ATE513917T1 - Bakterielle expression von proteaseinhibitoren und varianten davon - Google Patents
Bakterielle expression von proteaseinhibitoren und varianten davonInfo
- Publication number
- ATE513917T1 ATE513917T1 AT04800809T AT04800809T ATE513917T1 AT E513917 T1 ATE513917 T1 AT E513917T1 AT 04800809 T AT04800809 T AT 04800809T AT 04800809 T AT04800809 T AT 04800809T AT E513917 T1 ATE513917 T1 AT E513917T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- variants
- preferred embodiments
- protease inhibitors
- bacterial expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51815403P | 2003-11-06 | 2003-11-06 | |
US52040303P | 2003-11-13 | 2003-11-13 | |
US53118903P | 2003-12-19 | 2003-12-19 | |
US53120703P | 2003-12-19 | 2003-12-19 | |
US53095403P | 2003-12-19 | 2003-12-19 | |
PCT/US2004/036981 WO2005047511A2 (en) | 2003-11-06 | 2004-11-06 | Bacterial expression of protease inhibitors and variants thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE513917T1 true ATE513917T1 (de) | 2011-07-15 |
Family
ID=34596198
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04810432T ATE482972T1 (de) | 2003-11-06 | 2004-11-06 | Tgf-beta1-bindende und geträgerte peptide |
AT04810431T ATE530560T1 (de) | 2003-11-06 | 2004-11-06 | Vegf bindende und geträgerte peptide zur behandlung von hautkrankheiten |
AT04818640T ATE486087T1 (de) | 2003-11-06 | 2004-11-06 | Fgf-5-bindende und geträgerte peptide |
AT04800809T ATE513917T1 (de) | 2003-11-06 | 2004-11-06 | Bakterielle expression von proteaseinhibitoren und varianten davon |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04810432T ATE482972T1 (de) | 2003-11-06 | 2004-11-06 | Tgf-beta1-bindende und geträgerte peptide |
AT04810431T ATE530560T1 (de) | 2003-11-06 | 2004-11-06 | Vegf bindende und geträgerte peptide zur behandlung von hautkrankheiten |
AT04818640T ATE486087T1 (de) | 2003-11-06 | 2004-11-06 | Fgf-5-bindende und geträgerte peptide |
Country Status (9)
Country | Link |
---|---|
US (8) | US20080113917A1 (de) |
EP (4) | EP1692158B1 (de) |
JP (2) | JP4843497B2 (de) |
AT (4) | ATE482972T1 (de) |
CA (1) | CA2544820C (de) |
DE (2) | DE602004029393D1 (de) |
DK (2) | DK1692158T3 (de) |
ES (1) | ES2375360T3 (de) |
WO (4) | WO2005047511A2 (de) |
Families Citing this family (106)
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DK1689766T3 (da) * | 2003-11-06 | 2012-07-16 | Danisco Us Inc | Ekspression af proteaseinhibitorer og varianter deraf i filamentøse svampe |
EP1692158B1 (de) * | 2003-11-06 | 2011-10-26 | Danisco US Inc. | Vegf bindende und geträgerte peptide zur behandlung von hautkrankheiten |
ATE536552T1 (de) * | 2004-10-15 | 2011-12-15 | Danisco Us Inc | Kompetitven differential screening |
EP1880007A2 (de) * | 2005-05-05 | 2008-01-23 | Genencor International, Inc. | Körperpflegezusammensetzungen und verfahren zu ihrer verwendung |
AU2006256530B2 (en) | 2005-06-10 | 2012-12-20 | United Kingdom Research And Innovation | Scaffold |
TW200745159A (en) * | 2005-07-13 | 2007-12-16 | Avidia Inc | IL-6 binding proteins |
GB0601684D0 (en) * | 2006-01-27 | 2006-03-08 | Reckitt Benckiser Uk Ltd | Composition, process for preparation and method of use |
WO2007092465A2 (en) * | 2006-02-07 | 2007-08-16 | Dyao Pharmaceutical Corporation | Topical delivery compositions |
PL2061313T3 (pl) * | 2006-09-16 | 2014-01-31 | Soy Labs Llc | Zastosowanie peptydu sojowego (lunazyny) do obniżania poziomu cholesterolu całkowitego i ldl |
US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
US20080090745A1 (en) * | 2006-10-13 | 2008-04-17 | Fox Bryan P | Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp. |
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MX2009013084A (es) * | 2007-06-06 | 2010-01-18 | Danisco Us Inc Genencor Div | Metodos para mejorar las propiedades de la proteina. |
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US20100247693A1 (en) * | 2009-03-24 | 2010-09-30 | Marini Jan L | Cosmetic formulation to treat rosacea telangiectasia |
BRPI1012590A2 (pt) | 2009-04-08 | 2015-09-22 | Danisco Us Inc Genencor Div | alfa-amilases relacionadas à cepa wdg-195 de halomonas e métodos de uso das mesmas |
EP2421973B1 (de) | 2009-04-24 | 2018-05-23 | Danisco US Inc. | Proteasen mit modifizierten pro-bereichen |
WO2010127231A2 (en) * | 2009-05-01 | 2010-11-04 | Signal Investment And Management Co. | Moisturizing antimicrobial composition |
AR076941A1 (es) | 2009-06-11 | 2011-07-20 | Danisco Us Inc | Cepa de bacillus para una mayor produccion de proteina |
US20110052676A1 (en) * | 2009-09-01 | 2011-03-03 | James Vincent Gruber | Composition For Delaying Cellular Senescence |
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CN102762222B (zh) | 2009-12-09 | 2015-11-25 | 丹尼斯科美国公司 | 包含蛋白酶变体的组合物和方法 |
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US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
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