SI1567112T1 - Thiazolidin-4-oni za inhibiranje proteinov hyak3 - Google Patents
Thiazolidin-4-oni za inhibiranje proteinov hyak3Info
- Publication number
- SI1567112T1 SI1567112T1 SI200331463T SI200331463T SI1567112T1 SI 1567112 T1 SI1567112 T1 SI 1567112T1 SI 200331463 T SI200331463 T SI 200331463T SI 200331463 T SI200331463 T SI 200331463T SI 1567112 T1 SI1567112 T1 SI 1567112T1
- Authority
- SI
- Slovenia
- Prior art keywords
- thiazolidin
- ones
- hyak3 proteins
- inhibiting hyak3
- inhibiting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42838402P | 2002-11-22 | 2002-11-22 | |
| EP03796448A EP1567112B1 (en) | 2002-11-22 | 2003-11-18 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS |
| PCT/US2003/037658 WO2004047760A2 (en) | 2002-11-22 | 2003-11-18 | Novel chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1567112T1 true SI1567112T1 (sl) | 2009-02-28 |
Family
ID=32393394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200331463T SI1567112T1 (sl) | 2002-11-22 | 2003-11-18 | Thiazolidin-4-oni za inhibiranje proteinov hyak3 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7767701B2 (sl) |
| EP (1) | EP1567112B1 (sl) |
| JP (1) | JP2006509765A (sl) |
| KR (1) | KR20050085115A (sl) |
| CN (1) | CN100579978C (sl) |
| AP (1) | AP1967A (sl) |
| AR (1) | AR045407A1 (sl) |
| AT (1) | ATE411302T1 (sl) |
| AU (1) | AU2003298693B2 (sl) |
| BR (1) | BR0316502A (sl) |
| CA (1) | CA2507256A1 (sl) |
| CY (1) | CY1108655T1 (sl) |
| DE (1) | DE60324178D1 (sl) |
| DK (1) | DK1567112T3 (sl) |
| EA (1) | EA008865B1 (sl) |
| EC (1) | ECSP055808A (sl) |
| ES (1) | ES2315566T3 (sl) |
| HK (1) | HK1083443A1 (sl) |
| IS (1) | IS2659B (sl) |
| MA (1) | MA27701A1 (sl) |
| MX (1) | MXPA05005406A (sl) |
| MY (1) | MY140132A (sl) |
| NO (1) | NO20052928L (sl) |
| NZ (1) | NZ539873A (sl) |
| OA (1) | OA12963A (sl) |
| PL (1) | PL377564A1 (sl) |
| PT (1) | PT1567112E (sl) |
| SI (1) | SI1567112T1 (sl) |
| TW (1) | TWI309648B (sl) |
| UA (1) | UA80572C2 (sl) |
| WO (1) | WO2004047760A2 (sl) |
Families Citing this family (36)
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|---|---|---|---|---|
| SI1470124T1 (sl) | 2002-01-22 | 2006-04-30 | Warner Lambert Co | 2-(piridin-2-ilamino)-pirido(2,3-d)pirimidin-7-oni |
| EP1648889B1 (en) * | 2003-07-11 | 2008-10-29 | Warner-Lambert Company LLC | Isethionate salt of a selective cdk4 inhibitor |
| US8106214B2 (en) * | 2003-07-28 | 2012-01-31 | Merck Serono Sa | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors |
| EP2295418A1 (en) | 2003-11-21 | 2011-03-16 | Actelion Pharmaceuticals Ltd. | 5-(benz-(z)-ylidene)-thiazolidin-4-one derivatives as immunosuppressant agents |
| USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| JP2007523957A (ja) * | 2004-02-25 | 2007-08-23 | スミスクライン・ビーチャム・コーポレイション | 新規化学化合物 |
| AR050253A1 (es) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
| EP1765817A1 (en) * | 2004-07-01 | 2007-03-28 | F.Hoffmann-La Roche Ag | Thiazolinone unsubstituted quinolines |
| AU2005259511A1 (en) * | 2004-07-01 | 2006-01-12 | F. Hoffmann-La Roche Ag | Quinoline thiazolinones with CDK1 antiproliferative activity |
| US7241893B2 (en) * | 2004-09-17 | 2007-07-10 | Hoffman-La Roche Inc. | Thiazolinone 2-substituted quinolines |
| US7253285B2 (en) | 2004-09-17 | 2007-08-07 | Hoffmann-La Roche Inc. | Thiazolinone 4-monosubstituted quinolines |
| AU2005293556A1 (en) * | 2004-10-12 | 2006-04-20 | Merck Serono Sa | PI3 Kinase gamma inhibitors for the treatment of anaemia |
| ES2301066T3 (es) * | 2004-10-14 | 2008-06-16 | F. Hoffmann-La Roche Ag | Nuevas azaindol-tiazolinonas como agentes anti-cancerosos. |
| JP2008516905A (ja) * | 2004-10-14 | 2008-05-22 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｄｋ１抗増殖活性を有する１，５−ナフチリジンアゾリジノン |
