BR0015055A - Método de aumento estimulação ou potencialização da diferenciação de células t, método de tratamento de uma doença mediada por th1 em um mamìfero, método de prevenir, inibir ou atenuar a diferenciação de céluas t, método de tratamento de uma doença mediada por th2, em um mamìfero, método de determinação da presença de polipeptìdeo tccr em uma célula, método de diagnóstico de doenças mediadas por th1 ou mediadas por th2 em um mamìfero, método de identificação de compostos capazes de inibir a expressão de polipeptìdeos tccr e método para identificação de compostos capazes de inibir a atividade biológica de polipeptìdeo tccr, uso de antagonistas e agonistas de polipeptìdeos tccr - Google Patents
Método de aumento estimulação ou potencialização da diferenciação de células t, método de tratamento de uma doença mediada por th1 em um mamìfero, método de prevenir, inibir ou atenuar a diferenciação de céluas t, método de tratamento de uma doença mediada por th2, em um mamìfero, método de determinação da presença de polipeptìdeo tccr em uma célula, método de diagnóstico de doenças mediadas por th1 ou mediadas por th2 em um mamìfero, método de identificação de compostos capazes de inibir a expressão de polipeptìdeos tccr e método para identificação de compostos capazes de inibir a atividade biológica de polipeptìdeo tccr, uso de antagonistas e agonistas de polipeptìdeos tccrInfo
- Publication number
- BR0015055A BR0015055A BR0015055-0A BR0015055A BR0015055A BR 0015055 A BR0015055 A BR 0015055A BR 0015055 A BR0015055 A BR 0015055A BR 0015055 A BR0015055 A BR 0015055A
- Authority
- BR
- Brazil
- Prior art keywords
- tccr
- understanding
- polypeptides
- mammal
- mediated
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
"MéTODO DE AUMENTO, ESTIMULAçãO OU POTENCIALIZAçãO DA DIFERENCIAçãO DE CéLULAS T, MéTODO DE TRATAMENTO DE UMA DOENçA MEDIADA POR TH1 EM UM MAMìFERO, MéTODO DE PREVENIR, INIBIR OU ATENUAR A DIFERENCIAçãO DE CéLULAS T, MéTODO DE TRATAMENTO DE UMA DOENçA MEDIADA POR TH2 EM UM MAMìFERO, MéTODO DE DETERMINAçãO DA PRESENçA DE POLIPEPTìDEO TCCR EM UMA CéLULA, MéTODO DE DIAGNóSTICO DE DOENçAS MEDIADAS POR TH1 OU MEDIADAS POR TH2 EM UM MAMìFERO, MéTODO DE IDENTIFICAçãO DE COMPOSTOS CAPAZES DE INIBIR A EXPRESSãO DE POLIPEPTìDEOS TCCR E MéTODO PARA IDENTIFICAçãO DE COMPOSTOS CAPAZES DE INIBIR A ATIVIDADE BIOLóGICA DE POLIPEPTìDEO TCCR, USO DE ANTAGONISTAS E AGONISTAS DE POLIPEPTìDEOS TCCR". A presente invenção refere-se a métodos de tratamento e diagnóstico de doenças relacionadas com a imunidade, que incluem as doenças mediadas por citoquinas liberadas principalmente por células Th1 ou Th2 em resposta ao estímulo antigênico. A presente invenção refere-se ainda a métodos para induzir a diferenciação de células T tanto no subtipo Th1 ou no subtipo Th2, com base nos níveis de expressão relativos do gene TCCR e seus agonistas ou antagonistas. A presente invenção refere-se ainda a um método de diagnóstico de doenças mediadas por Th1 e Th2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16054299P | 1999-10-20 | 1999-10-20 | |
| PCT/US2000/028827 WO2001029070A2 (en) | 1999-10-20 | 2000-10-18 | Modulation of t cell differentiation for the treatment of t helper cell mediated diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0015055A true BR0015055A (pt) | 2002-07-16 |
Family
ID=22577314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0015055-0A BR0015055A (pt) | 1999-10-20 | 2000-10-18 | Método de aumento estimulação ou potencialização da diferenciação de células t, método de tratamento de uma doença mediada por th1 em um mamìfero, método de prevenir, inibir ou atenuar a diferenciação de céluas t, método de tratamento de uma doença mediada por th2, em um mamìfero, método de determinação da presença de polipeptìdeo tccr em uma célula, método de diagnóstico de doenças mediadas por th1 ou mediadas por th2 em um mamìfero, método de identificação de compostos capazes de inibir a expressão de polipeptìdeos tccr e método para identificação de compostos capazes de inibir a atividade biológica de polipeptìdeo tccr, uso de antagonistas e agonistas de polipeptìdeos tccr |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20040234522A1 (pt) |
| EP (1) | EP1222209A2 (pt) |
| JP (1) | JP4931310B2 (pt) |
| KR (3) | KR100874280B1 (pt) |
| CN (1) | CN1279054C (pt) |
| AU (2) | AU1095001A (pt) |
| BR (1) | BR0015055A (pt) |
| CA (1) | CA2389317A1 (pt) |
| IL (2) | IL148936A0 (pt) |
| MX (1) | MXPA02003897A (pt) |
| NZ (1) | NZ531141A (pt) |
| WO (1) | WO2001029070A2 (pt) |
