CU20100216A7 - Polipéptidos derivados de la il-2 con actividad agonista y mayor eficacia para la terapia del cáncer e infecciones crónicas - Google Patents

Polipéptidos derivados de la il-2 con actividad agonista y mayor eficacia para la terapia del cáncer e infecciones crónicas

Info

Publication number
CU20100216A7
CU20100216A7 CU20100216A CU20100216A CU20100216A7 CU 20100216 A7 CU20100216 A7 CU 20100216A7 CU 20100216 A CU20100216 A CU 20100216A CU 20100216 A CU20100216 A CU 20100216A CU 20100216 A7 CU20100216 A7 CU 20100216A7
Authority
CU
Cuba
Prior art keywords
present
polypeptides
relates
disclosed
cancer
Prior art date
Application number
CU20100216A
Other languages
English (en)
Other versions
CU23923B1 (es
Inventor
Escalona Neris Michel Enamorado
Rodriguez Saumel Perez
Monzon Kalet Leon
Portilla Tania Carmenate
Davila Agustin Bienvenido Lage
Original Assignee
Centro Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45350376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20100216(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Centro Inmunologia Molecular filed Critical Centro Inmunologia Molecular
Priority to CU2010000216A priority Critical patent/CU23923B1/es
Priority to MX2013005250A priority patent/MX346222B/es
Priority to BR112013010127-0A priority patent/BR112013010127B1/pt
Priority to CN201180054156.2A priority patent/CN103201284B/zh
Priority to EP11797102.8A priority patent/EP2639241B1/en
Priority to EA201390681A priority patent/EA026022B1/ru
Priority to US13/885,021 priority patent/US9206243B2/en
Priority to CA2814814A priority patent/CA2814814C/en
Priority to ES11797102.8T priority patent/ES2543915T3/es
Priority to JP2013538062A priority patent/JP5761831B2/ja
Priority to MYPI2013700752A priority patent/MY171356A/en
Priority to PCT/CU2011/000007 priority patent/WO2012062228A2/es
Priority to UAA201307450A priority patent/UA106318C2/ru
Priority to KR1020137012452A priority patent/KR101559330B1/ko
Priority to AU2011328688A priority patent/AU2011328688B2/en
Priority to PE2013001054A priority patent/PE20140382A1/es
Priority to ARP110104234A priority patent/AR083858A1/es
Priority to TW100141299A priority patent/TWI488864B/zh
Publication of CU20100216A7 publication Critical patent/CU20100216A7/es
Priority to CO13103448A priority patent/CO6700862A2/es
Priority to CL2013001107A priority patent/CL2013001107A1/es
Priority to IL226221A priority patent/IL226221B/en
Publication of CU23923B1 publication Critical patent/CU23923B1/es
Priority to HK13109794.4A priority patent/HK1182403A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A61K2039/55533—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a polipéptidos que comparten secuencia primaria con la IL-2 humana, excepto porque varios aminoácidos han sido mutados. Las mutaciones introducidas reducen sustancialmente la capacidad de estos polipéptidos para estimular in vitro e in vivo a las células T reguladoras (T CD4+CD5+FoxP3+) y le confieren una mayor eficacia en la terapia de tumores trasplantables murinos. La presente invención incluye además las aplicaciones terapéuticas de estas variantes mutadas, solas o en combinación con vacunas, para la terapia de enfermedades como el cáncer o infecciones donde la actividad de las células T reguladoras (Tregs) es relevante. La presente invención también se relaciona con plopéptidos específicos cuya secuencia de aminoácidos es divulgada en la presente invención. En otro aspecto la presente invención se relaciona con las composiciones farmacéuticas que comprenden como principio activo los polipéptidos divulgados. Por último, la presente invención se relaciona con el uso terapéutico de los polipéptidos y composiciones farmacéuticas divulgados dado su efecto modulador del sistema inmune sobre patologías como cáncer y enfermedades infecciosas crónicas.
CU2010000216A 2010-11-12 2010-11-12 Polipéptidos derivados de la il-2 con actividad agonista CU23923B1 (es)

Priority Applications (22)

