EA201792686A1 - Производные индазола в качестве модуляторов активности tnf - Google Patents

Производные индазола в качестве модуляторов активности tnf

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Publication number
EA201792686A1
EA201792686A1 EA201792686A EA201792686A EA201792686A1 EA 201792686 A1 EA201792686 A1 EA 201792686A1 EA 201792686 A EA201792686 A EA 201792686A EA 201792686 A EA201792686 A EA 201792686A EA 201792686 A1 EA201792686 A1 EA 201792686A1
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EA
Eurasian Patent Office
Prior art keywords
disorders
derivatives
indazol
module
tnf activity
Prior art date
Application number
EA201792686A
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English (en)
Inventor
Прафулкумар Тулшибхай Човатия
Мартин Клайв Хатчингс
Борис Кроплин
Джеймс Томас Рьюберсон
Original Assignee
Юсб Байофарма Спрл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Юсб Байофарма Спрл filed Critical Юсб Байофарма Спрл
Publication of EA201792686A1 publication Critical patent/EA201792686A1/ru

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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

В заявке описана серия замещенных производных индазола и их аналоги, которые являются активными модуляторами активности TNFα человека и поэтому полезны для лечения и/или предупреждения различных заболеваний человека, включая аутоиммунные и воспалительные нарушения; неврологические и нейродегенеративные нарушения; боль и ноцицептивные нарушения; сердечно-сосудистые нарушения; метаболические нарушения; глазные нарушения и онкологические нарушения.
EA201792686A 2015-06-08 2016-06-07 Производные индазола в качестве модуляторов активности tnf EA201792686A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1509885.8A GB201509885D0 (en) 2015-06-08 2015-06-08 Therapeutic agents
PCT/EP2016/062901 WO2016198401A1 (en) 2015-06-08 2016-06-07 Indazole derivatives as modulators of tnf activity

Publications (1)

Publication Number Publication Date
EA201792686A1 true EA201792686A1 (ru) 2018-06-29

Family

ID=53785095

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792686A EA201792686A1 (ru) 2015-06-08 2016-06-07 Производные индазола в качестве модуляторов активности tnf

Country Status (8)

Country Link
US (1) US20180222868A1 (ru)
EP (1) EP3303298A1 (ru)
JP (1) JP2018521023A (ru)
CN (1) CN107787319A (ru)
CA (1) CA2986972A1 (ru)
EA (1) EA201792686A1 (ru)
GB (1) GB201509885D0 (ru)
WO (1) WO2016198401A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9856253B2 (en) 2015-04-17 2018-01-02 Abbvie, Inc. Tricyclic modulators of TNF signaling
WO2016168638A1 (en) 2015-04-17 2016-10-20 Abbvie Inc. Indazolones as modulators of tnf signaling
UY36629A (es) 2015-04-17 2016-11-30 Abbvie Inc Indazolonas como moduladores de la señalización de tnf
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope
CN113683505A (zh) * 2021-09-29 2021-11-23 厦门大华本安化工安全研究院有限公司 一种含氧代环丁基的羧酸酯类化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2431166A1 (en) * 2000-12-08 2002-06-13 Ortho-Mcneil Pharmaceutical, Inc. Indazolyl-substituted pyrroline compounds as kinase inhibitors
US8318667B2 (en) * 2009-02-25 2012-11-27 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
CN102675286B (zh) * 2011-03-07 2015-08-19 中国科学院上海药物研究所 一类吲唑类化合物及其制备方法、用途和药物组合物
JP6359008B2 (ja) 2012-06-11 2018-07-18 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ−アルファ調節ベンゾイミダゾール
GB201212513D0 (en) 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
EA028722B1 (ru) * 2012-07-13 2017-12-29 Юсб Байофарма Спрл Производные имидазопиридина в качестве модуляторов активности tnf

Also Published As

Publication number Publication date
CA2986972A1 (en) 2016-12-15
GB201509885D0 (en) 2015-07-22
WO2016198401A1 (en) 2016-12-15
JP2018521023A (ja) 2018-08-02
US20180222868A1 (en) 2018-08-09
CN107787319A (zh) 2018-03-09
EP3303298A1 (en) 2018-04-11

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