MX2013010171A - Antagonistas del receptor de interleucina-1. - Google Patents

Antagonistas del receptor de interleucina-1.

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Publication number
MX2013010171A
MX2013010171A MX2013010171A MX2013010171A MX2013010171A MX 2013010171 A MX2013010171 A MX 2013010171A MX 2013010171 A MX2013010171 A MX 2013010171A MX 2013010171 A MX2013010171 A MX 2013010171A MX 2013010171 A MX2013010171 A MX 2013010171A
Authority
MX
Mexico
Prior art keywords
binding
inflammatory
receptor
nervous system
central nervous
Prior art date
Application number
MX2013010171A
Other languages
English (en)
Inventor
Vladimir Berezin
Elisabeth Bock
Original Assignee
Serodus Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serodus Asa filed Critical Serodus Asa
Publication of MX2013010171A publication Critical patent/MX2013010171A/es

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    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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Abstract

La presente invención describe péptidos novedosos derivados de la proteína antagonista de receptor de IL-1 (IL1 RA), capaces de unión al receptor 1 de IL-1 de superficie celular (IL1 R1) e interfieren con la unión de IL-1 a IL1 R1. Esta unión, por lo tanto antagoniza efectivamente los efectos inflamatorios de IL-1, por ejemplo por reducción de la secreción de TNF-a de los macrófagos. Esto es de uso potencial como un factor antiinflamatorio en el cuerpo humano, que incluye al sistema nervioso central. El uso de los péptidos como agentes antiinflamatorios para el tratamiento de condiciones patológicas en donde IL-1 juega un papel prominente, tales como condiciones inflamatorias del cuerpo y el sistema nervioso central, por lo tanto es un aspecto de la presente invención.
MX2013010171A 2011-03-14 2012-03-14 Antagonistas del receptor de interleucina-1. MX2013010171A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201170120 2011-03-14
PCT/DK2012/000022 WO2012122985A1 (en) 2011-03-14 2012-03-14 Antagonists of the interleukin- 1 receptor

Publications (1)

Publication Number Publication Date
MX2013010171A true MX2013010171A (es) 2013-11-20

Family

ID=45876525

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010171A MX2013010171A (es) 2011-03-14 2012-03-14 Antagonistas del receptor de interleucina-1.

Country Status (13)

Country Link
US (1) US9359405B2 (es)
EP (1) EP2686431B1 (es)
JP (1) JP6120782B2 (es)
KR (1) KR20140012127A (es)
CN (1) CN103476933B (es)
AU (1) AU2012228769B2 (es)
BR (1) BR112013023309A2 (es)
CA (1) CA2828504A1 (es)
ES (1) ES2600616T3 (es)
MX (1) MX2013010171A (es)
RU (1) RU2013145283A (es)
WO (1) WO2012122985A1 (es)
ZA (1) ZA201306744B (es)

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EP3773678A4 (en) * 2018-04-12 2022-05-04 Mayo Foundation for Medical Education and Research METHODS FOR GUIDING THERAPY DECISIONS IN SEIZURE DISORDERS
KR102022118B1 (ko) * 2019-01-07 2019-09-18 주식회사 아스트로젠 중추신경계 질환의 예방 또는 치료용 세린 유도체 화합물
WO2023284947A1 (en) * 2021-07-13 2023-01-19 Phlogo Aps Il1ra derived peptides for treatment of diabetic nephropathy
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ZA201306744B (en) 2014-11-26
CN103476933A (zh) 2013-12-25
AU2012228769A1 (en) 2013-10-10
WO2012122985A1 (en) 2012-09-20
JP6120782B2 (ja) 2017-04-26
US20140073556A1 (en) 2014-03-13
KR20140012127A (ko) 2014-01-29
JP2014510082A (ja) 2014-04-24
AU2012228769B2 (en) 2016-09-08
BR112013023309A2 (pt) 2017-09-19
RU2013145283A (ru) 2015-04-20
EP2686431B1 (en) 2016-08-03
US9359405B2 (en) 2016-06-07
EP2686431A1 (en) 2014-01-22
CN103476933B (zh) 2016-04-13

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