BR0316502A - Compostos quìmicos - Google Patents

Compostos quìmicos

Info

Publication number
BR0316502A
BR0316502A BR0316502-7A BR0316502A BR0316502A BR 0316502 A BR0316502 A BR 0316502A BR 0316502 A BR0316502 A BR 0316502A BR 0316502 A BR0316502 A BR 0316502A
Authority
BR
Brazil
Prior art keywords
chemical compounds
hyak3
compounds
inhibition
methods
Prior art date
Application number
BR0316502-7A
Other languages
English (en)
Inventor
Masaichi Hasegawa
Jun Tang
Hideyuki Sato
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR0316502A publication Critical patent/BR0316502A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTOS QUìMICOS". A presente invenção se refere a compostos recém identificados para a inibição de proteínas Hyak3 e a métodos para o tratamento de doenças associadas com o desequilíbrio ou com a atividade inadequada das proteínas Hyak3.
BR0316502-7A 2002-11-22 2003-11-18 Compostos quìmicos BR0316502A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42838402P 2002-11-22 2002-11-22
PCT/US2003/037658 WO2004047760A2 (en) 2002-11-22 2003-11-18 Novel chemical compounds

Publications (1)

Publication Number Publication Date
BR0316502A true BR0316502A (pt) 2005-10-04

Family

ID=32393394

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316502-7A BR0316502A (pt) 2002-11-22 2003-11-18 Compostos quìmicos

Country Status (31)

Country Link
US (1) US7767701B2 (pt)
EP (1) EP1567112B1 (pt)
JP (1) JP2006509765A (pt)
KR (1) KR20050085115A (pt)
CN (1) CN100579978C (pt)
AP (1) AP1967A (pt)
AR (1) AR045407A1 (pt)
AT (1) ATE411302T1 (pt)
AU (1) AU2003298693B2 (pt)
BR (1) BR0316502A (pt)
CA (1) CA2507256A1 (pt)
CY (1) CY1108655T1 (pt)
DE (1) DE60324178D1 (pt)
DK (1) DK1567112T3 (pt)
EA (1) EA008865B1 (pt)
EC (1) ECSP055808A (pt)
ES (1) ES2315566T3 (pt)
HK (1) HK1083443A1 (pt)
IS (1) IS2659B (pt)
MA (1) MA27701A1 (pt)
MX (1) MXPA05005406A (pt)
MY (1) MY140132A (pt)
NO (1) NO20052928L (pt)
NZ (1) NZ539873A (pt)
OA (1) OA12963A (pt)
PL (1) PL377564A1 (pt)
PT (1) PT1567112E (pt)
SI (1) SI1567112T1 (pt)
TW (1) TWI309648B (pt)
UA (1) UA80572C2 (pt)
WO (1) WO2004047760A2 (pt)

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DE602004022170D1 (de) * 2003-07-28 2009-09-03 Merck Serono Sa Coinsins 2-imino-4-(thio)oxo-5-polycyclovinylazoline zur verwendung als pi3-kinase-inhibtoren
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
BRPI0416752B8 (pt) 2003-11-21 2021-05-25 Actelion Pharmaceuticals Ltd composição farmacêutica, uso de um ou mais compostos, e, compostos
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ATE388149T1 (de) * 2004-10-14 2008-03-15 Hoffmann La Roche Neue azaindol-thiazolinone als krebsmittel
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US20080194466A1 (en) * 2005-06-08 2008-08-14 Duffy Kevin J (5Z)-5-(6-Quinoxalinylmethylidene)-2-[(2,4,6-Trichlorophenyl)Amino]-1,3-Thiazol-4(5H)-One
TW200745066A (en) 2005-09-16 2007-12-16 Torrent Pharmaceuticals Ltd Novel PTP1B inhibitors
JP2009514984A (ja) * 2005-11-08 2009-04-09 スミスクライン・ビーチャム・コーポレイション 新規化合物
JP2009528386A (ja) * 2006-03-02 2009-08-06 スミスクライン・ビーチャム・コーポレイション Ｐｉ３キナーゼ阻害剤として用いるためのチアゾロン
JP2009528383A (ja) * 2006-03-02 2009-08-06 スミスクライン・ビーチャム・コーポレイション Ｐｉ３キナーゼ阻害剤として用いるためのチアゾロン
KR100752757B1 (ko) * 2006-04-05 2007-08-29 한국과학기술연구원 2-페닐이미노-1,3-티아졸린을 포함하는 미백 조성물
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Also Published As

Publication number Publication date
DE60324178D1 (de) 2008-11-27
WO2004047760A3 (en) 2004-10-21
MY140132A (en) 2009-11-30
EP1567112A4 (en) 2006-11-15
CN100579978C (zh) 2010-01-13
PT1567112E (pt) 2009-01-08
US7767701B2 (en) 2010-08-03
OA12963A (en) 2006-10-13
NO20052928L (no) 2005-08-17
NO20052928D0 (no) 2005-06-15
MXPA05005406A (es) 2005-08-03
SI1567112T1 (sl) 2009-02-28
AU2003298693B2 (en) 2010-09-30
NZ539873A (en) 2008-09-26
AR045407A1 (es) 2005-10-26
AP2005003304A0 (en) 2005-06-30
IS2659B (is) 2010-08-15
MA27701A1 (fr) 2006-01-02
PL377564A1 (pl) 2006-02-06
IS7879A (is) 2005-06-02
TWI309648B (en) 2009-05-11
AP1967A (en) 2009-03-10
US20060293338A1 (en) 2006-12-28
DK1567112T3 (da) 2009-02-09
ECSP055808A (es) 2005-09-20
CA2507256A1 (en) 2004-06-10
EP1567112B1 (en) 2008-10-15
UA80572C2 (en) 2007-10-10
TW200418819A (en) 2004-10-01
ATE411302T1 (de) 2008-10-15
EA200500856A1 (ru) 2005-10-27
EA008865B1 (ru) 2007-08-31
ES2315566T3 (es) 2009-04-01
EP1567112A2 (en) 2005-08-31
CN1742010A (zh) 2006-03-01
KR20050085115A (ko) 2005-08-29
AU2003298693A1 (en) 2004-06-18
WO2004047760A2 (en) 2004-06-10
HK1083443A1 (en) 2006-07-07
JP2006509765A (ja) 2006-03-23
CY1108655T1 (el) 2014-04-09

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