TR200100410T2 - 2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri. - Google Patents
2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri.Info
- Publication number
- TR200100410T2 TR200100410T2 TR2001/00410T TR200100410T TR200100410T2 TR 200100410 T2 TR200100410 T2 TR 200100410T2 TR 2001/00410 T TR2001/00410 T TR 2001/00410T TR 200100410 T TR200100410 T TR 200100410T TR 200100410 T2 TR200100410 T2 TR 200100410T2
- Authority
- TR
- Turkey
- Prior art keywords
- purin
- tetrahydrofuran
- diol derivatives
- diol
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bulusa göre, yeni formül (I) bilesikleri saglanmaktadir ki burada R1, R2 ve R3 tarifnamede tanimlandigi gibi olup, ayrica bunlarin hazirlanmasi için islemler, bunlari içeren formülasyonlar ve bunlarin enflamatuar hastaliklarin tedavisi için kullanimi saglanmaktadir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9813538.7A GB9813538D0 (en) | 1998-06-23 | 1998-06-23 | Chemical compounds |
GBGB9909482.3A GB9909482D0 (en) | 1999-04-23 | 1999-04-23 | 2-(Purin-9-yl)-tetahydrofuran-3,4-diol derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200100410T2 true TR200100410T2 (tr) | 2001-06-21 |
Family
ID=26313917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/00410T TR200100410T2 (tr) | 1998-06-23 | 1999-06-23 | 2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri. |
Country Status (27)
Country | Link |
---|---|
US (1) | US6495528B1 (tr) |
EP (1) | EP1090022B1 (tr) |
JP (1) | JP3933870B2 (tr) |
KR (1) | KR20010071591A (tr) |
CN (1) | CN1313861A (tr) |
AP (1) | AP2000002016A0 (tr) |
AT (1) | ATE246701T1 (tr) |
AU (1) | AU750462B2 (tr) |
BR (1) | BR9911482A (tr) |
CA (1) | CA2335809A1 (tr) |
CZ (1) | CZ20004868A3 (tr) |
DE (1) | DE69910213T2 (tr) |
EA (1) | EA200001224A1 (tr) |
EE (1) | EE200000768A (tr) |
ES (1) | ES2204139T3 (tr) |
HR (1) | HRP20000894A2 (tr) |
HU (1) | HUP0103025A3 (tr) |
ID (1) | ID29609A (tr) |
IL (1) | IL140396A0 (tr) |
IS (1) | IS5779A (tr) |
NO (1) | NO20006548L (tr) |
NZ (1) | NZ509030A (tr) |
PL (1) | PL345062A1 (tr) |
SK (1) | SK19542000A3 (tr) |
TR (1) | TR200100410T2 (tr) |
WO (1) | WO1999067265A1 (tr) |
YU (1) | YU81100A (tr) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
PE20000270A1 (es) * | 1998-02-14 | 2000-05-20 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US7427606B2 (en) | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
US7189717B2 (en) * | 2000-04-26 | 2007-03-13 | Eisai Co., Ltd. | Medicinal compositions promoting bowel movement |
GB0022695D0 (en) | 2000-09-15 | 2000-11-01 | Pfizer Ltd | Purine Derivatives |
GB0104555D0 (en) * | 2001-02-23 | 2001-04-11 | Glaxo Group Ltd | New Therapeutic method |
WO2003029264A2 (en) | 2001-10-01 | 2003-04-10 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
GB0206655D0 (en) * | 2002-03-21 | 2002-05-01 | Glaxo Group Ltd | Novel process |
TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
TWI346109B (en) | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
EP2266994B1 (en) | 2004-08-02 | 2013-04-03 | University Of Virginia Patent Foundation | 2-propynyl adenosine analgos with modified 5'-ribose groups having A2A agonist activity |
WO2006023272A1 (en) | 2004-08-02 | 2006-03-02 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having a2a agonist activity |