| ZA (1) | ZA200202468B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100874280B1 (ko) * | 1999-10-20 | 2008-12-18 | 제넨테크, 인크. | Ｔ 헬퍼 세포 매개 질환의 치료를 위한 ｔ 세포 분화의조절 |
| US7393532B1 (en) | 2000-10-18 | 2008-07-01 | Genentech, Inc. | Modulation of T cell differentiation for the treatment of T helper cell mediated diseases |
| US9738700B2 (en) | 2002-01-18 | 2017-08-22 | Zymogenetics Inc. | ZCYTOR17 heterodimeric cytokine receptor |
| US7494804B2 (en) * | 2002-01-18 | 2009-02-24 | Zymogenetics, Inc. | Polynucleotide encoding cytokine receptor zcytor17 multimer |
| WO2004069173A2 (en) * | 2003-01-31 | 2004-08-19 | The Trustees Of The University Of Pennsylvania | Methods for modulating an inflammatory response |
| BRPI0507776A (pt) * | 2004-02-17 | 2007-07-10 | Schering Corp | métodos de modular a atividade de citocina; reagentes relacionados |
| KR20070095949A (ko) * | 2004-12-16 | 2007-10-01 | 제넨테크, 인크. | 자가면역 장애의 치료 방법 |
| ES2612383T3 (es) * | 2006-07-19 | 2017-05-16 | The Trustees Of The University Of Pennsylvania | WSX-1/IL-27 como una diana para respuestas antiinflamatorias |
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| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
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| US5010182A (en) | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
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| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
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| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| WO1991004753A1 (en) | 1989-10-02 | 1991-04-18 | Cetus Corporation | Conjugates of antisense oligonucleotides and therapeutic uses thereof |
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| KR20070095949A (ko) * | 2004-12-16 | 2007-10-01 | 제넨테크, 인크. | 자가면역 장애의 치료 방법 |
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2000
- 2000-10-18 KR KR1020077028670A patent/KR100874280B1/ko not_active IP Right Cessation
- 2000-10-18 NZ NZ531141A patent/NZ531141A/en not_active IP Right Cessation
- 2000-10-18 BR BR0015055-0A patent/BR0015055A/pt not_active Application Discontinuation
- 2000-10-18 KR KR1020087017088A patent/KR20080068767A/ko not_active Application Discontinuation
- 2000-10-18 EP EP00972264A patent/EP1222209A2/en not_active Withdrawn
- 2000-10-18 MX MXPA02003897A patent/MXPA02003897A/es active IP Right Grant
- 2000-10-18 WO PCT/US2000/028827 patent/WO2001029070A2/en active Application Filing
- 2000-10-18 CN CNB008171769A patent/CN1279054C/zh not_active Expired - Fee Related
- 2000-10-18 AU AU10950/01A patent/AU1095001A/en not_active Abandoned
- 2000-10-18 IL IL14893600A patent/IL148936A0/xx unknown
- 2000-10-18 CA CA002389317A patent/CA2389317A1/en not_active Abandoned
- 2000-10-18 KR KR1020027005032A patent/KR100840033B1/ko not_active IP Right Cessation
- 2000-10-18 JP JP2001531868A patent/JP4931310B2/ja not_active Expired - Fee Related
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2002
- 2002-03-27 IL IL148936A patent/IL148936A/en not_active IP Right Cessation
- 2002-03-27 ZA ZA200202468A patent/ZA200202468B/xx unknown
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2003
- 2003-09-15 US US10/663,158 patent/US20040234522A1/en not_active Abandoned
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2006
- 2006-01-27 AU AU2006200374A patent/AU2006200374B2/en not_active Ceased
- 2006-09-29 US US11/537,572 patent/US20070134238A1/en not_active Abandoned
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2009
- 2009-05-07 US US12/437,452 patent/US20110097325A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL148936A0 (en) | 2002-09-12 |
| US20070134238A1 (en) | 2007-06-14 |
| WO2001029070A8 (en) | 2001-09-20 |
| EP1222209A2 (en) | 2002-07-17 |
| ZA200202468B (en) | 2003-06-25 |
| JP4931310B2 (ja) | 2012-05-16 |
| US20110097325A1 (en) | 2011-04-28 |
| WO2001029070A3 (en) | 2002-05-02 |
| AU2006200374B2 (en) | 2009-12-10 |
| WO2001029070A2 (en) | 2001-04-26 |
| US20040234522A1 (en) | 2004-11-25 |
| KR20070121855A (ko) | 2007-12-27 |
| KR100840033B1 (ko) | 2008-06-19 |
| NZ531141A (en) | 2005-07-29 |
| AU1095001A (en) | 2001-04-30 |
| CN1279054C (zh) | 2006-10-11 |
| KR20020048971A (ko) | 2002-06-24 |
| CN1409726A (zh) | 2003-04-09 |
| IL148936A (en) | 2010-12-30 |
| CA2389317A1 (en) | 2001-04-26 |
| KR20080068767A (ko) | 2008-07-23 |
| JP2003512824A (ja) | 2003-04-08 |
| KR100874280B1 (ko) | 2008-12-18 |
| PL355284A1 (en) | 2004-04-05 |
| MXPA02003897A (es) | 2002-12-13 |
| AU2006200374A1 (en) | 2006-02-23 |
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