ATE509032T1 - Chimerizierte gm-csf antikörper - Google Patents
Chimerizierte gm-csf antikörperInfo
- Publication number
- ATE509032T1 ATE509032T1 AT03713430T AT03713430T ATE509032T1 AT E509032 T1 ATE509032 T1 AT E509032T1 AT 03713430 T AT03713430 T AT 03713430T AT 03713430 T AT03713430 T AT 03713430T AT E509032 T1 ATE509032 T1 AT E509032T1
- Authority
- AT
- Austria
- Prior art keywords
- antibodies
- chimerized
- disclosed
- well
- fusion proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35583802P | 2002-02-13 | 2002-02-13 | |
PCT/US2003/004185 WO2003068920A2 (en) | 2002-02-13 | 2003-02-12 | Humanized gm-csf antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE509032T1 true ATE509032T1 (de) | 2011-05-15 |
Family
ID=27734567
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03711002T ATE444308T1 (de) | 2002-02-13 | 2003-02-12 | Fusionsproteine humanisierter g250-spezifischer antikörper sowie verwendungen davon |
AT03713430T ATE509032T1 (de) | 2002-02-13 | 2003-02-12 | Chimerizierte gm-csf antikörper |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03711002T ATE444308T1 (de) | 2002-02-13 | 2003-02-12 | Fusionsproteine humanisierter g250-spezifischer antikörper sowie verwendungen davon |
Country Status (8)
Country | Link |
---|---|
US (5) | US7714113B2 (de) |
EP (2) | EP1507859B1 (de) |
JP (1) | JP2006500905A (de) |
AT (2) | ATE444308T1 (de) |
AU (2) | AU2003215188A1 (de) |
DE (1) | DE60329489D1 (de) |
ES (1) | ES2365606T3 (de) |
WO (2) | WO2003068924A2 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040077081A1 (en) | 2001-02-07 | 2004-04-22 | Egbert Oosterwijk | Hybridoma cell line g250 and its use for producing monoclonal antibodies |
EP1507859B1 (de) * | 2002-02-13 | 2009-09-30 | Ludwig Institute For Cancer Research | Fusionsproteine humanisierter g250-spezifischer antikörper sowie verwendungen davon |
US20090162382A1 (en) * | 2002-03-01 | 2009-06-25 | Bernett Matthew J | Optimized ca9 antibodies and methods of using the same |
US7632496B2 (en) | 2002-07-01 | 2009-12-15 | Wilex Ag | Co-administration of cG250 and IL-2 or IFN-α for treating cancer such as renal cell carcinomas |
GB0325836D0 (en) * | 2003-11-05 | 2003-12-10 | Celltech R&D Ltd | Biological products |
MXPA06013240A (es) * | 2004-07-02 | 2007-02-28 | Wilex Ag | Terapia adyuvante mejorada de tumores que expresan g250. |
EA013162B1 (ru) * | 2005-04-18 | 2010-02-26 | Микромет Аг | Антитела-нейтрализаторы гранулоцитарно-макрофагального колониестимулирующего фактора человека |
LT3620171T (lt) * | 2005-05-18 | 2022-06-10 | Morphosys Ag | Anti-gm-csf antikūnai ir jų panaudojimas |
JP4736037B2 (ja) | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトgm−csfに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
CA2961031C (en) | 2006-02-08 | 2020-02-25 | Morphotek, Inc. | Antigenic gm-csf peptides and antibodies to gm-csf |
AU2013201228B2 (en) * | 2006-02-08 | 2016-01-21 | Eisai, Inc. | Antigenic gm-csf peptides and antibodies to gm-csf |
US20080171038A1 (en) * | 2006-11-08 | 2008-07-17 | Kalobios Pharmaceuticals, Inc. | Methods of treating idiopathic thrombocytopenia purpura using a gm-csf antagonist |
US8398972B2 (en) * | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
CN101605547A (zh) | 2006-11-21 | 2009-12-16 | 卡罗拜奥斯制药公司 | 使用gm-csf拮抗剂治疗慢性炎症疾病的方法 |
JP5276017B2 (ja) | 2007-01-25 | 2013-08-28 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Egfr変異体仲介性疾患の治療における抗egfr抗体の使用 |
AU2008227123B2 (en) | 2007-03-15 | 2014-03-27 | Ludwig Institute For Cancer Research Ltd. | Treatment method using EGFR antibodies and src inhibitors and related formulations |
GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
EP2160407A4 (de) * | 2007-05-23 | 2011-07-27 | Crc For Asthma And Airways Ltd | Neutralisierende antikörper |
MX2010001757A (es) | 2007-08-14 | 2010-09-14 | Ludwig Inst Cancer Res | Anticuerpo monoclonal 175 que activa el receptor egf y derivados y usos del mismo. |
TW200918553A (en) * | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
CN101970489B (zh) * | 2007-11-13 | 2014-06-11 | Evec股份有限公司 | 与hGM-CSF结合的单克隆抗体及包含它的药物组合物 |
