ES2071620T3 - Mamiferos inmunodeficientes quimericos y su utilizacion. - Google Patents

Mamiferos inmunodeficientes quimericos y su utilizacion.

Info

Publication number
ES2071620T3
ES2071620T3 ES88312222T ES88312222T ES2071620T3 ES 2071620 T3 ES2071620 T3 ES 2071620T3 ES 88312222 T ES88312222 T ES 88312222T ES 88312222 T ES88312222 T ES 88312222T ES 2071620 T3 ES2071620 T3 ES 2071620T3
Authority
ES
Spain
Prior art keywords
tissue
xenogeneic
thymus
lymph node
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88312222T
Other languages
English (en)
Inventor
Joseph Mccrary Mccune
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22476130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2071620(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Application granted granted Critical
Publication of ES2071620T3 publication Critical patent/ES2071620T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals

Abstract

SE PREVEEN HUESPEDES QUIMERICOS POR INTRODUCCION EN UN HUESPED XENOGENICO MAMIFERO INMUNOCOMPROMETIDO, NORMALMENTE HUMANO, TEJIDO BAJO CONDICIONES EN LAS QUE EL TEJIDO XEROGENICO PUEDE CREAR O INTERACTUAR DE TAL MODO QUE SE PUEDEN OBSERVAR CELULAS INDIFERENCIADAS (STEM) SIN DIFERENCIADOS Y PROLIFERADOS. DENTRO DE RATONES S(II) SE PUEDEN INTRODUCIR TEJIDO FETAL, CELULAS STEM QUE PROVIENEN DE TEJIDO HEPATICO FETAL, DONDE EL FIMO CRECE EN UN ORGANO FINO COMPETENTE, Y TEJIDO DE MODULO LINFATICO, DONDE EL TEJIDO NO MODULO LINFATICO CRECE DENTRO DE UN MODULO LINFATICO COMPETENTE, Y SE PROCESAN LAS CELULAS STEM PARA PRODUCIR CELULAS B Y T FUNCIONALES HUMANAS.
ES88312222T 1987-12-23 1988-12-22 Mamiferos inmunodeficientes quimericos y su utilizacion. Expired - Lifetime ES2071620T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13717387A 1987-12-23 1987-12-23

Publications (1)

Publication Number Publication Date
ES2071620T3 true ES2071620T3 (es) 1995-07-01

Family

ID=22476130

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88312222T Expired - Lifetime ES2071620T3 (es) 1987-12-23 1988-12-22 Mamiferos inmunodeficientes quimericos y su utilizacion.

Country Status (8)

