MXPA02007137A - Fuente de tejido hepatico. - Google Patents

Fuente de tejido hepatico.

Info

Publication number
MXPA02007137A
MXPA02007137A MXPA02007137A MXPA02007137A MXPA02007137A MX PA02007137 A MXPA02007137 A MX PA02007137A MX PA02007137 A MXPA02007137 A MX PA02007137A MX PA02007137 A MXPA02007137 A MX PA02007137A MX PA02007137 A MXPA02007137 A MX PA02007137A
Authority
MX
Mexico
Prior art keywords
tissue
cells
donor
source
cadaveric
Prior art date
Application number
MXPA02007137A
Other languages
English (en)
Inventor
Lola Reid
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22645867&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA02007137(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of MXPA02007137A publication Critical patent/MXPA02007137A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion proporciona, por primera vez el uso de organos cadavericos de donadores con corazones no palpitantes como fuente de celulas funcionales como pueden ser las celulas progenitoras o primordiales para diferentes propositos medicos. Mas especificamente se describe un metodo con el cual se obtienen una fuente de tejido de celulas progenitoras, el cual consiste en cosechar el tejido de un donador, en donde el donador tiene un corazon no palpitante durante aproximadamente 30 horas post mortem, y el procesamiento del tejido cadaverico para obtener celulas progenitoras, las cuales se utilizan para diferentes propositos medicos como medio de tratamiento celular, tratamiento genico, organos artificiales, biorreactores, regeneracion de organos y similares.
MXPA02007137A 2000-01-19 2001-01-19 Fuente de tejido hepatico. MXPA02007137A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17679800P 2000-01-19 2000-01-19
PCT/US2001/001821 WO2001053462A1 (en) 2000-01-19 2001-01-19 Liver tissue source

Publications (1)

Publication Number Publication Date
MXPA02007137A true MXPA02007137A (es) 2004-09-06

Family

ID=22645867

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02007137A MXPA02007137A (es) 2000-01-19 2001-01-19 Fuente de tejido hepatico.

Country Status (16)

