|
US4943A
(en)
|
|
1847-01-26 |
|
Harness-buckle |
|
US533A
(en)
|
|
1837-12-26 |
|
Truss for hermta |
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
CU22545A1
(es)
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
US4318980A
(en)
|
1978-04-10 |
1982-03-09 |
Miles Laboratories, Inc. |
Heterogenous specific binding assay employing a cycling reactant as label
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
|
JP3040121B2
(ja)
|
1988-01-12 |
2000-05-08 |
ジェネンテク,インコーポレイテッド |
増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5750373A
(en)
|
1990-12-03 |
1998-05-12 |
Genentech, Inc. |
Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
DE69025946T2
(de)
|
1989-09-08 |
1996-10-17 |
Univ Duke |
Modifikationen der struktur des egf-rezeptor-gens in menschlichen glioma
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
CA2026147C
(en)
|
1989-10-25 |
2006-02-07 |
Ravi J. Chari |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
ES2284161T3
(es)
|
1990-01-12 |
2007-11-01 |
Amgen Fremont Inc. |
Generacion de anticuerpos xenogenicos.
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
CA2089661C
(en)
|
1990-08-29 |
2007-04-03 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
|
US20030206899A1
(en)
|
1991-03-29 |
2003-11-06 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
AU675916B2
(en)
|
1991-06-14 |
1997-02-27 |
Genentech Inc. |
Method for making humanized antibodies
|
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
|
FI941572A7
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
GB9300059D0
(en)
|
1992-01-20 |
1993-03-03 |
Zeneca Ltd |
Quinazoline derivatives
|
|
DE69334351D1
(de)
|
1992-02-06 |
2011-05-12 |
Novartis Vaccines & Diagnostic |
Biosynthetisches Bindeprotein für Tumormarker
|
|
DK1167384T3
(da)
|
1992-10-28 |
2007-04-10 |
Genentech Inc |
Vaskular endotheliel cellevækstfaktor antagonister
|
|
ATE196606T1
(de)
|
1992-11-13 |
2000-10-15 |
Idec Pharma Corp |
Therapeutische verwendung von chimerischen und markierten antikörpern, die gegen ein differenzierung-antigen gerichtet sind, dessen expression auf menschliche b lymphozyt beschränkt ist, für die behandlung von b-zell-lymphoma
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
EP0714409A1
(en)
|
1993-06-16 |
1996-06-05 |
Celltech Therapeutics Limited |
Antibodies
|
|
GB9314893D0
(en)
|
1993-07-19 |
1993-09-01 |
Zeneca Ltd |
Quinazoline derivatives
|
|
PT659439E
(pt)
|
1993-12-24 |
2002-04-29 |
Merck Patent Gmbh |
Imunoconjugados
|
|
US5679683A
(en)
|
1994-01-25 |
1997-10-21 |
Warner-Lambert Company |
Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
|
|
IL112249A
(en)
|
1994-01-25 |
2001-11-25 |
Warner Lambert Co |
Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5635388A
(en)
|
1994-04-04 |
1997-06-03 |
Genentech, Inc. |
Agonist antibodies against the flk2/flt3 receptor and uses thereof
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
US5804396A
(en)
|
1994-10-12 |
1998-09-08 |
Sugen, Inc. |
Assay for agents active in proliferative disorders
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
PT817775E
(pt)
|
1995-03-30 |
2002-01-30 |
Pfizer |
Derivados de quinazolina
|
|
IL117645A
(en)
|
1995-03-30 |
2005-08-31 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
GB9508537D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GB9508565D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quiazoline derivative
|
|
EP0822830B1
(en)
|
1995-04-27 |
2008-04-02 |
Amgen Fremont Inc. |
Human anti-IL-8 antibodies, derived from immunized xenomice
