MX420947B - Constructos que reconocen específicamente glipicano 3 y usos de estos. - Google Patents

Constructos que reconocen específicamente glipicano 3 y usos de estos.

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Publication number
MX420947B
MX420947B MX2019012133A MX2019012133A MX420947B MX 420947 B MX420947 B MX 420947B MX 2019012133 A MX2019012133 A MX 2019012133A MX 2019012133 A MX2019012133 A MX 2019012133A MX 420947 B MX420947 B MX 420947B
Authority
MX
Mexico
Prior art keywords
constructs
specifically recognize
glypican
recognize glypican
gpc3
Prior art date
Application number
MX2019012133A
Other languages
English (en)
Inventor
Hong Liu
Javier Morales
Jingyi Xiang
Pengbo Zhang
Timothy Acker
Yiyang Xu
Yoko Nakano
Original Assignee
Eureka Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eureka Therapeutics Inc filed Critical Eureka Therapeutics Inc
Publication of MX420947B publication Critical patent/MX420947B/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001181—Alpha-feto protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4261—Proteoglycans, e.g. glypican, brevican or CSPG4
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/303—Liver or Pancreas
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/46—Hybrid immunoglobulins
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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Abstract

La presente solicitud proporciona constructos que comprenden una porción de anticuerpo que reconoce específicamente el glipicano 3 (GPC3), tal como un GPC3 unido a la superficie celular. También se proporcionan métodos para producir y usar estos constructos.
MX2019012133A 2017-04-26 2018-04-24 Constructos que reconocen específicamente glipicano 3 y usos de estos. MX420947B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762490586P 2017-04-26 2017-04-26
PCT/US2018/029221 WO2018200586A1 (en) 2017-04-26 2018-04-24 Constructs specifically recognizing glypican 3 and uses thereof

Publications (1)

Publication Number Publication Date
MX420947B true MX420947B (es) 2025-02-10

Family

ID=63920003

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019012133A MX420947B (es) 2017-04-26 2018-04-24 Constructos que reconocen específicamente glipicano 3 y usos de estos.
MX2024009388A MX2024009388A (es) 2017-04-26 2019-10-09 Constructos que reconocen especificamente glipicano 3 y usos de estos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2024009388A MX2024009388A (es) 2017-04-26 2019-10-09 Constructos que reconocen especificamente glipicano 3 y usos de estos.

Country Status (15)

Country Link
US (2) US11447564B2 (es)
EP (1) EP3615574A4 (es)
JP (2) JP7295030B2 (es)
KR (2) KR102663596B1 (es)
CN (1) CN110741019B (es)
AU (1) AU2018258049B2 (es)
CA (1) CA3059820A1 (es)
IL (2) IL319308A (es)
MX (2) MX420947B (es)
MY (1) MY201065A (es)
PH (1) PH12019502412A1 (es)
SG (2) SG10201913582XA (es)
TW (1) TWI878207B (es)
WO (1) WO2018200586A1 (es)
ZA (1) ZA202000027B (es)

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WO2023249071A1 (ja) * 2022-06-24 2023-12-28 国立研究開発法人国立がん研究センター Ｔ細胞受容体
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