Country Link
US (2) US20020039786A1 (es)
EP (1) EP1252293B1 (es)
JP (1) JP2003520596A (es)
CN (2) CN101955906A (es)
AU (1) AU782683B2 (es)
BR (1) BR0107917A (es)
CA (1) CA2397927A1 (es)
DK (1) DK1252293T3 (es)
ES (1) ES2395821T3 (es)
HU (1) HUP0203781A2 (es)
IL (2) IL150819A0 (es)
MX (1) MXPA02007137A (es)
PT (1) PT1252293E (es)
RU (1) RU2002122108A (es)
WO (1) WO2001053462A1 (es)
ZA (1) ZA200205887B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
US7687057B2 (en) 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
RU2247565C2 (ru) * 1999-01-19 2005-03-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл Клетки-предшественники печени человека
EP1381673B1 (en) * 2001-03-27 2009-05-13 Vertex Pharmaceuticals Incorporated Compositions and methods useful for hcv infection
WO2003027253A2 (en) * 2001-09-26 2003-04-03 University Of North Carolina At Chapel Hill Variants of alpha-fetoprotein coding and expression sequences
JP2005533102A (ja) * 2002-07-12 2005-11-04 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 微小器官によって生物学的プロセスを誘発する方法と装置
EP1576117A4 (en) * 2002-07-19 2006-02-01 Vesta Therapeutics Inc METHOD FOR OBTAINING VIABLE HUMAN LIVER CELLS, INCLUDING STEM CELLS / HEPATIC PRECURSORS
US7074561B2 (en) * 2002-10-22 2006-07-11 Biomerieux, Inc. Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
JP2007516706A (ja) * 2003-12-01 2007-06-28 バーテックス　ファーマシューティカルズ　インコーポレイテッド 胎児肝臓細胞を含む組成物およびｈｃｖ感染で有用な方法
AU2005205240B2 (en) * 2004-01-14 2011-04-21 Novahep Ab Human hepatic progenitor cells and methods of use thereof
NZ554964A (en) * 2004-11-17 2008-11-28 Rogosin Inst Scoring method for determining pancreas suitability for islet isolation
US7604929B2 (en) * 2005-04-21 2009-10-20 In Vitro Technologies, Inc. Cellular compositions and methods for their preparation
WO2007071339A1 (en) 2005-12-21 2007-06-28 Universite Catholique De Louvain Isolated liver stem cells
JP5243456B2 (ja) 2007-03-02 2013-07-24 スミス アンド ネフュー ピーエルシー 生物学的サンプルろ過中の超音波、逆流洗浄、およびフィルタ運動によるフィルタ洗浄装置および方法
AU2008280143B2 (en) * 2007-07-20 2014-04-17 Cellartis Ab A novel population of hepatocytes derived via definitive endoderm (DE-hep) from human blastocysts stem cells
US8809303B2 (en) * 2008-04-09 2014-08-19 The University Of North Carolina At Chapel Hill Methods of regulating actin cytoskeletal rearrangement and intercellular gap formation
WO2010010355A2 (en) 2008-07-25 2010-01-28 Smith & Nephew Plc Controller for separation apparatus
WO2011002926A2 (en) * 2009-07-01 2011-01-06 The General Hospital Corporation Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
EP2392648A1 (en) 2010-06-04 2011-12-07 Institut Pasteur Methods for obtaining stem cells
JPWO2013115322A1 (ja) * 2012-02-02 2015-05-11 タカラバイオ株式会社 細胞の保存方法
WO2014200816A1 (en) 2013-06-14 2014-12-18 Biotranex, Llc Method for measuring bile salt export transport and/or formation activity
ES2759228T3 (es) 2013-07-05 2020-05-08 Univ Catholique Louvain Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
WO2016001839A1 (en) * 2014-06-30 2016-01-07 Stempeutics Research Pvt. Ltd. Management of liver disease using pooled mesenchymal stromal cells
US11697799B2 (en) 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
US20220330530A1 (en) * 2019-09-13 2022-10-20 The University Of North Carolina At Chapel Hill Method of making human mouse xenografts
WO2022020210A1 (en) 2020-07-18 2022-01-27 Ossium Health, Inc. Permeation of whole vertebral bodies with a cryoprotectant using vacuum assisted diffusion
CA3195653A1 (en) 2020-10-14 2022-04-21 Ossium Health, Inc. Systems and methods for extraction and cryopreservation of bone marrow
WO2022133282A1 (en) 2020-12-18 2022-06-23 Ossium Health, Inc. Methods of cell therapies
CN113804609B (zh) * 2021-09-13 2024-03-29 复旦大学附属中山医院 一种检测异位胸腺组织的方法及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
EP1559778A1 (en) * 1991-08-07 2005-08-03 Albert Einstein College Of Medicine Of Yeshiva University Proliferation of hepatocyte precursors
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
WO1995013697A1 (en) * 1993-11-19 1995-05-26 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Hepatoblasts and method of isolating same
CA2146735C (en) * 1994-04-11 2007-02-20 Chise Tateno Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes
US5843024A (en) 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US6908763B1 (en) * 1997-08-22 2005-06-21 The Board Of Trustees Of The Leland Stanford Junior University Mammalian common lymphoid progenitor cell
US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
RU2247565C2 (ru) 1999-01-19 2005-03-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл Клетки-предшественники печени человека

Also Published As

Publication number Publication date
EP1252293B1 (en) 2012-10-03
BR0107917A (pt) 2003-02-11
IL150819A (en) 2009-06-15
JP2003520596A (ja) 2003-07-08
HUP0203781A2 (hu) 2003-03-28
CN1411504A (zh) 2003-04-16
DK1252293T3 (da) 2013-01-14
RU2002122108A (ru) 2004-03-27
ZA200205887B (en) 2003-07-23
ES2395821T3 (es) 2013-02-15
CA2397927A1 (en) 2001-07-26
EP1252293A1 (en) 2002-10-30
IL150819A0 (en) 2003-02-12
US20100233808A1 (en) 2010-09-16
WO2001053462A1 (en) 2001-07-26
AU782683B2 (en) 2005-08-18
CN101955906A (zh) 2011-01-26
AU3099101A (en) 2001-07-31
US20020039786A1 (en) 2002-04-04
PT1252293E (pt) 2013-01-23

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