IS2659B - Þíasólidín-4-ón til að hamla gegn Hyak3 próteinum - Google Patents

Þíasólidín-4-ón til að hamla gegn Hyak3 próteinum

Info

Publication number
IS2659B
IS2659B IS7879A IS7879A IS2659B IS 2659 B IS2659 B IS 2659B IS 7879 A IS7879 A IS 7879A IS 7879 A IS7879 A IS 7879A IS 2659 B IS2659 B IS 2659B
Authority
IS
Iceland
Prior art keywords
thiazolidin
inhibit
protein
hyak3 protein
inhibit hyak3
Prior art date
Application number
IS7879A
Other languages
English (en)
Other versions
IS7879A (is
Inventor
Masaichi Hasegawa
Jun Tang
Hideyuki Sato
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of IS7879A publication Critical patent/IS7879A/is
Publication of IS2659B publication Critical patent/IS2659B/is

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IS7879A 2002-11-22 2005-06-02 Þíasólidín-4-ón til að hamla gegn Hyak3 próteinum IS2659B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42838402P 2002-11-22 2002-11-22
PCT/US2003/037658 WO2004047760A2 (en) 2002-11-22 2003-11-18 Novel chemical compounds

Publications (2)

Publication Number Publication Date
IS7879A IS7879A (is) 2005-06-02
IS2659B true IS2659B (is) 2010-08-15

Family

ID=32393394

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7879A IS2659B (is) 2002-11-22 2005-06-02 Þíasólidín-4-ón til að hamla gegn Hyak3 próteinum

Country Status (31)

Country Link
US (1) US7767701B2 (is)
EP (1) EP1567112B1 (is)
JP (1) JP2006509765A (is)
KR (1) KR20050085115A (is)
CN (1) CN100579978C (is)
AP (1) AP1967A (is)
AR (1) AR045407A1 (is)
AT (1) ATE411302T1 (is)
AU (1) AU2003298693B2 (is)
BR (1) BR0316502A (is)
CA (1) CA2507256A1 (is)
CY (1) CY1108655T1 (is)
DE (1) DE60324178D1 (is)
DK (1) DK1567112T3 (is)
EA (1) EA008865B1 (is)
EC (1) ECSP055808A (is)
ES (1) ES2315566T3 (is)
HK (1) HK1083443A1 (is)
IS (1) IS2659B (is)
MA (1) MA27701A1 (is)
MX (1) MXPA05005406A (is)
MY (1) MY140132A (is)
NO (1) NO20052928L (is)
NZ (1) NZ539873A (is)
OA (1) OA12963A (is)
PL (1) PL377564A1 (is)
PT (1) PT1567112E (is)
SI (1) SI1567112T1 (is)
TW (1) TWI309648B (is)
UA (1) UA80572C2 (is)
WO (1) WO2004047760A2 (is)

