UA106318C2 - Производный полипептид il-2 с агонистической активностью для лечения рака и хронических инфекций - Google Patents
Производный полипептид il-2 с агонистической активностью для лечения рака и хронических инфекцийInfo
- Publication number
- UA106318C2 UA106318C2 UAA201307450A UAA201307450A UA106318C2 UA 106318 C2 UA106318 C2 UA 106318C2 UA A201307450 A UAA201307450 A UA A201307450A UA A201307450 A UAA201307450 A UA A201307450A UA 106318 C2 UA106318 C2 UA 106318C2
- Authority
- UA
- Ukraine
- Prior art keywords
- polypeptide
- cancer
- therapy
- agonist activity
- polypeptide derived
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 9
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 239000000556 agonist Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 208000037581 Persistent Infection Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 102220507254 Rab11 family-interacting protein 1_R38K_mutation Human genes 0.000 abstract 6
- 230000035772 mutation Effects 0.000 abstract 6
- 102220513705 Calreticulin-3_E68V_mutation Human genes 0.000 abstract 5
- 102220252675 rs1555883975 Human genes 0.000 abstract 3
- 102220339220 rs771012029 Human genes 0.000 abstract 3
- 108010002350 Interleukin-2 Proteins 0.000 abstract 2
- 108700004922 F42A Proteins 0.000 abstract 1
- 102220505697 Palmitoyl-protein thioesterase 1_Y45F_mutation Human genes 0.000 abstract 1
- 102220495631 Putative uncharacterized protein LOC645739_F42A_mutation Human genes 0.000 abstract 1
- 102200041867 rs121918148 Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55533—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU2010000216A CU23923B1 (es) | 2010-11-12 | 2010-11-12 | Polipéptidos derivados de la il-2 con actividad agonista |
PCT/CU2011/000007 WO2012062228A2 (es) | 2010-11-12 | 2011-11-10 | Polipéptidos derivados de la il-2 con actividad agonista para la terapia del cáncer e infecciones crónicas. |
Publications (1)
Publication Number | Publication Date |
---|---|
UA106318C2 true UA106318C2 (ru) | 2014-08-11 |
Family
ID=45350376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201307450A UA106318C2 (ru) | 2010-11-12 | 2011-11-10 | Производный полипептид il-2 с агонистической активностью для лечения рака и хронических инфекций |
Country Status (22)
Country | Link |
---|---|
US (1) | US9206243B2 (ru) |
EP (1) | EP2639241B1 (ru) |
JP (1) | JP5761831B2 (ru) |
KR (1) | KR101559330B1 (ru) |
CN (1) | CN103201284B (ru) |
AR (1) | AR083858A1 (ru) |
AU (1) | AU2011328688B2 (ru) |
BR (1) | BR112013010127B1 (ru) |
CA (1) | CA2814814C (ru) |
CL (1) | CL2013001107A1 (ru) |
CO (1) | CO6700862A2 (ru) |
CU (1) | CU23923B1 (ru) |
EA (1) | EA026022B1 (ru) |
ES (1) | ES2543915T3 (ru) |
HK (1) | HK1182403A1 (ru) |
IL (1) | IL226221B (ru) |
MX (1) | MX346222B (ru) |
MY (1) | MY171356A (ru) |
PE (1) | PE20140382A1 (ru) |
TW (1) | TWI488864B (ru) |
UA (1) | UA106318C2 (ru) |
WO (1) | WO2012062228A2 (ru) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3489255T3 (da) | 2011-02-10 | 2021-08-23 | Roche Glycart Ag | Muterede interleukin-2-polypeptider |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
MA39250B1 (fr) | 2014-02-06 | 2018-09-28 | Hoffmann La Roche | Protéines hybrides de l'interleukine-2 et leurs utilisations |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
