EA201300239A1 - Антитела к fap и способы их применения - Google Patents

Антитела к fap и способы их применения

Info

Publication number
EA201300239A1
EA201300239A1 EA201300239A EA201300239A EA201300239A1 EA 201300239 A1 EA201300239 A1 EA 201300239A1 EA 201300239 A EA201300239 A EA 201300239A EA 201300239 A EA201300239 A EA 201300239A EA 201300239 A1 EA201300239 A1 EA 201300239A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fap
methods
antibodies
application
application describes
Prior art date
Application number
EA201300239A
Other languages
English (en)
Other versions
EA034742B1 (ru
Inventor
Марина Бакак
Анне Фраймозер-Грундшобер
Ральф Хоссе
Кристиан Клайн
Эккехард Мёсснер
Валерия Г. Николини
Пабло Умана
Original Assignee
Роше Гликарт Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44629814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201300239(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Роше Гликарт Аг filed Critical Роше Гликарт Аг
Publication of EA201300239A1 publication Critical patent/EA201300239A1/ru
Publication of EA034742B1 publication Critical patent/EA034742B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1075—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

В заявке описаны антитела к белку активации фибробластов (FAP) и способы их применения.
EA201300239A 2010-08-13 2011-08-09 Антитела к fap, полинуклеотид, вектор и клетка для их получения и их применения EA034742B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10172842 2010-08-13
PCT/EP2011/063648 WO2012020006A2 (en) 2010-08-13 2011-08-09 Anti-fap antibodies and methods of use

Publications (2)

Publication Number Publication Date
EA201300239A1 true EA201300239A1 (ru) 2013-08-30
EA034742B1 EA034742B1 (ru) 2020-03-16

Family

ID=44629814

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201790309A EA037977B1 (ru) 2010-08-13 2011-08-09 Антитела к fap, способы их получения и применения
EA201300239A EA034742B1 (ru) 2010-08-13 2011-08-09 Антитела к fap, полинуклеотид, вектор и клетка для их получения и их применения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201790309A EA037977B1 (ru) 2010-08-13 2011-08-09 Антитела к fap, способы их получения и применения

Country Status (37)

Country Link
US (5) US9011847B2 (ru)
EP (2) EP3333194B1 (ru)
JP (4) JP5793568B2 (ru)
KR (2) KR101780131B1 (ru)
CN (2) CN103154038B (ru)
AR (2) AR082629A1 (ru)
AU (1) AU2011288487B2 (ru)
BR (1) BR112013003361B8 (ru)
CA (1) CA2806021C (ru)
CL (2) CL2013000369A1 (ru)
CO (1) CO6670523A2 (ru)
CR (2) CR20180142A (ru)
DK (1) DK2603530T3 (ru)
EA (2) EA037977B1 (ru)
EC (1) ECSP13012440A (ru)
ES (1) ES2655616T3 (ru)
HK (1) HK1181402A1 (ru)
HR (1) HRP20172004T1 (ru)
HU (1) HUE036077T2 (ru)
IL (2) IL224355B (ru)
LT (1) LT2603530T (ru)
MA (1) MA34519B1 (ru)
MX (1) MX358859B (ru)
MY (2) MY184879A (ru)
NO (1) NO2603530T3 (ru)
NZ (2) NZ605980A (ru)
PE (2) PE20171512A1 (ru)
PH (1) PH12017501417A1 (ru)
PL (1) PL2603530T3 (ru)
PT (1) PT2603530T (ru)
RS (1) RS56702B1 (ru)
SG (1) SG187746A1 (ru)
SI (1) SI2603530T1 (ru)
TW (2) TWI599578B (ru)
UA (2) UA113712C2 (ru)
WO (1) WO2012020006A2 (ru)
ZA (2) ZA201600551B (ru)

Cited By (1)

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CN109796532A (zh) * 2017-11-17 2019-05-24 科济生物医药（上海）有限公司 靶向成纤维激活蛋白α的结合单元及其应用

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JP2015180632A (ja) 2015-10-15
AU2011288487A1 (en) 2013-01-31
LT2603530T (lt) 2018-01-25
BR112013003361A2 (pt) 2017-06-13
ZA201600551B (en) 2018-05-30
KR20150039890A (ko) 2015-04-13
DK2603530T3 (en) 2018-01-15
CR20130038A (es) 2013-04-29
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HUE036077T2 (hu) 2018-06-28
JP2020141674A (ja) 2020-09-10
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UA112416C2 (uk) 2016-09-12
UA113712C2 (xx) 2017-02-27
US20120128591A1 (en) 2012-05-24
EP3333194B1 (en) 2021-03-17
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ECSP13012440A (es) 2013-05-31
CN103154038A (zh) 2013-06-12
RS56702B1 (sr) 2018-03-30
BR112013003361B8 (pt) 2022-01-25
US11332545B2 (en) 2022-05-17
CL2016002116A1 (es) 2017-05-12
TWI599578B (zh) 2017-09-21
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PH12017501417A1 (en) 2020-07-13
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