RS58916B1 - Ciljani terapeutski lizozomalni fuzioni proteini i njihova primena - Google Patents

Ciljani terapeutski lizozomalni fuzioni proteini i njihova primena

Info

Publication number
RS58916B1
RS58916B1 RS20190585A RSP20190585A RS58916B1 RS 58916 B1 RS58916 B1 RS 58916B1 RS 20190585 A RS20190585 A RS 20190585A RS P20190585 A RSP20190585 A RS P20190585A RS 58916 B1 RS58916 B1 RS 58916B1
Authority
RS
Serbia
Prior art keywords
fusion proteins
lysosomal enzyme
targeted therapeutic
enzyme fusion
therapeutic lysosomal
Prior art date
Application number
RS20190585A
Other languages
English (en)
Inventor
Mika Aoyagi-Scharber
Teresa Margaret Christianson
Melita Dvorak-Ewell
Daniel Wendt
Shinong Long
Jonathan Lebowitz
Daniel Solomon Gold
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of RS58916B1 publication Critical patent/RS58916B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/65Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105Alpha-N-acetylglucosaminidase (3.2.1.50)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
RS20190585A 2012-11-27 2013-11-27 Ciljani terapeutski lizozomalni fuzioni proteini i njihova primena RS58916B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261730378P 2012-11-27 2012-11-27
US201361788968P 2013-03-15 2013-03-15
EP16182420.6A EP3115372B1 (en) 2012-11-27 2013-11-27 Targeted therapeutic lysosomal enzyme fusion proteins and uses thereof

Publications (1)

Publication Number Publication Date
RS58916B1 true RS58916B1 (sr) 2019-08-30

Family

ID=49753532

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20190585A RS58916B1 (sr) 2012-11-27 2013-11-27 Ciljani terapeutski lizozomalni fuzioni proteini i njihova primena

Country Status (27)

Country Link
US (8) US9376480B2 (sr)
EP (2) EP2925776B1 (sr)
JP (2) JP6831176B2 (sr)
KR (4) KR102521039B1 (sr)
CN (1) CN104822701B (sr)
AR (1) AR093626A1 (sr)
AU (1) AU2013352184B2 (sr)
BR (1) BR112015012152B1 (sr)
CA (1) CA2892146A1 (sr)
CL (1) CL2015001371A1 (sr)
CY (1) CY1122555T1 (sr)
DK (2) DK2925776T3 (sr)
ES (2) ES2679374T3 (sr)
HK (1) HK1216026A1 (sr)
HR (2) HRP20181351T1 (sr)
HU (2) HUE043679T2 (sr)
IL (3) IL238824B (sr)
LT (1) LT3115372T (sr)
MX (2) MX367024B (sr)
PL (2) PL3115372T3 (sr)
PT (2) PT3115372T (sr)
RS (1) RS58916B1 (sr)
RU (1) RU2680581C2 (sr)
SI (1) SI3115372T1 (sr)
TW (2) TWI711632B (sr)
WO (1) WO2014085621A1 (sr)
ZA (1) ZA201503509B (sr)

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SG11201509419QA (en) * 2013-05-15 2015-12-30 Univ Minnesota Adeno-associated virus mediated gene transfer to the central nervous system
CA2956469A1 (en) 2014-08-11 2016-02-18 Shire Human Genetic Therapies, Inc. Mannose-6-phosphate bearing peptides fused to lysosomal enzymes
US20180303877A1 (en) * 2014-09-25 2018-10-25 The General Hospital Corporation Cell-based targeted delivery of pseudonomas exotoxin
US10556015B2 (en) 2014-10-24 2020-02-11 Criteo S.A. Lysosomal targeting of enzymes, and uses thereof
TWI752907B (zh) * 2015-05-08 2022-01-21 美商拜奧馬林製藥公司 用於治療cln2疾病之tpp1調配物及方法
WO2017079729A1 (en) 2015-11-06 2017-05-11 Biomarin Pharmaceutical Inc. Cell-based assays for detection of antibodies or other factors that neutralize uptake of lysosomal enzymes
AU2017222620B2 (en) * 2016-02-24 2022-06-16 Biomarin Pharmaceutical Inc. Targeted therapeutic lysosomal enzyme fusion proteins, associated formulations and uses thereof
IL262211B2 (en) 2016-04-15 2024-01-01 Univ Pennsylvania Gene therapy for the treatment of type II mucositis
CL2016003282A1 (es) 2016-12-21 2017-08-18 Univ Chile Virus aav/igf2, método de tratamiento genético y su uso en enfermedades relacionadas con mal plegamiento de proteínas tal como la enfermedad de huntington
KR20200104852A (ko) 2017-09-22 2020-09-04 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Ii형 점액다당류증의 치료를 위한 유전자 요법
CA3076369A1 (en) 2017-10-02 2019-04-11 Denali Therapeutics Inc. Fusion proteins comprising enzyme replacement therapy enzymes
CA3092961A1 (en) * 2018-03-09 2019-09-12 Avrobio, Inc. Compositions and methods for treating parkinson's disease
CA3098674A1 (en) 2018-04-30 2019-11-07 Amicus Therapeutics, Inc. Gene therapy constructs and methods of use
WO2019233842A1 (en) 2018-06-08 2019-12-12 F. Hoffmann-La Roche Ag Peptidic linker with reduced post-translational modification
WO2020077114A2 (en) 2018-10-10 2020-04-16 Amicus Therapeutics, Inc. Disulfide bond stabilized polypeptide compositions and methods of use
AU2019381803A1 (en) * 2018-11-16 2021-06-10 Asklepios Biopharmaceutical, Inc. Vectors comprising a nucleic acid encoding lysosomal enzymes fused to a lysosomal targeting sequence
WO2021072372A1 (en) * 2019-10-10 2021-04-15 Amicus Therapeutics, Inc. Variant igf2 constructs
WO2021183895A1 (en) 2020-03-13 2021-09-16 Biomarin Pharmaceutical Inc. Treatment of fabry disease with aav gene therapy vectors
US20240279360A1 (en) 2021-06-23 2024-08-22 Lycia Therapeutics, Inc. Bifunctional compounds containing igf-2 polypeptides
CN115975039A (zh) * 2021-10-15 2023-04-18 中山大学 重组融合抗体和抗体-药物偶联物及其用途
WO2024159071A1 (en) * 2023-01-27 2024-08-02 Regeneron Pharmaceuticals, Inc. Modified rhabdovirus glycoproteins and uses thereof

