TR201904342T4 - Hümani̇ze il-15 hayvanlar - Google Patents

Hümani̇ze il-15 hayvanlar Download PDF

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Publication number
TR201904342T4
TR201904342T4 TR2019/04342T TR201904342T TR201904342T4 TR 201904342 T4 TR201904342 T4 TR 201904342T4 TR 2019/04342 T TR2019/04342 T TR 2019/04342T TR 201904342 T TR201904342 T TR 201904342T TR 201904342 T4 TR201904342 T4 TR 201904342T4
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gene
rodent
humanized
human
polypeptide
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TR2019/04342T
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English (en)
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F Rojas Jose
Venus Lai Ka-Man
J Murphy Andrew
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Regeneron Pharma
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Buluş, genomu şunları içeren genetiği değiştirilmiş bir kemirgen sağlamaktadır, hümanize bir IL-15 genini oluşturmak üzere olgun insan IL-15 polipeptidini kodlayan insan IL-15 geninin bir genomik fragmanı ile olgun kemirgen IL-15 polipeptidini kodlayan bir kemirgen genomik fragmanının endojen bir kemirgen IL-15 lokusunda yer değiştirilmesi, burada hümanize IL-15 geni, tüm kemirgen IL-15 protein kodlamayan ekzonları ve kemirgen IL-15 geninin birinci protein kodlama ekzonunun üstündeki düzenleyici bölgeleri içerir ve hümanize IL-15 geninin ekspresyonu, söz konusu düzenleyici bölgelerin kontrolü altındadır, ve burada hümanize IL-15 geni, olgunlaştığında tamamen insan olan bir IL-15 proteininin ekspresyonu ile sonuçlanır.
TR2019/04342T 2013-10-15 2014-10-15 Hümani̇ze il-15 hayvanlar TR201904342T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361891013P 2013-10-15 2013-10-15

Publications (1)

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TR201904342T4 true TR201904342T4 (tr) 2019-05-21

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ID=51830649

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US (5) US9155290B2 (tr)
EP (3) EP2908626B1 (tr)
JP (3) JP6492095B2 (tr)
KR (1) KR102376041B1 (tr)
CN (2) CN105744829B (tr)
AU (2) AU2014337526B2 (tr)
BR (1) BR112016008175A2 (tr)
CA (1) CA2926090C (tr)
CY (2) CY1118675T1 (tr)
DK (2) DK2908626T3 (tr)
ES (2) ES2613379T3 (tr)
HK (1) HK1210659A1 (tr)
HR (2) HRP20170380T1 (tr)
HU (2) HUE043969T2 (tr)
IL (2) IL244525B (tr)
LT (2) LT3138397T (tr)
MX (1) MX2016004781A (tr)
NZ (1) NZ718655A (tr)
PL (2) PL2908626T3 (tr)
PT (2) PT2908626T (tr)
RS (2) RS55472B1 (tr)
RU (1) RU2674910C2 (tr)
SG (2) SG11201601828XA (tr)
SI (2) SI2908626T1 (tr)
SM (1) SMT201700024B (tr)
TR (1) TR201904342T4 (tr)
WO (1) WO2015057758A1 (tr)
ZA (1) ZA201601676B (tr)

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SI3138397T1 (sl) 2019-04-30
HUE043969T2 (hu) 2019-09-30
SMT201700024B (it) 2017-03-08
ES2715949T3 (es) 2019-06-07
LT2908626T (lt) 2017-01-25
CY1121405T1 (el) 2020-05-29
AU2014337526A1 (en) 2016-04-28
PL3138397T3 (pl) 2019-06-28
ES2613379T3 (es) 2017-05-24
NZ718655A (en) 2022-08-26
EP3138397B1 (en) 2018-12-26
HK1210659A1 (en) 2016-05-06
IL269907B (en) 2020-09-30
RU2016116847A3 (tr) 2018-06-07
US20150106961A1 (en) 2015-04-16
JP6600061B2 (ja) 2019-10-30
RU2016116847A (ru) 2017-11-21
PT2908626T (pt) 2017-01-09
IL244525B (en) 2019-10-31
EP3138397A1 (en) 2017-03-08
EP2908626B1 (en) 2016-12-07
RS58465B1 (sr) 2019-04-30
US9155290B2 (en) 2015-10-13
CA2926090A1 (en) 2015-04-23
US10561125B2 (en) 2020-02-18
US20150366175A1 (en) 2015-12-24
PL2908626T3 (pl) 2017-05-31
CA2926090C (en) 2022-07-05
JP2019216750A (ja) 2019-12-26
HUE033272T2 (en) 2017-11-28
AU2020286186B2 (en) 2024-05-23
US11503813B2 (en) 2022-11-22
ZA201601676B (en) 2019-12-18
CN105744829A (zh) 2016-07-06
DK2908626T3 (en) 2017-03-20
US20180116192A1 (en) 2018-05-03
RU2674910C2 (ru) 2018-12-13
HRP20190542T1 (hr) 2019-07-26
JP2019022518A (ja) 2019-02-14
US20230189772A1 (en) 2023-06-22
JP6492095B2 (ja) 2019-03-27
WO2015057758A1 (en) 2015-04-23
CN109090037B (zh) 2021-05-28
MX2016004781A (es) 2016-07-26
US20200178508A1 (en) 2020-06-11
EP2908626A1 (en) 2015-08-26
LT3138397T (lt) 2019-04-10
CN109090037A (zh) 2018-12-28
EP3461331A1 (en) 2019-04-03
CY1118675T1 (el) 2018-03-07
PT3138397T (pt) 2019-03-26
HRP20170380T1 (hr) 2017-05-19
AU2014337526B2 (en) 2020-09-10
JP2016533192A (ja) 2016-10-27
RS55472B1 (sr) 2017-04-28
IL244525A0 (en) 2016-04-21
KR20160068774A (ko) 2016-06-15
DK3138397T3 (en) 2019-04-15
SG11201601828XA (en) 2016-04-28
SI2908626T1 (sl) 2017-02-28
CN105744829B (zh) 2018-08-07
AU2020286186A1 (en) 2021-01-07
KR102376041B1 (ko) 2022-03-18
BR112016008175A2 (pt) 2017-10-03
SG10201607768YA (en) 2016-11-29

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