Application Number Priority Date Filing Date Title
CU2010000216A CU23923B1 (es) 2010-11-12 2010-11-12 Polipéptidos derivados de la il-2 con actividad agonista
PE2013001054A PE20140382A1 (es) 2010-11-12 2011-11-10 Polipeptidos derivados de la il-2 con actividad agonista para la terapia del cancer e infecciones cronicas
MYPI2013700752A MY171356A (en) 2010-11-12 2011-11-10 Polypeptides derived from il-2 having agonist activity for the therapy of cancer and chronic infections
UAA201307450A UA106318C2 (ru) 2010-11-12 2011-11-10 Производный полипептид il-2 с агонистической активностью для лечения рака и хронических инфекций
CN201180054156.2A CN103201284B (zh) 2010-11-12 2011-11-10 用于癌症和慢性感染的治疗的具有激动剂活性的衍生自il-2的多肽
EP11797102.8A EP2639241B1 (en) 2010-11-12 2011-11-10 Polypeptides derived from il-2 having agonist activity, for the therapy of cancer and chronic infections
EA201390681A EA026022B1 (ru) 2010-11-12 2011-11-10 Производные полипептиды il-2 с агонистической активностью для лечения рака
US13/885,021 US9206243B2 (en) 2010-11-12 2011-11-10 IL-2 derivative polypeptides
CA2814814A CA2814814C (en) 2010-11-12 2011-11-10 Polypeptides derived from il-2 having agonist activity, for the therapy of cancer and chronic infections
ES11797102.8T ES2543915T3 (es) 2010-11-12 2011-11-10 Polipéptidos derivados de la IL-2 con actividad agonista para la terapia del cáncer e infecciones crónicas
JP2013538062A JP5761831B2 (ja) 2010-11-12 2011-11-10 癌及び慢性感染の治療のための作動薬活性を有するｉｌ−２由来のポリペプチド
MX2013005250A MX346222B (es) 2010-11-12 2011-11-10 Polipeptidos derivados de la il-2 con actividad agonista para la terapia del cancer e infecciones cronicas.
PCT/CU2011/000007 WO2012062228A2 (es) 2010-11-12 2011-11-10 Polipéptidos derivados de la il-2 con actividad agonista para la terapia del cáncer e infecciones crónicas.
BR112013010127-0A BR112013010127B1 (pt) 2010-11-12 2011-11-10 Polipeptídeo agonista da interleucina 2, proteína de fusão, composição farmacêutica útil na terapia do câncer e enfermidades infecciosas crônicas, e, uso do polipeptídeo
KR1020137012452A KR101559330B1 (ko) 2010-11-12 2011-11-10 암 및 만성 감염 치료를 위한, 효능제 활성을 갖는 인터루킨 2로부터 유도된 폴리펩티드
AU2011328688A AU2011328688B2 (en) 2010-11-12 2011-11-10 Polypeptides derived from IL-2 having agonist activity, for the therapy of cancer and chronic infections
TW100141299A TWI488864B (zh) 2010-11-12 2011-11-11 用於治療癌症及慢性感染之具有促效劑活性之介白素－２（ｉｌ－２）衍生物多肽
ARP110104234A AR083858A1 (es) 2010-11-12 2011-11-11 Polipeptidos derivados de la il-2 con actividad agonista para la terapia del cancer e infecciones cronicas
CO13103448A CO6700862A2 (es) 2010-11-12 2013-04-23 Polipéptidos derivados de la il-2 con actividad agonista para la terapia del cáncer e infecciones crónicas.
CL2013001107A CL2013001107A1 (es) 2010-11-12 2013-04-23 Polipeptido derivado de la il-2 con actividad agonista; proteina de fusion que lo comprende; composicion farmaceutica que lo comprende; y su uso para tratar cancer y enfermedades infecciosas cronicas.
IL226221A IL226221B (en) 2010-11-12 2013-05-07 Polypeptides derived from 2-il have agonistic activity, for the cure of cancer and chronic inflammations
HK13109794.4A HK1182403A1 (en) 2010-11-12 2013-08-21 Polypeptides derived from il-2 having agonist activity, for the therapy of cancer and chronic infections il-2

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU2010000216A CU23923B1 (es) 2010-11-12 2010-11-12 Polipéptidos derivados de la il-2 con actividad agonista

Publications (2)

Publication Number Publication Date
CU20100216A7 true CU20100216A7 (es) 2012-06-21
CU23923B1 CU23923B1 (es) 2013-07-31

Family

ID=45350376

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2010000216A CU23923B1 (es) 2010-11-12 2010-11-12 Polipéptidos derivados de la il-2 con actividad agonista

Country Status (22)

