05-30 | 2015-05-28 | Animales con dipeptidil peptidasa IV (DPP4) humanizada |
Country Status (17)
Country | Link |
---|---|
US (5) | US9497945B2 (es) |
EP (2) | EP3381279B1 (es) |
JP (2) | JP6212659B2 (es) |
KR (1) | KR101737432B1 (es) |
CN (2) | CN106413394B (es) |
AU (1) | AU2015266841C1 (es) |
BR (1) | BR112016026245A2 (es) |
CA (1) | CA2947899C (es) |
ES (2) | ES2691529T3 (es) |
HK (2) | HK1257297A1 (es) |
IL (1) | IL248702B (es) |
MX (2) | MX2020004803A (es) |
NZ (1) | NZ726355A (es) |
PH (1) | PH12016502170A1 (es) |
RU (1) | RU2648166C1 (es) |
SG (1) | SG11201609154TA (es) |
WO (1) | WO2015184164A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3701B1 (ar) * | 2014-05-23 | 2021-01-31 | Regeneron Pharma | مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي |
RU2648166C1 (ru) | 2014-05-30 | 2018-03-22 | Регенерон Фармасьютикалз, Инк. | Животные, содержащие гуманизированную дипептидилпептидазу iv (dpp4) |
CN111163633B (zh) * | 2017-09-29 | 2022-09-09 | 瑞泽恩制药公司 | 包含人源化ttr基因座的非人类动物及其使用方法 |
CN109022489B (zh) * | 2018-08-09 | 2023-03-31 | 中国食品药品检定研究院 | 人dpp4基因敲入的小鼠模型、其产生方法和用途 |
EP3927153A1 (en) | 2019-02-22 | 2021-12-29 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
AU2021212668A1 (en) * | 2020-01-28 | 2022-08-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized PNPLA3 locus and methods of use |
KR102207249B1 (ko) * | 2020-02-28 | 2021-01-25 | 대한민국(관리청: 특허청장, 승계청: 질병관리청장) | 한국형 중동호흡기증후군 코로나바이러스 감염에 감수성을 가지는 인간 dpp4 유전자를 전신에 발현하는 형질전환마우스와 이의 용도 |
KR102243416B1 (ko) * | 2020-02-28 | 2021-04-22 | 대한민국(질병관리청장) | 한국형 중동호흡기증후군 코로나바이러스 감염에 감수성을 가지는 인간 dpp4 유전자를 폐 조직 특이적으로 발현하는 형질전환마우스와 이의 용도 |
CN113355325B (zh) * | 2020-03-06 | 2023-07-14 | 中国科学院广州生物医药与健康研究院 | 人源化ace2基因改造小鼠胚胎干细胞模型制备方法及应用 |
WO2021263146A2 (en) * | 2020-06-26 | 2021-12-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ace2 locus |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6368604B1 (en) * | 1997-09-26 | 2002-04-09 | University Of Maryland Biotechnology Institute | Non-pyrogenic derivatives of lipid A |
AU2001273549A1 (en) | 2000-07-18 | 2002-01-30 | Geoff D. Koch | Remote control for a drilling machine |
US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
EP1631680A2 (en) * | 2003-05-21 | 2006-03-08 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4) |
PT1802193E (pt) | 2004-10-19 | 2014-06-23 | Regeneron Pharma | Método para gerar um murganho homozigótico para uma modificação genética |
WO2006128163A2 (en) | 2005-05-27 | 2006-11-30 | Memory Pharmaceuticals Corp. | Transgenic alzheimer's mouse model vectors and uses thereof |
WO2008080052A1 (en) * | 2006-12-22 | 2008-07-03 | Genentech, Inc. | Transgenic mice expressing humanized vegf |
WO2010110914A2 (en) * | 2009-03-27 | 2010-09-30 | Zirus, Inc. | Mammalian genes involved in infection |
US10765093B2 (en) * | 2010-11-27 | 2020-09-08 | James Zhu | Humanized transgenic animal |
PT2675271T (pt) * | 2011-02-15 | 2018-10-11 | Univ Yale | Ratinhos humanizados para m-csf |
EP2818478B1 (en) * | 2011-10-28 | 2017-02-01 | Regeneron Pharmaceuticals, Inc. | Humanized IL-6 and IL-6 receptor |
ES2790841T3 (es) | 2012-09-23 | 2020-10-29 | Univ Erasmus Med Ct Rotterdam | Betacoronavirus humano del Linaje C e identificación de la dipeptidil peptidasa N-terminal como su receptor viral |
ES2904803T3 (es) | 2013-02-20 | 2022-04-06 | Regeneron Pharma | Modificación genética de ratas |
PT3456831T (pt) | 2013-04-16 | 2021-09-10 | Regeneron Pharma | Modificação alvejada do genoma de rato |
CN103554235B (zh) * | 2013-06-17 | 2015-06-24 | 清华大学 | MERS-CoV病毒膜蛋白中的RBD片段及其编码基因和应用 |
CN103724406A (zh) * | 2013-11-20 | 2014-04-16 | 中国疾病预防控制中心病毒病预防控制所 | 一种具有中和活性的MERS-CoV合成肽疫苗及其应用 |
CN105980568B (zh) * | 2013-12-11 | 2019-12-03 | 瑞泽恩制药公司 | 用于靶向修饰基因组的方法和组合物 |
RU2648166C1 (ru) | 2014-05-30 | 2018-03-22 | Регенерон Фармасьютикалз, Инк. | Животные, содержащие гуманизированную дипептидилпептидазу iv (dpp4) |
-
2015
- 2015-05-28 RU RU2016150679A patent/RU2648166C1/ru active
- 2015-05-28 CN CN201580027887.6A patent/CN106413394B/zh active Active
