DE602004029393D1 - Tgf-beta1-bindende und geträgerte peptide - Google Patents

Tgf-beta1-bindende und geträgerte peptide

Info

Publication number
DE602004029393D1
DE602004029393D1 DE602004029393T DE602004029393T DE602004029393D1 DE 602004029393 D1 DE602004029393 D1 DE 602004029393D1 DE 602004029393 T DE602004029393 T DE 602004029393T DE 602004029393 T DE602004029393 T DE 602004029393T DE 602004029393 D1 DE602004029393 D1 DE 602004029393D1
Authority
DE
Germany
Prior art keywords
peptides
supported
tgf
preferred embodiments
supported peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004029393T
Other languages
English (en)
Inventor
Anthony G Day
David A Estell
Christopher J Murray
Scott D Power
Beverly R Turnquest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Danisco US Inc
Original Assignee
Danisco US Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco US Inc filed Critical Danisco US Inc
Publication of DE602004029393D1 publication Critical patent/DE602004029393D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
DE602004029393T 2003-11-06 2004-11-06 Tgf-beta1-bindende und geträgerte peptide Expired - Lifetime DE602004029393D1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US51815403P 2003-11-06 2003-11-06
US52040303P 2003-11-13 2003-11-13
US53095403P 2003-12-19 2003-12-19
US53120703P 2003-12-19 2003-12-19
US53118903P 2003-12-19 2003-12-19
PCT/US2004/036979 WO2005046710A2 (en) 2003-11-06 2004-11-06 Tgf-beta binding and supported peptides

Publications (1)

Publication Number Publication Date
DE602004029393D1 true DE602004029393D1 (de) 2010-11-11

Family

ID=34596198

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602004029393T Expired - Lifetime DE602004029393D1 (de) 2003-11-06 2004-11-06 Tgf-beta1-bindende und geträgerte peptide
DE602004029812T Expired - Lifetime DE602004029812D1 (de) 2003-11-06 2004-11-06 Fgf-5-bindende und geträgerte peptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE602004029812T Expired - Lifetime DE602004029812D1 (de) 2003-11-06 2004-11-06 Fgf-5-bindende und geträgerte peptide

Country Status (9)