MX2016013970A (es) * | 2014-04-25 | 2017-04-06 | Rinat Neuroscience Corp | Conjugados anticuerpo-farmaco con carga alta de farmacos. |
SG11201700629TA (en) | 2014-08-11 | 2017-02-27 | Delinia Inc | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗pd-l1およびil-2サイトカイン |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
US11077172B2 (en) | 2016-11-08 | 2021-08-03 | Delinia, Inc. | IL-2 variants for the treatment of psoriasis |
JP2019534308A (ja) * | 2016-11-10 | 2019-11-28 | ネクター セラピューティクス | 免疫療法的腫瘍治療方法 |
CU24483B1 (es) * | 2016-11-15 | 2020-04-02 | Ct Inmunologia Molecular | Método para incrementar los niveles de secreción de la interleucina-2 |
CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
CA3064435A1 (en) | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
US11542312B2 (en) * | 2017-06-19 | 2023-01-03 | Medicenna Therapeutics, Inc. | IL-2 superagonists in combination with anti-PD-1 antibodies |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
JP2021506291A (ja) * | 2017-12-19 | 2021-02-22 | ゼンコア インコーポレイテッド | 改変されたil−2 fc融合タンパク質 |
EP3762406A2 (en) | 2018-03-09 | 2021-01-13 | Askgene Pharma, Inc. | Cytokine prodrugs |
CU24554B1 (es) * | 2018-05-07 | 2021-11-04 | Ct Inmunologia Molecular | Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1 |
JP2021523741A (ja) | 2018-05-14 | 2021-09-09 | ウェアウルフ セラピューティクス, インコーポレイテッド | 活性化可能なインターロイキン12ポリペプチド及びその使用方法 |
CA3100007A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
EP3806888B1 (en) | 2018-06-12 | 2024-01-31 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
MX2020007072A (es) * | 2018-09-17 | 2020-11-11 | Gi Innovation Inc | Proteina de fusion que comprende proteina il-2 y proteina cd80 y uso de la misma. |
MX2021003543A (es) | 2018-09-27 | 2021-06-23 | Xilio Dev Inc | Polipeptidos de citocinas enmascaradas. |
CA3117853A1 (en) * | 2018-10-29 | 2020-05-07 | 1Globe Biomedical Co., Ltd. | Novel rationally designed protein compositions |
TW202034945A (zh) | 2018-12-21 | 2020-10-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種人白細胞介素2變體或其衍生物 |
CU20190021A7 (es) | 2019-03-15 | 2020-10-20 | Centre Hospitalier Univ Vaudois | Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva |
SG11202112541RA (en) | 2019-05-14 | 2021-12-30 | Werewolf Therapeutics Inc | Separation moieties and methods and use thereof |
BR112021023345A2 (pt) | 2019-05-20 | 2022-02-01 | Pandion Operations Inc | Imunotolerância com alvo em madcam |
US20220305124A1 (en) * | 2019-06-05 | 2022-09-29 | Emory University | Photolysis to Unlock Caged Protein Therapeutics |
CN114341189A (zh) | 2019-06-12 | 2022-04-12 | 奥美药业有限公司 | 全新il-15前药及其应用 |
CA3143034A1 (en) * | 2019-06-14 | 2020-12-17 | Cugene Inc. | Novel interleukin-2 variants for the treatment of cancer |
WO2021062406A1 (en) | 2019-09-28 | 2021-04-01 | AskGene Pharma, Inc. | Cytokine prodrugs and dual-prodrugs |
MX2022007754A (es) | 2019-12-20 | 2022-07-19 | Regeneron Pharma | Nuevos agonistas de il2 y metodos de uso de estos. |
US11633488B2 (en) | 2020-01-10 | 2023-04-25 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
KR102653906B1 (ko) | 2020-01-14 | 2024-04-03 | 신테카인, 인크. | 편향된 il2 뮤테인 방법 및 조성물 |
KR20230004682A (ko) | 2020-04-22 | 2023-01-06 | 머크 샤프 앤드 돔 엘엘씨 | 인터류킨-2 수용체 베타 감마c 이량체에 대해 편향되고 비펩티드성 수용성 중합체에 접합된 인간 인터류킨-2 접합체 |
