MX2014015679A - Roedores con il-7 humanizada. - Google Patents

Roedores con il-7 humanizada.

Info

Publication number
MX2014015679A
MX2014015679A MX2014015679A MX2014015679A MX2014015679A MX 2014015679 A MX2014015679 A MX 2014015679A MX 2014015679 A MX2014015679 A MX 2014015679A MX 2014015679 A MX2014015679 A MX 2014015679A MX 2014015679 A MX2014015679 A MX 2014015679A
Authority
MX
Mexico
Prior art keywords
humanized
human
gene
rodents
genetically modified
Prior art date
Application number
MX2014015679A
Other languages
English (en)
Other versions
MX363540B (es
Inventor
Andrew J Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2014015679A publication Critical patent/MX2014015679A/es
Publication of MX363540B publication Critical patent/MX363540B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Catching Or Destruction (AREA)

Abstract

La presente invención se refiere a animales no humanos genéticamente modificados que comprenden un gen de interleucina 7 (IL-7) humana o humanizada. A células, embriones, y animales no humanos que comprenden un gen de IL-7 humana o humanizada. A roedores que expresan una proteína lL-7 humana o humanizada. Y a ratones genéticamente modificados que comprenden un gen que codifica para IL-7 humana o humanizada en su línea germinal, en donde el gen que codifica para IL-7 humana o humanizada está bajo el control de secuencias reguladoras endógenas de lL-7 murina.
MX2014015679A 2012-06-18 2013-06-14 Roedores con il-7 humanizada. MX363540B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261660976P 2012-06-18 2012-06-18
US201261740074P 2012-12-20 2012-12-20
US13/795,765 US8962913B2 (en) 2012-06-18 2013-03-12 Humanized IL-7 rodents
PCT/US2013/045788 WO2013192030A1 (en) 2012-06-18 2013-06-14 Humanized il-7 rodents

Publications (2)

Publication Number Publication Date
MX2014015679A true MX2014015679A (es) 2015-04-08
MX363540B MX363540B (es) 2019-03-27

Family

ID=49757275

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014015679A MX363540B (es) 2012-06-18 2013-06-14 Roedores con il-7 humanizada.

Country Status (26)

Country Link
US (7) US8962913B2 (es)
EP (2) EP2861063A1 (es)
JP (1) JP6174134B2 (es)
KR (1) KR20150027752A (es)
CN (2) CN104378976B (es)
AU (1) AU2013277457B2 (es)
BR (1) BR112014029892A2 (es)
CA (1) CA2873134A1 (es)
CY (1) CY1119071T1 (es)
DK (1) DK2859793T3 (es)
ES (1) ES2626965T3 (es)
HK (2) HK1203302A1 (es)
HR (1) HRP20170974T1 (es)
HU (1) HUE034592T2 (es)
IL (3) IL235773B (es)
IN (1) IN2014DN10189A (es)
LT (1) LT2859793T (es)
MX (1) MX363540B (es)
NZ (1) NZ702943A (es)
PL (1) PL2859793T3 (es)
PT (1) PT2859793T (es)
RS (1) RS56039B1 (es)
RU (1) RU2654565C2 (es)
SG (3) SG10201609569PA (es)
SI (1) SI2859793T1 (es)
WO (1) WO2013192030A1 (es)

