IT1269989B - Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria - Google Patents

Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria

Info

Publication number
IT1269989B
IT1269989B ITMI941916A ITMI941916A IT1269989B IT 1269989 B IT1269989 B IT 1269989B IT MI941916 A ITMI941916 A IT MI941916A IT MI941916 A ITMI941916 A IT MI941916A IT 1269989 B IT1269989 B IT 1269989B
Authority
IT
Italy
Prior art keywords
antagonists
improved
inhibitory activity
receptor antagonists
increased inhibitory
Prior art date
Application number
ITMI941916A
Other languages
English (en)
Inventor
Diana Boraschi
Paola Bossu
Paolo Ruggiero
Giovanni Macchia
Aldo Tagliabue
Francesco Frigerio
Renata Grifantini
Guido Grandi
Gianni Frascotti
Original Assignee
Dompe Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Spa filed Critical Dompe Spa
Priority to ITMI941916A priority Critical patent/IT1269989B/it
Publication of ITMI941916A0 publication Critical patent/ITMI941916A0/it
Priority to EP95934082A priority patent/EP0782584A1/en
Priority to US08/809,185 priority patent/US5922573A/en
Priority to PCT/EP1995/003708 priority patent/WO1996009323A1/en
Publication of ITMI941916A1 publication Critical patent/ITMI941916A1/it
Application granted granted Critical
Publication of IT1269989B publication Critical patent/IT1269989B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Vengono descritte molecole di DNA che codificano per antagonisti di IL-1 con attività biologica migliorata. Vengono inoltre descritte molecole di DNA codificanti per antagonisti migliorati di IL-1 inserite in vettori di espressione e cellule ospite trasformate con detti vettori contenenti il DNA codificante per antagonisti migliorati di IL-1 e un metodo per produrre antagonisti migliorati di IL-1 in forma essenzialmente pura. Preparati iniettabili o somministrabili per altra via, consistenti in una preparazione farmaceutica di detti mutanti, sono particolarmente utili come farmaci in campo terapeutico.
ITMI941916A 1994-09-21 1994-09-21 Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria IT1269989B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITMI941916A IT1269989B (it) 1994-09-21 1994-09-21 Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria
EP95934082A EP0782584A1 (en) 1994-09-21 1995-09-20 Il-1 receptor antagonists with enhanced inhibitory activity
US08/809,185 US5922573A (en) 1994-09-21 1995-09-20 IL-1 receptor antagonists with enhanced inhibitory activity
PCT/EP1995/003708 WO1996009323A1 (en) 1994-09-21 1995-09-20 Il-1 receptor antagonists with enhanced inhibitory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941916A IT1269989B (it) 1994-09-21 1994-09-21 Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria

Publications (3)

Publication Number Publication Date
ITMI941916A0 ITMI941916A0 (it) 1994-09-21
ITMI941916A1 ITMI941916A1 (it) 1996-03-21
IT1269989B true IT1269989B (it) 1997-04-16

Family

ID=11369576

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941916A IT1269989B (it) 1994-09-21 1994-09-21 Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria

Country Status (4)

Country Link
US (1) US5922573A (it)
EP (1) EP0782584A1 (it)
IT (1) IT1269989B (it)
WO (1) WO1996009323A1 (it)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159460A (en) * 1988-05-27 2000-12-12 Amgen Inc. Method for treating interleukin-1 mediated diseases
US5075222A (en) 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
US6858409B1 (en) 1988-05-27 2005-02-22 Amgen Inc. Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors
JP4344404B2 (ja) 1996-02-09 2009-10-14 アムジェン インコーポレイテッド インターロイキン―１インヒビターおよび制御放出ポリマーを含む組成物
US5698399A (en) * 1996-04-05 1997-12-16 Duff; Gordon W. Detecting genetic predisposition for osteoporosis
US6573366B1 (en) * 1996-06-07 2003-06-03 Gruppo Lepetit S.P.A. Process for the purification of human interleukin-1 receptor antagonist from recombinant E. coli
US5986059A (en) 1996-06-14 1999-11-16 Bayer Corporation T-cell selective interleukin-4 agonists
US6335426B1 (en) 1996-06-14 2002-01-01 Bayer Corporation T-cell selective interleukin-4 agonists
US6028176A (en) 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
EP0944395A1 (en) * 1996-11-19 1999-09-29 The Schepens Eye Research Institute, Inc. Local use of il-1ra in corneal transplant rejection or disorders of the eye
ATE406176T1 (de) 1996-12-06 2008-09-15 Amgen Inc Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten
US5863769A (en) * 1997-01-28 1999-01-26 Smithkline Beecham Corporation DNA encoding interleukin-1 receptor antagonist (IL-1raβ)
US6054559A (en) * 1997-01-28 2000-04-25 Smithkline Beecham Corporation Interleukin-1 receptor antagonist beta (IL-1raβ)
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
US6437216B1 (en) 1997-11-13 2002-08-20 Interleukin Genetics Inc. Transgenic models of inflammatory disease
GB9723835D0 (en) * 1997-11-13 1998-01-07 Nicklin Martin Interleukin knockout
US6346247B1 (en) 1999-10-28 2002-02-12 Promega Corporation Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
US7455990B2 (en) * 1999-11-24 2008-11-25 Danisco A/S Method of extracting recombinant hexose oxidase
GB9927801D0 (en) * 1999-11-24 2000-01-26 Danisco Method
US20010053764A1 (en) 2000-05-12 2001-12-20 Sims John E. Interleukin-1 inhibitors in the treatment of diseases
US6497870B1 (en) 2000-05-22 2002-12-24 Hyseq, Inc. Therapeutic uses of il-1 receptor antagonist
US7087224B2 (en) 2000-10-31 2006-08-08 Amgen Inc. Method of treating anemia by administering IL-1ra
JP2004519230A (ja) * 2001-02-06 2004-07-02 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 低減された免疫原性を有する修飾されたインターロイキン−１受容体アンタゴニスト（ｉｌ−１ｒａ）
DE60235989D1 (de) 2001-06-26 2010-05-27 Amgen Fremont Inc Antikörper gegen opgl
BRPI0314038B8 (pt) 2002-09-06 2021-05-25 Amgen Inc anticorpo humano isolado, molécula de ácido nucleico isolada, vetor, uso de um anticorpo, e, composição farmacêutica
US20050159590A1 (en) * 2003-08-25 2005-07-21 Galit Rotman Variants of interleukin-1 receptor antagonist: compositions and uses thereof
CN1946734B (zh) 2004-02-26 2012-07-18 贝勒研究院 系统性治疗关节炎的组合物和方法
CN1837237B (zh) * 2005-02-25 2010-06-23 四川恒星生物医药有限公司 一种低热原重组人白细胞介素1受体拮抗剂(rhIL-1ra)及其高效制备方法
US20080166762A1 (en) * 2006-09-27 2008-07-10 Reliance Life Science Pvt.Ltd. HETEROLOGOUS PRODUCTION OF INTERLEUKIN 1 RECEPTOR ANTAGONIST (IL-1Ra) IN PICHIA PASTORIS
GB0708376D0 (en) 2007-05-01 2007-06-06 Alligator Bioscience Ab Novel polypeptides and uses thereof
WO2009062339A1 (en) 2007-11-14 2009-05-22 General Regeneratives, Ltd. Methods of using interleukin-1 receptor antagonist as a myeloprotective agent
CN101690801B (zh) 2009-10-26 2012-08-01 上海交通大学 白细胞介素-1受体拮抗剂的用途及其药物组合物
EP2598526B1 (en) 2010-07-29 2018-09-05 Eleven Biotherapeutics, Inc. Chimeric il-1 receptor type i agonists and antagonists
EP2686431B1 (en) 2011-03-14 2016-08-03 Phlogo ApS Antagonists of the interleukin- 1 receptor
MX2015012404A (es) 2013-03-13 2016-02-03 Eleven Biotherapeutics Inc Formulaciones de citoquinas quimericas para suministro ocular.
WO2015191783A2 (en) 2014-06-10 2015-12-17 Abbvie Inc. Biomarkers for inflammatory disease and methods of using same
ES3030707T3 (en) 2018-08-13 2025-07-01 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof
AU2020449791B2 (en) * 2020-05-25 2024-06-13 Beijing Vdjbio Co., Ltd. An interleukin-1 receptor antagonist and a fusion protein containing the same
EP4526469A1 (en) 2022-05-16 2025-03-26 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation
KR20240147776A (ko) * 2023-03-29 2024-10-10 주식회사 아이프로테인테라퓨틱스 인터류킨-1 수용체 길항제 변이체 및 이의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017184A1 (en) * 1990-04-27 1991-11-14 The Upjohn Company Modified interleukin-1 inhibitors
DK0575545T3 (da) * 1991-03-15 2003-09-15 Amgen Inc Pegylering af polypeptider

Also Published As

Publication number Publication date
EP0782584A1 (en) 1997-07-09
ITMI941916A0 (it) 1994-09-21
US5922573A (en) 1999-07-13
WO1996009323A1 (en) 1996-03-28
ITMI941916A1 (it) 1996-03-21

Similar Documents

Publication Publication Date Title
IT1269989B (it) Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria
AU3368497A (en) Human dnase i hyperactive variants
HUP0203409A2 (hu) Gamma-interferon-konjugátumok
GEP20002145B (en) Stem Cell Factor
SE9801992D0 (sv) New 3-aryl-2-hydroxypropionic acid derivative I
FI954536A0 (fi) Eristettyjä nukleiinihappomolekyylejä, jotka koodittavat kasvainhyljintäantigeenin esiastetta MAGE-3, ja niiden hyötykäyttö
DE3681466D1 (de) Insulin-receptor, seine reinigung, seine herstellung in rekombinanten zellen, dna hierfuer, antikoerper gegen den insulin-receptor und deren herstellung, sowie pharmazeutische zusammensetzungen, die diese antikoerper enthalten.
HUP9702377A2 (hu) Önfelerősítő, gyógyszeres úton szabályozható expressziós rendszerek
CA2223433A1 (en) Ob protein compositions and methods
CA2001303A1 (en) Endothelin dna and use thereof
ITMI932571A0 (it) Estratti della cucurbita sp., procedimento per la loro produzione ed impiego nella medicina e nella cosmetica
DK0665882T3 (da) DNA-forbindelser omfattende sekvenser kodende for mannuronan C-5-epimerase
DK0669979T3 (da) C-C CKR-1, kemokinreceptor
PT750672E (pt) Sequencias de adn para metaloproteases matriciais, sua preparacao e utilizacao.
IT1225506B (it) Preparato, in particolare preparato cosmetico antisolare, nonche' metodo per l'introduzione di una sostanza attiva nella pelle
BR9509317A (pt) Antagonista a interleucina-1
ATE283368T1 (de) Für die glutamatabhängigen chloridkanäle kodierende dna
EP1663201A4 (en) USE OF NOVEL 2-OXO-HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
ATE252374T1 (de) Eingekapselte antikörper-produzierende zellen
HUP9801681A2 (hu) Mutáns proteinek
CA2032167A1 (en) Dna coding for protein binds to enhancer of.alpha.-fetoprotein gene
MXPA02009781A (es) Isoformas de esfingosina cinasa tipo 2 de mamifero, clonacion, expresion y metodos de uso de las mismas.
Chen et al. In vitro production of interleukin-6 by human gingival, normal buccal mucosa, and oral submucous fibrosis fibroblasts treated with betel-nut alkaloids.
DE50301507D1 (de) 17a-FLUORALKYL-11BETA-BENZALDOXIM-STEROIDE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE STEROIDE ENTHALTENDE PHARMAZEUTISCHE PRÄPARATE SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN
WO2002000878A3 (fr) Dynamine mitochondriale humaine msp1, ses isoformes msp1-x, et leur utilisation en therapeutique

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970926