Country Link
US (8) US20080113917A1 (de)
EP (4) EP1692159B1 (de)
JP (2) JP4843497B2 (de)
AT (4) ATE486087T1 (de)
CA (1) CA2544820C (de)
DE (2) DE602004029393D1 (de)
DK (2) DK1680507T3 (de)
ES (1) ES2375360T3 (de)
WO (4) WO2005047314A2 (de)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1692159B1 (de) * 2003-11-06 2010-09-29 Danisco US Inc. Tgf-beta1-bindende und geträgerte peptide
EP2292641B1 (de) * 2003-11-06 2017-12-06 Danisco US Inc. Expression in faserigen Pilzen von Proteasehemmern und Varianten davon
DK1800136T3 (da) * 2004-10-15 2012-03-26 Danisco Us Inc Kompetitiv differentiel screening
CA2607142C (en) * 2005-05-05 2014-03-25 Genencor International, Inc. Personal care compositions and methods for their use
AU2006256530B2 (en) 2005-06-10 2012-12-20 United Kingdom Research And Innovation Scaffold
TW200745159A (en) * 2005-07-13 2007-12-16 Avidia Inc IL-6 binding proteins
GB0601684D0 (en) * 2006-01-27 2006-03-08 Reckitt Benckiser Uk Ltd Composition, process for preparation and method of use
WO2007092465A2 (en) * 2006-02-07 2007-08-16 Dyao Pharmaceutical Corporation Topical delivery compositions
PL2061313T3 (pl) * 2006-09-16 2014-01-31 Soy Labs Llc Zastosowanie peptydu sojowego (lunazyny) do obniżania poziomu cholesterolu całkowitego i ldl
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
US20080090745A1 (en) * 2006-10-13 2008-04-17 Fox Bryan P Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp.
MX2009005734A (es) * 2006-12-18 2009-06-10 Danisco Us Inc Genencor Div Mediadores de lacasa y metodos de uso.
CN101563451B (zh) * 2006-12-21 2012-09-05 丹尼斯科美国公司 芽孢杆菌属物种195的α-淀粉酶多肽的组合物及用途
BRPI0812206A2 (pt) * 2007-06-06 2014-10-14 Danisco Us Inc Genencor Div Métodos para melhorar o desempenho de proteínas
US20090048136A1 (en) * 2007-08-15 2009-02-19 Mcdonald Hugh C Kappa-carrageenase and kappa-carrageenase-containing compositions
CN105400760A (zh) * 2007-10-31 2016-03-16 丹尼斯科美国公司 中性金属蛋白酶在无丝氨酸蛋白酶背景中的用途和生产
MX2010004325A (es) * 2007-11-01 2010-05-20 Danisco Us Inc Secuencias de señal y chaperones co-expresados para mejorar produccion de proteinas en una celula hospedera.
GB0722332D0 (en) * 2007-11-14 2007-12-27 Reckitt Benckiser Uk Ltd Personal care article
CA2713993A1 (en) * 2008-01-29 2009-08-06 Danisco Us Inc. Expression of streptomyces subtilisin inhibitor (ssi) proteins in bacillus and streptomyces sp.
WO2009100102A2 (en) 2008-02-04 2009-08-13 Danisco Us Inc., Genencor Division Ts23 alpha-amylase variants with altered properties
US7803902B2 (en) 2008-10-15 2010-09-28 Danisco Us Inc. Modified variant bowman birk protease inhibitors
US7772181B2 (en) 2008-10-15 2010-08-10 Danisco Us Inc. Personal care compositions comprising modified variant Bowman Birk Protease Inhibitors
BRPI0823193A2 (pt) * 2008-10-15 2019-09-24 Danisco Us Inc inibidores de protease de bowman birk variantes modificados
US8241623B1 (en) 2009-02-09 2012-08-14 David Bermudes Protease sensitivity expression system
CN102341495A (zh) 2009-03-10 2012-02-01 丹尼斯科美国公司 巨大芽孢杆菌菌株DSM90相关的α-淀粉酶及其使用方法