US7576069B2 (en) | 2004-08-02 | 2009-08-18 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0505219D0 (en) * | 2005-03-14 | 2005-04-20 | Novartis Ag | Organic compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0514809D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
KR20130020850A (ko) | 2005-10-21 | 2013-02-28 | 노파르티스 아게 | Il-13에 대항한 인간 항체 및 치료적 용도 |
GB0523845D0 (en) * | 2005-11-23 | 2006-01-04 | Glaxo Group Ltd | Novel salts |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
BRPI0710573A2 (pt) | 2006-04-21 | 2012-02-28 | Novartis Ag | compostos orgánicos, usos e processos para a preparação dos referidos compostos, bem como composição farmacêutica compreendendo os mesmos |
GB0607950D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
EP1889846A1 (en) | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
EP1903044A1 (en) | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
CA2664378A1 (en) | 2006-09-29 | 2008-04-03 | Novartis Ag | Pyrazolopyrimidines as pi3k lipid kinase inhibitors |
KR20090075714A (ko) | 2006-10-30 | 2009-07-08 | 노파르티스 아게 | 소염제로서의 헤테로시클릭 화합물 |
US8431578B2 (en) | 2008-01-11 | 2013-04-30 | Novartis Ag | Organic compounds |
PL2391366T3 (pl) | 2009-01-29 | 2013-04-30 | Novartis Ag | Podstawione benzimidazole do leczenia gwiaździaków |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
MX2012001838A (es) | 2009-08-12 | 2012-02-29 | Novartis Ag | Compuestos de hidrazona heterociclico y sus usos para tratar cancer e inflamacion. |
US9085560B2 (en) | 2009-08-17 | 2015-07-21 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
CA2771432A1 (en) | 2009-08-20 | 2011-02-24 | Novartis Ag | Heterocyclic oxime compounds |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
EP2673277A1 (en) | 2011-02-10 | 2013-12-18 | Novartis AG | [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase |
JP5808826B2 (ja) | 2011-02-23 | 2015-11-10 | インテリカイン, エルエルシー | 複素環化合物およびその使用 |
JP5959541B2 (ja) | 2011-02-25 | 2016-08-02 | ノバルティス アーゲー | Trk阻害剤としてのピラゾロ[1,5−a]ピリジン |
AU2012310168B2 (en) | 2011-09-15 | 2015-07-16 | Novartis Ag | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
US20130209543A1 (en) | 2011-11-23 | 2013-08-15 | Intellikine Llc | Enhanced treatment regimens using mtor inhibitors |
RU2660354C2 (ru) | 2012-04-03 | 2018-07-05 | Новартис Аг | Комбинированные продукты, содержащие ингибиторы тирозинкиназ, и их применение |
CN105246482A (zh) | 2013-03-15 | 2016-01-13 | 因特利凯有限责任公司 | 激酶抑制剂的组合及其用途 |
TW201605450A (zh) | 2013-12-03 | 2016-02-16 | 諾華公司 | Mdm2抑制劑與BRAF抑制劑之組合及其用途 |
WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
RU2695230C2 (ru) | 2014-07-31 | 2019-07-22 | Новартис Аг | Сочетанная терапия |
CN106632572B (zh) * | 2016-12-16 | 2018-08-14 | 中国科学院成都生物研究所 | 一种黄芪甲苷衍生物及其制备方法和应用 |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3796700A (en) | 1970-06-30 | 1974-03-12 | Takedo Chem Ind Ltd | Adenosine derivatives and the production thereof |
US4224438A (en) | 1970-07-14 | 1980-09-23 | Boehringer Mannheim Gmbh | Adenosine-5'-carboxylic acid amides |
CA1019727A (en) | 1971-03-18 | 1977-10-25 | Abbott Laboratories | Adenosine-5'-carboxylic acid amides |
BE789773A (fr) | 1971-10-08 | 1973-04-06 | Schering Ag | Adenosines n6 -substituees et leur procede de |
