EA200100701A1 - Белки наружной поверхности, их гены и их применение - Google Patents
Белки наружной поверхности, их гены и их применениеInfo
- Publication number
- EA200100701A1 EA200100701A1 EA200100701A EA200100701A EA200100701A1 EA 200100701 A1 EA200100701 A1 EA 200100701A1 EA 200100701 A EA200100701 A EA 200100701A EA 200100701 A EA200100701 A EA 200100701A EA 200100701 A1 EA200100701 A1 EA 200100701A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- genes
- application
- surface proteins
- vaccines
- localized
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000018697 Membrane Proteins Human genes 0.000 title 1
- 108010052285 Membrane Proteins Proteins 0.000 title 1
- 241000194017 Streptococcus Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1018—Carboxy- and carbamoyl transferases (2.1.3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Согласно данному изобретению идентифицирована серия генов Streptococcus группы B, продукты которых могут быть локализованы на наружной поверхности организма. Гены или их функциональные фрагменты могут быть пригодны для получения терапевтических средств, например вакцин для иммунизации пациентов, направленных против микробной инфекции.Отчет о международном поиске был опубликован 2001.09.20.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9828346.8A GB9828346D0 (en) | 1998-12-22 | 1998-12-22 | Protein and compositions containing it |
GBGB9901233.8A GB9901233D0 (en) | 1999-01-20 | 1999-01-20 | Protein and compositions containing it |
GBGB9901234.6A GB9901234D0 (en) | 1999-01-20 | 1999-01-20 | Protein and compositions containing it |
GBGB9908321.4A GB9908321D0 (en) | 1999-04-12 | 1999-04-12 | Purine nucleoside phosphatase and compositions containing it |
GBGB9912036.2A GB9912036D0 (en) | 1999-05-24 | 1999-05-24 | Glucose-6-phosphate isomerase and compositions containing it |
GBGB9922596.3A GB9922596D0 (en) | 1999-09-23 | 1999-09-23 | Protein and compositions containing it |
PCT/GB1999/004376 WO2000037490A2 (en) | 1998-12-22 | 1999-12-22 | Outer surface proteins, their genes, and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100701A1 true EA200100701A1 (ru) | 2001-12-24 |
EA009885B1 EA009885B1 (ru) | 2008-04-28 |
Family
ID=27547330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100701A EA009885B1 (ru) | 1998-12-22 | 1999-12-22 | Применение пептидов бактерий streptococcus группы b, кодирующего их полинуклеотида, вакцина и антитело |
Country Status (24)
Country | Link |
---|---|
US (3) | US7217415B1 (ru) |
EP (2) | EP1140994B1 (ru) |
JP (1) | JP2002533065A (ru) |
KR (4) | KR100818815B1 (ru) |
CN (3) | CN1733800A (ru) |
AP (1) | AP2006003504A0 (ru) |
AT (1) | ATE297995T1 (ru) |
AU (1) | AU758722B2 (ru) |
BR (1) | BR9916473A (ru) |
CA (1) | CA2354843A1 (ru) |
CZ (1) | CZ20012174A3 (ru) |
DE (1) | DE69925866T2 (ru) |
DK (1) | DK1140994T3 (ru) |
EA (1) | EA009885B1 (ru) |
ES (1) | ES2241352T3 (ru) |
HK (1) | HK1039339A1 (ru) |
HU (1) | HUP0201022A3 (ru) |
NO (1) | NO20013101L (ru) |
NZ (4) | NZ542777A (ru) |
OA (1) | OA12425A (ru) |
PL (1) | PL351027A1 (ru) |
PT (1) | PT1140994E (ru) |
SI (1) | SI1140994T1 (ru) |
WO (1) | WO2000037490A2 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
OA12425A (en) * | 1998-12-22 | 2006-04-18 | Microscience Ltd | Outer surface proteins, their genes, and their use. |
PL201887B1 (pl) * | 1998-12-22 | 2009-05-29 | Microscience Ltd | Peptyd, polinukleotyd kodujący ten peptyd, szczepionka, zastosowanie peptydu i polinukleotydu kodującego ten peptyd oraz przeciwciało |
US6890539B2 (en) * | 1998-12-22 | 2005-05-10 | Microscience, Ltd. | Genes and proteins, and their use |
EP2104512A2 (en) * | 2006-12-21 | 2009-09-30 | Emergent Product Development UK Limited | Streptococcus proteins, and their use in vaccination |
CN103060284A (zh) * | 2012-10-31 | 2013-04-24 | 内蒙古民族大学 | 一种无乳链球菌pgk亚单位重组蛋白及其制备方法 |
CN110669711A (zh) * | 2019-08-09 | 2020-01-10 | 中国水产科学研究院珠江水产研究所 | 基于pgk基因的重组乳酸乳球菌和无乳链球菌病疫苗 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3678702D1 (de) * | 1985-12-28 | 1991-05-16 | Ohgen Research Lab Ltd | Antitumorprotein-gen von streptococcus pyogenes su, plasmide, die das gen enthalten, transformantenzellen, die die plasmide beherbergen, und verfahren zur herstellung des antitumorproteins. |
US5328996A (en) * | 1989-03-29 | 1994-07-12 | University Of Florida Research Foundation, Inc. | Bacterial plasmin receptors as fibrinolytic agents |
EP0672123A1 (en) * | 1992-01-08 | 1995-09-20 | The Rockefeller University | Multifunctional surface protein of streptococci |