US20100247693A1 (en) * 2009-03-24 2010-09-30 Marini Jan L Cosmetic formulation to treat rosacea telangiectasia
CN102388131B (zh) 2009-04-08 2014-04-30 丹尼斯科美国公司 盐单胞菌属菌株WDG195相关α-淀粉酶及其使用方法
CN102414321A (zh) 2009-04-24 2012-04-11 丹尼斯科美国公司 具有修饰的原区的蛋白酶
BRPI1009982A2 (pt) * 2009-05-01 2017-06-27 Signal Investment & Man Co composição antimicrobiana hidratante
AR076941A1 (es) 2009-06-11 2011-07-20 Danisco Us Inc Cepa de bacillus para una mayor produccion de proteina
US20110052676A1 (en) * 2009-09-01 2011-03-03 James Vincent Gruber Composition For Delaying Cellular Senescence
EP2478003A4 (de) 2009-09-15 2013-05-29 Five Prime Therapeutics Inc Haarwuchsverfahren unter verwendung extrazellulärer fgfr4-domänen
GB0921001D0 (en) * 2009-11-30 2010-01-13 Aqua Bio Technology Asa Products and uses
DK2510094T3 (en) 2009-12-09 2017-03-13 Danisco Us Inc COMPOSITIONS AND METHODS OF COMPREHENSIVE PROTEASE VARIETIES
WO2011084711A2 (en) 2009-12-17 2011-07-14 Five Prime Therapeutics, Inc. Hair growth methods using fgfr3 extracellular domains
WO2011082335A2 (en) * 2009-12-30 2011-07-07 Solae, Llc Purified bowman-birk protease inhibitor proteins isolated from a soy processing stream
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
US8999916B2 (en) 2010-03-31 2015-04-07 Agency For Science, Technology And Research Crosslinked peptide hydrogels
US9687591B2 (en) 2010-03-31 2017-06-27 Agency For Science, Technology And Research Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes
ES2574056T3 (es) 2010-03-31 2016-06-14 Agency For Science, Technology And Research Péptido/peptoide anfifílico lineal e hidrogel que comprende el mismo
US20110281327A1 (en) 2010-04-15 2011-11-17 Danisco Us Inc. Compositions And Methods Comprising Variant Proteases
HUE045202T2 (hu) 2010-05-06 2019-12-30 Procter & Gamble Fogyasztási cikkek proteáz variánsokkal
US8481038B2 (en) 2010-11-15 2013-07-09 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins
TR201901382T4 (tr) 2011-05-05 2019-02-21 Danisco Inc Serin proteaz varyantlarını içeren bileşimler ve yöntemler.
MX357386B (es) 2011-05-05 2018-07-06 Procter & Gamble Composiciones y metodos que comprenden variantes de proteasa serina.
WO2013033318A1 (en) 2011-08-31 2013-03-07 Danisco Us Inc. Compositions and methods comprising a lipolytic enzyme variant
WO2013096653A1 (en) 2011-12-22 2013-06-27 Danisco Us Inc. Compositions and methods comprising a lipolytic enzyme variant
US9120841B2 (en) 2012-09-28 2015-09-01 Agency For Science, Technology And Research Amphiphilic linear peptidepeptoid and hydrogel comprising the same
KR20150067336A (ko) 2012-10-12 2015-06-17 다니스코 유에스 인크. 지방분해 효소 변이체를 포함하는 조성물 및 방법
CN104781400A (zh) 2012-11-05 2015-07-15 丹尼斯科美国公司 包含嗜热菌蛋白酶变体的组合物和方法
EP2935573A1 (de) 2012-12-19 2015-10-28 Danisco US Inc. Neuartige mannase, zusammensetzungen und verfahren zur verwendung davon
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
EP3004341B1 (de) 2013-05-29 2017-08-30 Danisco US Inc. Neuartige metalloproteasen