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US20120204278A1 (en) 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
JP5813880B2 (ja) 2011-09-19 2015-11-17 カイマブ・リミテッド ヒトへの使用に合わせて作製された抗体、可変ドメインおよび鎖
US9001798B2 (en) * 2012-03-05 2015-04-07 Samsung Electronics Co., Ltd. HARQ-ACK signal transmission in response to detection of control channel type in case of multiple control channel types
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
IL297607B2 (en) 2013-09-23 2024-01-01 Regeneron Pharma Non-human animals with a humanized gene for SIGNAL-REGULATORY PROTEIN
NL2013554B1 (en) 2013-10-01 2016-01-08 Kymab Ltd Animal models and therapeutic molecules.
KR102376041B1 (ko) 2013-10-15 2022-03-18 리제너론 파마슈티칼스 인코포레이티드 인간화된 il-15 동물
AU2015256299C1 (en) * 2014-05-05 2022-01-06 Regeneron Pharmaceuticals, Inc. Humanized C5 and C3 animals
NO2785538T3 (es) 2014-05-07 2018-08-04
FI3850946T3 (fi) 2014-12-05 2023-12-28 Regeneron Pharma Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni
RU2020124128A (ru) * 2015-04-13 2020-09-22 Ридженерон Фармасьютикалз, Инк. Гуманизированные мыши с нокином sirpa-il15 и способы их использования
EP3411392B1 (en) 2016-02-04 2021-12-29 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered angptl8 gene
CN109068621B (zh) 2016-02-29 2021-07-20 再生元制药公司 具有人源化的tmprss基因的啮齿类动物
KR20210031868A (ko) 2018-07-16 2021-03-23 리제너론 파마슈티칼스 인코포레이티드 Ditra 질환의 비인간 동물 모델 및 이의 용도
CN114107385A (zh) * 2019-01-17 2022-03-01 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
WO2020206139A1 (en) 2019-04-04 2020-10-08 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized coagulation factor 12 locus
JP2022534867A (ja) 2019-06-04 2022-08-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法
BR112021022722A2 (pt) 2019-06-07 2022-01-04 Regeneron Pharma Animal não humano, célula de animal não humana, genoma de animal não humano, gene de albumina animal não humana humanizada, vetor de alvejamento, método de avaliação da atividade de um reagente, e, método de otimização da atividade de um reagente
US20220312749A1 (en) * 2019-08-09 2022-10-06 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
AU2021212668A1 (en) * 2020-01-28 2022-08-18 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized PNPLA3 locus and methods of use
KR102316506B1 (ko) 2020-02-26 2021-10-22 차의과학대학교 산학협력단 동물 면역계의 인간화 활성을 촉진하는 방법
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
JP2024500153A (ja) * 2020-12-21 2024-01-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｔｓｌｐ遺伝子、ヒト化ｔｓｌｐ受容体遺伝子、及び／又はヒト化ｉｌ７ｒａ遺伝子を有する非ヒト動物
WO2022247936A1 (en) * 2021-05-28 2022-12-01 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric cd36
WO2024054904A1 (en) * 2022-09-08 2024-03-14 The Jackson Laboratory Humanized immunodeficient mouse models

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CN101302517B (zh) * 2008-02-03 2010-11-03 中国科学院广州生物医药与健康研究院 人白细胞介素7在真核宿主中表达的方法
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PT2675271T (pt) 2011-02-15 2018-10-11 Univ Yale Ratinhos humanizados para m-csf
EP2818478B1 (en) 2011-10-28 2017-02-01 Regeneron Pharmaceuticals, Inc. Humanized IL-6 and IL-6 receptor
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents

Also Published As

Publication number Publication date
IL235773A0 (en) 2015-01-29
EP2861063A1 (en) 2015-04-22
HRP20170974T1 (hr) 2017-09-22
NZ702943A (en) 2017-07-28
HK1203761A1 (en) 2015-11-06
CN105779467A (zh) 2016-07-20
RU2014148107A (ru) 2016-08-10
MX363540B (es) 2019-03-27
IL260250B (en) 2019-08-29
AU2013277457B2 (en) 2018-03-15
KR20150027752A (ko) 2015-03-12
EP2859793A1 (en) 2015-04-15
US20170311581A1 (en) 2017-11-02
RU2654565C2 (ru) 2018-05-21
IL268674A (en) 2019-10-31
US20150082469A1 (en) 2015-03-19
WO2013192030A1 (en) 2013-12-27
PL2859793T3 (pl) 2017-09-29
CN104378976B (zh) 2016-03-23
US9737059B2 (en) 2017-08-22
BR112014029892A2 (pt) 2017-07-25
US8962913B2 (en) 2015-02-24
US9232776B2 (en) 2016-01-12
PT2859793T (pt) 2017-07-06
AU2013277457A1 (en) 2015-01-22
SG10201609569PA (en) 2016-12-29
CN104378976A (zh) 2015-02-25
IN2014DN10189A (es) 2015-08-21
SG10201609576YA (en) 2016-12-29
US20170064932A1 (en) 2017-03-09
US20190343093A1 (en) 2019-11-14
JP6174134B2 (ja) 2017-08-02
US10314298B2 (en) 2019-06-11
CY1119071T1 (el) 2018-01-10
LT2859793T (lt) 2017-07-10
CA2873134A1 (en) 2013-12-27
US9974291B2 (en) 2018-05-22
US20130340104A1 (en) 2013-12-19
SG11201407370QA (en) 2014-12-30
HK1203302A1 (en) 2015-10-30
US20160052986A1 (en) 2016-02-25
SI2859793T1 (sl) 2017-07-31
IL235773B (en) 2018-07-31
HUE034592T2 (en) 2018-02-28
US20180360007A1 (en) 2018-12-20
RS56039B1 (sr) 2017-09-29
ES2626965T3 (es) 2017-07-26
EP2859793B1 (en) 2017-04-05
DK2859793T3 (en) 2017-06-19
JP2015523863A (ja) 2015-08-20

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