DK3459558T3 - Glycoproteiner med lipidmobiliserende egenskaber og terapeutiske anvendelser deraf - Google Patents

Glycoproteiner med lipidmobiliserende egenskaber og terapeutiske anvendelser deraf Download PDF

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Publication number
DK3459558T3
DK3459558T3 DK18196382.8T DK18196382T DK3459558T3 DK 3459558 T3 DK3459558 T3 DK 3459558T3 DK 18196382 T DK18196382 T DK 18196382T DK 3459558 T3 DK3459558 T3 DK 3459558T3
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Prior art keywords
glycoproteins
therapeutic applications
lipid mobilizing
mobilizing properties
properties
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DK18196382.8T
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English (en)
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Michael J Tisdale
Steven Russell
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Univ Aston
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/473Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used alpha-Glycoproteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61K38/1741Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals alpha-Glycoproteins
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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
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DK18196382.8T 2010-06-25 2011-06-27 Glycoproteiner med lipidmobiliserende egenskaber og terapeutiske anvendelser deraf DK3459558T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35859610P 2010-06-25 2010-06-25
US38465210P 2010-09-20 2010-09-20
US42067710P 2010-12-07 2010-12-07
EP11729337.3A EP2585097B1 (en) 2010-06-25 2011-06-27 Glycoproteins having lipid mobilizing properties and therapeutic uses thereof

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Publication Number Publication Date
DK3459558T3 true DK3459558T3 (da) 2020-11-02

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DK18196382.8T DK3459558T3 (da) 2010-06-25 2011-06-27 Glycoproteiner med lipidmobiliserende egenskaber og terapeutiske anvendelser deraf

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US (6) US20130143797A1 (da)
EP (2) EP2585097B1 (da)
JP (2) JP2013530981A (da)
CN (1) CN103068400A (da)
AU (2) AU2011268780A1 (da)
DK (1) DK3459558T3 (da)
ES (1) ES2706913T3 (da)
WO (1) WO2011161427A2 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801375B (zh) 2007-01-25 2014-01-01 韦尔瓦制药有限公司 胰岛素增敏剂和治疗方法
DK3459558T3 (da) 2010-06-25 2020-11-02 Univ Aston Glycoproteiner med lipidmobiliserende egenskaber og terapeutiske anvendelser deraf
ITRM20120214A1 (it) * 2012-05-14 2013-11-15 Alfonso Baldi Metodo in vitro per la diagnosi di endometriosi.
MX2014014316A (es) * 2012-05-24 2015-07-06 Verva Pharmaceuticals Ltd Método de reducción de peso.
EP2879690A1 (en) 2012-07-31 2015-06-10 Aston University Targeted oesophageal administration of zn-alpha2-glycoproteins (zag), methods and formulations thereof
ES2394349B1 (es) * 2012-08-29 2013-11-04 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar
EP2994119A1 (en) 2013-05-10 2016-03-16 CNIC Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III Compounds suitable for the treatment of myeloproliferative neoplasms
KR102028245B1 (ko) * 2016-04-06 2019-10-04 연세대학교 산학협력단 피부 건조증 또는 피부 장벽 개선용 조성물 및 항알러지 조성물
WO2018062258A1 (ja) * 2016-09-30 2018-04-05 キリン株式会社 低糖類のニンジン搾汁液およびニンジン含有飲料
IT201600130491A1 (it) * 2016-12-23 2018-06-23 Azienda Ospedaliero Univ Meyer Uso di composti β-bloccanti per il trattamento dell’immuno-tolleranza associata a stati patologici
JP7602857B2 (ja) * 2017-08-10 2024-12-19 小林製薬株式会社 加齢性肥満改善剤及び脂肪分解力改善剤
US11213567B2 (en) * 2017-09-29 2022-01-04 L&C Bio Co., Ltd. ZAG-derived peptide and use thereof
WO2019182745A1 (en) 2018-03-19 2019-09-26 Bryn Pharma, LLC Epinephrine spray formulations
WO2022234868A1 (ko) * 2021-05-03 2022-11-10 주식회사 엘앤씨바이오 Zag 유래 펩타이드를 포함하는 흉터 및 켈로이드 개선용 조성물
WO2023028602A1 (en) * 2021-08-27 2023-03-02 The Board Of Regents Of The University Of Texas System Beta adrenergic receptor compositions and methods of use thereof