| US7501428B2 (en) | 2004-10-14 | 2009-03-10 | Hoffmann-La Roche Inc. | Quinazoline thiazolinones |
| US7304074B2 (en) | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| AR053602A1 (es) * | 2005-05-03 | 2007-05-09 | Smithkline Beecham Corp | Compuesto de 2- arilamino -4-oxo-1,3-tiazol-5(4h)- substituido, composicion farmaceutica que lo comprende, proceso para prepararla y uso del compuesto para preparar un medicamento |
| JP2008545690A (ja) * | 2005-05-23 | 2008-12-18 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
| PE20070083A1 (es) * | 2005-06-08 | 2007-01-27 | Smithkline Beecham Corp | (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona |
| US20080194466A1 (en) * | 2005-06-08 | 2008-08-14 | Duffy Kevin J | (5Z)-5-(6-Quinoxalinylmethylidene)-2-[(2,4,6-Trichlorophenyl)Amino]-1,3-Thiazol-4(5H)-One |
| TW200745066A (en) | 2005-09-16 | 2007-12-16 | Torrent Pharmaceuticals Ltd | Novel PTP1B inhibitors |
| JP2009514984A (ja) * | 2005-11-08 | 2009-04-09 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
| US20100216801A1 (en) * | 2006-03-02 | 2010-08-26 | Dashyant Dhanak | Thiazolones for use as pi3 kinase inhibitors |
| JP2009528383A (ja) * | 2006-03-02 | 2009-08-06 | スミスクライン・ビーチャム・コーポレイション | Ｐｉ３キナーゼ阻害剤として用いるためのチアゾロン |
| KR100752757B1 (ko) * | 2006-04-05 | 2007-08-29 | 한국과학기술연구원 | 2-페닐이미노-1,3-티아졸린을 포함하는 미백 조성물 |
| CA2650028A1 (en) * | 2006-04-25 | 2007-11-08 | The Cleveland Clinic Foundation | Anti-viral agents that activate rnase l |
| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| CN101541772B (zh) * | 2006-11-23 | 2013-04-17 | 埃科特莱茵药品有限公司 | 一种制备2-亚氨基-四氢噻唑-4-酮衍生物的新方法 |
| US20100286041A1 (en) * | 2007-03-22 | 2010-11-11 | Smithkline Beecham Corporation | (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one |
| CN101274918A (zh) * | 2007-03-30 | 2008-10-01 | 中国科学院上海药物研究所 | 一类取代五元杂环化合物,其制备方法和医学用途 |
| WO2010122979A1 (ja) | 2009-04-20 | 2010-10-28 | Ｓｂｉバイオテック株式会社 | チアゾリジノン誘導体 |
| ES2820553T3 (es) | 2012-07-30 | 2021-04-21 | Univ Kyoto | Compuesto y composición farmacéutica para trastorno neuropsicológico o tumor maligno |
| DK2885266T3 (da) | 2012-08-17 | 2020-06-08 | Actelion Pharmaceuticals Ltd | Fremgangsmåde til fremstilling af (2z,5z)-5-(3-chlor-4-((r)-2,3-dihydroxypropoxy)benzyliden)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-on og mellemprodukt, der anvendes i fremgangsmåden |
| RU2521390C1 (ru) * | 2013-03-14 | 2014-06-27 | Общество с ограниченной ответственностью "Тиацен" | Производное роданина и средство для профилактики опухолевых заболеваний |
| WO2015181337A1 (en) * | 2014-05-28 | 2015-12-03 | Universität Bern | Thiazolidinone compounds and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation |
| CN104370852B (zh) * | 2014-11-26 | 2016-04-20 | 山东大学 | 一种噻唑烷酮类化合物及其在制备治疗铁紊乱相关疾病药物中的应用 |
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| DE10115227A1 (de) | 2001-03-28 | 2002-12-19 | Bayer Ag | Optischer Datenträger enthaltend in der Informationsschicht eine lichtabsorbierende Verbindung mit mehreren chromophoren Zentren |
| US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
| TW200304375A (en) | 2001-12-06 | 2003-10-01 | Maxia Pharmaceuticals Inc | 2-Substituted thiazolidinone and oxazolidinone derivatives for the inhibition of phosphatases and the treatment of cancer |
-
2003
- 2003-11-18 UA UAA200504788A patent/UA80572C2/uk unknown
- 2003-11-18 CA CA002507256A patent/CA2507256A1/en not_active Abandoned
- 2003-11-18 CN CN200380109119A patent/CN100579978C/zh not_active Expired - Fee Related
- 2003-11-18 EP EP03796448A patent/EP1567112B1/en not_active Expired - Lifetime
- 2003-11-18 US US10/535,690 patent/US7767701B2/en not_active Expired - Fee Related
- 2003-11-18 AU AU2003298693A patent/AU2003298693B2/en not_active Ceased
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