CY1117698T1 - Θεραπεια οστεοαρθριτιδας - Google Patents
Θεραπεια οστεοαρθριτιδαςInfo
- Publication number
- CY1117698T1 CY1117698T1 CY20161100433T CY161100433T CY1117698T1 CY 1117698 T1 CY1117698 T1 CY 1117698T1 CY 20161100433 T CY20161100433 T CY 20161100433T CY 161100433 T CY161100433 T CY 161100433T CY 1117698 T1 CY1117698 T1 CY 1117698T1
- Authority
- CY
- Cyprus
- Prior art keywords
- csf
- present
- osteoarthritis
- antagonist
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Virology (AREA)
- Glass Compositions (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Polarising Elements (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Η παρούσα εφεύρεση αφορά γενικώς σε μια μέθοδο για την θεραπεία ή/και προφύλαξη οστεοαρθρίτιδας (OA). Σύμφωνα με την παρούσα εφεύρεση, ένας ανταγωνιστής του GM-CSF μπορεί να είναι αποτελεσματικός στην θεραπεία οστεοαρθρίτιδας. Ένας ανταγωνιστής του GM-CSF περιλαμβάνει, αλλά δεν περιορίζεται σε αυτά, ένα αντίσωμα το οποίο είναι ειδικό για GM-CSF ή τον υποδοχέα GM-CSF. Η παρούσα εφεύρεση περαιτέρω παρέχει διαγονιδιακά ζώα, όπως GM-CSF knock-out ποντικό, χρήσιμα για εξέταση ανταγωνιστών σε ορισμένα μοντέλα ασθένειας.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13967908P | 2008-12-22 | 2008-12-22 | |
US16448609P | 2009-03-30 | 2009-03-30 | |
PCT/AU2009/001672 WO2010071924A1 (en) | 2008-12-22 | 2009-12-21 | Osteoarthritis treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117698T1 true CY1117698T1 (el) | 2017-05-17 |
Family
ID=42286786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100433T CY1117698T1 (el) | 2008-12-22 | 2016-05-18 | Θεραπεια οστεοαρθριτιδας |
Country Status (19)
Country | Link |
---|---|
US (4) | US9243061B2 (el) |
EP (2) | EP2376121B2 (el) |
JP (3) | JP5727379B2 (el) |
KR (2) | KR101799264B1 (el) |
CN (2) | CN102271705A (el) |
AU (1) | AU2009329814B2 (el) |
BR (1) | BRPI0918356B1 (el) |
CA (1) | CA2746827C (el) |
CY (1) | CY1117698T1 (el) |
DK (1) | DK2376121T4 (el) |
ES (2) | ES2886063T3 (el) |
HK (1) | HK1226938A1 (el) |
HR (1) | HRP20160577T4 (el) |
HU (1) | HUE028615T2 (el) |
PL (1) | PL2376121T5 (el) |
RU (2) | RU2712273C2 (el) |
SI (2) | SI2376121T1 (el) |
SM (1) | SMT201600156B (el) |
WO (1) | WO2010071924A1 (el) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102256621B (zh) | 2008-12-22 | 2017-12-12 | 墨尔本大学 | 疼痛治疗 |
US9243061B2 (en) | 2008-12-22 | 2016-01-26 | University Of Melbourne | Osteoarthritis treatment |
WO2014044768A1 (en) | 2012-09-20 | 2014-03-27 | Morphosys Ag | Treatment for rheumatoid arthritis |
DE102013222200A1 (de) * | 2013-10-31 | 2015-08-27 | Osram Opto Semiconductors Gmbh | Elektronisches Bauelement und Verfahren zum Herstellen eines elektronischen Bauelements |
BR112020003025A2 (pt) * | 2017-08-14 | 2020-08-04 | Zynerba Pharmaceuticals, Inc. | métodos de tratamento de osteoartrite com gel transdérmico de canabidiol |
WO2020104833A1 (en) * | 2018-11-19 | 2020-05-28 | 4P-Pharma | Composition and methods for regulating chondrocyte proliferation and increasing of cartilage matrix production |
CN110075304B (zh) * | 2019-05-29 | 2020-02-11 | 四川大学华西医院 | 一种治疗骨关节炎的药物组合物及其用途 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
HUT63181A (en) | 1989-07-14 | 1993-07-28 | Schering Corp | Process for producing gm-csf antagonists originating from carboxy terminal of gm-csf |
WO1991002063A1 (en) | 1989-08-11 | 1991-02-21 | Amrad Corporation Limited | Improvements in granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof |
WO1994009149A1 (en) | 1990-08-10 | 1994-04-28 | Amrad Corporation Limited | Monoclonal antibody |
CA2149881A1 (en) | 1992-11-19 | 1994-05-26 | Paul T. Jubinsky | Antibodies for gm-csf receptor and uses thereof |
DK1143006T3 (da) | 1995-08-18 | 2008-07-14 | Morphosys Ip Gmbh | Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker |
AUPP525198A0 (en) | 1998-08-13 | 1998-09-03 | Medvet Science Pty. Ltd. | Monoclonal antibody inhibitor of GM-CSF, IL-3 and IL-5 and other cytokines and uses thereof |
US7108852B2 (en) | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
US7455836B2 (en) * | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
WO2003035048A2 (en) * | 2001-10-26 | 2003-05-01 | Novartis Ag | Methods for the treatment of osteoarthritis and compositions thereof |
ES2365606T3 (es) | 2002-02-13 | 2011-10-07 | Ludwig Institute For Cancer Research Ltd. | Anticuerpos contra gm-csf quiméricos. |
US20040241755A1 (en) * | 2003-06-02 | 2004-12-02 | Pfizer Inc. | Human cell assay to determine effect of sample compounds on Col2 enhancer expression |
ATE464908T1 (de) | 2004-02-11 | 2010-05-15 | Warner Lambert Co | Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern |
EP1759710B1 (en) * | 2004-03-31 | 2014-05-07 | Kazuwa Nakao | Remedy or preventive for arthritis |
DE602004021773D1 (de) | 2004-05-05 | 2009-08-13 | Micromet Ag | Herstellung eines einkettigen fv Antikörperfragments |
EP1782074A2 (en) * | 2004-08-18 | 2007-05-09 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Biomarkers for osteoarthritis |
US20060040258A1 (en) | 2004-08-23 | 2006-02-23 | Huiyan Guo | Water-soluble conjugates and methods of preparation |
SG161292A1 (en) | 2005-04-18 | 2010-05-27 | Micromet Ag | Antibody neutralizers of human granulocyte macrophage colony stimulating factor |
ES2527428T3 (es) * | 2005-05-18 | 2015-01-23 | Morphosys Ag | Anticuerpos anti-GM-CSF y usos de los mismos |
JP4736037B2 (ja) | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトgm−csfに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
CN101466734A (zh) * | 2005-12-01 | 2009-06-24 | 杜门蒂斯有限公司 | 与白细胞介素-1受体1型结合的竞争性域抗体形式 |
KR101486183B1 (ko) * | 2006-02-08 | 2015-01-28 | 모르포테크, 인크. | 항원성 gm-csf 펩티드 및 gm-csf에 대한 항체 |
DK1999152T3 (da) | 2006-03-27 | 2013-01-14 | Medimmune Ltd | Bindende element til gm-csf-receptor |
US7741273B2 (en) | 2006-04-13 | 2010-06-22 | Warsaw Orthopedic, Inc. | Drug depot implant designs |
ES2432173T3 (es) * | 2006-11-21 | 2013-12-02 | Kalobios Pharmaceuticals, Inc. | Métodos de tratamiento de enfermedades inflamatorias crónicas usando un antagonista de GM-CSF |
WO2008080134A2 (en) * | 2006-12-22 | 2008-07-03 | Rigel Pharmaceuticals, Inc. | 4-amin0-2- (hetero) arylamino-5- (hetero) arylthiazoles useful as axl inhibitors |
CN101687926A (zh) * | 2007-05-23 | 2010-03-31 | 哮喘和气道Crc有限公司 | 中和抗体 |
TW200918553A (en) * | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
WO2009042854A1 (en) * | 2007-09-26 | 2009-04-02 | Musculoskeletal Research Llc | Ion-channel regulator compositions and methods of using same |
US20100297135A1 (en) | 2007-11-12 | 2010-11-25 | Crc For Asthma And Airways Ltd. | Epitope for neutralizing antibodies |
AR069290A1 (es) * | 2007-11-13 | 2010-01-13 | Evec Inc | Anticuerpos monoclonales que se unen al hgm -csf (factor estimulante de la colonia de granulocitos-macrofagos) y las composiciones medicas que los comprenden |
CN102282173A (zh) | 2008-03-24 | 2011-12-14 | 艾博特生物技术有限公司 | 用于治疗骨丢失的方法和组合物 |
EP3449941A1 (en) | 2008-04-28 | 2019-03-06 | Humanigen, Inc. | Antibodies to granulocyte-macrophage colony-stimulating factor |
US9243061B2 (en) | 2008-12-22 | 2016-01-26 | University Of Melbourne | Osteoarthritis treatment |
CN102256621B (zh) | 2008-12-22 | 2017-12-12 | 墨尔本大学 | 疼痛治疗 |
SG175305A1 (en) | 2009-04-23 | 2011-11-28 | Theraclone Sciences Inc | Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies |
-
2009
- 2009-12-21 US US13/140,467 patent/US9243061B2/en active Active
- 2009-12-21 HU HUE09833924A patent/HUE028615T2/en unknown
- 2009-12-21 KR KR1020117017015A patent/KR101799264B1/ko active IP Right Grant