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
AU2466895A
(en)
|
1995-04-28 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
AU6267896A
(en)
|
1995-06-07 |
1996-12-30 |
Imclone Systems Incorporated |
Antibody and antibody fragments for inhibiting the growth oftumors
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
IL122855A
(en)
|
1995-07-06 |
2004-08-31 |
Novartis Ag |
History of N-Phenyl (Alkyl) - 7H-Pyrolo [-3,2d] Pyrimidine - 4 Amine, their preparation and pharmaceutical preparations containing them
|
|
US5760041A
(en)
|
1996-02-05 |
1998-06-02 |
American Cyanamid Company |
4-aminoquinazoline EGFR Inhibitors
|
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GB9603256D0
(en)
|
1996-02-16 |
1996-04-17 |
Wellcome Found |
Antibodies
|
|
CZ295468B6
(cs)
|
1996-04-12 |
2005-08-17 |
Warner-Lambert Company |
Polycyklické sloučeniny
|
|
WO1998002434A1
(en)
|
1996-07-13 |
1998-01-22 |
Glaxo Group Limited |
Fused heterocyclic compounds as protein tyrosine kinase inhibitors
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
DE69738539T2
(de)
|
1996-12-03 |
2009-03-26 |
Amgen Fremont Inc. |
Vollkommen humane Antikörper die EGFR binden
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
US6002008A
(en)
|
1997-04-03 |
1999-12-14 |
American Cyanamid Company |
Substituted 3-cyano quinolines
|
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
|
DK1695985T3
(da)
|
1997-04-07 |
2011-06-14 |
Genentech Inc |
Fremgangsmåde til dannelse af humaniserede antistoffer ved tilfældig mutagenese
|
|
DE122005000026I1
(de)
|
1997-04-07 |
2005-08-04 |
Genentech Inc |
Anti-VEGF Antik¦rper.
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
PT980244E
(pt)
|
1997-05-06 |
2003-10-31 |
Wyeth Corp |
Utilizacao de compostos de quinazolina para o tratamento da doenca policistica renal
|
|
DE69830315T2
(de)
|
1997-06-24 |
2006-02-02 |
Genentech Inc., San Francisco |
Galactosylierte glykoproteine enthaltende zusammensetzungen und verfahren zur deren herstellung
|
|
ZA986732B
(en)
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitiors of tyrosine kinases
|
|
ZA986729B
(en)
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitors of tyrosine kinases
|
|
TW436485B
(en)
|
1997-08-01 |
2001-05-28 |
American Cyanamid Co |
Substituted quinazoline derivatives
|
|
AU759779B2
(en)
|
1997-10-31 |
2003-05-01 |
Genentech Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
|
AU1308799A
(en)
|
1997-11-06 |
1999-05-31 |
American Cyanamid Company |
Use of quinazoline derivatives as tyrosine kinase inhibitors for treating colonic polyps
|
|
US6610833B1
(en)
|
1997-11-24 |
2003-08-26 |
The Institute For Human Genetics And Biochemistry |
Monoclonal human natural antibodies
|
|
CA2312208C
(en)
|
1997-12-05 |
2011-01-25 |
The Scripps Research Institute |
Humanization of murine antibody
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
IL138608A0
(en)
|
1998-04-02 |
2001-10-31 |
Genentech Inc |
Antibody variants and fragments thereof
|
|
JP4334141B2
(ja)
|
1998-04-20 |
2009-09-30 |
グリカート バイオテクノロジー アクチェンゲゼルシャフト |
抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
|
|
NZ512189A
(en)
|
1998-11-19 |
2003-10-31 |
Warner Lambert Co |
N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4- yl-propoxy)-quinazolin-6-yl]-acrylamide useful as an irreversible inhibitor of tyrosine kinases
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
PL209786B1
(pl)
|
1999-01-15 |
2011-10-31 |
Genentech Inc |
Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna
|
|
PT1914244E
(pt)
|
1999-04-09 |
2013-07-26 |