EP3004342B1 (de) 2013-05-29 2023-01-11 Danisco US Inc. Neuartige metalloproteasen
EP3636662B1 (de) 2013-05-29 2022-07-13 Danisco US Inc. Neuartige metalloproteasen
US20160160202A1 (en) 2013-05-29 2016-06-09 Danisco Us Inc. Novel metalloproteases
EP3022299B1 (de) 2013-07-19 2020-03-18 Danisco US Inc. Zusammensetzungen und verfahren mit einer variante eines lipolytischen enzyms
EP3653707B1 (de) 2013-09-12 2025-07-16 Danisco US Inc. Zusammensetzungen und verfahren mit lg12-klade-protease-varianten
CN105814078A (zh) 2013-10-11 2016-07-27 豪夫迈·罗氏有限公司 Nsp4抑制剂及其使用方法
RU2016117275A (ru) 2013-11-01 2017-12-04 Сфериум Биомед С.Л. Тельца включения для трансдермальной доставки терапевтических и косметических средств
EP3553173B1 (de) 2013-12-13 2021-05-19 Danisco US Inc. Serinproteasen des bazillus gibsonii-clade
DK3080262T3 (da) 2013-12-13 2019-05-06 Danisco Us Inc Serinproteaser af bacillus-arter
US9737592B1 (en) * 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
DK3119884T3 (da) 2014-03-21 2019-10-14 Danisco Us Inc Serinproteaser af bacillus-arter
WO2016061438A1 (en) 2014-10-17 2016-04-21 Danisco Us Inc. Serine proteases of bacillus species
EP4403631A3 (de) 2014-10-27 2024-10-30 Danisco US Inc. Serinproteasen
EP3212662B1 (de) 2014-10-27 2020-04-08 Danisco US Inc. Serinproteasen
EP3957729A1 (de) 2014-10-27 2022-02-23 Danisco US Inc. Serinproteasen
WO2016069557A1 (en) 2014-10-27 2016-05-06 Danisco Us Inc. Serine proteases of bacillus species
DK3212781T3 (da) 2014-10-27 2019-12-16 Danisco Us Inc Serinproteaser
EP3611259A1 (de) 2015-03-12 2020-02-19 Danisco US Inc. Zusammensetzungen und verfahren mit lg12-klade-proteasevarianten
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
JP7274819B2 (ja) 2015-05-13 2023-05-17 ダニスコ・ユーエス・インク ＡｐｒＬ－ＣＬＡＤＥプロテアーゼ変異体及びその使用
JP7015695B2 (ja) 2015-06-17 2022-02-03 ダニスコ・ユーエス・インク バチルス・ギブソニイ（Ｂａｃｉｌｌｕｓ ｇｉｂｓｏｎｉｉ）クレードセリンプロテアーゼ
CN107922934A (zh) 2015-06-17 2018-04-17 丹尼斯科美国公司 具有经修饰的前肽区域的蛋白酶
CN107022432A (zh) * 2016-01-29 2017-08-08 高露洁-棕榄公司 清洁组合物
EP3452584B1 (de) 2016-05-05 2021-01-06 Danisco US Inc. Proteasevarianten und verwendungen davon
MX2018014768A (es) 2016-05-31 2019-03-06 Danisco Us Inc Variantes de proteasa y sus usos.
JP7152319B2 (ja) 2016-06-17 2022-10-12 ダニスコ・ユーエス・インク プロテアーゼ変異体およびその使用
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP3559227B1 (de) 2016-12-21 2025-02-19 Danisco US Inc. Proteasevarianten und verwendungen davon
WO2018118950A1 (en) 2016-12-21 2018-06-28 Danisco Us Inc. Bacillus gibsonii-clade serine proteases
US11298391B1 (en) * 2017-04-27 2022-04-12 Lorenol Laboratories, Inc. Topical skin health improvement compositions and administrations thereof
WO2019108599A1 (en) 2017-11-29 2019-06-06 Danisco Us Inc Subtilisin variants having improved stability
EP3799601A1 (de) 2018-06-19 2021-04-07 Danisco US Inc. Subtilisinvarianten
WO2019245704A1 (en) 2018-06-19 2019-12-26 Danisco Us Inc Subtilisin variants
US20240279627A1 (en) 2018-08-30 2024-08-22 Danisco Us Inc Compositions comprising a lipolytic enzyme variant and methods of use thereof
