DK3841877T3 - Genetisk modificeret mus, der eksprimerer human EPO - Google Patents

Genetisk modificeret mus, der eksprimerer human EPO Download PDF

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Publication number
DK3841877T3
DK3841877T3 DK20209073.4T DK20209073T DK3841877T3 DK 3841877 T3 DK3841877 T3 DK 3841877T3 DK 20209073 T DK20209073 T DK 20209073T DK 3841877 T3 DK3841877 T3 DK 3841877T3
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Denmark
Prior art keywords
genetically modified
expressing human
human epo
modified mouse
mouse expressing
Prior art date
Application number
DK20209073.4T
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English (en)
Inventor
Andrew J Murphy
Sean Stevens
Richard Flavell
Markus Manz
Liang Shan
Original Assignee
Regeneron Pharma
Univ Yale
Institute For Res In Biomedicine Irb
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Application filed by Regeneron Pharma, Univ Yale, Institute For Res In Biomedicine Irb filed Critical Regeneron Pharma
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Publication of DK3841877T3 publication Critical patent/DK3841877T3/da

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
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    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
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    • C07K—PEPTIDES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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    • C—CHEMISTRY; METALLURGY
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • A—HUMAN NECESSITIES
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    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
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    • A01K2267/0337—Animal models for infectious diseases
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DK20209073.4T 2014-05-19 2015-05-18 Genetisk modificeret mus, der eksprimerer human EPO DK3841877T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462000460P 2014-05-19 2014-05-19
EP18214077.2A EP3482629B1 (en) 2014-05-19 2015-05-18 Genetically modified non-human animals expressing human epo

Publications (1)

Publication Number Publication Date
DK3841877T3 true DK3841877T3 (da) 2023-11-27

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Application Number Title Priority Date Filing Date
DK20209073.4T DK3841877T3 (da) 2014-05-19 2015-05-18 Genetisk modificeret mus, der eksprimerer human EPO
DK15756500.3T DK3145307T3 (da) 2014-05-19 2015-05-18 Genmodificerede ikke-humane dyr, der eksprimerer human epo
DK18214077.2T DK3482629T3 (da) 2014-05-19 2015-05-18 Genmodificerede ikke-humane dyr, der eksprimerer humant epo

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DK15756500.3T DK3145307T3 (da) 2014-05-19 2015-05-18 Genmodificerede ikke-humane dyr, der eksprimerer human epo
DK18214077.2T DK3482629T3 (da) 2014-05-19 2015-05-18 Genmodificerede ikke-humane dyr, der eksprimerer humant epo

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US (3) US10463028B2 (da)
EP (4) EP3841877B1 (da)
JP (4) JP6672171B2 (da)
KR (4) KR20240017405A (da)
CN (2) CN106536546B (da)
AU (2) AU2015264427B2 (da)
CA (1) CA2947309A1 (da)
DK (3) DK3841877T3 (da)
ES (3) ES2964597T3 (da)
FI (1) FI3841877T3 (da)
IL (5) IL296315A (da)
MX (3) MX2020001344A (da)
MY (1) MY179927A (da)
PT (3) PT3145307T (da)
RU (1) RU2711744C1 (da)
SG (2) SG11201608999SA (da)
WO (1) WO2015179317A2 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2591107T3 (es) 2009-10-06 2016-11-24 Regeneron Pharmaceuticals, Inc. Ratones modificados genéticamente e injerto
RU2730643C2 (ru) 2011-02-15 2020-08-24 Ридженерон Фармасьютикалз, Инк. Гуманизированные m-csf мыши
KR102594390B1 (ko) 2012-09-07 2023-10-27 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
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