DK3115372T3 - Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf - Google Patents
Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf Download PDFInfo
- Publication number
- DK3115372T3 DK3115372T3 DK16182420.6T DK16182420T DK3115372T3 DK 3115372 T3 DK3115372 T3 DK 3115372T3 DK 16182420 T DK16182420 T DK 16182420T DK 3115372 T3 DK3115372 T3 DK 3115372T3
- Authority
- DK
- Denmark
- Prior art keywords
- enzymfusion
- proteins
- targeted therapeutic
- therapeutic lysosomal
- lysosomal
- Prior art date
Links
- 230000002132 lysosomal effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261730378P | 2012-11-27 | 2012-11-27 | |
| US201361788968P | 2013-03-15 | 2013-03-15 | |
| EP13802834.5A EP2925776B1 (en) | 2012-11-27 | 2013-11-27 | Targeted therapeutic lysosomal enzyme fusion proteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3115372T3 true DK3115372T3 (da) | 2019-06-11 |
Family
ID=49753532
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16182420.6T DK3115372T3 (da) | 2012-11-27 | 2013-11-27 | Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf |
| DK13802834.5T DK2925776T3 (da) | 2012-11-27 | 2013-11-27 | Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13802834.5T DK2925776T3 (da) | 2012-11-27 | 2013-11-27 | Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf |
Country Status (27)
| Country | Link |
|---|---|
| US (8) | US9376480B2 (da) |
| EP (2) | EP2925776B1 (da) |
| JP (2) | JP6831176B2 (da) |
| KR (4) | KR102262882B1 (da) |
| CN (1) | CN104822701B (da) |
| AR (1) | AR093626A1 (da) |
| AU (1) | AU2013352184B2 (da) |
| BR (1) | BR112015012152B1 (da) |
| CA (1) | CA2892146A1 (da) |
| CL (1) | CL2015001371A1 (da) |
| CY (1) | CY1122555T1 (da) |
| DK (2) | DK3115372T3 (da) |
| ES (2) | ES2729997T3 (da) |
| HK (1) | HK1216026A1 (da) |
| HR (2) | HRP20181351T1 (da) |
| HU (2) | HUE039334T2 (da) |
| IL (3) | IL238824B (da) |
| LT (1) | LT3115372T (da) |
| MX (2) | MX367024B (da) |
| PL (2) | PL3115372T3 (da) |
| PT (2) | PT2925776T (da) |
| RS (1) | RS58916B1 (da) |
| RU (1) | RU2680581C2 (da) |
| SI (1) | SI3115372T1 (da) |
| TW (2) | TWI626250B (da) |
| WO (1) | WO2014085621A1 (da) |
| ZA (1) | ZA201503509B (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009137721A2 (en) | 2008-05-07 | 2009-11-12 | Zystor Therapeutics, Inc. | Lysosomal targeting peptides and uses thereof |
| PT2925776T (pt) | 2012-11-27 | 2018-07-30 | Biomarin Pharm Inc | Proteínas de fusão de enzima lisossomal terapêuticas alvo e suas utilizações |
| EP3622821A1 (en) * | 2013-05-15 | 2020-03-18 | Regents of the University of Minnesota | Adeno-associated virus mediated gene transfer to the central nervous system |
| WO2016025519A1 (en) * | 2014-08-11 | 2016-02-18 | Shire Human Genetic Therapies, Inc. | Mannose-6-phosphate bearing peptides fused to lysosomal enzymes |
| EP3197503A4 (en) * | 2014-09-25 | 2018-05-16 | The General Hospital Corporation | Cell-based targeted delivery of pseudonomas exotoxin |
| EP3220958A1 (en) | 2014-10-24 | 2017-09-27 | Shire Human Genetic Therapies, Inc. | Lysosomal targeting of enzymes, and uses thereof |
| TWI752907B (zh) | 2015-05-08 | 2022-01-21 | 美商拜奧馬林製藥公司 | 用於治療cln2疾病之tpp1調配物及方法 |
| JP2018538008A (ja) | 2015-11-06 | 2018-12-27 | バイオマリン ファーマシューティカル インコーポレイテッド | リソソーム酵素の取り込みを中和する抗体または他の因子の検出のための細胞ベースアッセイ |