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AUPN674895A0 (en) 1995-11-23 1995-12-14 Women's And Children's Hospital Synthetic mammalian alpha-N-acetylglucosaminidase and genetic sequences encoding same
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Also Published As

Publication number Publication date
PT2925776T (pt) 2018-07-30
BR112015012152A2 (pt) 2017-08-15
RU2015125491A (ru) 2017-01-10
AU2013352184A1 (en) 2015-06-04
TWI626250B (zh) 2018-06-11
AR093626A1 (es) 2015-06-17
IL272854A (en) 2020-04-30
US11254725B2 (en) 2022-02-22
ES2679374T3 (es) 2018-08-24
KR102262882B1 (ko) 2021-06-10
US9845346B2 (en) 2017-12-19
KR20210070389A (ko) 2021-06-14
IL238824A0 (en) 2015-06-30
KR20150088317A (ko) 2015-07-31
PL3115372T3 (pl) 2019-09-30
HRP20181351T1 (hr) 2018-11-02
US9376480B2 (en) 2016-06-28
PL2925776T3 (pl) 2018-11-30
PT3115372T (pt) 2019-06-12
KR102385392B1 (ko) 2022-04-11
US10301369B2 (en) 2019-05-28
US9834587B2 (en) 2017-12-05
HUE043679T2 (hu) 2019-09-30
US20160031963A1 (en) 2016-02-04
WO2014085621A1 (en) 2014-06-05
EP3115372A1 (en) 2017-01-11
EP2925776A1 (en) 2015-10-07
EP3115372B1 (en) 2019-03-06
JP6831176B2 (ja) 2021-02-17
IL272854B (en) 2021-07-29
IL238824B (en) 2018-11-29
JP2016505539A (ja) 2016-02-25
KR102521039B1 (ko) 2023-04-12
US9834588B2 (en) 2017-12-05
KR20220047892A (ko) 2022-04-19
IL262976A (en) 2018-12-31
CN104822701B (zh) 2018-09-21
CN104822701A (zh) 2015-08-05
LT3115372T (lt) 2019-06-25
US20170355744A1 (en) 2017-12-14
CY1122555T1 (el) 2021-01-27
US20140161788A1 (en) 2014-06-12
RU2680581C2 (ru) 2019-02-22
US9771408B2 (en) 2017-09-26
TWI711632B (zh) 2020-12-01
CA2892146A1 (en) 2014-06-05
MX2019009191A (es) 2019-10-09
HUE039334T2 (hu) 2018-12-28
EP2925776B1 (en) 2018-05-30
US20190225666A1 (en) 2019-07-25
BR112015012152B1 (pt) 2023-04-25
TW201431884A (zh) 2014-08-16
IL262976B (en) 2020-02-27
HRP20190918T1 (hr) 2019-09-20
ES2729997T3 (es) 2019-11-07
DK2925776T3 (en) 2018-09-03
MX2015006644A (es) 2015-08-10
JP6913719B2 (ja) 2021-08-04
US20160031965A1 (en) 2016-02-04
US20160039900A1 (en) 2016-02-11
KR20230054482A (ko) 2023-04-24
ZA201503509B (en) 2016-11-30
SI3115372T1 (sl) 2019-08-30
TW201827468A (zh) 2018-08-01
MX367024B (es) 2019-08-02
HK1216026A1 (zh) 2016-10-07
US20220127326A1 (en) 2022-04-28
JP2019206556A (ja) 2019-12-05
US20160031964A1 (en) 2016-02-04
CL2015001371A1 (es) 2015-10-09
AU2013352184B2 (en) 2018-05-31
DK3115372T3 (da) 2019-06-11

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