Country Link
EP (1) EP0322240B1 (es)
JP (1) JP2801228B2 (es)
AT (1) ATE119197T1 (es)
AU (1) AU2754888A (es)
DE (1) DE3853201T2 (es)
DK (1) DK720488A (es)
ES (1) ES2071620T3 (es)
IL (1) IL88779A (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2981486B2 (ja) * 1988-06-14 1999-11-22 メディカル・バイオロジー・インスティチュート 哺乳動物の免疫系研究方法
US6673986B1 (en) * 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6713610B1 (en) 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
US6657103B1 (en) 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) * 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) * 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP1690935A3 (en) * 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
DE69131331T2 (de) * 1990-01-15 2000-03-02 Yeda Res & Dev Dauerhafte Verpflanzung und Entwicklung menschlicher hämatopoietischer Zellinien bei normalen Säugetieren
US5849288A (en) * 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
US5652373A (en) * 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5147784A (en) * 1990-04-12 1992-09-15 Systemix, Inc. T-lymphocyte progenitor cell assay
DK0481058T3 (da) * 1990-05-03 1996-12-02 Systemix Inc Humant, lymfatisk væv i en immunokompromitteret vært
CA2064075A1 (en) * 1990-05-25 1991-11-26 Charles M. Baum Human peripheral blood cells in an immunocompromised host
DK9091D0 (da) * 1991-01-18 1991-01-18 Novo Nordisk As Fremgangsmaade til fremstilling af antistoffer
US5804160A (en) * 1991-06-04 1998-09-08 Yeda Research And Development Co. Ltd Animal model for hepatitis virus infection
US5858328A (en) * 1991-06-04 1999-01-12 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5849987A (en) * 1992-06-02 1998-12-15 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
EP0539970B1 (en) * 1991-10-30 1999-05-26 Idemitsu Kosan Company Limited Methods for producing human lymphocytes and human monoclonal antibodies, and human monoclonal antibodies produced thereby
US6353150B1 (en) * 1991-11-22 2002-03-05 Hsc Research And Development Limited Partnership Chimeric mammals with human hematopoietic cells
NL9102122A (nl) * 1991-12-18 1993-07-16 Tno Werkwijze voor het testen van antivirale middelen; daarvoor bruikbare proefdieren.
US5866757A (en) * 1992-06-02 1999-02-02 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
AU5965294A (en) * 1993-01-08 1994-08-15 Exemplar Corporation An (in vitro)/(in vivo) method for identifying anti-neoplastic drugs
GB9317766D0 (en) * 1993-08-26 1993-10-13 Agricultural & Food Res Animal models
US5985660A (en) * 1994-06-15 1999-11-16 Systemix, Inc. Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation
US5972627A (en) * 1994-06-15 1999-10-26 Systemix, Inc. Method of purifying a population of cells enriched for dendritic and/or lymphoid progenitors and populations of cells obtained thereby
AU7236094A (en) * 1994-07-03 1996-01-25 P.N. Gerolymatos S.A. Thymus products and applications
US6455756B1 (en) * 1994-08-12 2002-09-24 Novartis Ag Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice
US6015554A (en) * 1995-06-07 2000-01-18 Systemix, Inc. Method of reconstituting human lymphoid and dendritic cells
AU6223096A (en) * 1995-06-07 1996-12-30 Novartis Ag Immunocompromised animals comprising human synovial tissue
US5986170A (en) * 1995-11-13 1999-11-16 Corixa Corporation Murine model for human carcinoma
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
AU735644B2 (en) 1997-03-26 2001-07-12 Reprogen, Inc. Endometriosis mouse model
WO1998044788A2 (en) * 1997-04-09 1998-10-15 Chang Lung Ji Animal model for evaluation of vaccines
AU751647B2 (en) * 1998-05-26 2002-08-22 Innogenetics N.V. Method for expanding primate B cells selectively in immunocompromised mice and producing large numbers of antigen-specific B lymphocytes for the production of primate monoclonal antibodies
US20070266448A1 (en) * 2006-05-11 2007-11-15 Alexander Lifke Method for the production of antibodies
US20120157667A1 (en) * 2009-06-29 2012-06-21 Qingfeng Chen Methods Of Producing Humanized Non-Human Mammals
US8541646B2 (en) 2009-10-06 2013-09-24 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
RU2730643C2 (ru) 2011-02-15 2020-08-24 Ридженерон Фармасьютикалз, Инк. Гуманизированные m-csf мыши
AU2013312359B8 (en) 2012-09-07 2019-08-15 Institute For Research In Biomedicine (Irb) Genetically modified non-human animals and methods of use thereof
RU2673156C2 (ru) 2012-11-05 2018-11-22 Ридженерон Фармасьютикалз, Инк. Генетически модифицированные не относящиеся к человеческому роду животные и способы их применения
CN113045639A (zh) 2014-05-19 2021-06-29 再生元制药公司 表达人epo的经遗传修饰的非人动物
IL254727B2 (en) 2015-04-13 2023-10-01 Regeneron Pharma Mice genetically engineered to express signal-regulating protein alpha and interleukin 15 and methods of using them

Also Published As

Publication number Publication date
DK720488A (da) 1989-06-24
DE3853201D1 (de) 1995-04-06
ATE119197T1 (de) 1995-03-15
JPH0231632A (ja) 1990-02-01
EP0322240A2 (en) 1989-06-28
EP0322240B1 (en) 1995-03-01
AU2754888A (en) 1989-06-29
IL88779A0 (en) 1989-07-31
IL88779A (en) 1995-07-31
DE3853201T2 (de) 1995-09-14
JP2801228B2 (ja) 1998-09-21
EP0322240A3 (en) 1990-04-18
DK720488D0 (da) 1988-12-23

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