Kyowa Hakko Kirin Co Ltd |
Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico
|
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
|
JP4668498B2
(ja)
|
1999-10-19 |
2011-04-13 |
協和発酵キリン株式会社 |
ポリペプチドの製造方法
|
|
IL149809A0
(en)
|
1999-12-15 |
2002-11-10 |
Genentech Inc |
Shotgun scanning, a combinatorial method for mapping functional protein epitopes
|
|
WO2001049698A1
(en)
|
1999-12-29 |
2001-07-12 |
Immunogen, Inc. |
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
|
|
ATE360430T1
(de)
|
2000-02-14 |
2007-05-15 |
Univ California |
Impfstoff spezifisch gegen nierentumore, gerichtet gegen das antigen g-250 des nierentumors
|
|
CN100390288C
(zh)
|
2000-04-11 |
2008-05-28 |
杰南技术公司 |
多价抗体及其应用
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
WO2002031140A1
(en)
|
2000-10-06 |
2002-04-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions
|
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
AU2002239422B2
(en)
|
2000-11-30 |
2006-12-07 |
E. R. Squibb & Sons, L.L.C. |
Transgenic transchromosomal rodents for making human antibodies
|
|
US7038015B2
(en)
|
2001-04-06 |
2006-05-02 |
Maxygen Holdings, Ltd. |
Interferon gamma polypeptide variants
|
|
US7235358B2
(en)
|
2001-06-08 |
2007-06-26 |
Expression Diagnostics, Inc. |
Methods and compositions for diagnosing and monitoring transplant rejection
|
|
CA2454048C
(en)
|
2001-07-17 |
2011-05-03 |
Research Development Foundation |
Therapeutic agents comprising pro-apoptotic proteins
|
|
IL160170A0
(en)
|
2001-08-03 |
2004-07-25 |
Glycart Biotechnology Ag |
A host cell engineered to produce a polypeptide having increased cytotoxicity
|
|
DK1443961T3
(da)
|
2001-10-25 |
2009-08-24 |
Genentech Inc |
Glycoprotein-sammensætninger
|
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
|
CA2481925A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Therapeutic agent for patients having human fc.gamma.riiia
|
|
AU2003236015A1
(en)
|
2002-04-09 |
2003-10-20 |
Kyowa Hakko Kirin Co., Ltd. |
Process for producing antibody composition
|
|
KR20050000380A
(ko)
|
2002-04-09 |
2005-01-03 |
교와 핫꼬 고교 가부시끼가이샤 |
게놈이 개변된 세포
|
|
AU2003236017B2
(en)
|
2002-04-09 |
2009-03-26 |
Kyowa Kirin Co., Ltd. |
Drug containing antibody composition
|
|
US7749753B2
(en)
|
2002-04-09 |
2010-07-06 |
Kyowa Hakko Kirin Co., Ltd |
Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost
|
|
WO2003085119A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcϜ RECEPTOR IIIa
|
|
CA2488441C
(en)
|
2002-06-03 |
2015-01-27 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
WO2004056312A2
(en)
|
2002-12-16 |
2004-07-08 |
Genentech, Inc. |
Immunoglobulin variants and uses thereof
|
|
US20050079574A1
(en)
|
2003-01-16 |
2005-04-14 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
CA2527109A1
(en)
|
2003-05-30 |
2004-12-09 |
Nippon Shinyaku Co., Ltd. |
Oligo double-stranded rna inhibiting the expression of bcl-2 and medicinal composition containing the same
|
|
RS20181002A1
(sr)
|
2003-05-30 |
2018-12-31 |
Genentech Inc |
Tretman sa anti-vegf antitelima
|
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
|
JPWO2005035586A1
(ja)
|
2003-10-08 |
2007-11-22 |
協和醗酵工業株式会社 |
融合蛋白質組成物
|
|
US20070134759A1
(en)
|
2003-10-09 |
2007-06-14 |
Harue Nishiya |
Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase
|
|
DK2380910T3
(en)
|
2003-11-05 |
2015-10-19 |
Roche Glycart Ag |
Antigen binding molecules with increased Fc receptor binding affinity and effector function
|
|
DK2489364T3
(en)
|
2003-11-06 |
2015-03-02 |
Seattle Genetics Inc |