US3864483A (en) | 1972-03-22 | 1975-02-04 | Abbott Lab | Adenosine-5{40 -carboxylic acid amides |
CA1082695A (en) | 1972-04-10 | 1980-07-29 | Francis E. Fischer | Process for preparing adenosine-5'-carboxamides |
US3966917A (en) | 1974-07-30 | 1976-06-29 | Abbott Laboratories | Platelet aggregation inhibitors |
DE2621470A1 (de) | 1976-05-14 | 1977-12-01 | Pharma Waldhof Gmbh & Co | Nucleosidcarbonsaeurenitrile und ihre derivate, und verfahren zu ihrer herstellung |
US4167565A (en) | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
AU8379182A (en) | 1981-06-04 | 1982-12-09 | Procter & Gamble Company, The | Composition of salicylates and purine derivatives |
JPS58167599A (ja) | 1982-03-29 | 1983-10-03 | Tanabe Seiyaku Co Ltd | アデノシン誘導体及びその製法 |
JPS58174322A (ja) | 1982-04-07 | 1983-10-13 | Tanabe Seiyaku Co Ltd | 線溶促進剤 |
CA1239397A (en) | 1983-08-01 | 1988-07-19 | James A. Bristol | N.sup.6-substituted adenosines |
DE3406533A1 (de) | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
US4496643A (en) | 1984-03-23 | 1985-01-29 | Eastman Kodak Company | Two-component dry electrostatic developer composition containing onium charge control agent |
JPH0655756B2 (ja) | 1984-04-18 | 1994-07-27 | ネルソン・リサ−チ・アンド・デベロツプメント・カンパニ− | 心臓血管拡張薬としてのn−6置換アデノシン誘導体 |
US5310731A (en) | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
US4663313A (en) | 1984-10-26 | 1987-05-05 | Warner-Lambert Company | N6 -tricyclic adenosines for treating hypertension |
AU575438B2 (en) | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
US4738954A (en) | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
US4755594A (en) | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
US5106837A (en) | 1988-03-16 | 1992-04-21 | The Scripps Research Institute | Adenosine derivatives with therapeutic activity |
JPH0696534B2 (ja) | 1986-04-25 | 1994-11-30 | ヘキストジヤパン株式会社 | 抗痴呆剤 |
US4767747A (en) | 1986-08-28 | 1988-08-30 | Warner-Lambert Company | Method for treating congestive heart failure with N6 -acenaphthyl adenosine |
WO1988003147A1 (en) | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
AU8274187A (en) | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
HU198950B (en) | 1986-12-15 | 1989-12-28 | Sandoz Ag | Process for producing new furanuronic acid derivatives and pharmaceutical compositions comprising such compounds |
US4968697A (en) | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
PT86660B (pt) | 1987-02-04 | 1992-02-28 | Ciba Geigy Ag | Processo para a preparacao de derivados de adenosina-5'-carboxamida |
US4962194A (en) | 1987-04-02 | 1990-10-09 | Warner-Lambert Company | Method of preparing 51,N6-disubstituted adenosines from inosines |
US5219840A (en) | 1987-04-06 | 1993-06-15 | Sandoz Ltd. | Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives |
LU87181A1 (fr) | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
JPH0725785B2 (ja) | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
US5506347A (en) | 1993-02-03 | 1996-04-09 | Gensia, Inc. | Lyxofuranosyl analogues of adenosine |
KR910007655A (ko) | 1989-10-03 | 1991-05-30 | 엠. 피. 잭슨 | 치료용 뉴클레오시드 |
US5055569A (en) | 1989-10-19 | 1991-10-08 | G. D. Searle & Co. | N-(6)-substituted adenosine compounds |
IE903747A1 (en) | 1989-10-19 | 1991-04-24 | Searle & Co | Method of treating gastrointestinal motility disorders |