US20090181020A1 (en) * | 2008-01-15 | 2009-07-16 | Kalobios Pharmaceuticals, Inc. | Methods of Treating Bone-Loss Disorders Using a GM-CSF Antagonist |
EP2282757B1 (de) * | 2008-04-07 | 2013-05-22 | Kalobios Pharmaceuticals, Inc. | Neutralisation von gm-csf zur behandlung von herzversagen |
EA201001691A1 (ru) | 2008-04-28 | 2011-10-31 | Калобайос Фармасьютикалз, Инк. | Антитела к гранулоцитарно-макрофагальному колониестимулирующему фактору |
NZ590668A (en) * | 2008-07-02 | 2012-12-21 | Emergent Product Dev Seattle | TNF-alpha ANTAGONIST MULTI-TARGET BINDING PROTEINS |
BRPI0916366B1 (pt) * | 2008-07-21 | 2021-08-10 | Probiodrug Ag | Anticorpo que se liga às variantes de peptídeos abeta, sua composição, seu uso, seu kit de diagnóstico, e linhagem celular de hibridoma |
DK2328930T3 (da) * | 2008-08-20 | 2015-03-30 | Probiodrug Ag | Antistoffer rettet mod pyroglutamat-monocyt-kemoattraktant-protein-1 (mcp-1N1pE) |
US8475796B2 (en) | 2008-12-22 | 2013-07-02 | University Of Melbourne | Method of treating pain using an antagonist of GM-CSF |
RU2011127334A (ru) | 2008-12-22 | 2013-01-27 | Де Юниверсити Оф Мельбурн | Лечение остеоартрита |
WO2010093814A1 (en) | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
SG175305A1 (en) | 2009-04-23 | 2011-11-28 | Theraclone Sciences Inc | Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies |
WO2011040973A2 (en) | 2009-10-02 | 2011-04-07 | Ludwig Institute For Cancer Research Ltd. | Tnf-immunoconjugates with fibroblast activation protein antibodies and methods and uses thereof |
MX360097B (es) | 2010-07-29 | 2018-10-22 | Eleven Biotherapeutics Inc | Agonistas y antagonistas del receptor tipo i de il-1 quimérico. |
KR20140061379A (ko) | 2011-07-06 | 2014-05-21 | 모르포시스 아게 | 항cd20 및 항gmcsf 항체의 치료 조합물 및 이의 용도 |
WO2013120060A1 (en) | 2012-02-09 | 2013-08-15 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents by a collagen binding protein |
WO2013090989A1 (en) | 2011-12-22 | 2013-06-27 | Csl Limited | Method of treating inflammatory bowel disease |
DK3838923T3 (da) | 2012-08-24 | 2024-07-29 | Univ California | Antistoffer og vacciner til anvendelse ved behandling af ror1-cancere og hæmning af metastase |
US9833410B2 (en) | 2012-10-31 | 2017-12-05 | Takeda Gmbh | Lyophilized formulation comprising GM-CSF neutralizing compound |
AR093297A1 (es) | 2012-10-31 | 2015-05-27 | Amgen Res (Munich) Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
MX2015012404A (es) | 2013-03-13 | 2016-02-03 | Eleven Biotherapeutics Inc | Formulaciones de citoquinas quimericas para suministro ocular. |
WO2015028657A1 (en) | 2013-08-30 | 2015-03-05 | Takeda Gmbh | Antibodies neutralizing gm-csf for use in the treatment of rheumatoid arthritis or as analgesics |
US9714953B2 (en) | 2014-04-04 | 2017-07-25 | Autotelic Llc | Methods, devices, and reagents for monitoring paclitaxel concentration in plasma for pharmacokinetic-guided dosing of paclitaxel |
CA2944775A1 (en) * | 2014-04-04 | 2015-10-08 | Autotelic Llc | Methods, devices, and reagents for monitoring paclitaxel concentration in plasma for pharmacokinetic-guided dosing of paclitaxel |
US20160000936A1 (en) | 2014-06-10 | 2016-01-07 | Abbvie Inc. | Biomarkers for inflammatory disease and methods of using same |
TWI767915B (zh) | 2016-06-27 | 2022-06-21 | 加州大學董事會 | Ror-1與btk拮抗劑的組合 |
US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
US11673962B2 (en) | 2017-10-02 | 2023-06-13 | Humanigen, Inc. | Method of increasing the efficacy of CAR-T immunotherapy using lenzilumab |
US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
CN112166122A (zh) * | 2018-12-13 | 2021-01-01 | 丁邦 | 抗体-肿瘤坏死因子α融合蛋白及其制法和应用 |
US20210284744A1 (en) * | 2020-03-15 | 2021-09-16 | Kiniksa Pharmaceuticals, Ltd. | Treatment of cytokine release syndrome with gm-csf antagonists |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
AU594014B2 (en) | 1984-03-21 | 1990-03-01 | Research Corporation Technologies, Inc. | Recombinant DNA molecules |
EP0366707A1 (de) | 1987-05-06 | 1990-05-09 | OOSTERWIJK, Egbert | Monoklonale antikörper gegen nierenzellen-karzinom |
