TR201910983T4 - Tnf aktivitesinin modülatörleri olarak imidazotiazol türevleri. - Google Patents
Tnf aktivitesinin modülatörleri olarak imidazotiazol türevleri. Download PDFInfo
- Publication number
- TR201910983T4 TR201910983T4 TR2019/10983T TR201910983T TR201910983T4 TR 201910983 T4 TR201910983 T4 TR 201910983T4 TR 2019/10983 T TR2019/10983 T TR 2019/10983T TR 201910983 T TR201910983 T TR 201910983T TR 201910983 T4 TR201910983 T4 TR 201910983T4
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- TR
- Turkey
- Prior art keywords
- disorders
- modulators
- derivatives
- tnf activity
- relates
- Prior art date
Links
- UMZCLZPXPCNKML-UHFFFAOYSA-N 2h-imidazo[4,5-d][1,3]thiazole Chemical class C1=NC2=NCSC2=N1 UMZCLZPXPCNKML-UHFFFAOYSA-N 0.000 title 1
- 229940058300 antinematodal imidazothiazole derivative Drugs 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000022873 Ocular disease Diseases 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 230000003040 nociceptive effect Effects 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 150000007979 thiazole derivatives Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Mevcut buluş, kaynaşık imidazol türevleri sınıfına ve bunların tedavide kullanımlarına ilişkindir. Daha özel olarak, bu buluş, farmakolojik olarak aktif ikameli imidazo[2,1-?]tiazol türevleri ve bunların analogları ile ilgilidir. Bu bileşikler, TNFa'nın sinyallemesinin modülatörleridir ve buna göre farmasötik maddeler olarak özellikle otoimmün ve enflamatuar bozukluklar; nörolojik ve nörodejeneratif hastalıklar; ağrı ve nosiseptif bozukluklar; kardiyovasküler hastalıklar; metabolik bozukluklar; oküler bozukluklar; ve onkolojik bozukluklarda fayda sağlarlar.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1321731.0A GB201321731D0 (en) | 2013-12-09 | 2013-12-09 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201910983T4 true TR201910983T4 (tr) | 2019-08-21 |
Family
ID=50000414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/10983T TR201910983T4 (tr) | 2013-12-09 | 2014-12-08 | Tnf aktivitesinin modülatörleri olarak imidazotiazol türevleri. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10273247B2 (tr) |
| EP (1) | EP3080133B1 (tr) |
| JP (1) | JP6483700B2 (tr) |
| CN (1) | CN105814065B (tr) |
| BR (1) | BR112016011522B1 (tr) |
| CA (1) | CA2930912C (tr) |
| ES (1) | ES2743190T3 (tr) |
| GB (1) | GB201321731D0 (tr) |
| RU (1) | RU2683940C1 (tr) |
| TR (1) | TR201910983T4 (tr) |
| WO (1) | WO2015086504A1 (tr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201321735D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| US9856253B2 (en) | 2015-04-17 | 2018-01-02 | Abbvie, Inc. | Tricyclic modulators of TNF signaling |
| WO2016168638A1 (en) | 2015-04-17 | 2016-10-20 | Abbvie Inc. | Indazolones as modulators of tnf signaling |
| UY36629A (es) | 2015-04-17 | 2016-11-30 | Abbvie Inc | Indazolonas como moduladores de la señalización de tnf |
| GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
| GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
| US11267824B2 (en) * | 2017-08-17 | 2022-03-08 | Idorsia Pharmaceuticals Ltd | Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase |