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CN101906104B (zh) 2002-01-22 2013-06-05 沃尼尔·朗伯有限责任公司 2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮
CN1835951B (zh) * 2003-07-11 2010-06-02 沃尼尔·朗伯有限责任公司 选择性cdk4抑制剂的羟乙基磺酸盐
DE602004022170D1 (de) * 2003-07-28 2009-09-03 Merck Serono Sa Coinsins 2-imino-4-(thio)oxo-5-polycyclovinylazoline zur verwendung als pi3-kinase-inhibtoren
PL1689726T3 (pl) 2003-11-21 2011-05-31 Actelion Pharmaceuticals Ltd Pochodne 5-(benz-(z)-ylideno)tiazolidyn-4-onu jako środki immunosupresyjne
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
WO2005082901A1 (en) * 2004-02-25 2005-09-09 Smithkline Beecham Corporation Novel chemical compounds
PE20060373A1 (es) 2004-06-24 2006-04-29 Smithkline Beecham Corp Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2
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CN100569773C (zh) * 2004-10-14 2009-12-16 霍夫曼-拉罗奇有限公司 作为抗癌剂的新型吖吲哚噻唑啉酮
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TW200716580A (en) * 2005-06-08 2007-05-01 Smithkline Beecham Corp (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one
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JP2009514984A (ja) * 2005-11-08 2009-04-09 スミスクライン・ビーチャム・コーポレイション 新規化合物
US20100216801A1 (en) * 2006-03-02 2010-08-26 Dashyant Dhanak Thiazolones for use as pi3 kinase inhibitors
WO2007103754A2 (en) * 2006-03-02 2007-09-13 Smithkline Beecham Corporation Thiazolones for use as pi3 kinase inhibitors
KR100752757B1 (ko) * 2006-04-05 2007-08-29 한국과학기술연구원 2-페닐이미노-1,3-티아졸린을 포함하는 미백 조성물
KR20090007609A (ko) * 2006-04-25 2009-01-19 더 클리브랜드 클리닉 파운데이션 ＲＮａｓｅ Ｌ을 활성화시키는 항-바이러스 제제
CN101541772B (zh) * 2006-11-23 2013-04-17 埃科特莱茵药品有限公司 一种制备2-亚氨基-四氢噻唑-4-酮衍生物的新方法
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
US20100286041A1 (en) * 2007-03-22 2010-11-11 Smithkline Beecham Corporation (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one
CN101274918A (zh) * 2007-03-30 2008-10-01 中国科学院上海药物研究所 一类取代五元杂环化合物,其制备方法和医学用途
US8119812B2 (en) 2009-04-20 2012-02-21 Sbi Biotech Co., Ltd. Thiazolidinone derivative
CN106986865B (zh) * 2012-07-30 2020-02-28 国立大学法人京都大学 关于精神神经疾病或恶性肿瘤的化合物及医药组合物
CN104540800B (zh) 2012-08-17 2017-05-10 埃科特莱茵药品有限公司 制备(2z,5z)‑5‑(3‑氯‑4‑((r)‑2,3‑二羟基丙氧基)苯亚甲基)‑2‑(丙亚氨基)‑3‑(邻甲苯基)噻唑烷‑4‑酮的方法及在该方法中所用的中间产物
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Also Published As

Publication number Publication date
AU2003298693A1 (en) 2004-06-18
ATE411302T1 (de) 2008-10-15
NO20052928L (no) 2005-08-17
WO2004047760A2 (en) 2004-06-10
DK1567112T3 (da) 2009-02-09
DE60324178D1 (de) 2008-11-27
ES2315566T3 (es) 2009-04-01
IS7879A (is) 2005-06-02
PL377564A1 (pl) 2006-02-06
NZ539873A (en) 2008-09-26
MA27701A1 (fr) 2006-01-02
OA12963A (en) 2006-10-13
TWI309648B (en) 2009-05-11
MXPA05005406A (es) 2005-08-03
CY1108655T1 (el) 2014-04-09
BR0316502A (pt) 2005-10-04
MY140132A (en) 2009-11-30
JP2006509765A (ja) 2006-03-23
EA200500856A1 (ru) 2005-10-27
HK1083443A1 (en) 2006-07-07
KR20050085115A (ko) 2005-08-29
US7767701B2 (en) 2010-08-03
CA2507256A1 (en) 2004-06-10
CN100579978C (zh) 2010-01-13
AU2003298693B2 (en) 2010-09-30
WO2004047760A3 (en) 2004-10-21
ECSP055808A (es) 2005-09-20
AP1967A (en) 2009-03-10
SI1567112T1 (sl) 2009-02-28
TW200418819A (en) 2004-10-01
CN1742010A (zh) 2006-03-01
NO20052928D0 (no) 2005-06-15
EP1567112A2 (en) 2005-08-31
UA80572C2 (en) 2007-10-10
EA008865B1 (ru) 2007-08-31
US20060293338A1 (en) 2006-12-28
AR045407A1 (es) 2005-10-26
EP1567112B1 (en) 2008-10-15
EP1567112A4 (en) 2006-11-15
PT1567112E (pt) 2009-01-08
AP2005003304A0 (en) 2005-06-30

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