SG10201908089VA - Novel dosing regimens of celgosivir for the treatment of dengue - Google Patents

Novel dosing regimens of celgosivir for the treatment of dengue

Info

Publication number
SG10201908089VA
SG10201908089VA SG10201908089VA SG10201908089VA SG 10201908089V A SG10201908089V A SG 10201908089VA SG 10201908089V A SG10201908089V A SG 10201908089VA SG 10201908089V A SG10201908089V A SG 10201908089VA
Authority
SG
Singapore
Prior art keywords
dengue
celgosivir
treatment
dosing regimens
compound
Prior art date
Application number
Inventor
Subhash Vasudevan
Cynthia Sung
Abhay Rathore
Satoru Watanabe
Jenny Low
Eng Eong Ooi
Geoffrey S Dow
Glynn Morrish
Mark Reid
Original Assignee
60 Pharmaceuticals Llc
Nat Univ Singapore
Singapore Health Serv Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 60 Pharmaceuticals Llc, Nat Univ Singapore, Singapore Health Serv Pte Ltd filed Critical 60 Pharmaceuticals Llc
Publication of SG10201908089VA publication Critical patent/SG10201908089VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Novel Dosing Regimens of Celgosivir For The Treatment of Dengue Methods of treating a dengue virus (DENV) infection in a human subject, comprising administering to the human subject a compound of Formula (I), or pharmaceutical composition comprising a compound of Formula (I): OH (I) A compound of Formula (I) can be administered within onset of fever to hours of fever onset due to dengue infection and then every 6 to 12 hours until there is an improvement in the infection or between from about 1 day to about 10 days. The methods of the invention can be used to treat primary and secondary DENVl-4 viral infections. FIG. 1 61
SG10201908089V 2013-03-15 2014-03-14 Novel dosing regimens of celgosivir for the treatment of dengue SG10201908089VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361798100P 2013-03-15 2013-03-15
US201361911795P 2013-12-04 2013-12-04

Publications (1)

Publication Number Publication Date
SG10201908089VA true SG10201908089VA (en) 2019-10-30

Family

ID=51537558

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201908089V SG10201908089VA (en) 2013-03-15 2014-03-14 Novel dosing regimens of celgosivir for the treatment of dengue
SG11201507254VA SG11201507254VA (en) 2013-03-15 2014-03-14 Novel dosing regimens of celgosivir for the treatment of dengue

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201507254VA SG11201507254VA (en) 2013-03-15 2014-03-14 Novel dosing regimens of celgosivir for the treatment of dengue

Country Status (8)

Country Link
US (3) US9763921B2 (en)
AU (1) AU2014228035B2 (en)
BR (1) BR112015023806A2 (en)
MX (1) MX2015013115A (en)
MY (1) MY170991A (en)
PH (1) PH12015502128A1 (en)
SG (2) SG10201908089VA (en)
WO (1) WO2014143907A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201908089VA (en) * 2013-03-15 2019-10-30 60 Pharmaceuticals Llc Novel dosing regimens of celgosivir for the treatment of dengue
US11000516B2 (en) * 2015-12-11 2021-05-11 60 Degrees Pharmaceuticals, LLC Dosing regimens of celgosivir for the prevention of dengue
WO2018017426A1 (en) 2016-07-16 2018-01-25 Florida State University Research Foundation, Inc. Compounds and methods for treatment and prevention of flavivirus infection
US10555942B2 (en) 2017-10-10 2020-02-11 Florida State University Research Foundation, Inc. Emetine compounds for treatment and prevention of flavivirus infection
US11369592B2 (en) 2020-02-21 2022-06-28 Florida State University Research Foundation, Inc. Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001234596A1 (en) 2000-01-28 2001-08-07 Timothy M Block Use of castanospermine and substituted-castanospermine compounds for treating hepatitis virus infections
GB0110832D0 (en) * 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
GB0401238D0 (en) 2004-01-21 2004-02-25 Molecularnature Ltd Immunomodulatory alkaloids
SG10201908089VA (en) * 2013-03-15 2019-10-30 60 Pharmaceuticals Llc Novel dosing regimens of celgosivir for the treatment of dengue

Also Published As

Publication number Publication date
US20160030403A1 (en) 2016-02-04
BR112015023806A2 (en) 2017-08-22
AU2014228035A1 (en) 2015-09-24
US11219616B2 (en) 2022-01-11
US20180064693A1 (en) 2018-03-08
WO2014143907A1 (en) 2014-09-18
SG11201507254VA (en) 2015-10-29
US10517854B2 (en) 2019-12-31
MX2015013115A (en) 2016-06-21
PH12015502128A1 (en) 2016-01-25
US9763921B2 (en) 2017-09-19
MY170991A (en) 2019-09-23
US20200338050A1 (en) 2020-10-29
AU2014228035B2 (en) 2018-12-06

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