| CA3199039A1 (en) * | 2020-11-16 | 2022-05-19 | Qingan ZOU | Imidazothiazole compounds,pharmaceutical compositions, and use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0463212A1 (en) * | 1990-06-27 | 1992-01-02 | Nikken Chemicals Co., Ltd. | Imidazo[2,1-b]thiazole compound anti-ulcer agent containing the same |
| US5577987A (en) | 1994-07-07 | 1996-11-26 | Precise Exercise Equipment Co. | Abdominal exerciser device |
| US5552422A (en) * | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
| US7105550B2 (en) * | 2000-03-01 | 2006-09-12 | Christopher Love | 2,4-disubstituted thiazolyl derivatives |
| JP2002167389A (ja) * | 2000-09-20 | 2002-06-11 | Nikken Chem Co Ltd | 新規チアゾールニ環化合物 |
| EP1635829A1 (en) | 2003-04-30 | 2006-03-22 | Merck Frosst Canada Ltd. | 8-(3-biaryl)phenylquinoline phosphodiesterase-4-inhibitors |
| AU2004247626B8 (en) * | 2003-05-15 | 2011-05-19 | Arqule, Inc. | Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38 |
| CN1823072A (zh) * | 2003-05-15 | 2006-08-23 | 艾科尔公司 | 作为p38抑制剂的咪唑并噻唑和咪唑并噁唑衍生物 |
| DE102006011574A1 (de) | 2006-03-10 | 2007-10-31 | Grünenthal GmbH | Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln |
| WO2011132048A1 (en) * | 2010-04-19 | 2011-10-27 | Glenmark Pharmaceutical S.A. | Heteroaryl compounds as pde10a inhibitors |
| JP6359008B2 (ja) | 2012-06-11 | 2018-07-18 | ユーシービー バイオファルマ エスピーアールエル | Ｔｎｆ−アルファ調節ベンゾイミダゾール |
| EA028722B1 (ru) | 2012-07-13 | 2017-12-29 | Юсб Байофарма Спрл | Производные имидазопиридина в качестве модуляторов активности tnf |
| GB201212513D0 (en) | 2012-07-13 | 2012-08-29 | Ucb Pharma Sa | Therapeutic agents |
-
2013
- 2013-12-09 GB GBGB1321731.0A patent/GB201321731D0/en not_active Ceased
-
2014
- 2014-12-08 CA CA2930912A patent/CA2930912C/en active Active
- 2014-12-08 TR TR2019/10983T patent/TR201910983T4/tr unknown
- 2014-12-08 BR BR112016011522-8A patent/BR112016011522B1/pt not_active IP Right Cessation
- 2014-12-08 US US15/038,986 patent/US10273247B2/en not_active Expired - Fee Related
- 2014-12-08 EP EP14808644.0A patent/EP3080133B1/en active Active
- 2014-12-08 JP JP2016537505A patent/JP6483700B2/ja not_active Expired - Fee Related
- 2014-12-08 WO PCT/EP2014/076842 patent/WO2015086504A1/en active Application Filing
- 2014-12-08 CN CN201480067061.8A patent/CN105814065B/zh not_active Expired - Fee Related
- 2014-12-08 RU RU2016127226A patent/RU2683940C1/ru active
- 2014-12-08 ES ES14808644T patent/ES2743190T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015086504A1 (en) | 2015-06-18 |
| US10273247B2 (en) | 2019-04-30 |
| US20160376290A1 (en) | 2016-12-29 |
| JP6483700B2 (ja) | 2019-03-13 |
| JP2016539968A (ja) | 2016-12-22 |
| CN105814065A (zh) | 2016-07-27 |
| EP3080133A1 (en) | 2016-10-19 |
| RU2016127226A (ru) | 2018-01-23 |
| CA2930912A1 (en) | 2015-06-18 |
| RU2683940C1 (ru) | 2019-04-03 |
| GB201321731D0 (en) | 2014-01-22 |
| CN105814065B (zh) | 2018-11-23 |
| EP3080133B1 (en) | 2019-07-10 |
| BR112016011522A2 (tr) | 2017-08-08 |
| BR112016011522B1 (pt) | 2022-10-25 |
| ES2743190T3 (es) | 2020-02-18 |
| CA2930912C (en) | 2021-10-26 |
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