PL2567709T3 - Cząsteczki i sposoby modulowania białka związanego z receptorem dla lipoproteiny o niskiej gęstości 6 (LRP6) - Google Patents
Cząsteczki i sposoby modulowania białka związanego z receptorem dla lipoproteiny o niskiej gęstości 6 (LRP6)Info
- Publication number
- PL2567709T3 PL2567709T3 PL12188230T PL12188230T PL2567709T3 PL 2567709 T3 PL2567709 T3 PL 2567709T3 PL 12188230 T PL12188230 T PL 12188230T PL 12188230 T PL12188230 T PL 12188230T PL 2567709 T3 PL2567709 T3 PL 2567709T3
- Authority
- PL
- Poland
- Prior art keywords
- lrp6
- molecules
- density
- methods
- related protein
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98482707P | 2007-11-02 | 2007-11-02 | |
| EP12188230.2A EP2567709B1 (en) | 2007-11-02 | 2008-10-31 | Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (LRP6) |
| EP08844924.4A EP2209491B1 (en) | 2007-11-02 | 2008-10-31 | Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (lrp6) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2567709T3 true PL2567709T3 (pl) | 2018-06-29 |
Family
ID=40591553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12188230T PL2567709T3 (pl) | 2007-11-02 | 2008-10-31 | Cząsteczki i sposoby modulowania białka związanego z receptorem dla lipoproteiny o niskiej gęstości 6 (LRP6) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100254980A1 (pl) |
| EP (3) | EP2567709B1 (pl) |
| JP (1) | JP5764329B2 (pl) |
| KR (1) | KR20100091170A (pl) |
| CN (1) | CN101951954A (pl) |
| AU (1) | AU2008320823B2 (pl) |
| BR (1) | BRPI0820327A2 (pl) |
| CA (1) | CA2700433A1 (pl) |
| DK (1) | DK2567709T3 (pl) |
| EA (1) | EA201000718A1 (pl) |
| ES (2) | ES2560532T3 (pl) |
| HK (1) | HK1252539A1 (pl) |
| MX (1) | MX2010004761A (pl) |
| PL (1) | PL2567709T3 (pl) |
| WO (1) | WO2009056634A2 (pl) |
Families Citing this family (57)
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| DE69942782D1 (de) | 1998-11-27 | 2010-10-28 | Ucb Sa | Zusammensetzungen und Verfahren zur Erhöhung der Knochenmineralisierung |
| EP1636270B1 (en) | 2003-06-16 | 2016-07-20 | UCB Pharma S.A. | Antibodies specific for sclerostin and methods for increasing bone mineralization |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
| PL2567709T3 (pl) | 2007-11-02 | 2018-06-29 | Novartis Ag | Cząsteczki i sposoby modulowania białka związanego z receptorem dla lipoproteiny o niskiej gęstości 6 (LRP6) |
| EP2220247A4 (en) * | 2007-11-16 | 2011-10-26 | Nuvelo Inc | ANTIBODY AGAINST LRP6 |
| ES2341419B1 (es) * | 2008-08-14 | 2011-05-03 | Hospital Clinic I Provincial De Barcelona | Wnt1 como biomarcador de daño renal. |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
| EP2536761B1 (en) * | 2010-02-19 | 2017-09-20 | The Board Of Regents Of The University Of Oklahoma | Monoclonal antibodies that inhibit the wnt signaling pathway and methods of production and use thereof |
| MX2012010853A (es) * | 2010-03-24 | 2013-01-29 | Genentech Inc | Anticuerpos anti-lrp6. |
| KR101441163B1 (ko) | 2010-04-05 | 2014-09-19 | 울산대학교 산학협력단 | 메갈린을 표적으로 하는 체중 조절 장애 관련 질환의 진단, 예방 또는 치료 방법 |
| PH12012502193A1 (en) * | 2010-05-06 | 2021-08-09 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies |
| EA201291180A1 (ru) * | 2010-05-06 | 2013-05-30 | Новартис Аг | Композиции и способы применения терапевтических антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6) |