Country Link
US (1) US9206243B2 (es)
EP (1) EP2639241B1 (es)
JP (1) JP5761831B2 (es)
KR (1) KR101559330B1 (es)
CN (1) CN103201284B (es)
AR (1) AR083858A1 (es)
AU (1) AU2011328688B2 (es)
BR (1) BR112013010127B1 (es)
CA (1) CA2814814C (es)
CL (1) CL2013001107A1 (es)
CO (1) CO6700862A2 (es)
CU (1) CU23923B1 (es)
EA (1) EA026022B1 (es)
ES (1) ES2543915T3 (es)
HK (1) HK1182403A1 (es)
IL (1) IL226221B (es)
MX (1) MX346222B (es)
MY (1) MY171356A (es)
PE (1) PE20140382A1 (es)
TW (1) TWI488864B (es)
UA (1) UA106318C2 (es)
WO (1) WO2012062228A2 (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088446A1 (en) 2010-12-22 2012-06-28 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
HUE029139T2 (hu) 2011-02-10 2017-02-28 Roche Glycart Ag Mutáns interleukin-2 polipeptidek
EA201892619A1 (ru) 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
US20140044675A1 (en) 2012-08-10 2014-02-13 Roche Glycart Ag Interleukin-2 fusion proteins and uses thereof
LT3102595T (lt) 2014-02-06 2019-01-25 F. Hoffmann-La Roche Ag Interleukino-2 sulieti baltymai ir jų panaudojimas
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
KR20190072663A (ko) * 2014-04-25 2019-06-25 리나트 뉴로사이언스 코프. 약물이 고도로 로딩된 항체-약물 접합체
ES2807260T3 (es) 2014-08-11 2021-02-22 Delinia Inc Variantes de IL-2 modificadas que activan selectivamente las células T reguladoras para el tratamiento de enfermedades autoinmunes
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
JP7261379B2 (ja) 2016-06-20 2023-04-20 カイマブ・リミテッド 抗ｐｄ－ｌ１抗体
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
WO2018083248A1 (en) 2016-11-03 2018-05-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
EA201991142A1 (ru) 2016-11-08 2019-10-31 Варианты il-2 для лечения аутоиммунных заболеваний
CN109890406A (zh) * 2016-11-10 2019-06-14 尼克塔治疗公司 肿瘤免疫治疗性治疗方法
CU24483B1 (es) * 2016-11-15 2020-04-02 Ct Inmunologia Molecular Método para incrementar los niveles de secreción de la interleucina-2
CA3056630A1 (en) 2017-03-15 2018-09-20 Pandion Therapeutics, Inc. Targeted immunotolerance
MX2019014023A (es) 2017-05-24 2020-02-17 Novartis Ag Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer.
US10676516B2 (en) 2017-05-24 2020-06-09 Pandion Therapeutics, Inc. Targeted immunotolerance
CA3067909A1 (en) * 2017-06-19 2018-12-27 Medicenna Therapeutics Inc. Uses and methods for il-2 superagonists, agonists, and fusions thereof
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
CA3086199A1 (en) * 2017-12-19 2019-06-27 Xencor, Inc. Engineered il-2 fc fusion proteins
JP2021515599A (ja) * 2018-03-09 2021-06-24 アスクジーン・ファーマ・インコーポレイテッドＡｓｋＧｅｎｅ Ｐｈａｒｍａ， Ｉｎｃ． 新規のサイトカインプロドラッグ
CU24554B1 (es) * 2018-05-07 2021-11-04 Ct Inmunologia Molecular Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1
JP7460609B2 (ja) 2018-05-14 2024-04-02 ウェアウルフ セラピューティクス， インコーポレイテッド 活性化可能なインターロイキン－２ポリペプチド及びその使用方法
CA3100018A1 (en) 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable interleukin 12 polypeptides and methods of use thereof
WO2019241315A1 (en) 2018-06-12 2019-12-19 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
PE20201418A1 (es) 2018-09-17 2020-12-09 Gi Innovation Inc Proteina de fusion que comprende proteina il-2 y proteina cd80 y uso de la misma
EP3856764A4 (en) 2018-09-27 2022-11-02 Xilio Development, Inc. MASKED CYTOKINE POLYPEPTIDES
BR112021008204A2 (pt) * 2018-10-29 2021-08-10 1Globe Biomedical Co., Ltd. novas composições de proteínas racionalmente projetadas
CN113383013B (zh) 2018-12-21 2022-11-04 江苏恒瑞医药股份有限公司 一种人白细胞介素2变体或其衍生物
CU20190021A7 (es) * 2019-03-15 2020-10-20 Centre Hospitalier Univ Vaudois Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
JP2022532217A (ja) 2019-05-14 2022-07-13 ウェアウルフ セラピューティクス， インコーポレイテッド 分離部分及びその使用方法
KR20220035333A (ko) 2019-05-20 2022-03-22 팬디온 오퍼레이션스, 인코포레이티드 Madcam 표적 면역관용
US20220305124A1 (en) * 2019-06-05 2022-09-29 Emory University Photolysis to Unlock Caged Protein Therapeutics
KR20220020879A (ko) 2019-06-12 2022-02-21 에스크진 파마, 아이엔씨. 새로운 il-15 프로드럭 및 이를 사용하는 방법
EP3983433A4 (en) * 2019-06-14 2023-08-09 Cugene Inc. NOVEL INTERLEUKIN-2 VARIANTS FOR CANCER TREATMENT
EP4034551A1 (en) 2019-09-28 2022-08-03 AskGene Pharma, Inc. Cytokine prodrugs and dual-prodrugs
JP2023510115A (ja) 2019-12-20 2023-03-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 新規ｉｌ２アゴニストおよびそれらの使用方法
KR20220140514A (ko) 2020-01-10 2022-10-18 브라이트 피크 테라퓨틱스 아게 변형된 il-2 폴리펩타이드 및 그의 용도
US11491205B2 (en) 2020-01-14 2022-11-08 Synthekine, Inc. Biased IL2 muteins methods and compositions
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
WO2021216478A1 (en) 2020-04-22 2021-10-28 Merck Sharp & Dohme Corp. HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA GAMMAc DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER
JPWO2022059794A1 (es) * 2020-09-18 2022-03-24
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
AU2021379816A1 (en) 2020-11-13 2023-06-22 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition comprising human interleukin 2 variant or derivative thereof and use thereof
EP4366778A1 (en) 2021-07-09 2024-05-15 Bright Peak Therapeutics AG Antibody conjugates and manufacture thereof
US20230250181A1 (en) 2021-07-09 2023-08-10 Bright Peak Therapeutics Ag Modified checkpoint inhibitors and uses thereof
CA3222359A1 (en) 2021-07-09 2023-01-12 Bright Peak Therapeutics Ag Conjugates of checkpoint inhibitors with il-2, and uses thereof
US20230201365A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Modified cd20 antibodies and uses thereof
KR20240036511A (ko) 2021-07-30 2024-03-20 윈취안 바이오테크놀로지 (베이징) 씨오., 엘티디. 인간 인터루킨-2 변이체 및 이의 용도
CU20210104A7 (es) 2021-12-21 2023-07-12 Ct Inmunologia Molecular Proteínas de fusión compuestas por un anticuerpo y una muteína agonista de interleucina 2
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
US20240132563A1 (en) 2022-02-23 2024-04-25 Bright Peak Therapeutics Ag Bifunctional cytokine compositions
WO2023180527A1 (en) 2022-03-25 2023-09-28 Universität Zürich Adenoviral mediated targeting of activated immune cells
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
WO2024119193A2 (en) 2022-12-02 2024-06-06 AskGene Pharma, Inc. Mutant il-2 polypeptides and il-2 prodrugs