WO2020088393A1 (zh) * 2018-10-31 2020-05-07 青岛蔚蓝生物集团有限公司 一种生产具有蛋白酶抗性的洗涤用酶的方法
EP3887515A1 (de) 2018-11-28 2021-10-06 Danisco US Inc. Subtilisin-varianten mit verbesserter stabilität
WO2020242858A1 (en) 2019-05-24 2020-12-03 Danisco Us Inc Subtilisin variants and methods of use
CN112062828B (zh) * 2019-06-10 2022-04-29 温州医科大学 Fgf-5多肽抑制剂及其生发应用
US12285437B2 (en) 2019-10-30 2025-04-29 The Research Foundation For The State University Of New York Reversing the undesirable pH-profile of doxorubicin via activation of a disubstituted maleamic acid prodrug at tumor acidity
EP4090727A1 (de) 2020-01-13 2022-11-23 Danisco US Inc. Zusammensetzungen mit einer lipolytischen enzymvariante und verfahren zur verwendung davon
EP3872088A1 (de) * 2020-02-28 2021-09-01 Alganelle Verwendung von aprotinin als träger zum herstellen eines rekombinanten proteins, polypeptides oder peptids in algen
US20240034960A1 (en) 2020-08-27 2024-02-01 Danisco Us Inc Enzymes and enzyme compositions for cleaning
GB202019817D0 (en) * 2020-12-15 2021-01-27 Univ Oxford Innovation Ltd Ligand-binding polypeptides and uses thereof
CN113307857B (zh) * 2021-01-14 2022-11-01 艾时斌 从表皮生长因子、凝集素和Tat蛋白衍生的支架蛋白
WO2023278297A1 (en) 2021-06-30 2023-01-05 Danisco Us Inc Variant lipases and uses thereof
CN117916354A (zh) 2021-09-03 2024-04-19 丹尼斯科美国公司 用于清洁的衣物洗涤组合物
EP4448750A2 (de) 2021-12-16 2024-10-23 Danisco US Inc. Subtilisinvarianten und verwendungen davon
CA3240641A1 (en) 2021-12-16 2023-06-22 Michelle Jackson Automatic dishwashing composition comprising a protease
CN118679252A (zh) 2021-12-16 2024-09-20 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
WO2023114794A1 (en) 2021-12-16 2023-06-22 The Procter & Gamble Company Fabric and home care composition comprising a protease
WO2023114936A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
US20250163396A1 (en) 2022-03-01 2025-05-22 Danisco Us Inc. Enzymes and enzyme compositions for cleaning
WO2024050346A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. Detergent compositions and methods related thereto
EP4581138A1 (de) 2022-09-02 2025-07-09 Danisco US Inc. Subtilisinvarianten und damit in zusammenhang stehende verfahren
WO2024102698A1 (en) 2022-11-09 2024-05-16 Danisco Us Inc. Subtilisin variants and methods of use
EP4658776A1 (de) 2023-02-01 2025-12-10 Danisco US Inc. Subtilisinvarianten und verfahren zur verwendung
US20240263162A1 (en) 2023-02-01 2024-08-08 The Procter & Gamble Company Detergent compositions containing enzymes
EP4677080A1 (de) 2023-03-06 2026-01-14 Danisco US Inc. Subtilisinvarianten und verfahren zur verwendung
WO2025071996A1 (en) 2023-09-28 2025-04-03 Danisco Us Inc. Variant cutinase enzymes with improved solubility and uses thereof
WO2025085351A1 (en) 2023-10-20 2025-04-24 Danisco Us Inc. Subtilisin variants and methods of use
WO2026024921A1 (en) 2024-07-25 2026-01-29 The Procter & Gamble Company Detergent composition comprising a subtilisin variant and methods of use