IL107458A0 (en) | 1992-11-02 | 1994-02-27 | Gen Hospital Corp | Conjugate vaccine against group b streptococcus |
US6015889A (en) * | 1993-03-19 | 2000-01-18 | Gunnar Lindahl | Protein rib, a cell surface protein that confers immunity to many strains of the group B streptococcus: process for purification of the protein, reagent kit and pharmaceutical composition |
CA2158658A1 (en) * | 1993-03-19 | 1994-09-29 | Margaretha Stalhammar-Carlemalm | Protein rib, a cell surface protein that confers immunity to many strains of the group b streptococcus; process for purification of the protein, reagent kit and pharmaceutical composition |
US6346392B1 (en) * | 1996-11-27 | 2002-02-12 | Smithkline Beecham Corporation | Polynucleotides encoding a novel glutamine transport ATP-binding protein |
EP1400592A1 (en) * | 1996-10-31 | 2004-03-24 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
US7196164B2 (en) * | 1997-07-08 | 2007-03-27 | Human Genome Sciences, Inc. | Secreted protein HHTLF25 |
US6800744B1 (en) * | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
US7081530B1 (en) * | 1997-07-02 | 2006-07-25 | sanofi pasteur limitée | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
US6380370B1 (en) * | 1997-08-14 | 2002-04-30 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics |
US6165763A (en) * | 1997-10-30 | 2000-12-26 | Smithkline Beecham Corporation | Ornithine carbamoyltransferase |
US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
PL201887B1 (pl) * | 1998-12-22 | 2009-05-29 | Microscience Ltd | Peptyd, polinukleotyd kodujący ten peptyd, szczepionka, zastosowanie peptydu i polinukleotydu kodującego ten peptyd oraz przeciwciało |
OA12425A (en) * | 1998-12-22 | 2006-04-18 | Microscience Ltd | Outer surface proteins, their genes, and their use. |
US6890539B2 (en) * | 1998-12-22 | 2005-05-10 | Microscience, Ltd. | Genes and proteins, and their use |
US6605709B1 (en) * | 1999-04-09 | 2003-08-12 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Proteus mirabilis for diagnostics and therapeutics |
-
1999
- 1999-12-22 OA OA1000162A patent/OA12425A/en unknown
- 1999-12-22 AU AU18779/00A patent/AU758722B2/en not_active Ceased
- 1999-12-22 NZ NZ542777A patent/NZ542777A/en unknown
- 1999-12-22 PT PT99962421T patent/PT1140994E/pt unknown
- 1999-12-22 BR BR9916473-6A patent/BR9916473A/pt not_active Application Discontinuation
- 1999-12-22 DK DK99962421T patent/DK1140994T3/da active
- 1999-12-22 EA EA200100701A patent/EA009885B1/ru not_active IP Right Cessation
- 1999-12-22 US US09/868,195 patent/US7217415B1/en not_active Expired - Fee Related
- 1999-12-22 NZ NZ512296A patent/NZ512296A/en unknown
- 1999-12-22 DE DE69925866T patent/DE69925866T2/de not_active Expired - Fee Related
- 1999-12-22 CN CNA2005100047117A patent/CN1733800A/zh active Pending
- 1999-12-22 CA CA002354843A patent/CA2354843A1/en not_active Abandoned
- 1999-12-22 NZ NZ552871A patent/NZ552871A/en unknown
- 1999-12-22 WO PCT/GB1999/004376 patent/WO2000037490A2/en not_active Application Discontinuation
- 1999-12-22 JP JP2000589559A patent/JP2002533065A/ja active Pending
- 1999-12-22 ES ES99962421T patent/ES2241352T3/es not_active Expired - Lifetime
- 1999-12-22 AP AP2006003504A patent/AP2006003504A0/xx unknown
- 1999-12-22 EP EP99962421A patent/EP1140994B1/en not_active Expired - Lifetime
- 1999-12-22 EP EP05009397A patent/EP1574579A3/en not_active Withdrawn
- 1999-12-22 SI SI9930811T patent/SI1140994T1/sl unknown
- 1999-12-22 AT AT99962421T patent/ATE297995T1/de not_active IP Right Cessation
- 1999-12-22 CN CN99814781A patent/CN1357045A/zh active Pending
- 1999-12-22 CN CNA2008101761856A patent/CN101486756A/zh active Pending
- 1999-12-22 CZ CZ20012174A patent/CZ20012174A3/cs unknown
- 1999-12-22 KR KR1020017007910A patent/KR100818815B1/ko not_active IP Right Cessation
- 1999-12-22 HU HU0201022A patent/HUP0201022A3/hu unknown
- 1999-12-22 KR KR1020067017195A patent/KR100866170B1/ko not_active IP Right Cessation
- 1999-12-22 PL PL99351027A patent/PL351027A1/xx not_active IP Right Cessation
- 1999-12-22 NZ NZ525538A patent/NZ525538A/en unknown
-
2001
- 2001-06-21 NO NO20013101A patent/NO20013101L/no not_active Application Discontinuation
- 2001-12-20 HK HK01108929A patent/HK1039339A1/xx not_active IP Right Cessation
-
2005
- 2005-12-29 US US11/321,475 patent/US20060104990A1/en not_active Abandoned
-
2007
- 2007-01-26 KR KR1020070008368A patent/KR20070027665A/ko not_active Application Discontinuation
- 2007-08-17 US US11/892,013 patent/US20080226641A1/en not_active Abandoned
-
2008
- 2008-05-02 KR KR1020080041439A patent/KR20080052527A/ko not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |