ATE411302T1 - Thiazolidin-4-ones um hyak3 proteinen zu hemmen - Google Patents

Thiazolidin-4-ones um hyak3 proteinen zu hemmen

Info

Publication number
ATE411302T1
ATE411302T1 AT03796448T AT03796448T ATE411302T1 AT E411302 T1 ATE411302 T1 AT E411302T1 AT 03796448 T AT03796448 T AT 03796448T AT 03796448 T AT03796448 T AT 03796448T AT E411302 T1 ATE411302 T1 AT E411302T1
Authority
AT
Austria
Prior art keywords
thiazolidin
ones
inhibit
hyak3 proteins
proteins
Prior art date
Application number
AT03796448T
Other languages
English (en)
Inventor
Masaichi Hasegawa
Jun Tang
Hideyuki Sato
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE411302T1 publication Critical patent/ATE411302T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03796448T 2002-11-22 2003-11-18 Thiazolidin-4-ones um hyak3 proteinen zu hemmen ATE411302T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42838402P 2002-11-22 2002-11-22

Publications (1)

Publication Number Publication Date
ATE411302T1 true ATE411302T1 (de) 2008-10-15

Family

ID=32393394

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03796448T ATE411302T1 (de) 2002-11-22 2003-11-18 Thiazolidin-4-ones um hyak3 proteinen zu hemmen

Country Status (31)

Country Link
US (1) US7767701B2 (de)
EP (1) EP1567112B1 (de)
JP (1) JP2006509765A (de)
KR (1) KR20050085115A (de)
CN (1) CN100579978C (de)
AP (1) AP1967A (de)
AR (1) AR045407A1 (de)
AT (1) ATE411302T1 (de)
AU (1) AU2003298693B2 (de)
BR (1) BR0316502A (de)
CA (1) CA2507256A1 (de)
CY (1) CY1108655T1 (de)
DE (1) DE60324178D1 (de)
DK (1) DK1567112T3 (de)
EA (1) EA008865B1 (de)
EC (1) ECSP055808A (de)
ES (1) ES2315566T3 (de)
HK (1) HK1083443A1 (de)
IS (1) IS2659B (de)
MA (1) MA27701A1 (de)
MX (1) MXPA05005406A (de)
MY (1) MY140132A (de)
NO (1) NO20052928L (de)
NZ (1) NZ539873A (de)
OA (1) OA12963A (de)
PL (1) PL377564A1 (de)
PT (1) PT1567112E (de)
SI (1) SI1567112T1 (de)
TW (1) TWI309648B (de)
UA (1) UA80572C2 (de)
WO (1) WO2004047760A2 (de)

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Also Published As

Publication number Publication date
DE60324178D1 (de) 2008-11-27
OA12963A (en) 2006-10-13
MA27701A1 (fr) 2006-01-02
AR045407A1 (es) 2005-10-26
UA80572C2 (en) 2007-10-10
IS2659B (is) 2010-08-15
EA200500856A1 (ru) 2005-10-27
EP1567112A4 (de) 2006-11-15
AU2003298693A1 (en) 2004-06-18
PT1567112E (pt) 2009-01-08
EP1567112A2 (de) 2005-08-31
CA2507256A1 (en) 2004-06-10
WO2004047760A2 (en) 2004-06-10
WO2004047760A3 (en) 2004-10-21
TWI309648B (en) 2009-05-11
NZ539873A (en) 2008-09-26
NO20052928D0 (no) 2005-06-15
CY1108655T1 (el) 2014-04-09
KR20050085115A (ko) 2005-08-29
AP1967A (en) 2009-03-10
PL377564A1 (pl) 2006-02-06
DK1567112T3 (da) 2009-02-09
AU2003298693B2 (en) 2010-09-30
ECSP055808A (es) 2005-09-20
TW200418819A (en) 2004-10-01
NO20052928L (no) 2005-08-17
CN100579978C (zh) 2010-01-13
CN1742010A (zh) 2006-03-01
SI1567112T1 (sl) 2009-02-28
JP2006509765A (ja) 2006-03-23
MXPA05005406A (es) 2005-08-03
MY140132A (en) 2009-11-30
ES2315566T3 (es) 2009-04-01
US7767701B2 (en) 2010-08-03
EP1567112B1 (de) 2008-10-15
AP2005003304A0 (en) 2005-06-30
BR0316502A (pt) 2005-10-04
HK1083443A1 (en) 2006-07-07
IS7879A (is) 2005-06-02
US20060293338A1 (en) 2006-12-28
EA008865B1 (ru) 2007-08-31

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