EA201500133A1 - Производные имидазопиразина в качестве модуляторов активности tnf - Google Patents

Производные имидазопиразина в качестве модуляторов активности tnf

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Publication number
EA201500133A1
EA201500133A1 EA201500133A EA201500133A EA201500133A1 EA 201500133 A1 EA201500133 A1 EA 201500133A1 EA 201500133 A EA201500133 A EA 201500133A EA 201500133 A EA201500133 A EA 201500133A EA 201500133 A1 EA201500133 A1 EA 201500133A1
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EA
Eurasian Patent Office
Prior art keywords
disorders
derivatives
imidazopirazine
tnf activity
activity modulators
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Application number
EA201500133A
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English (en)
Other versions
EA028041B1 (ru
Inventor
Джонатан Марк Бентли
Даниель Кристофер Брукингз
Джулиен Алистэр Браун
Томас Пол Кейн
Лора Джейн Глив
Александер Хейфетц
Виктория Элизабет Джексон
Крейг Джонстоун
Дебора Лей
Джеймс Мадден
Джон Роберт Портер
Маттью Данкан Селби
Чжаонин Чжу
Original Assignee
Юсб Байофарма Спрл
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Application filed by Юсб Байофарма Спрл filed Critical Юсб Байофарма Спрл
Publication of EA201500133A1 publication Critical patent/EA201500133A1/ru
Publication of EA028041B1 publication Critical patent/EA028041B1/ru

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    • C07—ORGANIC CHEMISTRY
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявке описана серия производных имидазо[1,2-а]пиразина, которые являются активными модуляторами активности TNFα человека и поэтому полезны для лечения и/или предупреждения различных заболеваний человека, включая аутоиммунные и воспалительные нарушения; неврологические и нейродегенеративные нарушения; боль и ноцицептивные нарушения; сердечно-сосудистые нарушения; метаболические нарушения; глазные нарушения и онкологические нарушения.
EA201500133A 2012-07-13 2013-07-05 Производные имидазопиразина в качестве модуляторов активности tnf EA028041B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1212513.4A GB201212513D0 (en) 2012-07-13 2012-07-13 Therapeutic agents
PCT/EP2013/064332 WO2014009296A1 (en) 2012-07-13 2013-07-05 Imidazopyrazine derivatives as modulators of tnf activity

Publications (2)

Publication Number Publication Date
EA201500133A1 true EA201500133A1 (ru) 2015-07-30
EA028041B1 EA028041B1 (ru) 2017-09-29

Family

ID=46799593

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EA201500133A EA028041B1 (ru) 2012-07-13 2013-07-05 Производные имидазопиразина в качестве модуляторов активности tnf

Country Status (11)

Country Link
US (1) US9475820B2 (ru)
EP (1) EP2872511B1 (ru)
JP (1) JP6259824B2 (ru)
CN (1) CN104470924B (ru)
BR (1) BR112015000790B1 (ru)
CA (1) CA2877543C (ru)
EA (1) EA028041B1 (ru)
ES (1) ES2711131T3 (ru)
GB (1) GB201212513D0 (ru)
TR (1) TR201901652T4 (ru)
WO (1) WO2014009296A1 (ru)

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BR112015000790A2 (pt) 2017-06-27
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