US4937190A (en) | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
US5747032A (en) * | 1990-08-10 | 1998-05-05 | Amrad Corporation Limited | Monoclonal antibody to human granulocyte macrophage colony stimulating factor |
CA2060741A1 (en) * | 1991-02-11 | 1992-08-12 | Robert S. Greenfield | Gm-csf inhibiting oligopeptides |
US5919452A (en) * | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
US5714350A (en) * | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
US5955075A (en) * | 1992-03-11 | 1999-09-21 | Institute Of Virology, Slovak Academy Of Sciences | Method of inhibiting tumor growth using antibodies to MN protein |
US6027887A (en) | 1992-03-11 | 2000-02-22 | Institute Of Virology, Solvak Academy Of Sciences | MN gene and protein |
US5981711A (en) | 1992-03-11 | 1999-11-09 | Institute Of Virology, Slovak Academy Of Sciences | MN-specific antibodies and hybridomas |
US5387676A (en) | 1992-03-11 | 1995-02-07 | Ciba Corning Diagnostics Corp. | MN gene and protein |
FR2723462B1 (fr) | 1994-08-02 | 1996-09-06 | Thomson Lcd | Procede d'adressage optimise d'ecran a cristaux liquides et dispositif pour sa mise en oeuvre |
US6406909B1 (en) * | 1998-07-10 | 2002-06-18 | Chugai Seiyaku Kabushiki Kaisha | Serum-free medium for culturing animal cells |
US6475749B1 (en) * | 1999-08-11 | 2002-11-05 | The Regents Of The University Of California | Rh hybrid antibody |
AU4002001A (en) * | 2000-03-01 | 2001-09-12 | Med Immune Inc | High potency recombinant antibodies and method for producing them |
US7455836B2 (en) * | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
EP1507859B1 (de) * | 2002-02-13 | 2009-09-30 | Ludwig Institute For Cancer Research | Fusionsproteine humanisierter g250-spezifischer antikörper sowie verwendungen davon |
-
2003
- 2003-02-12 EP EP03711002A patent/EP1507859B1/de not_active Expired - Lifetime
- 2003-02-12 ES ES03713430T patent/ES2365606T3/es not_active Expired - Lifetime
- 2003-02-12 US US10/504,389 patent/US7714113B2/en not_active Expired - Fee Related
- 2003-02-12 US US10/365,123 patent/US7381801B2/en not_active Expired - Lifetime
- 2003-02-12 DE DE60329489T patent/DE60329489D1/de not_active Expired - Lifetime
- 2003-02-12 AU AU2003215188A patent/AU2003215188A1/en not_active Abandoned
- 2003-02-12 WO PCT/US2003/004243 patent/WO2003068924A2/en not_active Application Discontinuation
- 2003-02-12 AU AU2003217386A patent/AU2003217386B2/en not_active Expired
- 2003-02-12 WO PCT/US2003/004185 patent/WO2003068920A2/en active Application Filing
- 2003-02-12 AT AT03711002T patent/ATE444308T1/de active
- 2003-02-12 EP EP03713430A patent/EP1530580B1/de not_active Expired - Lifetime
- 2003-02-12 AT AT03713430T patent/ATE509032T1/de not_active IP Right Cessation
- 2003-02-12 JP JP2003568035A patent/JP2006500905A/ja active Pending
-
2008
- 2008-01-31 US US12/012,028 patent/US7897743B2/en active Active
- 2008-05-29 US US12/156,063 patent/US20090259027A1/en not_active Abandoned
-
2011
- 2011-01-31 US US12/931,442 patent/US20120029172A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003068924A2 (en) | 2003-08-21 |
EP1507859A4 (de) | 2007-05-30 |
AU2003217386A1 (en) | 2003-09-04 |
EP1530580A4 (de) | 2006-02-01 |
AU2003217386B2 (en) | 2008-06-26 |
WO2003068924A3 (en) | 2004-12-29 |
AU2003215188A8 (en) | 2003-09-04 |
US20040053365A1 (en) | 2004-03-18 |
WO2003068920A3 (en) | 2004-07-01 |
WO2003068920A8 (en) | 2004-07-29 |
WO2003068920A9 (en) | 2004-06-03 |
ATE444308T1 (de) | 2009-10-15 |
US7714113B2 (en) | 2010-05-11 |
EP1530580A2 (de) | 2005-05-18 |
ES2365606T3 (es) | 2011-10-07 |
WO2003068920A2 (en) | 2003-08-21 |
EP1530580B1 (de) | 2011-05-11 |
US20090259027A1 (en) | 2009-10-15 |
DE60329489D1 (de) | 2009-11-12 |
US20100167395A1 (en) | 2010-07-01 |
JP2006500905A (ja) | 2006-01-12 |
US7897743B2 (en) | 2011-03-01 |
US20120029172A1 (en) | 2012-02-02 |
EP1507859B1 (de) | 2009-09-30 |
AU2003215188A1 (en) | 2003-09-04 |
EP1507859A2 (de) | 2005-02-23 |
US7381801B2 (en) | 2008-06-03 |
US20060045876A1 (en) | 2006-03-02 |
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