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853332A (en) 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US5116943A (en) 1985-01-18 1992-05-26 Cetus Corporation Oxidation-resistant muteins of Il-2 and other protein
FR2624741B1 (fr) * 1987-12-21 1991-06-28 Pasteur Institut Compositions a base d'une combinaison de liposomes et de lymphokine presentant des proprietes immunostimulantes et leurs applications en medecine humaine et veterinaire
WO1990004412A1 (en) * 1988-10-27 1990-05-03 Regents Of The University Of Minnesota Liposome immunoadjuvants containing il-2
US5229109A (en) 1992-04-14 1993-07-20 Board Of Regents, The University Of Texas System Low toxicity interleukin-2 analogues for use in immunotherapy
US6955807B1 (en) 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists
DZ2788A1 (fr) * 1998-05-15 2003-12-01 Bayer Ag Agonistes et antagonistes selectifs à IL-2.
CN100390282C (zh) 2001-12-04 2008-05-28 默克专利有限公司 具有调节的选择性的il-2融合蛋白
WO2005007121A2 (en) 2003-07-18 2005-01-27 Massachusetts Institute Of Technology Mutant interleukin-2(il-2) polypeptides
CN1609227A (zh) * 2003-10-24 2005-04-27 中国科学院沈阳应用生态研究所 一种白介素－4突变基因il－4－13及其制备和应用
WO2005117945A1 (en) * 2004-06-04 2005-12-15 Regeneron Pharmaceuticals, Inc. Methods of using il-1 antagonists to treat autoinflammatory disease
JP2009542592A (ja) * 2006-07-06 2009-12-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｉｌ−２媒介性免疫応答の有効性を高める組成物および方法
US8906356B2 (en) * 2007-11-05 2014-12-09 Massachusetts Institute Of Technology Mutant interleukin-2 (IL-2) polypeptides
DE102008023820A1 (de) * 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
CA2749539C (en) * 2009-01-21 2022-07-19 Amgen Inc. Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases

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