US5140015A (en) | 1990-02-20 | 1992-08-18 | Whitby Research, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
DK0550631T3 (da) | 1990-09-25 | 1997-01-20 | Rhone Poulenc Rorer Int | Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi |
FR2685918B1 (fr) | 1992-01-08 | 1995-06-23 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
FR2687678B1 (fr) | 1992-01-31 | 1995-03-31 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
US5424297A (en) | 1992-04-27 | 1995-06-13 | University Of Virginia Alumni Patents Foundation | Adenosine dextran conjugates |
AU4772493A (en) | 1992-07-15 | 1994-02-14 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Sulfo-derivatives of adenosine |
GB9301000D0 (en) | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
ATE206432T1 (de) | 1993-07-13 | 2001-10-15 | Nasa | A3 -adenosin -rezeptor agonisten |
US5446046A (en) | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
WO1995018817A1 (fr) | 1994-01-07 | 1995-07-13 | Laboratoires Upsa | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant |
GB9414208D0 (en) | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
GB9414193D0 (en) | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
AU3255097A (en) | 1996-07-05 | 1998-02-02 | Novo Nordisk A/S | Novel (n)-alkoxyadenine derivatives acting as cytokine inhibitors |
UA51716C2 (uk) | 1996-07-08 | 2002-12-16 | Авентіс Фармасьютікалз Продактс Інк. | Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування |
AU4377397A (en) | 1996-10-14 | 1998-05-11 | Novo Nordisk A/S | Novel therapeutically active adenosine derivatives |
TW528755B (en) * | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
ZA9810766B (en) | 1997-11-28 | 1999-05-25 | Mochida Pharm Co Ltd | Novel compounds having cgmp-pde inhibitory activity |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
PE20000270A1 (es) | 1998-02-14 | 2000-05-20 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
-
1999
- 1999-06-23 CN CN99809892A patent/CN1313861A/zh active Pending
- 1999-06-23 IL IL14039699A patent/IL140396A0/xx unknown
- 1999-06-23 YU YU81100A patent/YU81100A/sh unknown
- 1999-06-23 AP APAP/P/2000/002016A patent/AP2000002016A0/en unknown
- 1999-06-23 EA EA200001224A patent/EA200001224A1/ru unknown
- 1999-06-23 AT AT99931113T patent/ATE246701T1/de not_active IP Right Cessation
- 1999-06-23 US US09/720,390 patent/US6495528B1/en not_active Expired - Fee Related
- 1999-06-23 HU HU0103025A patent/HUP0103025A3/hu unknown
- 1999-06-23 EP EP99931113A patent/EP1090022B1/en not_active Expired - Lifetime
- 1999-06-23 TR TR2001/00410T patent/TR200100410T2/tr unknown
- 1999-06-23 DE DE69910213T patent/DE69910213T2/de not_active Expired - Lifetime
- 1999-06-23 KR KR1020007014720A patent/KR20010071591A/ko not_active Application Discontinuation
- 1999-06-23 BR BR9911482-8A patent/BR9911482A/pt not_active IP Right Cessation
- 1999-06-23 AU AU47744/99A patent/AU750462B2/en not_active Ceased
- 1999-06-23 EE EEP200000768A patent/EE200000768A/xx unknown
- 1999-06-23 ES ES99931113T patent/ES2204139T3/es not_active Expired - Lifetime
- 1999-06-23 NZ NZ509030A patent/NZ509030A/en not_active Application Discontinuation
- 1999-06-23 WO PCT/EP1999/004269 patent/WO1999067265A1/en not_active Application Discontinuation
