IT1269989B - Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria - Google Patents

Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria

Info

Publication number
IT1269989B
IT1269989B ITMI941916A ITMI941916A IT1269989B IT 1269989 B IT1269989 B IT 1269989B IT MI941916 A ITMI941916 A IT MI941916A IT MI941916 A ITMI941916 A IT MI941916A IT 1269989 B IT1269989 B IT 1269989B
Authority
IT
Italy
Prior art keywords
antagonists
improved
inhibitory activity
receptor antagonists
increased inhibitory
Prior art date
Application number
ITMI941916A
Other languages
English (en)
Inventor
Diana Boraschi
Paola Bossu
Paolo Ruggiero
Giovanni Macchia
Aldo Tagliabue
Francesco Frigerio
Renata Grifantini
Guido Grandi
Gianni Frascotti
Original Assignee
Dompe Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Spa filed Critical Dompe Spa
Priority to ITMI941916A priority Critical patent/IT1269989B/it
Publication of ITMI941916A0 publication Critical patent/ITMI941916A0/it
Priority to PCT/EP1995/003708 priority patent/WO1996009323A1/en
Priority to EP95934082A priority patent/EP0782584A1/en
Priority to US08/809,185 priority patent/US5922573A/en
Publication of ITMI941916A1 publication Critical patent/ITMI941916A1/it
Application granted granted Critical
Publication of IT1269989B publication Critical patent/IT1269989B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Vengono descritte molecole di DNA che codificano per antagonisti di IL-1 con attività biologica migliorata. Vengono inoltre descritte molecole di DNA codificanti per antagonisti migliorati di IL-1 inserite in vettori di espressione e cellule ospite trasformate con detti vettori contenenti il DNA codificante per antagonisti migliorati di IL-1 e un metodo per produrre antagonisti migliorati di IL-1 in forma essenzialmente pura. Preparati iniettabili o somministrabili per altra via, consistenti in una preparazione farmaceutica di detti mutanti, sono particolarmente utili come farmaci in campo terapeutico.
ITMI941916A 1994-09-21 1994-09-21 Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria IT1269989B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITMI941916A IT1269989B (it) 1994-09-21 1994-09-21 Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria
PCT/EP1995/003708 WO1996009323A1 (en) 1994-09-21 1995-09-20 Il-1 receptor antagonists with enhanced inhibitory activity
EP95934082A EP0782584A1 (en) 1994-09-21 1995-09-20 Il-1 receptor antagonists with enhanced inhibitory activity
US08/809,185 US5922573A (en) 1994-09-21 1995-09-20 IL-1 receptor antagonists with enhanced inhibitory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941916A IT1269989B (it) 1994-09-21 1994-09-21 Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria

Publications (3)

Publication Number Publication Date
ITMI941916A0 ITMI941916A0 (it) 1994-09-21
ITMI941916A1 ITMI941916A1 (it) 1996-03-21
IT1269989B true IT1269989B (it) 1997-04-16

Family

ID=11369576

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941916A IT1269989B (it) 1994-09-21 1994-09-21 Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria

Country Status (4)