| CA3015358A1 (en) | 2016-02-24 | 2017-08-31 | Biomarin Pharmaceutical Inc. | Targeted therapeutic lysosomal enzyme fusion proteins, associated formulations and uses thereof |
| KR20230125339A (ko) | 2016-04-15 | 2023-08-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Ii형 점액다당류증의 치료를 위한 유전자 요법 |
| CL2016003282A1 (es) | 2016-12-21 | 2017-08-18 | Univ Chile | Virus aav/igf2, método de tratamiento genético y su uso en enfermedades relacionadas con mal plegamiento de proteínas tal como la enfermedad de huntington |
| AU2018335752A1 (en) | 2017-09-22 | 2020-03-12 | Christian HINDERER | Gene therapy for treating Mucopolysaccharidosis type ii |
| CN111278859A (zh) | 2017-10-02 | 2020-06-12 | 戴纳立制药公司 | 包含酶替代疗法酶的融合蛋白 |
| WO2019173756A1 (en) * | 2018-03-09 | 2019-09-12 | Avrobio, Inc. | Compositions and methods for treating parkinson's disease |
| TWI808169B (zh) * | 2018-04-30 | 2023-07-11 | 美商阿米庫斯醫療股份有限公司 | 基因治療構築體及使用方法 |
| EP3802619A1 (en) | 2018-06-08 | 2021-04-14 | F. Hoffmann-La Roche AG | Peptidic linker with reduced post-translational modification |
| WO2020077114A2 (en) | 2018-10-10 | 2020-04-16 | Amicus Therapeutics, Inc. | Disulfide bond stabilized polypeptide compositions and methods of use |
| WO2020102667A2 (en) * | 2018-11-16 | 2020-05-22 | Asklepios Biopharmaceutical, Inc. | Vectors comprising a nucleic acid encoding lysosomal enzymes fused to a lysosomal targeting sequence |
| TW202128740A (zh) * | 2019-10-10 | 2021-08-01 | 美商阿米庫斯醫療股份有限公司 | 變體ｉｇｆ２構築體 |
| WO2021183895A1 (en) | 2020-03-13 | 2021-09-16 | Biomarin Pharmaceutical Inc. | Treatment of fabry disease with aav gene therapy vectors |
| CN117343197A (zh) * | 2021-10-15 | 2024-01-05 | 中山大学 | 重组融合抗体 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| AUPN674895A0 (en) | 1995-11-23 | 1995-12-14 | Women's And Children's Hospital | Synthetic mammalian alpha-N-acetylglucosaminidase and genetic sequences encoding same |
| US6217552B1 (en) | 1999-03-01 | 2001-04-17 | Coaxia, Inc. | Medical device for selective intrathecal spinal cooling in aortic surgery and spinal trauma |
| DE10035433C2 (de) | 2000-07-20 | 2002-07-18 | Tuma Wolfgang | Schonende Hochanreicherung von fetalen Zellen aus pripherem Blut und Verwendung derselben |
| US7629309B2 (en) | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US20040005309A1 (en) | 2002-05-29 | 2004-01-08 | Symbiontics, Inc. | Targeted therapeutic proteins |
| ES2300439T3 (es) | 2001-04-30 | 2008-06-16 | Zystor Therapeutics , Inc. | Reconocimiento subcelular de proteinas terapeuticas. |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| WO2003032913A2 (en) | 2001-10-16 | 2003-04-24 | Symbiontics Inc. | Methods and compositions for targeting proteins across the blood brain barrier |
| US7485314B2 (en) | 2002-05-06 | 2009-02-03 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Induction of antigen specific immunologic tolerance |
| AU2003237314B2 (en) | 2002-05-29 | 2010-03-04 | Biomarin Pharmaceutical Inc. | Targeted therapeutic proteins |
| US7452966B2 (en) | 2003-06-12 | 2008-11-18 | Eli Lilly And Company | GLP-1 analog fusion proteins |
| US7442372B2 (en) | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| AU2005212435B2 (en) | 2004-02-10 | 2010-09-09 | Biomarin Pharmaceutical Inc. | Acid alpha-glucosidase and fragments thereof |