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
ES2087997T3 (es) 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
MX9204374A (es) 1991-07-25 1993-03-01 Idec Pharma Corp Anticuerpo recombinante y metodo para su produccion.
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
ATE463573T1 (de) 1991-12-02 2010-04-15 Medimmune Ltd Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
ES2136664T3 (es) 1992-06-09 1999-12-01 Hoppe Ag Sistema de cierre y conjunto de cerradura.
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
CA2219486A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
EP2305027B1 (en) 1996-12-03 2014-07-02 Amgen Fremont Inc. Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
SI0970126T1 (en) 1997-04-14 2001-08-31 Micromet Ag Novel method for the production of antihuman antigen receptors and uses thereof
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
WO1999031222A1 (en) 1997-12-18 1999-06-24 Willem Frederik Van Eelen Industrial scale production of meat from in vitro cell cultures
GB9811465D0 (en) * 1998-05-29 1998-07-29 Tisdale Michael J Glycoproteins having lipid mobilising properties and therapeutic applications thereof
US20030236190A1 (en) * 1998-09-02 2003-12-25 Renuka Pillutla Isulin and IGF-1 receptor agonists and antagonists
AUPQ981700A0 (en) * 2000-09-01 2000-09-28 Metabolic Pharmaceuticals Limited Product and method for control of obesity
US6835390B1 (en) 2000-11-17 2004-12-28 Jon Vein Method for producing tissue engineered meat for consumption
KR100508369B1 (ko) * 2001-10-31 2005-08-17 주식회사 바이오폴리메드 펩타이드 스페이서를 갖는 생체적합성 고분자
US20050148763A1 (en) * 2002-02-01 2005-07-07 Chugai Seiyaku Kabushiki Kaisha Peg-binding pth or peg-binding pth derivative
GB0313259D0 (en) * 2003-06-09 2003-07-16 Consejo Superior Investigacion Magnetic nanoparticles
JP2010525033A (ja) * 2007-04-30 2010-07-22 ノボ・ノルデイスク・エー/エス 高濃縮のインスリン溶液及び組成物
US20100173829A1 (en) * 2008-11-07 2010-07-08 Aston University Glycoproteins Having Lipid Mobilizing Properties and Therapeutic Uses Thereof
WO2011157819A2 (en) 2010-06-18 2011-12-22 Xiberscience Gmbh Peptides as active agents to stabilize biological barriers
DK3459558T3 (da) * 2010-06-25 2020-11-02 Univ Aston Glycoproteiner med lipidmobiliserende egenskaber og terapeutiske anvendelser deraf
EP2879690A1 (en) * 2012-07-31 2015-06-10 Aston University Targeted oesophageal administration of zn-alpha2-glycoproteins (zag), methods and formulations thereof

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AU2011268780A1 (en) 2013-02-07
US20140235534A1 (en) 2014-08-21
WO2011161427A2 (en) 2011-12-29
US20130143797A1 (en) 2013-06-06
JP2013530981A (ja) 2013-08-01
JP2016199568A (ja) 2016-12-01
US20200339642A1 (en) 2020-10-29
US20170088594A1 (en) 2017-03-30
AU2017201718B2 (en) 2018-12-20
US10077295B2 (en) 2018-09-18
WO2011161427A3 (en) 2012-03-08
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EP3459558A1 (en) 2019-03-27
US20190002512A1 (en) 2019-01-03
US20240301022A1 (en) 2024-09-12
ES2706913T3 (es) 2019-04-01
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EP2585097A2 (en) 2013-05-01
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