Monomethylvaline compounds conjugated to antibodies
|
|
JPWO2005053742A1
(ja)
|
2003-12-04 |
2007-06-28 |
協和醗酵工業株式会社 |
抗体組成物を含有する医薬
|
|
WO2005097832A2
(en)
|
2004-03-31 |
2005-10-20 |
Genentech, Inc. |
Humanized anti-tgf-beta antibodies
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
NZ549872A
(en)
|
2004-04-13 |
2009-09-25 |
Hoffmann La Roche |
Anti-P-selectin antibodies
|
|
US20060009360A1
(en)
|
2004-06-25 |
2006-01-12 |
Robert Pifer |
New adjuvant composition
|
|
TWI380996B
(zh)
|
2004-09-17 |
2013-01-01 |
Hoffmann La Roche |
抗ox40l抗體
|
|
HUE030079T2
(en)
|
2004-09-23 |
2017-04-28 |
Genentech Inc |
Cysteine-manipulated antibodies and conjugates
|
|
RU2406760C3
(ru)
|
2005-05-09 |
2017-11-28 |
Оно Фармасьютикал Ко., Лтд. |
Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами
|
|
US8219149B2
(en)
|
2005-06-29 |
2012-07-10 |
Nokia Corporation |
Mobile communication terminal
|
|
EA019344B1
(ru)
|
2005-07-01 |
2014-03-31 |
МЕДАРЕКС, Эл.Эл.Си. |
Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения
|
|
US8679490B2
(en)
|
2005-11-07 |
2014-03-25 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
|
|
US20070237764A1
(en)
|
2005-12-02 |
2007-10-11 |
Genentech, Inc. |
Binding polypeptides with restricted diversity sequences
|
|
EP2021534B1
(en)
|
2006-04-27 |
2011-12-28 |
Université de Montréal |
Assessment and reduction of risk of graft-versus-host disease
|
|
JP2009536527A
(ja)
|
2006-05-09 |
2009-10-15 |
ジェネンテック・インコーポレーテッド |
最適化されたスキャフォールドを備えた結合ポリペプチド
|
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
|
CN100592373C
(zh)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
液晶显示面板驱动装置及其驱动方法
|
|
ES2666206T3
(es)
|
2007-10-02 |
2018-05-03 |
Universität Zu Köln |
Genes marcadores novedosos para linfocitos T reguladores de sangre humana
|
|
ES2563027T3
(es)
|
2008-01-07 |
2016-03-10 |
Amgen Inc. |
Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática
|
|
PL2242773T3
(pl)
|
2008-02-11 |
2017-11-30 |
Cure Tech Ltd. |
Przeciwciała monoklonalne do leczenia nowotworu
|
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
JP2012510429A
(ja)
|
2008-08-25 |
2012-05-10 |
アンプリミューン、インコーポレーテッド |
Pd−1アンタゴニストおよびその使用方法
|
|
BRPI0914859A2
(pt)
|
2008-08-27 |
2015-11-03 |
Lundbeck & Co As H |
método para diagnosticar um distúrbio afetivo, produto de programa de computador, computador, e, método para determinar uma probabilidade de que um indivíduo de teste exiba um sintoma de um distúrbio afetivo
|
|
ES2974437T3
(es)
|
2008-12-09 |
2024-06-27 |
Hoffmann La Roche |
Anticuerpos ANTI-PD-L1 y su uso para mejorar la función de las células T
|
|
US20110076271A1
(en)
|
2009-07-13 |
2011-03-31 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
|
MX2012001716A
(es)
|
2009-08-14 |
2012-04-02 |
Genentech Inc |
Marcadores biologicos para monitorizar la respuesta del paciente a los antagonistas vegf.
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
SI3279215T1
(sl)
|
2009-11-24 |
2020-07-31 |
Medimmune Limited |
Usmerjena vezavna sredstva proti B7-H1
|
|
EP3178944B1
(en)
|
2010-01-11 |
2019-05-15 |
Genomic Health, Inc. |
Method to use gene expression to determine likelihood of clinical outcome of renal cancer
|
|
US9404926B2
(en)
|
2010-01-29 |
2016-08-02 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Immune gene signatures in cancer
|
|
TWI426920B
(zh)
|
2010-03-26 |
2014-02-21 |
Hoffmann La Roche |
雙專一性、雙價抗-vegf/抗-ang-2抗體
|
|
ES2841809T3
(es)
|
2011-06-03 |
2021-07-09 |
Eisai R&D Man Co Ltd |
Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
|
|
KR20140071340A
(ko)