| US7678371B2 (en) | 2005-03-04 | 2010-03-16 | Biogen Idec Ma Inc. | Methods of humanizing immunoglobulin variable regions through rational modification of complementarity determining residues |
| WO2009137721A2 (en) | 2008-05-07 | 2009-11-12 | Zystor Therapeutics, Inc. | Lysosomal targeting peptides and uses thereof |
| US8697654B2 (en) * | 2008-12-18 | 2014-04-15 | E I Du Pont De Nemours And Company | Peptide linkers for effective multivalent peptide binding |
| US9029530B2 (en) | 2009-01-02 | 2015-05-12 | Biomarin Pharmaceutical Inc. | Detection of oligosaccharides |
| EP3075386B1 (en) * | 2009-06-17 | 2019-10-16 | BioMarin Pharmaceutical Inc. | Formulations for lysosomal enzymes |
| US20110318327A1 (en) * | 2010-06-25 | 2011-12-29 | Shire Human Genetic Therapies, Inc. | Treatment of sanfilippo syndrome type b |
| US9108176B2 (en) | 2010-06-25 | 2015-08-18 | Amcor Limited | Oxygen scavenging system for a container |
| EP2655624B1 (en) * | 2010-12-23 | 2017-11-29 | Biogen MA Inc. | Linker peptides and polypeptides comprising same |
| US8580922B2 (en) | 2011-03-04 | 2013-11-12 | Shire Human Genetic Therapies, Inc. | Peptide linkers for polypeptide compositions and methods for using same |
| CA2828966C (en) * | 2011-03-04 | 2020-07-14 | Shire Human Genetic Therapies, Inc. | Peptide linkers for polypeptide compositions and methods for using same |
| US9409958B2 (en) * | 2011-03-10 | 2016-08-09 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| PT2925776T (pt) | 2012-11-27 | 2018-07-30 | Biomarin Pharm Inc | Proteínas de fusão de enzima lisossomal terapêuticas alvo e suas utilizações |
-
2013
- 2013-11-27 PT PT138028345T patent/PT2925776T/pt unknown
- 2013-11-27 PL PL16182420T patent/PL3115372T3/pl unknown
- 2013-11-27 KR KR1020157017224A patent/KR102262882B1/ko active IP Right Grant
- 2013-11-27 BR BR112015012152-7A patent/BR112015012152B1/pt active IP Right Grant
- 2013-11-27 DK DK16182420.6T patent/DK3115372T3/da active
- 2013-11-27 SI SI201331450T patent/SI3115372T1/sl unknown
- 2013-11-27 ES ES16182420T patent/ES2729997T3/es active Active
- 2013-11-27 ES ES13802834.5T patent/ES2679374T3/es active Active
- 2013-11-27 RU RU2015125491A patent/RU2680581C2/ru active
- 2013-11-27 TW TW102143329A patent/TWI626250B/zh active
- 2013-11-27 AU AU2013352184A patent/AU2013352184B2/en active Active
- 2013-11-27 KR KR1020237012007A patent/KR20230054482A/ko not_active Application Discontinuation
- 2013-11-27 TW TW107114660A patent/TWI711632B/zh active
- 2013-11-27 AR ARP130104367A patent/AR093626A1/es active IP Right Grant
- 2013-11-27 CA CA2892146A patent/CA2892146A1/en active Pending
- 2013-11-27 CN CN201380061935.4A patent/CN104822701B/zh active Active
- 2013-11-27 US US14/092,336 patent/US9376480B2/en active Active
- 2013-11-27 WO PCT/US2013/072287 patent/WO2014085621A1/en active Application Filing
- 2013-11-27 KR KR1020227011416A patent/KR102521039B1/ko active IP Right Grant
- 2013-11-27 EP EP13802834.5A patent/EP2925776B1/en active Active
- 2013-11-27 HU HUE13802834A patent/HUE039334T2/hu unknown
- 2013-11-27 LT LTEP16182420.6T patent/LT3115372T/lt unknown
- 2013-11-27 KR KR1020217017007A patent/KR102385392B1/ko active IP Right Grant
- 2013-11-27 HU HUE16182420A patent/HUE043679T2/hu unknown
- 2013-11-27 PL PL13802834T patent/PL2925776T3/pl unknown
- 2013-11-27 MX MX2015006644A patent/MX367024B/es active IP Right Grant
- 2013-11-27 EP EP16182420.6A patent/EP3115372B1/en active Active