- 2009-12-21 CN CN2009801516359A patent/CN102271705A/zh active Pending
- 2009-12-21 SI SI200931446A patent/SI2376121T1/sl unknown
- 2009-12-21 ES ES15194091T patent/ES2886063T3/es active Active
- 2009-12-21 JP JP2011541030A patent/JP5727379B2/ja active Active
- 2009-12-21 EP EP09833924.5A patent/EP2376121B2/en active Active
- 2009-12-21 PL PL09833924T patent/PL2376121T5/pl unknown
- 2009-12-21 BR BRPI0918356-6A patent/BRPI0918356B1/pt active IP Right Grant
- 2009-12-21 WO PCT/AU2009/001672 patent/WO2010071924A1/en active Application Filing
- 2009-12-21 ES ES09833924T patent/ES2572368T5/es active Active
- 2009-12-21 KR KR1020177032850A patent/KR101898982B1/ko active IP Right Grant
- 2009-12-21 RU RU2016102339A patent/RU2712273C2/ru active
- 2009-12-21 EP EP15194091.3A patent/EP3056217B1/en active Active
- 2009-12-21 SI SI200931446T patent/SI2376121T2/sl unknown
- 2009-12-21 DK DK09833924.5T patent/DK2376121T4/da active
- 2009-12-21 RU RU2011127334/15A patent/RU2011127334A/ru unknown
- 2009-12-21 AU AU2009329814A patent/AU2009329814B2/en active Active
- 2009-12-21 CA CA2746827A patent/CA2746827C/en active Active
- 2009-12-21 CN CN201610822096.9A patent/CN106397591A/zh active Pending
-
2015
- 2015-02-20 JP JP2015031198A patent/JP2015143233A/ja active Pending
- 2015-12-18 US US14/975,024 patent/US20160185868A1/en not_active Abandoned
-
2016
- 2016-05-18 CY CY20161100433T patent/CY1117698T1/el unknown
- 2016-05-30 HR HRP20160577TT patent/HRP20160577T4/hr unknown
- 2016-06-01 SM SM201600156T patent/SMT201600156B/it unknown
- 2016-12-06 HK HK16113893A patent/HK1226938A1/zh unknown
-
2017
- 2017-06-12 JP JP2017114806A patent/JP6458086B2/ja active Active
- 2017-11-13 US US15/811,279 patent/US20180066062A1/en not_active Abandoned
-
2020
- 2020-03-31 US US16/836,464 patent/US20200247895A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1117698T1 (el) | Θεραπεια οστεοαρθριτιδας | |
CY1120665T1 (el) | Ανθρωποποιημενα αντισωματα anti-cxcr5, παραγωγα αυτων και χρησεις τους | |
CY1119664T1 (el) | Συνθεσεις και μεθοδοι αυξησης της μυϊκης αναπτυξης | |
CY1119994T1 (el) | Συνθεσεις και μεθοδοι για αυξηση της μυϊκης μαζας και της μυϊκης δυναμης ανταγωνιζοντας ειδικα ton gdf8 και/ή την ακτιβινη α | |
CY1123534T1 (el) | Αντισωματα που περιλαμβανουν τροποποιημενες βαριες σταθερες περιοχες | |
CY1114872T1 (el) | Συνθεσεις και μεθοδοι χρησης αντισωματων εναντι της σκληροστεϊνης | |
CY1121204T1 (el) | Συνθεσεις και μεθοδοι για τη θεραπευτικη αγωγη για διαταραχες που προκαλουνται απο την ige | |
CY1122676T1 (el) | Αντισωματα εναντι της κλαυδινης 18.2 που ειναι χρησιμα στη διαγνωση του καρκινου | |
CY1120181T1 (el) | Αντι-cd40 αντισωματα | |
CY1124891T1 (el) | Pd-1/pd-l1 αναστολεις | |
CY1112739T1 (el) | Αντισωματα και ανοσοσυζευγματα αντι-cd79β και μεθοδοι χρησης | |
CY1121542T1 (el) | Μορια αντισωματων σε pd-1 και χρηση αυτων | |
CY1122593T1 (el) | Αντισωματα εναντι-cd40 και χρησεις αυτων | |
CY1118069T1 (el) | Αντισωματα anti-bcma | |
CY1122205T1 (el) | Ποντικοι adam6 | |
CY1119942T1 (el) | Μεθοδοι θεραπειας της ψωριασης χρησιμοποιωντας ανταγωνιστες της il-17 | |
CY1123587T1 (el) | Συσκευη για παροχη ηλεκτρομαγνητικης ακτινοβολιας σε ενα δειγμα | |
CY1120626T1 (el) | Αντισωματα και αλλα μορια που δεσμευουν β7-η1 και pd-1 | |
CY1119510T1 (el) | Συνδυασμος dr5 αγωνιστη και anti-pd1 ανταγωνιστη και μεθοδοι χρησης | |
CY1118562T1 (el) | Ποντικοι οι οποιοι δημιουργουν πρωτεϊνες δεσμευσης οι οποιες περιλαμβανουν επικρατειες vl | |
CY1120471T1 (el) | Αντισωματα κατα του cd70 | |
CY1114830T1 (el) | Θηλαστικα διαφορετικα απο ανθρωπο που παραγουν αντισωματα | |
EA201400875A1 (ru) | Антитела к cd47 и способы их применения | |
CY1122025T1 (el) | Βελτιωμενη διεργασια για τη δημιουργια προφαρμακων ντουοκαρμυκινης | |
EA201492137A1 (ru) | Антитела к cd33 и их применение в лечении рака |