|
2011-07-22 |
2014-06-11 |
파웰 카린스키 |
종양 선택적 케모카인 조절
|
|
CA2862835A1
(en)
|
2012-01-13 |
2013-07-18 |
Genentech, Inc. |
Biological markers for identifying patients for treatment with vegf antagonists
|
|
BR112014029887A8
(pt)
|
2012-05-31 |
2021-09-14 |
Genentech Inc |
Método para tratar ou retardar a progressão do câncer, kits e uso de um antagonista de ligação do eixo pd-1, oxaliplatina, leucovorina e 5-fu
|
|
US11242564B2
(en)
|
2012-07-12 |
2022-02-08 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes
|
|
AU2013301609B2
(en)
|
2012-08-06 |
2019-03-14 |
Assistance Publique Hopitaux De Paris |
Methods and kits for screening patients with a cancer
|
|
JP6368308B2
(ja)
|
2012-09-07 |
2018-08-01 |
トラスティーズ・オブ・ダートマス・カレッジ |
癌の診断および治療のためのvista調節剤
|
|
AU2013353839A1
(en)
|
2012-12-03 |
2015-06-18 |
Almac Diagnostics Limited |
Molecular diagnostic test for cancer
|
|
WO2014151006A2
(en)
|
2013-03-15 |
2014-09-25 |
Genentech, Inc. |
Biomarkers and methods of treating pd-1 and pd-l1 related conditions
|
|
US20150071910A1
(en)
*
|
2013-03-15 |
2015-03-12 |
Genentech, Inc. |
Biomarkers and methods of treating pd-1 and pd-l1 related conditions
|
|
RU2658601C2
(ru)
|
2013-05-14 |
2018-06-21 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Биомаркер для прогнозирования и оценки чувствительности субъектов с раком эндометрия к соединениям ленватиниба
|
|
MY183503A
(en)
|
2013-07-16 |
2021-02-23 |
Genentech Inc |
Method of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
|
|
IL311399A
(en)
*
|
2014-02-04 |
2024-05-01 |
Pfizer |
Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer
|
|
EP3114144A1
(en)
|
2014-03-05 |
2017-01-11 |
Bristol-Myers Squibb Company |
Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
|
|
WO2015157655A2
(en)
*
|
2014-04-10 |
2015-10-15 |
University Of Tennessee Research Foundation |
Method for predicting response to vegf targeted therapeutics
|
|
GB201408091D0
(en)
|
2014-05-07 |
2014-06-18 |
Univ Edinburgh |
Methods and uses
|
|
CN107208138A
(zh)
|
2014-12-30 |
2017-09-26 |
豪夫迈·罗氏有限公司 |
用于癌症预后和治疗的方法和组合物
|
|
AU2016262074A1
(en)
|
2015-05-12 |
2017-11-09 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
|
MX392671B
(es)
|
2015-05-29 |
2025-03-24 |
Genentech Inc |
Antagonistas de unión a pd-l1 y usos de los mismos para el tratamiento de cáncer
|
|
CA2988420A1
(en)
*
|
2015-06-08 |
2016-12-15 |
Genentech, Inc. |
Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
|
|
UA126892C2
(uk)
|
2015-06-16 |
2023-02-22 |
Мерк Патент Гмбх |
Спосіб лікування запущеної поширеної нирковоклітинної карциноми (arcc)
|
|
CN105256036B
(zh)
*
|
2015-10-26 |
2019-02-12 |
中国人民解放军第二军医大学 |
一种检测血清中lncARSR的试剂盒及其在检测肾癌舒尼替尼耐药中的应用
|
|
KR20190003957A
(ko)
*
|
2016-04-15 |
2019-01-10 |
제넨테크, 인크. |
암 모니터링 및 치료 방법
|
|
MX384141B
(es)
|
2016-04-15 |
2025-03-14 |
Genentech Inc |
Métodos para monitorear y terapias para usarse en tratar el cáncer.
|
|
AU2017336547A1
(en)
|
2016-09-27 |
2019-05-02 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Method of treating urothelial carcinoma and other genitourinary malignancies using N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
|
|
PL3589754T3
(pl)
|
2017-03-01 |
2023-10-09 |
F. Hoffmann-La Roche Ag |
Sposoby diagnostyczne i terapeutyczne w chorobach nowotworowych
|
|
EP3610042A1
(en)
|
2017-04-14 |
2020-02-19 |
H. Hoffnabb-La Roche Ag |
Diagnostic and therapeutic methods for cancer
|
|
AU2019361983A1
(en)
|
2018-10-18 |
2021-05-20 |
Genentech, Inc. |
Diagnostic and therapeutic methods for sarcomatoid kidney cancer
|