- 2013-11-27 PT PT16182420T patent/PT3115372T/pt unknown
- 2013-11-27 RS RS20190585A patent/RS58916B1/sr unknown
- 2013-11-27 DK DK13802834.5T patent/DK2925776T3/da active
- 2013-11-27 JP JP2015544209A patent/JP6831176B2/ja active Active
-
2015
- 2015-05-14 IL IL238824A patent/IL238824B/en active IP Right Grant
- 2015-05-19 ZA ZA2015/03509A patent/ZA201503509B/en unknown
- 2015-05-20 CL CL2015001371A patent/CL2015001371A1/es unknown
- 2015-05-26 MX MX2019009191A patent/MX2019009191A/es active IP Right Grant
- 2015-10-14 US US14/883,193 patent/US9834587B2/en active Active
- 2015-10-14 US US14/883,211 patent/US9771408B2/en active Active
- 2015-10-14 US US14/883,203 patent/US9834588B2/en active Active
- 2015-10-14 US US14/883,169 patent/US9845346B2/en active Active
-
2016
- 2016-04-06 HK HK16103915.8A patent/HK1216026A1/zh unknown
-
2017
- 2017-08-28 US US15/688,438 patent/US10301369B2/en active Active
-
2018
- 2018-08-23 HR HRP20181351TT patent/HRP20181351T1/hr unknown
- 2018-11-13 IL IL262976A patent/IL262976B/en active IP Right Grant
-
2019
- 2019-04-08 US US16/378,163 patent/US11254725B2/en active Active
- 2019-05-17 HR HRP20190918TT patent/HRP20190918T1/hr unknown
- 2019-06-06 CY CY20191100600T patent/CY1122555T1/el unknown
- 2019-07-24 JP JP2019136013A patent/JP6913719B2/ja active Active
-
2020
- 2020-02-23 IL IL272854A patent/IL272854B/en unknown
-
2022
- 2022-01-10 US US17/572,018 patent/US20220127326A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3115372T3 (da) | Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf | |
| DK2920197T3 (da) | Prolinlåste sammenhæftede peptider og anvendelser deraf | |
| DK3597644T3 (da) | Kationiske aminlipider og anvendelser deraf | |
| DK3346008T3 (da) | Rekombinante mikroorganismer og anvendelser deraf | |
| DK2850202T3 (da) | Fremgangsmåder og grupper | |
| DK2920313T3 (da) | Rekombinante adenovira og anvendelse deraf | |
| DK2839860T3 (da) | Pyrrolobenzodiazepiner og konjugater deraf | |
| DK3470086T3 (da) | Pyrrolobenzodiazepiner og konjugater deraf | |
| DK2903600T3 (da) | Virusholdig formulering og anvendelse deraf | |
| DK3489254T3 (da) | Målrettede/immunmodulatoriske fusionsproteiner og fremgangsmåder til fremstilling deraf | |
| DK3608325T3 (da) | Polycykliske-carbamoylpyridonforbindelser og deres farmaceutiske anvendelse | |
| DK2920167T3 (da) | Hydrazinyl-indol-forbindelser og konjugater | |
| DK2914633T3 (da) | Antistof/lægemiddel-konjugater og anvendelsesfremgangsmåder | |
| DK2928533T3 (da) | Medicinske slanger og fremgangsmåder til fremstilling | |
| BR112014009050A2 (pt) | pirrolbenzodiazepinas e conjugados destas | |
| BR112015002790A2 (pt) | anticorpos asgpr e usos dos mesmos. | |
| DK3415157T3 (da) | N-acyldipeptidderivater og anvendelser deraf | |
| BR112013021524A2 (pt) | micro-organismos recombinantes e usos dos mesmos | |
| DK3550836T3 (da) | Fremgangsmåde og anordning til afkodning | |
| DK3456734T3 (da) | Serinproteasemolekyler og behandlinger | |
| BR112015011111A2 (pt) | proteína multifuncional e formulação farmacêutica | |
| DK2917181T3 (da) | Heteroarylderivater og anvendelser deraf | |
| DK3453723T3 (da) | Anti-ASIC1-antistoffer og anvendelser deraf | |
| DK2782598T3 (da) | Rekombinante proteiner og terapeutiske anvendelser deraf | |
| DK3173102T3 (da) | FGFR-FC-fusionsprotein og anvendelse deraf |