MX2019007032A - Operaciones de cosecha mejoradas para proteinas recombinadas. - Google Patents
Operaciones de cosecha mejoradas para proteinas recombinadas.Info
- Publication number
- MX2019007032A MX2019007032A MX2019007032A MX2019007032A MX2019007032A MX 2019007032 A MX2019007032 A MX 2019007032A MX 2019007032 A MX2019007032 A MX 2019007032A MX 2019007032 A MX2019007032 A MX 2019007032A MX 2019007032 A MX2019007032 A MX 2019007032A
- Authority
- MX
- Mexico
- Prior art keywords
- recombinant protein
- host cell
- prokaryotic host
- filtered bulk
- recombinant proteins
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Sustainable Development (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención contempla un método para la producción de una proteína recombinada que comprende (a) la fermentación de una célula huésped procariota, donde dicha célula huésped procariota ha sido transformada con un ácido nucleico que codifica dicha proteína recombinada, y (b) la cosecha de dicha proteína recombinada en condiciones donde los niveles de dO2 son superiores a 0%, y (c) la purificación de dicha proteína recombinada hasta un volumen filtrado, donde dicho volumen filtrado no contiene una cantidad detectable de aducto de DHNA-proteína recombinada, medida por un ensayo de IEC a 310 nm. La presente invención además contempla un método para la producción de una proteína recombinada que comprende (a) la fermentación de una célula huésped procariota con deleción del gen menE, donde dicha célula huésped procariota ha sido transformada con un ácido nucleico que codifica dicha proteína recombinada, (b) la cosecha de dicha proteína recombinada; y (c) la purificación de dicha proteína recombinada hasta un volumen filtrado, donde dicho volumen filtrado no contiene una cantidad detectable de aducto de DHNA-proteína recombinada, medida por un ensayo de IEC a 310 nm, y donde el rendimiento de proteína recombinada se incrementa alrededor de 20% o más.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616297P | 2012-03-27 | 2012-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019007032A true MX2019007032A (es) | 2019-08-16 |
Family
ID=48040433
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014011558A MX365947B (es) | 2012-03-27 | 2013-03-14 | Operaciones de cosecha mejoradas para proteinas recombinadas. |
| MX2018007677A MX2018007677A (es) | 2012-03-27 | 2014-09-25 | Operaciones de cosecha mejoradas para proteinas recombinadas. |
| MX2019007032A MX2019007032A (es) | 2012-03-27 | 2014-09-25 | Operaciones de cosecha mejoradas para proteinas recombinadas. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014011558A MX365947B (es) | 2012-03-27 | 2013-03-14 | Operaciones de cosecha mejoradas para proteinas recombinadas. |
| MX2018007677A MX2018007677A (es) | 2012-03-27 | 2014-09-25 | Operaciones de cosecha mejoradas para proteinas recombinadas. |
Country Status (21)
| Country | Link |
|---|---|
| US (8) | US20140080180A1 (es) |
| EP (1) | EP2831261B1 (es) |
| JP (4) | JP6225162B2 (es) |
| KR (2) | KR102096678B1 (es) |
| CN (2) | CN109880867A (es) |
| AR (2) | AR090340A1 (es) |
| AU (3) | AU2013240280A1 (es) |
| BR (1) | BR112014023176B1 (es) |
| CA (2) | CA3086730A1 (es) |
| ES (1) | ES2654424T3 (es) |
| HK (1) | HK1207120A1 (es) |
| HR (1) | HRP20171966T1 (es) |
| IL (1) | IL234377B (es) |
| MX (3) | MX365947B (es) |
| MY (1) | MY171729A (es) |
| PL (1) | PL2831261T3 (es) |
| RU (2) | RU2017139267A (es) |
| SG (4) | SG10201912877SA (es) |
| SI (1) | SI2831261T1 (es) |
| WO (1) | WO2013148249A1 (es) |
| ZA (1) | ZA201406434B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102499718B1 (ko) * | 2016-06-10 | 2023-02-13 | 론자 리미티드 | 단백질을 안정화시키는 방법 |
| TWI763732B (zh) * | 2016-11-07 | 2022-05-11 | 美商西雅圖遺傳學公司 | 工程化半胱胺酸帽之分佈 |
| CN111918873A (zh) * | 2018-03-27 | 2020-11-10 | 百时美施贵宝公司 | 使用紫外线信号实时监测滴度 |
| CN109725088B (zh) * | 2019-03-16 | 2021-05-18 | 丁立平 | 一种测定豆芽中2-萘甲酸及其衍生物的气相色谱-质谱联用法 |