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755560A (en) * 1971-06-30 1973-08-28 Dow Chemical Co Nongreasy cosmetic lotions
DE2437090A1 (de) * 1974-08-01 1976-02-19 Hoechst Ag Reinigungsmittel
JPS51125468A (en) * 1975-03-27 1976-11-01 Sanyo Chem Ind Ltd Method of preparing resins of high water absorbency
US4152416A (en) * 1976-09-17 1979-05-01 Marra Dorothea C Aerosol antiperspirant compositions delivering astringent salt with low mistiness and dustiness
US4421769A (en) * 1981-09-29 1983-12-20 The Procter & Gamble Company Skin conditioning composition
FI69503C (fi) * 1984-03-13 1986-02-10 Neste Oy Ytbelagd bergsbehaollare eller tunnel
US5411873A (en) 1984-05-29 1995-05-02 Genencor, Inc. Process for producing heterologous polypeptides
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5679543A (en) 1985-08-29 1997-10-21 Genencor International, Inc. DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
US4999186A (en) * 1986-06-27 1991-03-12 The Procter & Gamble Company Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
US4937370A (en) * 1987-06-02 1990-06-26 The Procter & Gamble Company Novel chromophores, sunscreen compositions and methods for preventing sunburn
US5322770A (en) * 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
WO1988002025A1 (en) * 1986-09-17 1988-03-24 Sri International Expression vectors for bacilli
US5087372A (en) * 1989-03-24 1992-02-11 Asahi Kasei Kogyo Kabushiki Kaisha Method for removing heavy metal ions from contaminated water and a porous membrane usable therefor
US5011681A (en) * 1989-10-11 1991-04-30 Richardson-Vicks, Inc. Facial cleansing compositions
US5073371A (en) * 1990-11-30 1991-12-17 Richardson-Vicks, Inc. Leave-on facial emulsion compositions
US5073372A (en) * 1990-11-30 1991-12-17 Richardson-Vicks, Inc. Leave-on facial emulsion compositions
US5436228A (en) * 1990-12-12 1995-07-25 Postlethwaite; Arnold E. Chemotactic wound healing peptides
US5429950A (en) 1992-03-30 1995-07-04 Genencor International, Inc. Heterologous gene expression in bacillus subtilis: fusion approach
GB9415421D0 (en) 1994-07-30 1994-09-21 Procter & Gamble Cosmetic compositions and processes for manufacture thereof
CA2206048C (en) 1994-11-28 2002-03-19 Darrell Gene Doughty Topical skin care compositions containing thickened polyol carboxylic acid esters as skin conditioning agents
WO1997034005A1 (en) 1996-03-12 1997-09-18 Genencor International, Inc. Alkaline cellulase and method of producing same
EP0991422A1 (de) * 1996-04-18 2000-04-12 The General Hospital Corporation Modulierende interaktionen des epitheliums und des mesenchyms
US5827508A (en) * 1996-09-27 1998-10-27 The Procter & Gamble Company Stable photoprotective compositions
US5976838A (en) * 1996-12-18 1999-11-02 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
AU734338B2 (en) 1996-11-22 2001-06-14 Procter & Gamble Company, The Cosmetic compositions
DE19735587B4 (de) * 1997-08-16 2012-03-22 Eberhard-Karls-Universität Tübingen Universitätsklinikum Peptid mit radioprotektiver Wirkung, dieses enthaltende kosmetische oder pharmazeutische Zusammensetzung, für dieses kodierende Nukleinsäure, Herstellungsverfahren für dieses Peptid und die Verwendung als radioprotektives Agens
US6747137B1 (en) * 1998-02-13 2004-06-08 Genome Therapeutics Corporation Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics
CA2335343A1 (en) * 1998-07-20 2000-02-03 M&E Biotech A/S Novel methods for the identification of ligand and target biomolecules
US5989528A (en) 1998-07-30 1999-11-23 The Procter & Gamble Company Sunscreen compositions
US5935556A (en) * 1998-07-30 1999-08-10 The Procter & Gamble Company Sunscreen compositions
JP3855042B2 (ja) * 1998-09-22 2006-12-06 独立行政法人産業技術総合研究所 毛髪の鑑別法
US5968485A (en) * 1998-10-16 1999-10-19 The Procter & Gamble Company UV protection compositions
US5972316A (en) * 1998-10-16 1999-10-26 The Procter & Gamble Company UV protection compositions
AU1275599A (en) 1998-10-23 2000-05-15 Procter & Gamble Company, The Skin care compositions
GB9825854D0 (en) * 1998-11-25 1999-01-20 Univ Bristol Peptide
JP3106191B1 (ja) * 1999-03-30 2000-11-06 工業技術院長 Ｆｇｆ−５の生理的機能制御ペプチド及び該ペプチドを含有する医薬組成物
US7090973B1 (en) * 1999-04-09 2006-08-15 Oscient Pharmaceuticals Corporation Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics
US20100293669A2 (en) * 1999-05-06 2010-11-18 Jingdong Liu Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
US20040031072A1 (en) * 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
US6872563B1 (en) * 1999-10-05 2005-03-29 President And Fellows Of Harvard College Compositions and methods for production of disulfide bond containing proteins in host cells
AU5056501A (en) * 2000-03-31 2001-10-08 Nobuyuki Itoh Fibroblast growth factor-like molecules and uses thereof
DK1360500T3 (da) * 2000-04-14 2010-05-25 Genencor Int Fremgangsmåde til selektiv målretning
US20110131679A2 (en) * 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
AU2001271589A1 (en) * 2000-06-30 2002-01-14 Zymogenetics Inc. Mammalian secreted proteins
US6537968B1 (en) 2000-07-24 2003-03-25 Alphamed Pharmaceuticals Corp Treatment of lupus erythematosus
BR0116138A (pt) * 2000-12-13 2003-09-23 Borean Pharma As Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c
US7214786B2 (en) * 2000-12-14 2007-05-08 Kovalic David K Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
EP1379549A2 (de) * 2001-02-07 2004-01-14 Institut Pasteur Genomsequenz des photorhabdus luminescens stamms tt01 und verwendungen
EP1592788A2 (de) * 2003-02-11 2005-11-09 Institut Pasteur Identifizierung und charakterisierung von racemasen, definition von protein-signaturen und tests für die identifizierung von d-aminosäuren und zum screenen von molekülen, die die aktivität von racemasen, insbesondere prolin-racemasen inhibieren
EP2292641B1 (de) * 2003-11-06 2017-12-06 Danisco US Inc. Expression in faserigen Pilzen von Proteasehemmern und Varianten davon
EP1692159B1 (de) * 2003-11-06 2010-09-29 Danisco US Inc. Tgf-beta1-bindende und geträgerte peptide
US7319142B1 (en) * 2004-08-31 2008-01-15 Monsanto Technology Llc Nucleotide and amino acid sequences from Xenorhabdus and uses thereof
US7772181B2 (en) * 2008-10-15 2010-08-10 Danisco Us Inc. Personal care compositions comprising modified variant Bowman Birk Protease Inhibitors
US7803902B2 (en) * 2008-10-15 2010-09-28 Danisco Us Inc. Modified variant bowman birk protease inhibitors