- 2015-05-28 NZ NZ726355A patent/NZ726355A/en not_active IP Right Cessation
- 2015-05-28 CN CN202010059426.XA patent/CN111118047B/zh active Active
- 2015-05-28 JP JP2016566982A patent/JP6212659B2/ja active Active
- 2015-05-28 SG SG11201609154TA patent/SG11201609154TA/en unknown
- 2015-05-28 CA CA2947899A patent/CA2947899C/en active Active
- 2015-05-28 EP EP18173004.5A patent/EP3381279B1/en active Active
- 2015-05-28 WO PCT/US2015/033024 patent/WO2015184164A1/en active Application Filing
- 2015-05-28 BR BR112016026245A patent/BR112016026245A2/pt not_active IP Right Cessation
- 2015-05-28 ES ES15727832T patent/ES2691529T3/es active Active
- 2015-05-28 ES ES18173004T patent/ES2877275T3/es active Active
- 2015-05-28 MX MX2020004803A patent/MX2020004803A/es unknown
- 2015-05-28 EP EP15727832.6A patent/EP2993977B1/en active Active
- 2015-05-28 AU AU2015266841A patent/AU2015266841C1/en active Active
- 2015-05-28 MX MX2016015609A patent/MX2016015609A/es active IP Right Grant
- 2015-05-28 US US14/723,855 patent/US9497945B2/en active Active
- 2015-05-28 KR KR1020167031766A patent/KR101737432B1/ko active IP Right Grant
- 2015-08-12 US US14/824,475 patent/US9532555B2/en active Active
-
2016
- 2016-04-29 HK HK18116446.6A patent/HK1257297A1/zh unknown
- 2016-04-29 HK HK16104919.2A patent/HK1216822A1/zh unknown
- 2016-10-17 US US15/295,955 patent/US10212923B2/en active Active
- 2016-11-02 IL IL248702A patent/IL248702B/en active IP Right Grant
- 2016-11-02 PH PH12016502170A patent/PH12016502170A1/en unknown
-
2017
- 2017-09-15 JP JP2017177761A patent/JP6636486B2/ja active Active
-
2019
- 2019-01-03 US US16/239,028 patent/US11013220B2/en active Active
-
2021
- 2021-04-21 US US17/236,083 patent/US20210235674A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2691529T3 (es) | Animales con dipeptidil peptidasa iv (dpp4) humanizada | |
EA201691911A1 (ru) | Быстродействующие композиции инсулина | |
EA201791117A1 (ru) | Частичные агонисты инсулинового рецептора | |
ECSP17010156A (es) | Compuestos aminopirimidinilo como inhibidores jak | |
GT201600233A (es) | Compuestos y composiciones como agonistas del receptor tipo toll 7 | |
CL2016003075A1 (es) | Composición para tratar diabetes, que contiene un conjugado de análogo de insulina de acción prolongada y un conjugado de péptido insulinotrópico de acción prolongada | |
CL2016001889A1 (es) | (2s)-n-[(1s)-1-ciano-2-feniletil]-1,4-oxazepan-2-carboxamidas como inhibidores de dipeptidil peptidasa 1. | |
DK3212208T3 (da) | Anvendelse af l. reuteri til forebyggelse eller behandling af mikrobiotadysbiose tidligt i livet | |
CL2017003096A1 (es) | Vectores virales adenoasociados para el tratamiento de mucopolisacaridosis | |
DK3841877T3 (da) | Genetisk modificeret mus, der eksprimerer human EPO | |
DK3191449T3 (da) | Forbindelser som ret- (rearranged during transfection) hæmmere | |
CL2016003246A1 (es) | Compuestos de dihidroisoquinolinona sustituida | |
PH12016501441A1 (en) | Chimeric alkaline phosphate-like proteins | |
DOP2015000288A (es) | Composiciones de arni de serpina1 y sus métodos de uso. | |
EA201691582A1 (ru) | Новые фармацевтические препараты | |
DK3099333T3 (da) | Bag3 som mål for behandling af hjertesvigt | |
CL2016002764A1 (es) | Composiciones y métodos para modular la expresión del factor b del complemento | |
EA201791508A1 (ru) | Способы трансдифференцировки и способы их использования | |
BR112016017402A2 (pt) | fusões anti-pcsk9~glp-1 e métodos para uso | |
BR112016024539A8 (pt) | Combinador óptico ativo para rede catv | |
CL2015001936A1 (es) | Composición y su uso que sirve para preparar un medicamento útil para tratar enfermedades relacionadas con el factor inducible por hipoxia (hif). | |
CL2016002779A1 (es) | Composición para el cuidado de la piel | |
BR112016026143A2 (pt) | os métodos e composições compreendendo ácido 10-hidroxi-2-decenóico. | |
MY181685A (en) | Methods and compositions comprising ursolic acid and/or resveratrol for treating obesity, diabetes, or cancer | |
BR112016018452A2 (pt) | vaso sanguíneo artificial. |