| CN110305903B (zh) * | 2019-07-31 | 2021-10-01 | 江苏璟泽生物医药有限公司 | 重组人促卵泡激素及其制备方法 |
| CN113155776A (zh) * | 2021-04-29 | 2021-07-23 | 华东交通大学 | 一种柑桔最佳采收期预测方法 |
| FR3146146A1 (fr) | 2023-02-24 | 2024-08-30 | Bgene Genetics | Production d’acide 1-4-dihydroxy-2-naphtoïque par Escherichia coli |
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2013
- 2013-03-14 SI SI201330894T patent/SI2831261T1/en unknown
- 2013-03-14 WO PCT/US2013/031383 patent/WO2013148249A1/en active Application Filing
- 2013-03-14 CN CN201910197577.9A patent/CN109880867A/zh active Pending
- 2013-03-14 AU AU2013240280A patent/AU2013240280A1/en not_active Abandoned
- 2013-03-14 KR KR1020147026772A patent/KR102096678B1/ko active IP Right Grant
- 2013-03-14 EP EP13713295.7A patent/EP2831261B1/en active Active
- 2013-03-14 BR BR112014023176-1A patent/BR112014023176B1/pt active IP Right Grant
- 2013-03-14 ES ES13713295.7T patent/ES2654424T3/es active Active
- 2013-03-14 RU RU2017139267A patent/RU2017139267A/ru not_active Application Discontinuation
- 2013-03-14 PL PL13713295T patent/PL2831261T3/pl unknown
- 2013-03-14 AR ARP130100828A patent/AR090340A1/es active IP Right Grant
- 2013-03-14 SG SG10201912877SA patent/SG10201912877SA/en unknown
- 2013-03-14 CN CN201380027623.1A patent/CN104350156B/zh active Active
- 2013-03-14 CA CA3086730A patent/CA3086730A1/en not_active Abandoned
- 2013-03-14 MX MX2014011558A patent/MX365947B/es active IP Right Grant
- 2013-03-14 JP JP2015503300A patent/JP6225162B2/ja active Active
- 2013-03-14 RU RU2014137554A patent/RU2636353C2/ru active
- 2013-03-14 SG SG10201508420VA patent/SG10201508420VA/en unknown
- 2013-03-14 KR KR1020207008828A patent/KR20200037425A/ko not_active Application Discontinuation
- 2013-03-14 SG SG10202007206WA patent/SG10202007206WA/en unknown
- 2013-03-14 CA CA2866753A patent/CA2866753C/en active Active
- 2013-03-14 SG SG11201406112TA patent/SG11201406112TA/en unknown
- 2013-03-14 MY MYPI2014002775A patent/MY171729A/en unknown
- 2013-03-14 US US13/826,166 patent/US20140080180A1/en not_active Abandoned
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2014
- 2014-08-31 IL IL234377A patent/IL234377B/en active IP Right Grant
- 2014-09-02 ZA ZA2014/06434A patent/ZA201406434B/en unknown
- 2014-09-25 MX MX2018007677A patent/MX2018007677A/es unknown
- 2014-09-25 MX MX2019007032A patent/MX2019007032A/es unknown
- 2014-09-26 US US14/497,964 patent/US9765379B2/en active Active
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2015
- 2015-06-09 US US14/734,848 patent/US20160130624A1/en not_active Abandoned
- 2015-08-10 HK HK15107689.4A patent/HK1207120A1/xx unknown
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2017
- 2017-04-13 AU AU2017202484A patent/AU2017202484B2/en active Active
- 2017-10-05 JP JP2017195016A patent/JP2018046825A/ja active Pending
- 2017-12-19 HR HRP20171966TT patent/HRP20171966T1/hr unknown
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2018
- 2018-02-28 US US15/908,526 patent/US20180291411A1/en not_active Abandoned
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2019
- 2019-02-07 US US16/270,494 patent/US20200199639A1/en not_active Abandoned
- 2019-03-18 JP JP2019049717A patent/JP2019141049A/ja not_active Withdrawn
- 2019-09-05 AU AU2019226192A patent/AU2019226192A1/en not_active Abandoned
- 2019-10-09 AR ARP190102873A patent/AR116615A2/es unknown
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2020
- 2020-08-14 JP JP2020137053A patent/JP2020202849A/ja not_active Withdrawn
- 2020-10-09 US US17/067,059 patent/US20210171997A1/en not_active Abandoned
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2022
- 2022-07-13 US US17/864,255 patent/US20230069966A1/en not_active Abandoned
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2024
- 2024-01-22 US US18/419,368 patent/US20240158825A1/en active Pending
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