DE69910213D1 - 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivate - Google Patents

2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivate

Info

Publication number
DE69910213D1
DE69910213D1 DE69910213T DE69910213T DE69910213D1 DE 69910213 D1 DE69910213 D1 DE 69910213D1 DE 69910213 T DE69910213 T DE 69910213T DE 69910213 T DE69910213 T DE 69910213T DE 69910213 D1 DE69910213 D1 DE 69910213D1
Authority
DE
Germany
Prior art keywords
purin
tetrahydrofuran
diol derivatives
diol
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69910213T
Other languages
English (en)
Other versions
DE69910213T2 (de
Inventor
David George Allen
Chuen Chan
Richard Peter Charles Cousins
Brian Cox
Joanna Victoria Geden
Heather Hobbs
Suzanne Elaine Keeling
Alison Judith Redgrave
Thomas Davis Roper Iv
Shiping Xie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9813538.7A external-priority patent/GB9813538D0/en
Priority claimed from GBGB9909482.3A external-priority patent/GB9909482D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE69910213D1 publication Critical patent/DE69910213D1/de
Publication of DE69910213T2 publication Critical patent/DE69910213T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
DE69910213T 1998-06-23 1999-06-23 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivate Expired - Lifetime DE69910213T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9813538.7A GB9813538D0 (en) 1998-06-23 1998-06-23 Chemical compounds
GB9813538 1998-06-23
GBGB9909482.3A GB9909482D0 (en) 1999-04-23 1999-04-23 2-(Purin-9-yl)-tetahydrofuran-3,4-diol derivatives
GB9909482 1999-04-23
PCT/EP1999/004269 WO1999067265A1 (en) 1998-06-23 1999-06-23 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives

Publications (2)

Publication Number Publication Date
DE69910213D1 true DE69910213D1 (de) 2003-09-11
DE69910213T2 DE69910213T2 (de) 2004-07-01

Family

ID=26313917

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69910213T Expired - Lifetime DE69910213T2 (de) 1998-06-23 1999-06-23 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivate

Country Status (27)

Country Link
US (1) US6495528B1 (de)
EP (1) EP1090022B1 (de)
JP (1) JP3933870B2 (de)
KR (1) KR20010071591A (de)
CN (1) CN1313861A (de)
AP (1) AP2000002016A0 (de)
AT (1) ATE246701T1 (de)
AU (1) AU750462B2 (de)
BR (1) BR9911482A (de)
CA (1) CA2335809A1 (de)
CZ (1) CZ20004868A3 (de)
DE (1) DE69910213T2 (de)
EA (1) EA200001224A1 (de)
EE (1) EE200000768A (de)
ES (1) ES2204139T3 (de)
HR (1) HRP20000894A2 (de)
HU (1) HUP0103025A3 (de)
ID (1) ID29609A (de)
IL (1) IL140396A0 (de)
IS (1) IS5779A (de)
NO (1) NO20006548L (de)
NZ (1) NZ509030A (de)
PL (1) PL345062A1 (de)
SK (1) SK19542000A3 (de)
TR (1) TR200100410T2 (de)
WO (1) WO1999067265A1 (de)
YU (1) YU81100A (de)

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US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
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GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
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GB0514809D0 (en) * 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
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GB0523845D0 (en) * 2005-11-23 2006-01-04 Glaxo Group Ltd Novel salts
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
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Also Published As

Publication number Publication date
AP2000002016A0 (en) 2000-12-31
YU81100A (sh) 2003-10-31
CN1313861A (zh) 2001-09-19
ES2204139T3 (es) 2004-04-16
WO1999067265A1 (en) 1999-12-29
US6495528B1 (en) 2002-12-17
IS5779A (is) 2000-12-19
IL140396A0 (en) 2002-02-10
NO20006548D0 (no) 2000-12-21
KR20010071591A (ko) 2001-07-28
ATE246701T1 (de) 2003-08-15
DE69910213T2 (de) 2004-07-01
CA2335809A1 (en) 1999-12-29
NZ509030A (en) 2003-07-25
PL345062A1 (en) 2001-11-19
TR200100410T2 (tr) 2001-06-21
JP3933870B2 (ja) 2007-06-20
NO20006548L (no) 2001-02-22
HUP0103025A3 (en) 2002-04-29
HRP20000894A2 (en) 2001-12-31
HUP0103025A2 (hu) 2001-12-28
CZ20004868A3 (cs) 2001-08-15
EA200001224A1 (ru) 2001-08-27
EE200000768A (et) 2002-04-15
SK19542000A3 (sk) 2001-09-11
JP2002518512A (ja) 2002-06-25
ID29609A (id) 2001-09-06
EP1090022A1 (de) 2001-04-11
BR9911482A (pt) 2002-01-22
EP1090022B1 (de) 2003-08-06
AU4774499A (en) 2000-01-10
AU750462B2 (en) 2002-07-18

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