- 1999-06-23 JP JP2000555916A patent/JP3933870B2/ja not_active Expired - Fee Related
- 1999-06-23 CA CA002335809A patent/CA2335809A1/en not_active Abandoned
- 1999-06-23 PL PL99345062A patent/PL345062A1/xx unknown
- 1999-06-23 SK SK1954-2000A patent/SK19542000A3/sk unknown
- 1999-06-23 CZ CZ20004868A patent/CZ20004868A3/cs unknown
- 1999-06-23 ID IDW20010189D patent/ID29609A/id unknown
-
2000
- 2000-12-19 IS IS5779A patent/IS5779A/is unknown
- 2000-12-21 HR HR20000894A patent/HRP20000894A2/hr not_active Application Discontinuation
- 2000-12-21 NO NO20006548A patent/NO20006548L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HRP20000894A2 (en) | 2001-12-31 |
CA2335809A1 (en) | 1999-12-29 |
JP2002518512A (ja) | 2002-06-25 |
CZ20004868A3 (cs) | 2001-08-15 |
YU81100A (sh) | 2003-10-31 |
KR20010071591A (ko) | 2001-07-28 |
AP2000002016A0 (en) | 2000-12-31 |
SK19542000A3 (sk) | 2001-09-11 |
ATE246701T1 (de) | 2003-08-15 |
IS5779A (is) | 2000-12-19 |
US6495528B1 (en) | 2002-12-17 |
NZ509030A (en) | 2003-07-25 |
AU4774499A (en) | 2000-01-10 |
EP1090022A1 (en) | 2001-04-11 |
DE69910213D1 (de) | 2003-09-11 |
CN1313861A (zh) | 2001-09-19 |
ES2204139T3 (es) | 2004-04-16 |
HUP0103025A2 (hu) | 2001-12-28 |
DE69910213T2 (de) | 2004-07-01 |
ID29609A (id) | 2001-09-06 |
JP3933870B2 (ja) | 2007-06-20 |
HUP0103025A3 (en) | 2002-04-29 |
EP1090022B1 (en) | 2003-08-06 |
AU750462B2 (en) | 2002-07-18 |
PL345062A1 (en) | 2001-11-19 |
WO1999067265A1 (en) | 1999-12-29 |
BR9911482A (pt) | 2002-01-22 |
NO20006548D0 (no) | 2000-12-21 |
EA200001224A1 (ru) | 2001-08-27 |
NO20006548L (no) | 2001-02-22 |
EE200000768A (et) | 2002-04-15 |
IL140396A0 (en) | 2002-02-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200100410T2 (tr) | 2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri. | |
DE69912606D1 (de) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate | |
AP2000001875A0 (en) | 2-(Purin-9-yl)-tetrahydrofuran -3,4-diol derivatives. | |
TR199901905T2 (tr) | 2-(Pürin-9-il)-tetrahidrofuran-3,4-diol türevleri. | |
AP2000001881A0 (en) | 2-(Purine-9-YL)-tetrahydrofuran-3,4 4-diol derivatives. | |
TR200101709T2 (tr) | İltihabik hastalıkların tedavisinde yararlı olan bileşikler | |
TR200100411T2 (tr) | 2-(Pürin-9-il)-tetrahidrofuran-3,4-diol türevleri. | |
FI93831B (fi) | Tetratsolit, jotka ovat verenpainetta alentavien yhdisteiden välituotteita | |
TR200003011T2 (tr) | Yeni dihidropirimidinler. | |
DK1200418T3 (da) | Nematodicide trifluorbutener | |
AR010062A1 (es) | Nuevos benzamidaldehidos y su utilizacion | |
TR200100448T2 (tr) | Fenil ksantin türevleri | |
BR0109780A (pt) | Soluções de ácido ascórbico estabilizadas; uso das mesmas; processo para sua obtenção e formulações compreendendo as mesmas | |
SE9804212D0 (sv) | Compounds | |
TR200002380T2 (tr) | Yeni triazolo (4,5-d) pirimidin bileşikleri | |
AR020563A1 (es) | Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion | |
SE9802574D0 (sv) | Novel compounds | |
SE9904128D0 (sv) | Novel compounds | |
TR200100475T2 (tr) | N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları. | |
SE9803107D0 (sv) | Novel Compunds | |
MXPA03003466A (es) | Derivados de piranosido. | |
SE9803277D0 (sv) | Novel compounds | |
ECSP972255A (es) | Nuevos derivados de piranosido |