TN2013000151A1 - Polypeptides derived from il-2 having agonist activity for the therapy of cancer and chronic infections - Google Patents
Polypeptides derived from il-2 having agonist activity for the therapy of cancer and chronic infectionsInfo
- Publication number
- TN2013000151A1 TN2013000151A1 TNP2013000151A TN2013000151A TN2013000151A1 TN 2013000151 A1 TN2013000151 A1 TN 2013000151A1 TN P2013000151 A TNP2013000151 A TN P2013000151A TN 2013000151 A TN2013000151 A TN 2013000151A TN 2013000151 A1 TN2013000151 A1 TN 2013000151A1
- Authority
- TN
- Tunisia
- Prior art keywords
- polypeptides
- cancer
- therapy
- relates
- regulatory
- Prior art date
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention relates to polypeptides that have the same primary sequence as human IL-2, except that some amino acids have been mutated. The mutations introduced substantially reduce the capacity of these polypeptides for the in vitro and in vivo stimulation of regulatory T cells (T CD4+CD25+FoxP3+) and increase the efficacy of said polypeptides in the therapy of murine transplantable tumours. The invention also relates to the therapeutic uses of these variants, either alone or combined with vaccines, for the therapy of diseases, such as cancer or infections in which the activity of the regulatory T cells (Tregs) is relevant. The invention further relates to pharmaceutical compositions comprising the aforementioned polypeptides as an active principle. In addition, the invention relates to the therapeutic use of said polypeptides and pharmaceutical compositions, making use of their ability to modulate the immune system in relation to pathologies such as cancer and chronic infectious diseases.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CU2011/000007 WO2012062228A2 (en) | 2010-11-12 | 2011-11-10 | Polypeptides derived from il-2 having agonist activity, for the therapy of cancer and chronic infections |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2013000151A1 true TN2013000151A1 (en) | 2014-11-10 |
Family
ID=54360593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2013000151A TN2013000151A1 (en) | 2011-11-10 | 2013-04-04 | Polypeptides derived from il-2 having agonist activity for the therapy of cancer and chronic infections |
Country Status (1)
Country | Link |
---|---|
TN (1) | TN2013000151A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022078185A1 (en) * | 2020-10-18 | 2022-04-21 | 北京志道生物科技有限公司 | Interleukin-2 mutant |
-
2013
- 2013-04-04 TN TNP2013000151A patent/TN2013000151A1/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022078185A1 (en) * | 2020-10-18 | 2022-04-21 | 北京志道生物科技有限公司 | Interleukin-2 mutant |
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