| SMT202000095T1 (it) | 2010-05-14 | 2020-03-13 | Amgen Inc | Formulazioni di anticorpi anti-sclerostina ad alta concentrazione |
| EP2605652B1 (en) | 2010-08-18 | 2017-11-08 | Samumed, LLC | Diketones and hydroxyketones as catenin signaling pathway activators |
| US9133272B2 (en) | 2011-03-01 | 2015-09-15 | Amgen Inc. | Bispecific binding agents |
| JP2014511842A (ja) | 2011-03-25 | 2014-05-19 | アムジエン・インコーポレーテツド | 抗スクレロスチン抗体結晶およびその製剤 |
| EP2508158B1 (en) | 2011-04-04 | 2014-07-02 | Arjo Hospital Equipment AB | Hoist apparatus |
| HUE052094T2 (hu) | 2011-04-19 | 2021-04-28 | Amgen Inc | Osteoporosis kezelési módszere |
| US8790650B2 (en) * | 2011-04-28 | 2014-07-29 | Vanderbilt University | Methods of using an antibody to inhibit WNT-mediated cardiac remodeling |
| JP2014515759A (ja) * | 2011-04-29 | 2014-07-03 | ノバルティス アーゲー | 扁平上皮がんを治療する方法関連出願 |
| DK2739311T3 (en) | 2011-08-04 | 2018-04-23 | Amgen Inc | Method of treating bone slit defects |
| KR101399062B1 (ko) * | 2011-08-18 | 2014-05-27 | 한양대학교 산학협력단 | Wnt 유인 수용체를 포함하는 항암 조성물 |
| CN109111523B (zh) * | 2011-10-14 | 2022-06-07 | 诺华股份有限公司 | 用于Wnt途径相关疾病的抗体和方法 |
| SG11201401717VA (en) * | 2011-11-04 | 2014-05-29 | Novartis Ag | Low density lipoprotein-related protein 6 (lrp6) - half life extender constructs |
| EA036740B1 (ru) | 2011-12-28 | 2020-12-15 | Эмджен Инк. | Способ увеличения высоты альвеолярного отростка посредством применения антител к склеростину |
| WO2014006100A1 (en) | 2012-07-05 | 2014-01-09 | Ucb Pharma S.A. | Treatment for bone diseases |
| EP2888279A1 (en) * | 2012-08-22 | 2015-07-01 | Glaxo Group Limited | Anti lrp6 antibodies |
| WO2014071211A2 (en) * | 2012-11-01 | 2014-05-08 | University Of Washington Through Its Center For Commercialization | Molecules, compositions and methods to treat organ scarring |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| US20190194314A1 (en) * | 2012-12-21 | 2019-06-27 | Stowers Institute For Medical Research | Antibodies for modulating binding between lrp and wise |
| JP2016510411A (ja) * | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路インヒビターによる処置の方法およびモニタリング |
| ES2709824T3 (es) | 2013-02-22 | 2019-04-17 | Samumed Llc | Gamma-dicetonas como activadores de la ruta de señalización Wnt/beta-catenina |
| SG10201709273WA (en) * | 2013-11-13 | 2018-01-30 | Superlab Far East Ltd | Methods of determining interferon having direct inhibitory effects on tumors and uses thereof |
| CN103893781B (zh) * | 2014-04-10 | 2016-03-30 | 武汉大学 | Dickkopf-3(DKK3)基因在冠状动脉粥样硬化性心脏病中的功能和应用 |
| DK3206686T3 (da) | 2014-08-20 | 2019-12-16 | Samumed Llc | Gamma-diketoner til behandling og forebyggelse af ældning af huden og rynker |
| US11142577B2 (en) | 2014-09-12 | 2021-10-12 | The Board Of Trustees Of The Leland Stanford Junior University | WNT signaling agonist molecules |
| MA41142A (fr) | 2014-12-12 | 2017-10-17 | Amgen Inc | Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement |
| LT3383425T (lt) | 2015-12-04 | 2020-10-12 | Boehringer Ingelheim International Gmbh | Biparatopiniai polipeptidai, veikiantys antagonistiškai wnt signaliniam keliui vėžinėse ląstelėse |
| EP3394265A1 (en) * | 2015-12-23 | 2018-10-31 | Biogen MA Inc. | Dkk2 cysteine rich domain 2 containing proteins and uses thereof |
