ATE361975T1 - Tiermodell für hepatitis-virus infektion - Google Patents
Tiermodell für hepatitis-virus infektionInfo
- Publication number
- ATE361975T1 ATE361975T1 AT94917988T AT94917988T ATE361975T1 AT E361975 T1 ATE361975 T1 AT E361975T1 AT 94917988 T AT94917988 T AT 94917988T AT 94917988 T AT94917988 T AT 94917988T AT E361975 T1 ATE361975 T1 AT E361975T1
- Authority
- AT
- Austria
- Prior art keywords
- mammal
- liver tissue
- transplanted
- preparation
- human
- Prior art date
Links
- 238000010171 animal model Methods 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 11
- 210000005228 liver tissue Anatomy 0.000 abstract 5
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 4
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
- C07K16/109—Hepatitis C virus; Hepatitis G virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/061,706 US5652373A (en) | 1990-01-15 | 1993-05-17 | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
IL10695193A IL106951A0 (en) | 1993-05-17 | 1993-09-08 | Engraftment of xenogeneic non-hematopoietic cells and tissue in normal mammals |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE361975T1 true ATE361975T1 (de) | 2007-06-15 |
Family
ID=26322684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94917988T ATE361975T1 (de) | 1993-05-17 | 1994-05-13 | Tiermodell für hepatitis-virus infektion |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0699235B1 (de) |
JP (1) | JP3064421B2 (de) |
AT (1) | ATE361975T1 (de) |
AU (1) | AU6949994A (de) |
CA (1) | CA2161798C (de) |
DE (1) | DE69434968T2 (de) |
ES (1) | ES2287929T3 (de) |
WO (1) | WO1994027556A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5980886A (en) * | 1994-12-14 | 1999-11-09 | University Of Washington | Recombinant vectors for reconstitution of liver |
US6107027A (en) * | 1994-12-14 | 2000-08-22 | University Of Washington | Ribozymes for treating hepatitis C |
EP0866654B1 (de) * | 1995-09-27 | 2007-11-14 | The General Hospital Corporation | Methode für die behandlung einer hepatitisvirusinfektion |
US6296844B1 (en) | 1995-09-27 | 2001-10-02 | The General Hospital Corporation | Asialocytokines and treatment of liver disease |
US6034297A (en) * | 1997-09-26 | 2000-03-07 | Cedars-Sinai Medical Center | In vivo, animal model for expression of hepatitis C virus |
US6995299B2 (en) | 1999-11-02 | 2006-02-07 | University Of Connecticut | Propagation of human hepatocytes in non-human animals |
US6525242B1 (en) | 1999-11-02 | 2003-02-25 | The University Of Connecticut | Propagation of human hepatocytes in non-human mammals |
US6509514B1 (en) | 2000-03-17 | 2003-01-21 | Kmt Hepatech, Inc. | Chimeric animal model susceptible to human hepatitis C virus infection |
WO2004006664A1 (ja) * | 2002-07-16 | 2004-01-22 | Japan Science And Technology Agency | 非癌部肝臓組織が移植されたモデル動物およびその作製方法 |
JP2008510465A (ja) | 2004-08-20 | 2008-04-10 | ケイエムティー ヒパテック インコーポレイテッド | キメラヒト肝臓を有するマラリア動物モデル |
WO2017035375A1 (en) * | 2015-08-25 | 2017-03-02 | The Uab Research Foundation | Methods for stem cell transplantation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0438053B1 (de) * | 1990-01-15 | 1999-06-16 | Yeda Research And Development Company Limited | Dauerhafte Verpflanzung und Entwicklung menschlicher hämatopoietischer Zellinien bei normalen Säugetieren |
JPH04252128A (ja) * | 1990-08-03 | 1992-09-08 | Systemix Inc | 免疫化された宿主における変性された異種移植器官系 |
EP0517199A1 (de) * | 1991-06-04 | 1992-12-09 | Yeda Research And Development Company, Ltd. | Dauerhafte Transplantation von menschlichen Zellen und Geweben in normalen Säugetieren |
-
1994
- 1994-05-13 AU AU69499/94A patent/AU6949994A/en not_active Abandoned
- 1994-05-13 CA CA002161798A patent/CA2161798C/en not_active Expired - Fee Related
- 1994-05-13 ES ES94917988T patent/ES2287929T3/es not_active Expired - Lifetime
- 1994-05-13 AT AT94917988T patent/ATE361975T1/de not_active IP Right Cessation
- 1994-05-13 DE DE69434968T patent/DE69434968T2/de not_active Expired - Fee Related
- 1994-05-13 WO PCT/US1994/005410 patent/WO1994027556A2/en active IP Right Grant
- 1994-05-13 EP EP94917988A patent/EP0699235B1/de not_active Expired - Lifetime
- 1994-05-13 JP JP7500728A patent/JP3064421B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2287929T3 (es) | 2007-12-16 |
DE69434968T2 (de) | 2008-01-10 |
CA2161798C (en) | 2005-04-05 |
EP0699235A1 (de) | 1996-03-06 |
WO1994027556A2 (en) | 1994-12-08 |
WO1994027556A3 (en) | 1995-06-08 |
JPH08511937A (ja) | 1996-12-17 |
AU6949994A (en) | 1994-12-20 |
DE69434968D1 (de) | 2007-06-21 |
JP3064421B2 (ja) | 2000-07-12 |
CA2161798A1 (en) | 1994-12-08 |
EP0699235B1 (de) | 2007-05-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |