HUP9801681A2 - Mutáns proteinek - Google Patents
Mutáns proteinekInfo
- Publication number
- HUP9801681A2 HUP9801681A2 HU9801681A HUP9801681A HUP9801681A2 HU P9801681 A2 HUP9801681 A2 HU P9801681A2 HU 9801681 A HU9801681 A HU 9801681A HU P9801681 A HUP9801681 A HU P9801681A HU P9801681 A2 HUP9801681 A2 HU P9801681A2
- Authority
- HU
- Hungary
- Prior art keywords
- genes
- proteins
- sequences
- mutant proteins
- pharmaceutical preparations
- Prior art date
Links
- 102000008300 Mutant Proteins Human genes 0.000 title abstract 2
- 108010021466 Mutant Proteins Proteins 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 102100026761 Eukaryotic translation initiation factor 5A-1 Human genes 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108010085279 eukaryotic translation initiation factor 5A Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány tárgyát a Rev-fűnkciót inhibiáló, tehát a Rev-fűnkcióvalszemben inhibitőr fentípűsú eIF-5A műtáns fehérjék, az azőkat kódőlógének, DNS-, illetve cDNS-szekvenciák, az ilyen génekkel vagyszekvenciákkal transzfőrmált vagy transzfektált gazdasejtek, az ilyenfehérjék, gének, és szekvenciák előállítására szőlgáló eljárásők,valamint a fehérjéket tartalmazó gyógyszerkészítmények képezik. A találmány szerinti fehérjéket tartalmazó gyógyszerkészítmények azeIF-5A-tól függő retrővírűsők által őkőzőtt betegségek kezelésérehasználhatók. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9502771.0A GB9502771D0 (en) | 1995-02-13 | 1995-02-13 | Organic compounds |
| GBGB9513505.9A GB9513505D0 (en) | 1995-07-03 | 1995-07-03 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9801681A2 true HUP9801681A2 (hu) | 1998-10-28 |
| HUP9801681A3 HUP9801681A3 (en) | 2000-10-30 |
Family
ID=26306494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9801681A HUP9801681A3 (en) | 1995-02-13 | 1996-02-12 | Mutant proteins |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0811060A1 (hu) |
| JP (1) | JPH10509327A (hu) |
| KR (1) | KR19980702160A (hu) |
| CN (1) | CN1173897A (hu) |
| AU (1) | AU4665196A (hu) |
| BR (1) | BR9606951A (hu) |
| CA (1) | CA2210538A1 (hu) |
| CZ (1) | CZ255397A3 (hu) |
| FI (1) | FI972763A (hu) |
| HU (1) | HUP9801681A3 (hu) |
| IL (1) | IL117113A0 (hu) |
| NO (1) | NO973679L (hu) |
| PL (1) | PL321239A1 (hu) |
| SK (1) | SK109997A3 (hu) |
| WO (1) | WO1996025492A1 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999001551A2 (en) * | 1997-06-30 | 1999-01-14 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Novel inhibitor of cellular proliferation |
| US6867237B1 (en) * | 2001-07-23 | 2005-03-15 | Senesco Technologies, Inc. | DNA encoding apoptosis-induced eucaryotic initiation factor-5A and deoxyhypusine synthase and a method for controlling apoptosis in animals and humans |
| US7968523B2 (en) * | 2001-07-23 | 2011-06-28 | Senesco Technologies, Inc. | Method for inducing apoptosis using apoptosis-specific EIF5-A |
| US7381708B2 (en) | 2001-07-23 | 2008-06-03 | Sensco Technologies, Inc. | Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye |
| US7217517B2 (en) * | 2001-07-23 | 2007-05-15 | Senesco Technologies, Inc. | Nucleic acids, polypeptides, and methods for modulating apoptosis |
| US7166467B2 (en) * | 2001-07-23 | 2007-01-23 | Senesco Technologies, Inc. | Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis |
| AU2004217437B2 (en) | 2003-03-05 | 2009-11-19 | Senesco Technologies, Inc. | Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 |
| CA2528372A1 (en) * | 2003-06-06 | 2005-01-27 | Senesco Technologies, Inc. | Inhibition of apoptosis-specific elf-5a ("eif-5a1") with antisense oligonucleotides and sirnas as anti-inflammatory therapeutics |
| US8703929B2 (en) | 2008-03-07 | 2014-04-22 | Senesco Technologies, Inc. | Compositions comprising siRNA and plasmids |
| US8445638B2 (en) | 2008-09-03 | 2013-05-21 | Senesco Technologies, Inc. | Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells |
-
1996
- 1996-02-12 KR KR1019970705555A patent/KR19980702160A/ko not_active Application Discontinuation
- 1996-02-12 CZ CZ972553A patent/CZ255397A3/cs unknown
- 1996-02-12 HU HU9801681A patent/HUP9801681A3/hu unknown
- 1996-02-12 PL PL96321239A patent/PL321239A1/xx unknown
- 1996-02-12 CN CN96191901A patent/CN1173897A/zh active Pending
- 1996-02-12 BR BR9606951A patent/BR9606951A/pt not_active Application Discontinuation
- 1996-02-12 AU AU46651/96A patent/AU4665196A/en not_active Abandoned
- 1996-02-12 SK SK1099-97A patent/SK109997A3/sk unknown
- 1996-02-12 EP EP96902265A patent/EP0811060A1/en not_active Withdrawn
- 1996-02-12 JP JP8524649A patent/JPH10509327A/ja active Pending
- 1996-02-12 WO PCT/EP1996/000585 patent/WO1996025492A1/en not_active Application Discontinuation
- 1996-02-12 IL IL11711396A patent/IL117113A0/xx unknown
- 1996-02-12 CA CA002210538A patent/CA2210538A1/en not_active Abandoned
-
1997
- 1997-06-26 FI FI972763A patent/FI972763A/fi unknown
- 1997-08-11 NO NO973679A patent/NO973679L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9606951A (pt) | 1997-10-28 |
| HUP9801681A3 (en) | 2000-10-30 |
| SK109997A3 (en) | 1998-04-08 |
| KR19980702160A (ko) | 1998-07-15 |
| CZ255397A3 (cs) | 1998-02-18 |
| AU4665196A (en) | 1996-09-04 |
| NO973679L (no) | 1997-10-13 |
| IL117113A0 (en) | 1996-06-18 |
| FI972763A (fi) | 1997-10-10 |
| WO1996025492A1 (en) | 1996-08-22 |
| EP0811060A1 (en) | 1997-12-10 |
| PL321239A1 (en) | 1997-11-24 |
| CA2210538A1 (en) | 1996-08-22 |
| CN1173897A (zh) | 1998-02-18 |
| MX9705757A (es) | 1998-07-31 |
| NO973679D0 (no) | 1997-08-11 |
| FI972763A0 (fi) | 1997-06-26 |
| JPH10509327A (ja) | 1998-09-14 |
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