Also Published As

Publication number Publication date
US20050238607A1 (en) 2005-10-27
US7413877B2 (en) 2008-08-19
WO2005047511A3 (en) 2005-11-24
ATE530560T1 (de) 2011-11-15
EP1692160A2 (de) 2006-08-23
US20050202535A1 (en) 2005-09-15
WO2005046710A3 (en) 2005-11-24
US7524816B2 (en) 2009-04-28
US20050203026A1 (en) 2005-09-15
WO2005047314A3 (en) 2006-04-20
DE602004029812D1 (de) 2010-12-09
EP1680507A2 (de) 2006-07-19
DK1680507T3 (da) 2011-10-10
EP1692158A2 (de) 2006-08-23
JP4843497B2 (ja) 2011-12-21
DK1692158T3 (da) 2012-02-06
EP1680507B1 (de) 2011-06-22
US20110230405A1 (en) 2011-09-22
CA2544820A1 (en) 2005-05-26
ATE482972T1 (de) 2010-10-15
EP1692158B1 (de) 2011-10-26
ATE513917T1 (de) 2011-07-15
JP5728329B2 (ja) 2015-06-03
US20130065829A1 (en) 2013-03-14
WO2005046710A2 (en) 2005-05-26
WO2005047314A2 (en) 2005-05-26
ES2375360T3 (es) 2012-02-29
US7485618B2 (en) 2009-02-03
JP2008500805A (ja) 2008-01-17
US20080113917A1 (en) 2008-05-15
US7696173B2 (en) 2010-04-13
WO2005047511A2 (en) 2005-05-26
US20080269139A1 (en) 2008-10-30
EP1692159A2 (de) 2006-08-23
EP1692160B1 (de) 2010-10-27
US20090111160A1 (en) 2009-04-30
WO2005046709A2 (en) 2005-05-26
ATE486087T1 (de) 2010-11-15
WO2005046709A3 (en) 2005-11-24
EP1692159B1 (de) 2010-09-29
CA2544820C (en) 2014-02-18
JP2012024091A (ja) 2012-02-09

Similar Documents

Publication Publication Date Title
ATE482972T1 (de) Tgf-beta1-bindende und geträgerte peptide
YU9404A (sh) Multimerna, usmerena kontrastna sredstva na bazi peptida
CY1111225T1 (el) Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c
ATE542920T1 (de) Modifiziertes menschliches wachstumshormon
CY1105616T1 (el) ΠΕΠΤΙΔΙΑ ΑΝΑΣΤΟΛΕΙΣ ΤΟΥ TGFβ1
DE602004011770D1 (de) Fusionsproteine
DK1434791T3 (da) Specifikke bindingsmidler til human angiopoietin-2
CY1111212T1 (el) Θειικες ενωσεις ως αναστολεις της πρωτεασης σερινης ns3 του ιου της ηπατιτιδας γ
ATE424842T1 (de) Proteine der bcl-2-familie und fragmente davon, und ihre verwendung bei krebspatienten
DK1534830T3 (da) In vito-peptid-ekspressionsbibliotek
CY1112267T1 (el) Νεα πεπτιδια ως αναστολεις πρωτεασης ns3-σερινης του ιου ηπατιτιδας c
ATE382364T1 (de) Von igf-bindungsprotein stammendes peptid
NO20082345L (no) Selektive VPAC2 reseptorpeptidagonister
ATE466080T1 (de) Formulierungen und verfahren zum denaturieren von proteinen
CY1111285T1 (el) Θεραπεια αυτοανοσων ασθενειων
ATE363531T1 (de) Claudin polypeptide
ATE397016T1 (de) Von rasgap-abgeleitetes peptid zur gezielten tötung von krebszellen
ATE504602T1 (de) Für humane matriptase spezifische bindungsproteine
WO2003087138A3 (en) Methods for identifying polypeptide factors interacting with rna
HRP20050024A2 (en) Pegylated t20 polypeptide
EA200600042A1 (ru) Способы образования дисульфидных связей и гликозилирования белков и реагенты, применяемые в этих способах
DE602004015142D1 (de) Antiangiogene peptide zur behandlung oder vorbeugung von endometriose
ATE543833T1 (de) Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen
DE602004007924D1 (de) Thrombopoietinproteine mit verbesserten eigenschaften
DE602005013650D1 (de) Proteinhydrolysat zur behandlung von müdigkeit