JPWO2022059794A1 (ru) * | 2020-09-18 | 2022-03-24 | ||
TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
JP2023549191A (ja) | 2020-11-13 | 2023-11-22 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ヒトインターロイキン2の変異体又はその誘導体を含む医薬組成物及びその用途 |
CA3222359A1 (en) | 2021-07-09 | 2023-01-12 | Bright Peak Therapeutics Ag | Conjugates of checkpoint inhibitors with il-2, and uses thereof |
KR20240041379A (ko) | 2021-07-09 | 2024-03-29 | 브라이트 피크 테라퓨틱스 아게 | Il-2에 접합된 체크포인트 억제제 및 이의 용도 |
US20230201365A1 (en) | 2021-07-09 | 2023-06-29 | Bright Peak Therapeutics Ag | Modified cd20 antibodies and uses thereof |
WO2023281481A1 (en) | 2021-07-09 | 2023-01-12 | Bright Peak Therapeutics | Antibody conjugates and manufacture thereof |
AU2022320553A1 (en) | 2021-07-30 | 2024-02-01 | Yunquan Biotechnology (Beijing) Co., Ltd. | Human interleukin-2 variant and use thereof |
CU20210104A7 (es) | 2021-12-21 | 2023-07-12 | Ct Inmunologia Molecular | Proteínas de fusión compuestas por un anticuerpo y una muteína agonista de interleucina 2 |
WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
WO2023161857A1 (en) | 2022-02-23 | 2023-08-31 | Bright Peak Therapeutics Ag | Bifunctional cytokine compositions |
WO2023180527A1 (en) | 2022-03-25 | 2023-09-28 | Universität Zürich | Adenoviral mediated targeting of activated immune cells |
WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4853332A (en) | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US5116943A (en) | 1985-01-18 | 1992-05-26 | Cetus Corporation | Oxidation-resistant muteins of Il-2 and other protein |
FR2624741B1 (fr) * | 1987-12-21 | 1991-06-28 | Pasteur Institut | Compositions a base d'une combinaison de liposomes et de lymphokine presentant des proprietes immunostimulantes et leurs applications en medecine humaine et veterinaire |
AU4525589A (en) * | 1988-10-27 | 1990-05-14 | Regents Of The University Of Minnesota | Liposome immunoadjuvants containing il-2 |
US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
US6955807B1 (en) | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
DZ2788A1 (fr) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
WO2005007121A2 (en) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Mutant interleukin-2(il-2) polypeptides |
CN1609227A (zh) * | 2003-10-24 | 2005-04-27 | 中国科学院沈阳应用生态研究所 | 一种白介素-4突变基因il-4-13及其制备和应用 |
CN1964737B (zh) * | 2004-06-04 | 2011-04-20 | 瑞泽恩制药公司 | 利用il-1拮抗剂治疗自身炎症性疾病的方法 |
EP2038417A2 (en) * | 2006-07-06 | 2009-03-25 | Merck Patent GmbH | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
WO2009061853A2 (en) * | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Mutant interleukin-2 (il-2) polypeptides |
DE102008023820A1 (de) * | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
CA2749539C (en) * | 2009-01-21 | 2022-07-19 | Amgen Inc. | Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases |
-
2010
- 2010-11-12 CU CU2010000216A patent/CU23923B1/es active IP Right Grant
-
2011
- 2011-11-10 MX MX2013005250A patent/MX346222B/es active IP Right Grant
- 2011-11-10 EP EP11797102.8A patent/EP2639241B1/en active Active
- 2011-11-10 JP JP2013538062A patent/JP5761831B2/ja active Active
- 2011-11-10 EA EA201390681A patent/EA026022B1/ru not_active IP Right Cessation
- 2011-11-10 CN CN201180054156.2A patent/CN103201284B/zh active Active
- 2011-11-10 AU AU2011328688A patent/AU2011328688B2/en active Active
- 2011-11-10 KR KR1020137012452A patent/KR101559330B1/ko active IP Right Grant
- 2011-11-10 UA UAA201307450A patent/UA106318C2/ru unknown
- 2011-11-10 MY MYPI2013700752A patent/MY171356A/en unknown
- 2011-11-10 US US13/885,021 patent/US9206243B2/en active Active
- 2011-11-10 CA CA2814814A patent/CA2814814C/en active Active
- 2011-11-10 WO PCT/CU2011/000007 patent/WO2012062228A2/es active Application Filing
- 2011-11-10 BR BR112013010127-0A patent/BR112013010127B1/pt active IP Right Grant
- 2011-11-10 ES ES11797102.8T patent/ES2543915T3/es active Active
- 2011-11-10 PE PE2013001054A patent/PE20140382A1/es not_active Application Discontinuation
- 2011-11-11 TW TW100141299A patent/TWI488864B/zh active
- 2011-11-11 AR ARP110104234A patent/AR083858A1/es active IP Right Grant
-
2013
- 2013-04-23 CL CL2013001107A patent/CL2013001107A1/es unknown
- 2013-04-23 CO CO13103448A patent/CO6700862A2/es unknown
- 2013-05-07 IL IL226221A patent/IL226221B/en active IP Right Grant
- 2013-08-21 HK HK13109794.4A patent/HK1182403A1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA106318C2 (ru) | Производный полипептид il-2 с агонистической активностью для лечения рака и хронических инфекций | |
ZA202201361B (en) | Methods and compositions comprising purified recombinant polypeptides | |
PH12017500954A1 (en) | Mutant interleukin-2 polypeptides | |
MX2017016811A (es) | Metodos para mejorar el rendimiento del animal. | |
NZ599792A (en) | Immunomodulatory polypeptides derived from il- 2 and their use thereof in the therapeutic of cancer and chronic infections | |
MX2020010991A (es) | Composicion para la estimulacion ovarica controlada. | |
EP4036240A3 (en) | Transduction buffer | |
MX2018012394A (es) | Variantes de polipeptido ph20, formulaciones y usos de las mismas. | |
MX2013004897A (es) | Anticuerpos y composiciones anti-her3. | |
NZ706189A (en) | Monoclonal antibodies to growth and differentiation factor 15 (gdf-15) | |
MX2011010908A (es) | Anticuerpos anti-tnf-alfa y sus usos. | |
MX2016008448A (es) | Conjugados de var2csa-farmaco. | |
MY162576A (en) | Modified factor ix polypeptides and uses thereof | |
PH12014502537A1 (en) | Therapeutic uses of fibroblast growth factor 21 proteins | |
MY180613A (en) | Combination therapies for melanoma comprising administering cobimetinib and vemurafinib | |
MX2017002852A (es) | Activacion de linfocitos que infiltran la medula en condiciones hipoxicas alternando con normoxicas. | |
UA106900C2 (ru) | LibreOffice????!"'!DR5-!/+.)" | |
MX2012013735A (es) | Isoformas de neuregulina, polipeptidos de neuregulina y usos de los mismos. | |
IN2014MN00125A (ru) | ||
SG10201803370XA (en) | Conjugates of somatostatin and its analogs | |
EP2590652A4 (en) | PHARMACEUTICAL COMPOSITIONS CONTAINING VANOXERIN | |
MX2015008373A (es) | Peptidos antimicrobianos, composiciones que los comprende y usos. | |
MX2018013556A (es) | Polipeptidos variantes con rendimiento mejorado y uso de los mismos. | |
MX369389B (es) | Apoaecuorina para usarse en aliviar un síntoma asociado con esclerosis múltiple en un sujeto. | |
MX2014004655A (es) | Compuestos peptídicos derivados de melanotransferrina y usos de estos. |