BR112016011789A2 - Derivados de purina, composição farmacêutica compreendendo os mesmos e uso dos mesmos - Google Patents

Derivados de purina, composição farmacêutica compreendendo os mesmos e uso dos mesmos

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Publication number
BR112016011789A2
BR112016011789A2 BR112016011789A BR112016011789A BR112016011789A2 BR 112016011789 A2 BR112016011789 A2 BR 112016011789A2 BR 112016011789 A BR112016011789 A BR 112016011789A BR 112016011789 A BR112016011789 A BR 112016011789A BR 112016011789 A2 BR112016011789 A2 BR 112016011789A2
Authority
BR
Brazil
Prior art keywords
disorders
purine derivatives
pharmaceutical composition
composition including
neurological
Prior art date
Application number
BR112016011789A
Other languages
English (en)
Inventor
Elizabeth Jackson Victoria
Kroeplien Boris
Alexander Lowe Martin
Robert Porter John
Original Assignee
Ucb Biopharma Sprl
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Biopharma Sprl, UCB Biopharma SRL filed Critical Ucb Biopharma Sprl
Publication of BR112016011789A2 publication Critical patent/BR112016011789A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom

Abstract

DERIVADOS DE PURINA, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS MESMOS E USO DOS MESMOS. Trata-se de uma série de derivados de purina substituídos, que são moduladores potentes da atividade de TNF(Alfa) humano, que são, consequentemente, benéficos no tratamento e/ou prevenção de várias enfermidades humanas, incluindo distúrbios inflamatórios ou autoimunes; distúrbios neurológicos e neurodegenerativos; dor e distúrbios nociceptivos; distúrbios cardiovasculares; distúrbios metabólicos; distúrbios oculares; e distúrbios oncológicos.
BR112016011789A 2013-12-09 2014-12-08 Derivados de purina, composição farmacêutica compreendendo os mesmos e uso dos mesmos BR112016011789A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1321737.7A GB201321737D0 (en) 2013-12-09 2013-12-09 Therapeutic Agents
PCT/EP2014/076843 WO2015086505A1 (en) 2013-12-09 2014-12-08 Purine derivatives as modulators of tnf activity

Publications (1)

Publication Number Publication Date
BR112016011789A2 true BR112016011789A2 (pt) 2017-08-08

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ID=50000420

Family Applications (1)

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BR112016011789A BR112016011789A2 (pt) 2013-12-09 2014-12-08 Derivados de purina, composição farmacêutica compreendendo os mesmos e uso dos mesmos

Country Status (10)

Country Link
US (1) US9988383B2 (pt)
EP (1) EP3080126B1 (pt)
JP (1) JP6495917B2 (pt)
CN (1) CN105814056B (pt)
BR (1) BR112016011789A2 (pt)
CA (1) CA2931581C (pt)
ES (1) ES2751491T3 (pt)
GB (1) GB201321737D0 (pt)
RU (1) RU2684644C1 (pt)
WO (1) WO2015086505A1 (pt)

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Also Published As

Publication number Publication date
JP2016539980A (ja) 2016-12-22
WO2015086505A1 (en) 2015-06-18
CN105814056B (zh) 2017-10-10
US9988383B2 (en) 2018-06-05
GB201321737D0 (en) 2014-01-22
CN105814056A (zh) 2016-07-27
EP3080126A1 (en) 2016-10-19
JP6495917B2 (ja) 2019-04-03
CA2931581A1 (en) 2015-06-18
RU2016127229A (ru) 2018-01-23
CA2931581C (en) 2021-10-26
US20160297818A1 (en) 2016-10-13
EP3080126B1 (en) 2019-08-28
ES2751491T3 (es) 2020-03-31
RU2684644C1 (ru) 2019-04-11

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