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| EP3496744A1 (en) | 2016-08-08 | 2019-06-19 | Amgen Inc. | Method of improving connective tissue attachment using anti-sclerostin antibodies |
| US11702480B2 (en) * | 2016-11-18 | 2023-07-18 | The Regents Of The University Of California | Engineered antibodies and uses thereof |
| JP7037165B2 (ja) * | 2017-03-21 | 2022-03-16 | 国立大学法人東海国立大学機構 | 抗adamタンパク質基質抗体及びその利用 |
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| CN119241705A (zh) | 2018-03-30 | 2025-01-03 | 安姆根有限公司 | C末端抗体变体 |
| US20210292422A1 (en) * | 2018-07-05 | 2021-09-23 | Surrozen, Inc. | Multi-specific wnt surrogate molecules and uses thereof |
| MA53272A (fr) | 2018-08-10 | 2021-11-17 | Amgen Inc | Procédé de préparation d'une formulation pharmaceutique d'anticorps |
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| CN114832106A (zh) * | 2022-03-25 | 2022-08-02 | 中山大学附属第七医院(深圳) | 靶向激活lrp6的工具在制备防治阿尔兹海默症药物中的应用 |
| CN121532171A (zh) | 2023-07-19 | 2026-02-13 | 美国安进公司 | 用于治疗性蛋白质配制品的缓冲液制备方法 |
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-
2008
- 2008-10-31 PL PL12188230T patent/PL2567709T3/pl unknown
- 2008-10-31 DK DK12188230.2T patent/DK2567709T3/en active
- 2008-10-31 US US12/740,134 patent/US20100254980A1/en not_active Abandoned
- 2008-10-31 EP EP12188230.2A patent/EP2567709B1/en not_active Revoked
- 2008-10-31 EA EA201000718A patent/EA201000718A1/ru unknown
- 2008-10-31 ES ES08844924.4T patent/ES2560532T3/es active Active
- 2008-10-31 EP EP08844924.4A patent/EP2209491B1/en not_active Revoked
- 2008-10-31 BR BRPI0820327-0A patent/BRPI0820327A2/pt not_active Application Discontinuation
- 2008-10-31 MX MX2010004761A patent/MX2010004761A/es not_active Application Discontinuation
- 2008-10-31 KR KR1020107009595A patent/KR20100091170A/ko not_active Ceased
- 2008-10-31 CN CN2008801145208A patent/CN101951954A/zh active Pending
- 2008-10-31 ES ES12188230.2T patent/ES2663077T3/es active Active
- 2008-10-31 WO PCT/EP2008/064821 patent/WO2009056634A2/en not_active Ceased
- 2008-10-31 CA CA2700433A patent/CA2700433A1/en not_active Abandoned
- 2008-10-31 AU AU2008320823A patent/AU2008320823B2/en not_active Ceased
- 2008-10-31 EP EP17196705.2A patent/EP3305324A1/en not_active Withdrawn
- 2008-10-31 JP JP2010532556A patent/JP5764329B2/ja not_active Ceased
-
2018
- 2018-09-14 HK HK18111852.4A patent/HK1252539A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011503025A (ja) | 2011-01-27 |
| AU2008320823B2 (en) | 2013-01-17 |
| EP2567709A3 (en) | 2013-05-08 |
| US20100254980A1 (en) | 2010-10-07 |
| EP2567709A2 (en) | 2013-03-13 |
| EP3305324A1 (en) | 2018-04-11 |
| DK2567709T3 (en) | 2018-03-12 |
| ES2560532T3 (es) | 2016-02-19 |
| CA2700433A1 (en) | 2009-05-07 |
| BRPI0820327A2 (pt) | 2020-10-06 |
| MX2010004761A (es) | 2010-05-19 |
| JP5764329B2 (ja) | 2015-08-19 |
| WO2009056634A2 (en) | 2009-05-07 |
| CN101951954A (zh) | 2011-01-19 |
| AU2008320823A1 (en) | 2009-05-07 |
| WO2009056634A3 (en) | 2009-12-10 |
| EP2567709B1 (en) | 2017-12-27 |
| HK1252539A1 (en) | 2019-05-31 |
| EA201000718A1 (ru) | 2011-06-30 |
| EP2209491A2 (en) | 2010-07-28 |
| KR20100091170A (ko) | 2010-08-18 |
| ES2663077T3 (es) | 2018-04-11 |
| EP2209491B1 (en) | 2015-10-28 |
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