Country Link
US (1) US5922573A (it)
EP (1) EP0782584A1 (it)
IT (1) IT1269989B (it)
WO (1) WO1996009323A1 (it)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159460A (en) * 1988-05-27 2000-12-12 Amgen Inc. Method for treating interleukin-1 mediated diseases
US5075222A (en) 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
US6858409B1 (en) 1988-05-27 2005-02-22 Amgen Inc. Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors
KR20040010739A (ko) 1996-02-09 2004-01-31 암젠 인코포레이티드 인터루킨-1 수용체 길항물질을 포함하는 융합 단백질 및 이를 포함하는 제약학적 조성물
US5698399A (en) * 1996-04-05 1997-12-16 Duff; Gordon W. Detecting genetic predisposition for osteoporosis
US6573366B1 (en) * 1996-06-07 2003-06-03 Gruppo Lepetit S.P.A. Process for the purification of human interleukin-1 receptor antagonist from recombinant E. coli
US6335426B1 (en) 1996-06-14 2002-01-01 Bayer Corporation T-cell selective interleukin-4 agonists
US5986059A (en) 1996-06-14 1999-11-16 Bayer Corporation T-cell selective interleukin-4 agonists
US6028176A (en) 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
CA2272073A1 (en) * 1996-11-19 1998-05-28 The Schepens Eye Research Institute, Inc. Local use of il-1ra in corneal transplant rejection or disorders of the eye
ES2615357T3 (es) 1996-12-06 2017-06-06 Amgen Inc. Terapia de combinación usando un inhibidor de IL-1 para tratar enfermedades mediadas por IL-1
US6054559A (en) * 1997-01-28 2000-04-25 Smithkline Beecham Corporation Interleukin-1 receptor antagonist beta (IL-1raβ)
US5863769A (en) * 1997-01-28 1999-01-26 Smithkline Beecham Corporation DNA encoding interleukin-1 receptor antagonist (IL-1raβ)
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
GB9723835D0 (en) * 1997-11-13 1998-01-07 Nicklin Martin Interleukin knockout
US6437216B1 (en) 1997-11-13 2002-08-20 Interleukin Genetics Inc. Transgenic models of inflammatory disease
US6346247B1 (en) 1999-10-28 2002-02-12 Promega Corporation Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
GB9927801D0 (en) * 1999-11-24 2000-01-26 Danisco Method
US7455990B2 (en) * 1999-11-24 2008-11-25 Danisco A/S Method of extracting recombinant hexose oxidase
EP2241328A1 (en) 2000-05-12 2010-10-20 Immunex Corporation Interleukin-1 inhibitors in the treatment of diseases
US6497870B1 (en) 2000-05-22 2002-12-24 Hyseq, Inc. Therapeutic uses of il-1 receptor antagonist
US7087224B2 (en) 2000-10-31 2006-08-08 Amgen Inc. Method of treating anemia by administering IL-1ra
HUP0400698A3 (en) * 2001-02-06 2006-01-30 Merck Patent Gmbh Modified interleukin-1 receptor antagonist (il-1ra) with reduced immunogenicity
DK2270052T3 (en) 2001-06-26 2018-07-02 Amgen Inc Antibodies to OPGL
WO2004022718A2 (en) 2002-09-06 2004-03-18 Amgen, Inc. Therapeutic human anti-il-1r1 monoclonal antibody
WO2005019259A2 (en) * 2003-08-25 2005-03-03 Compugen Ltd. Variants of interleukin-1 receptor antagonist: compositions and uses thereof
ES2523147T3 (es) * 2004-02-26 2014-11-21 Baylor Research Institute Composiciones y métodos para el tratamiento sistémico de la artritis
CN1837237B (zh) * 2005-02-25 2010-06-23 四川恒星生物医药有限公司 一种低热原重组人白细胞介素1受体拮抗剂(rhIL-1ra)及其高效制备方法
US20080166762A1 (en) * 2006-09-27 2008-07-10 Reliance Life Science Pvt.Ltd. HETEROLOGOUS PRODUCTION OF INTERLEUKIN 1 RECEPTOR ANTAGONIST (IL-1Ra) IN PICHIA PASTORIS
GB0708376D0 (en) * 2007-05-01 2007-06-06 Alligator Bioscience Ab Novel polypeptides and uses thereof
CN101918018B (zh) 2007-11-14 2012-12-05 再生医药有限公司 使用白介素-1受体拮抗剂作为骨髓保护剂的方法
CN101690801B (zh) 2009-10-26 2012-08-01 上海交通大学 白细胞介素-1受体拮抗剂的用途及其药物组合物
US8853150B2 (en) 2010-07-29 2014-10-07 Eleven Biotherapeutics, Inc. Chimeric IL-1 receptor type I antagonists
ES2600616T3 (es) 2011-03-14 2017-02-10 Phlogo Aps Antagonistas del receptor de la interleucina-1
AU2014243839B2 (en) 2013-03-13 2019-01-03 Buzzard Pharmaceuticals AB Chimeric cytokine formulations for ocular delivery
US20160000936A1 (en) 2014-06-10 2016-01-07 Abbvie Inc. Biomarkers for inflammatory disease and methods of using same
EP3836954A1 (en) 2018-08-13 2021-06-23 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof
EP4157860A4 (en) * 2020-05-25 2024-03-06 Beijing Vdjbio Co Ltd INTERLEUKIN-1 RECEPTOR ANTAGONIST AND FUSION PROTEIN WITH IT
WO2023222565A1 (en) 2022-05-16 2023-11-23 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7683391A (en) * 1990-04-27 1991-11-27 Upjohn Company, The Modified interleukin-1 inhibitors
GEP20033082B (en) * 1991-03-15 2003-10-27 Amgen Inc Pegylation of Polypeptides

Also Published As

Publication number Publication date
US5922573A (en) 1999-07-13
WO1996009323A1 (en) 1996-03-28
EP0782584A1 (en) 1997-07-09
ITMI941916A0 (it) 1994-09-21
ITMI941916A1 (it) 1996-03-21

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970926